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Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

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Francois, V, Solloway, M, O'Neill, J W, Emery, J, Bier, E·1994·Genes & Development

DOI 10.1101/gad.8.21.2602

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Abstract

Pattern formation in the dorsal region of the Drosophila embryo depends on the activity of a small group of zygotically acting genes. dpp, a key gene in this group, encodes a TGF-beta-like product (Dpp) that has been proposed to function as a morphogen with peak levels of Dpp-specifying amnioserosa, the dorsal-most cell type, and lower Dpp levels specifying dorsal ectoderm. The short gastrulation gene also contributes to patterning the dorsal region, but unlike the other genes involved in this process, sog activity is only required in ventral cells. Genetic evidence indicates that sog functions to antagonize dpp activity. In this report we present further phenotypic characterization of sog mutant embryos in dorsal and lateral regions and describe the cloning of the sog locus. sog is expressed in a broad lateral stripe of cells that abuts the dorsal territory of dpp-expressing cells. sog is predicted to encode a protein with an internal signal sequence and a large extracellular domain containing four repeats of a novel motif defined by the spacing of 10 cysteine residues that is distantly related to domains present in thrombospondin and procollagen. We propose that one or more of these cysteine repeats can be liberated by proteolytic cleavage of the primary Sog protein. These putative soluble Sog peptides may then diffuse into the dorsal region to antagonize the activity of Dpp, leading to the subdivision of the dorsal territory into amnioserosa and dorsal ectoderm.

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Authors: Francois, V, Solloway, M., O'Neill, J. W., Emery, J., & Bier, E.
Affiliations: University of California San Diego (US)
ORCID: Solloway, M
Bier, E
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1994-11-01
Volume: 8
Issue: 21
Pages: 2602-2616
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.8.21.2602
OpenAlex: W2172086325
Cited by: 308
References: 76
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 6 · 2016: 13 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 5
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: Alfred P. Sloan Foundation
March of Dimes Foundation
McKnight Foundation
Centre National de la Recherche Scientifique
National Institutes of Health (RO1-NS29870, NS29870)
National Institute of Neurological Disorders and Stroke (R01-NS29870-01, R01NS029870)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: short gastrulation, SOG, dorsoventral patterning, Drosophila embryo, DPP, TGF-beta, amnioserosa, dorsal ectoderm, proteolytic cleavage, gene cloning
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Drosophila, Embryo, Nonmammalian, Female, Gastrula, Gene Expression Regulation, Genes, Lethal, Heterozygote, Insect Hormones, Male, Molecular Sequence Data, Gene Expression, Polymerase Chain Reaction, Transforming Growth Factor beta, Genes, Insect, Sequence Homology, Amino Acid, Drosophila Proteins

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Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

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