The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.
Open accessAbstract
The AP-1 transcription factors are considered immediate-early response genes and are thought to be involved in a wide range of transcriptional regulatory processes linked to cellular proliferation and differentiation. To study one of the key members of this family, the proto-oncogene c-jun, we have used homologous recombination-mediated gene targeting to produce mice with a c-jun null mutation. c-jun null embryos die at mid-gestation, with an average time of death of 12.5 days postcoitus. Homozygous mutant embryos are indistinguishable from wild-type littermates both grossly and histologically until the time of death. However, primary fibroblasts derived from live heterozygous and homozygous mutant embryos show greatly reduced growth rates in culture. The subnormal mitogenic response of these cells cannot be overcome by the addition of a number of purified mitogens. These studies indicate that although c-jun is not required for cellular proliferation and differentiation up to mid-gestation, it is required for survival past that stage as well as for the mitogenic response of embryonic fibroblasts in culture.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
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A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
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Cited by
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961
AP-1 in cell proliferation and survival
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Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728
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Mitogen-activated protein kinases in apoptosis regulation
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Metadata
- Authors
- Johnson, R. S., van Lingen, B., Papaioannou, V. E., & Spiegelman, B. M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1993-07-01
- Volume
- 7
- Issue
- 7b
- Pages
- 1309-1317
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W1986660515
- Cited by
- 388
- References
- 24
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Johnson, R. S., van Lingen, B., Papaioannou, V. E., & Spiegelman, B. M. (1993). A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes & Development. https://doi.org/10.1101/gad.7.7b.1309
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