In Vivo Fate Mapping and Expression Analysis Reveals Molecular Hallmarks of Prospectively Isolated Adult Neural Stem Cells
Open accessAbstract
Until now, limitations in the ability to enrich adult NSCs (aNSCs) have hampered meaningful analysis of these cells at the transcriptome level. Here we show via a split-Cre technology that coincident activity of the hGFAP and prominin1 promoters is a hallmark of aNSCs in vivo. Sorting of cells from the adult mouse subependymal zone (SEZ) based on their expression of GFAP and prominin1 isolates all self-renewing, multipotent stem cells at high purity. Comparison of the transcriptome of these purified aNSCs to parenchymal nonneurogenic astrocytes and other SEZ cells reveals aNSC hallmarks, including neuronal lineage priming and the importance of cilia- and Ca-dependent signaling pathways. Inducible deletion of the ciliary protein IFT88 in aNSCs validates the role of ciliary function in aNSCs. Our work reveals candidate molecular regulators for unique features of aNSCs and facilitates future selective analysis of aNSCs in other functional contexts, such as aging and injury.
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Collectively, these data indicate that the aging process may not be identical in all cell types.
“Collectively, these data indicate that the aging process may not be identical in all cell types, which is in line with our findings and with a recent transcriptome analysis of the Drosophila brain that showed a differential aging trajectory in the transcriptional profile of neurons and glial cells 59 .”
From Single-cell transcriptomic profiling of the aging mouse brain (2019) · cites this paper as [59]
The findings underline the sensitivity and power of single-cell transcriptomics to reveal differences in cell identities and changes within individual cell types under different treatments and conditions, including organismal aging.
“Our findings, in agreement with recent studies, underline the sensitivity and power of single-cell transcriptomics not only to reveal differences in cell identities, but also to reveal changes within individual cell types under different treatments and conditions 23,26,27,70 , including organismal aging 59,60 .”
From Single-cell transcriptomic profiling of the aging mouse brain (2019) · cites this paper as [59]
Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898 · see citing works
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,974 · see citing works
A Stem Cell Molecular Signature
Ivanova, N. B., Dimos, J. T., Schaniel, C., Hackney, J. A., Moore, K. A., & Lemischka, I. R. (2002) · Science · doi:10.1126/science.1073823 · Cited by 1,543 · see citing works
A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
Reynolds, B. A., Tetzlaff, W., & Weiss, S. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04565.1992 · Cited by 1,509 · see citing works
Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.004 · Cited by 1,015 · see citing works
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 990 · see citing works
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
Buffo, A., Rite, I., Tripathi, P., Lepier, A., Colak, D., Horn, A.-P., Mori, T., & Götz, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709002105 · Cited by 766 · see citing works
Self-citationLeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal
Capela, A., & Temple, S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00835-8 · Cited by 671 · see citing works
Purification of a pluripotent neural stem cell from the adult mouse brain
Rietze, R. L., Valcanis, H., Brooker, G. J. F., Thomas, T., Voss, A. K., & Bartlett, P. F. (2001) · Nature · doi:10.1038/35089085 · Cited by 665 · see citing works
Neuronal fate determinants of adult olfactory bulb neurogenesis
Hack, M., Saghatelyan, A., de Chevigny, A., Pfeifer, A., Ashery-Padan, R., Lledo, P., & Götz, M. (2005) · Nature Neuroscience · doi:10.1038/nn1479 · Cited by 648 · see citing works
Self-citationWeigmann, A., Corbeil, D., Hellwig, A., & Huttner, W. Β. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12425 · Cited by 601 · see citing works
Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
Han, Y.-G., Spassky, N., Romaguera-Ros, M., Garcia-Verdugo, J.-M., Aguilar, A., Schneider-Maunoury, S., & Alvarez-Buylla, A. (2008) · Nature Neuroscience · doi:10.1038/nn2059 · Cited by 547 · see citing works
De novo generation of neuronal cells from the adult mouse brain.
Richards, L. J., Kilpatrick, T. J., & Bartlett, P. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8591 · Cited by 544 · see citing works
Cilia and Developmental Signaling
Eggenschwiler, J. T., & Anderson, K. V. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123249 · Cited by 530 · see citing works
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
Lovatt, D., Sonnewald, U., Waagepetersen, H. S., Schousboe, A., He, W., Lin, J. H.-C., Han, X., Takano, T., Wang, S., Sim, F. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3404-07.2007 · Cited by 488 · see citing works
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Carlén, M., Meletis, K., Göritz, C., Darsalia, V., Evergren, E., Tanigaki, K., Amendola, M., Barnabé‐Heider, F., Yeung, M. S. Y., Naldini, L., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2268 · Cited by 453 · see citing works
NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells
Horsley, V., Aliprantis, A. O., Polak, L., Glimcher, L. H., & Fuchs, E. (2008) · Cell · doi:10.1016/j.cell.2007.11.047 · Cited by 424 · see citing works
Mash1 specifies neurons and oligodendrocytes in the postnatal brain
Parras, C., Galli, R., Britz, O., Soares, S., Galichet, C., Battiste, J., Johnson, J. E., Nakafuku, M., Vescovi, A., & Guillemot, F. (2004) · EMBO Journal · doi:10.1038/sj.emboj.7600447 · Cited by 404 · see citing works
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
Lim, D., Huang, Y.-C., Swigut, T., Mirick, A. L., García-Verdugo, J., Wysocka, J., Ernst, P., & Álvarez-Buylla, A. (2009) · Nature · doi:10.1038/nature07726 · Cited by 400 · see citing works
Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398 · see citing works
Self-citationIntraflagellar transport is essential for endochondral bone formation
Haycraft, C. J., Zhang, Q., Song, B., Jackson, W. S., Detloff, P. J., Serra, R. A., & Yoder, B. K. (2006) · Development · doi:10.1242/dev.02732 · Cited by 395 · see citing works
Self-citationPastrana, É., Cheng, L.-C., & Doetsch, F. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810407106 · Cited by 381 · see citing works
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling
Breunig, J. J., Sarkisian, M. R., Arellano, J. I., Morozov, Y. M., Ayoub, A. E., Sojitra, S., Wang, B., Flavell, R. A., Rakic, P., & Town, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804558105 · Cited by 344 · see citing works
The establishment of neuronal properties is controlled by Sox4 and Sox11Preprint
Bergsland, M., Werme, M., Malewicz, M., Perlmann, T., & Muhr, J. (2006) · Genes & Development · doi:10.1101/gad.403406 · Cited by 341 · see citing works
CD133 + neural stem cells in the ependyma of mammalian postnatal forebrain
Coskun, V., Wu, H., Blanchi, B., Tsao, S. W., Kim, K., Zhao, J., Biancotti, J. C., Hutnick, L. K., Krueger, R. C., Fan, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710000105 · Cited by 331 · see citing works
Gabay, L., Lowell, S., Lee, R.-B. L., & Anderson, D. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00637-8 · Cited by 326 · see citing works
Nestin-EGFP Transgenic Mice: Visualization of the Self-Renewal and Multipotency of CNS Stem Cells
Kawaguchi, A., Miyata, T., Sawamoto, K., Takashita, N., Murayama, A. Y., Akamatsu, W., Ogawa, M., Okabe, M., Tano, Y., Goldman, S. A., et al. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0925 · Cited by 307 · see citing works
Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6.
Hack, M., Sugimori, M., Lundberg, C., Nakafuku, M., & Götz, M. (2004) · Molecular and cellular neurosciences · doi:10.1016/j.mcn.2003.12.012 · Cited by 294 · see citing works
Self-citationJacquet, B. V., Salinas-Mondragon, R., Liang, H.-X., Therit, B., Buie, J. D., Dykstra, M., Campbell, K., Ostrowski, L., Brody, S., & Ghashghaei, H. T. (2009) · Development · doi:10.1242/dev.041129 · Cited by 277 · see citing works
Chitaev, N. A., & Troyanovsky, S. M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.1.193 · Cited by 241 · see citing works
Distinct Modes of Neuron Addition in Adult Mouse Neurogenesis
Ninkovic, J., Mori, T., & Götz, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2572-07.2007 · Cited by 235 · see citing works
Self-citationDNER acts as a neuron-specific Notch ligand during Bergmann glial development
Eiraku, M., Tohgo, A., Ono, K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1492 · Cited by 233 · see citing works
Platel, J., Dave, K. A., Gordon, V., Lacar, B., Rubio, M. E., & Bordey, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.009 · Cited by 225 · see citing works
Brill, M. S., Snapyan, M., Wohlfrom, H., Ninkovic, J., Jawerka, M., Mastick, G. S., Ashery‐Padan, R., Saghatelyan, A., Berninger, B., & Götz, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0700-08.2008 · Cited by 212 · see citing works
Self-citationChojnacki, A. K., Mak, G. K., & Weiss, S. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2571 · Cited by 187 · see citing works
Sun, L.-Q., Lee, D. W., Zhang, Q., Xiao, W., Raabe, E. H., Meeker, A. K., Miao, D., Huso, D. L., & Arceci, R. J. (2004) · Genes & Development · doi:10.1101/gad.1176104 · Cited by 182 · see citing works
The multi-domain protein Np95 connects DNA methylation and histone modification
Rottach, A., Frauer, C., Pichler, G., Bonapace, I. M., Spada, F., & Leonhardt, H. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1152 · Cited by 164 · see citing works
Başak, O., & Taylor, V. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05370.x · Cited by 152 · see citing works
Split-Cre Complementation Indicates Coincident Activity of Different Genes In Vivo
Hirrlinger, J., Scheller, A., Hirrlinger, P. G., Kellert, B., Tang, W., Wehr, M. C., Goebbels, S., Reichenbach, A., Sprengel, R., Rossner, M. J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004286 · Cited by 151 · see citing works
Self-citationIsolation and characterization of murine neural stem/progenitor cells based on Prominin-1 expression
Corti, S. P., Nizzardo, M., Nardini, M., Donadoni, C., Locatelli, F., Papadimitriou, D. A., Salani, S., Bo, R. D., Ghezzi, S., Strazzer, S., et al. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.021 · Cited by 125 · see citing works
Platel, J., Gordon, V., Heintz, T. G., & Bordey, A. (2008) · Glia · doi:10.1002/glia.20735 · Cited by 110 · see citing works
Pinto, L., Mader, M., Irmler, M., Gentilini, M., Santoni, F., Drechsel, D., Blum, R., Stahl, R., Bulfone, A., Malatesta, P., et al. (2008) · Molecular and cellular neurosciences · doi:10.1016/j.mcn.2008.01.012 · Cited by 105 · see citing works
Self-citationWarnecke, M., Oster, H., Revelli, J.-P., Álvarez-Bolado, G., & Gregor Eichele, C. (2005) · Genes & Development · doi:10.1101/gad.317905 · Cited by 95 · see citing works
Tao, R., Lau, C., Tse, H., et al. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00268.2008 · Cited by 87 · see citing works
Prospective isolation of late development multipotent precursors whose migration is promoted by EGFR
Ciccolini, F., Mandl, C., Hölzl‐Wenig, G., et al. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.007 · Cited by 81 · see citing works
Lim, D. A., Suárez‐Fariñas, M., Naef, F., Hacker, C. R., Menn, B., Takebayashi, H., Magnasco, M. O., Patil, N., & Álvarez-Buylla, A. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.005 · Cited by 81 · see citing works
Analysis of the Spatiotemporal Activation of Rho GTPases Using Raichu Probes
Nakamura, T., Kurokawa, K., Kiyokawa, E., et al. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)06023-x · Cited by 73 · see citing works
KCa3.1 Ca2+Activated K+ Channels Regulate Human Airway Smooth Muscle Proliferation
Shepherd, M. C., Duffy, S. M., Harris, T., et al. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0358oc · Cited by 73 · see citing works
Contributions of Ca2+ to Galectin-1-induced Exposure of Phosphatidylserine on Activated Neutrophils
Karmakar, S., Cummings, R. D., & McEver, R. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414140200 · Cited by 35 · see citing works
Expression and function of galectin-1 in adult neural stem cells
Sakaguchi, M., Imaizumi, Y., & Okano, H. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6476-5 · Cited by 30 · see citing works
Modeling and functional analysis of AEBP1, a transcriptional repressor
Lyons, P. J., Mattatall, N. R., & Ro, J. (2006) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20946 · Cited by 20 · see citing works
Nolte (2001) · doi:10.1002/1098-1136(20010101)33:1
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Batiuk, M. Y., Martirosyan, A., Wahis, J., de Vin, F., Marneffe, C., Kusserow, C., Koeppen, J., Viana, J. F., Oliveira, J. F., Voet, T., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14198-8 · Cited by 805 · see citing works
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Ximerakis, M., Lipnick, S. L., Innes, B. T., Simmons, S. K., Adiconis, X., Dionne, D., Mayweather, B. A., Nguyen, L., Niziolek, Z., Ozek, C., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0491-3 · Cited by 736 · see citing works
Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.039 · Cited by 634 · see citing works
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Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571 · see citing works
Mostafavi, S., Gaiteri, C., Sullivan, S. E., White, C. C., Tasaki, S., Xu, J., Taga, M., Klein, H.-U., Patrick, E., Komashko, V., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0154-9 · Cited by 509 · see citing works
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Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578 · see citing works
Neurogenesis in the embryonic and adult brain: same regulators, different roles
Urbán, N., & Guillemot, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00396 · Cited by 493 · see citing works
Dulken, B. W., Leeman, D. S., Boutet, S. C., Hebestreit, K., & Brunet, A. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.060 · Cited by 334 · see citing works
The neurovascular link in health and disease: molecular mechanisms and therapeutic implications
Quaegebeur, A., Lange, C., & Carmeliet, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.013 · Cited by 247 · see citing works
Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation
Obernier, K., Cebrian-Silla, A., Thomson, M., Parraguez, J. I., Anderson, R., Guinto, C., Rodas Rodriguez, J., Garcia-Verdugo, J.-M., & Alvarez-Buylla, A. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.01.003 · Cited by 250 · see citing works
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Douglass, J. D., Dorfman, M. D., Fasnacht, R., Shaffer, L. D., & Thaler, J. P. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.01.010 · Cited by 248 · see citing works
Ortega, F., Gascón, S., Masserdotti, G., Deshpande, A., Simon, C., Fischer, J., Dimou, L., Chichung Lie, D., Schroeder, T., & Berninger, B. (2013) · Nature Cell Biology · doi:10.1038/ncb2736 · Cited by 247 · see citing works
Shah, P. T., Stratton, J. A., Stykel, M. G., Abbasi, S., Sharma, S., Mayr, K. A., Koblinger, K., Whelan, P. J., & Biernaskie, J. (2018) · Cell · doi:10.1016/j.cell.2018.03.063 · Cited by 221 · see citing works
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Zywitza, V., Misios, A., Bunatyan, L., Willnow, T. E., & Rajewsky, N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.003 · Cited by 183 · see citing works
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Azim, K., Fischer, B., Hurtado‐Chong, A., Draganova, K., Cantù, C., Zemke, M., Sommer, L., Butt, A., & Raineteau, O. (2014) · Stem Cells · doi:10.1002/stem.1639 · Cited by 88 · see citing works
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- Authors
- Beckervordersandforth, R., Tripathi, P., Ninkovic, J., Bayam, E., Lepier, A., Stempfhuber, B., Kirchhoff, F., Hirrlinger, J., Haslinger, A., Lie, D. C., Beckers, J., Yoder, B., Irmler, M., & Götz, M.
- Affiliations
- Helmholtz Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
- Max Planck Institute of Experimental Medicine (DE)
- Leipzig University (DE)
- University of Alabama at Birmingham (US)
- Corresponding author
- Götz, Magdalena
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 7
- Issue
- 6
- Pages
- 744-758
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1964417952
- Cited by
- 335
- References
- 52
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 9 · 2023: 15 · 2022: 13 · 2021: 18 · 2020: 23 · 2019: 21 · 2018: 22 · 2017: 24 · 2016: 28 · 2015: 29 · 2014: 28 · 2013: 34 · 2012: 27
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 959 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Site cant be reached (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- adult neural stem cells, subventricular zone, fate mapping, glial fibrillary acidic protein, cell isolation, transcriptome, ciliary signaling, IFT88, calcium signaling, self-renewal, astrocytes
- MeSH terms
- Animals, Glial Fibrillary Acidic Protein, Humans, Mice, Inbred C57BL, Tumor Suppressor Proteins, Mice, Adult Stem Cells, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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