TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest

Production of high-titer helper-free retroviruses by transient transfection.

Pear, W. S., Nolan, G. P., Scott, M. L., & Baltimore, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8392 · Cited by 2,267

Controlling TGF-beta signaling.

Massagué, J., & Chen, Y. (2000) · PubMed · Cited by 1,780

Controlling TGF-β signalingPreprint

Massagué, J., & Chen, Y. (2000) · Genes & Development · doi:10.1101/gad.14.6.627 · Cited by 1,589

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

Cheatham, B., Vlahos, C. J., Cheatham, L. A., Wang, L., Blenis, J., & Kahn, C. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4902-4911.1994 · Cited by 1,062

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

Lagna, G., Hata, A., Hemmati‐Brivanlou, A., & Massagué, J. (1996) · Nature · doi:10.1038/383832a0 · Cited by 905

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF‐β

Yang, X. Y., Letterio, J. J., Lechleider, R. J., Chen, L., Hayman, R., Gu, H., Roberts, A. B., & Deng, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1280 · Cited by 889

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

Zhang, Y. E., Feng, X., Wu, R.-Y., & Derynck, R. (1996) · Nature · doi:10.1038/383168a0 · Cited by 873

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

Eppert, K., Scherer, S. W., Özçelik, H., Pirone, R., Hoodless, P. A., Kim, H., Tsui, L.-C., Bapat, B. V., Gallinger, S., Andrulis, I. L., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80128-2 · Cited by 845

Phosphorylation and Activation of p70 s6k by PDK1

Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G. (1998) · Science · doi:10.1126/science.279.5351.707 · Cited by 826

Regulation of protein kinase cascades by protein phosphatase 2A

Millward, T. A., Zołnierowicz, S., & Hemmings, B. A. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01375-4 · Cited by 793

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860

Smad-dependent and Smad-independent pathways in TGF-β family signalling

Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,498

TGF-β Signaling in Tumor Suppression and Cancer Progression

Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275

Non-Smad pathways in TGF-β signaling

Zhang, Y. E. (2008) · Cell Research · doi:10.1038/cr.2008.328 · Cited by 1,834

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,626

TGFβ: the molecular Jekyll and Hyde of cancer

Bierie, B., & Moses, H. L. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1926 · Cited by 1,291

Non-Smad TGF-β signals

Moustakas, A., & Heldin, C.-H. (2005) · Journal of Cell Science · doi:10.1242/jcs.02554 · Cited by 958

TGF-β Signaling from Receptors to SmadsPreprint

Hata, A., & Chen, Y. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022061 · Cited by 929

TGF-β signaling: positive and negative effects on tumorigenesis

Wakefield, L. M. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00259-3 · Cited by 827

Signaling Receptors for TGF-β Family Members

Heldin, C.-H., & Moustakas, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022053 · Cited by 711

Role of Transforming Growth Factor Beta in Human Cancer

Elliott, R. L., & Blobe, G. C. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.047 · Cited by 717

Mechanisms of TGF-β signaling in regulation of cell growth and differentiation

Moustakas, A., Pardali, K., Gaál, A., & Heldin, C. (2002) · Immunology Letters · doi:10.1016/s0165-2478(02)00023-8 · Cited by 541

Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer

Pardali, K., & Moustakas, A. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.06.004 · Cited by 549

TGF-β Family Signaling in Tumor Suppression and Cancer ProgressionPreprint

Seoane, J., & Gomis, R. R. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022277 · Cited by 528

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

Liu, R.-M., & Pravia, K. A. G. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.026 · Cited by 473

TGF-β receptors: In and beyond TGF-β signaling

Ark, A. V., Cao, J., & Li, X. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.09.002 · Cited by 481

The transforming growth factor-β superfamily of receptors

de Caestecker, M. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.004 · Cited by 464

A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets

Arsham, A. M., Howell, J. J., & Simon, M. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212770200 · Cited by 463

Regulation of cell proliferation by Smad proteins

ten Dijke, P., Goumans, M., Itoh, F., & Itoh, S. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10066 · Cited by 453

Dysregulation of growth factor signaling in human hepatocellular carcinoma

Breuhahn, K., Longerich, T., & Schirmacher, P. (2006) · Oncogene · doi:10.1038/sj.onc.1209556 · Cited by 394

N-Glycans in cancer progression

Lau, K. S., & Dennis, J. W. (2008) · Glycobiology · doi:10.1093/glycob/cwn071 · Cited by 390

TGF‐β signaling: A tale of two responses

Rahimi, R. A., & Leof, E. B. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21501 · Cited by 371

Phospho-control of TGF-β superfamily signaling

Wrighton, K. H., Lin, X., & Feng, X. (2008) · Cell Research · doi:10.1038/cr.2008.327 · Cited by 366

Functions and regulation of the 70 kDa ribosomal S6 kinases

Fenton, T. R., & Gout, I. T. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.09.018 · Cited by 350

New regulatory mechanisms of TGF-β receptor function

Kang, J. S., Liu, C., & Derynck, R. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.05.008 · Cited by 335

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

An, W.-L., Cowburn, R. F., Li, L., Braak, H., Alafuzoff, I., Iqbal, K., Iqbal, I.-G., Winblad, B., & Pei, J.-J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63687-5 · Cited by 312

Transforming Growth Factor β-Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

Daly, A. C., Randall, R. A., & Hill, C. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01192-08 · Cited by 280

Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s)

Foster, D. A., Yellen, P., Xu, L., & Saqcena, M. (2010) · Genes & Cancer · doi:10.1177/1947601910392989 · Cited by 279

TGFβ pathobiology in the eye

Saika, S. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700375 · Cited by 276

Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers

Sierra-Filardi, E., Puig-Kröger, A., Blanco, F. J., Nieto, C., Bragado, R., Palomero, M. I., Bernabéu, C., Vega, M. A., & Corbí, A. L. (2011) · Blood · doi:10.1182/blood-2010-09-306993 · Cited by 268

Micropeptide CIP2A-BP encoded by LINC00665 inhibits triple-negative breast cancer progression

Guo, B., Wu, S., Zhu, X., Zhang, L., Deng, J., Li, F., Wang, Y., Zhang, S., Wu, R., Lu, J., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019102190 · Cited by 243

The S6K protein family in health and disease

Tavares, M. R., Pavan, I. C. B., do Amaral, C. L., Meneguello, L., Luchessi, A. D., & Simabuco, F. M. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.03.001 · Cited by 252

The Stress-activated Protein Kinases p38α and JNK1 Stabilize p21Cip1 by Phosphorylation

Kim, G.-Y., Mercer, S. E., Ewton, D. Z., Yan, Z., Jin, K., & Friedman, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201299200 · Cited by 231

TGF‐β control of cell proliferation

Huang, S. S., & Huang, J. S. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20558 · Cited by 221

Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses

Itoh, S., Thorikay, M., Kowanetz, M., Moustakas, A., Itoh, F., Heldin, C., & ten Dijke, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208258200 · Cited by 211

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

Yu, S., Shen, G., Khor, T. O., Kim, J. H., & Kong, A. T. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2400 · Cited by 192

A Novel Mechanism for Regulating Transforming Growth Factor β (TGF-β) Signaling

Blobe, G. C., Liu, X., Fang, S. J., How, T., & Lodish, H. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106831200 · Cited by 187

Role of p38 MAP Kinase in Regulation of Cell Migration and Proliferation in Healing Corneal Epithelium

Saika, S., Okada, Y., Miyamoto, T., Yamanaka, O., Ohnishi, Y., Ooshima, A., Liu, C., Weng, D. Y., & Kao, W. W. ‐. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0700 · Cited by 177

TGF-β and the Smad signal transduction pathway

Mehra, A., & Wrana, J. L. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-161 · Cited by 174

Cellular growth inhibition by IGFBP‐3 and TGF‐β 1 requires LRP‐1

Huang, S. S., Ling, T., Tseng, W.-F., Huang, Y.-H., Tang, F.-M., Leal, S. M., & Huang, J. S. (2003) · The FASEB Journal · doi:10.1096/fj.03-0256com · Cited by 161

Escaping from the TGF anti-proliferative control

Seoane, J. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl068 · Cited by 151

Smad3 Is Essential for TGF-β1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation

McKarns, S. C., Schwartz, R. H., & Kaminski, N. E. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4275 · Cited by 141

Regulated Phosphorylation of 40S Ribosomal Protein S6 in Root Tips of Maize

Williams, A. J., Werner-Fraczek, J., Chang, I., & Bailey-Serres, J. N. (2003) · PLANT PHYSIOLOGY · doi:10.1104/pp.103.022749 · Cited by 127

Activation of the p70 S6 Kinase and Phosphorylation of the 4E-BP1 Repressor of mRNA Translation by Type I Interferons

Lekmine, F., Shahab Uddin, M. S., Sassano, A., Parmar, S., Brachmann, S. M., Majchrzak, B., Sonenberg, N., Hay, N., Fish, E. N., & Platanias, L. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301364200 · Cited by 125

P70 S6 kinase mediates tau phosphorylation and synthesis

Pei, J.-J., An, W., Zhou, X., Nishimura, T., Norberg, J., Benedikz, E., Götz, J., & Winblad, B. G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.11.059 · Cited by 121

Functions and regulation of transforming growth factor-beta (TGF-β) in the prostate

Danielpour, D. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2004.12.027 · Cited by 115

Akt Controls Vascular Smooth Muscle Cell Proliferation In Vitro and In Vivo by Delaying G1/S Exit

Stabile, E., Zhou, Y. F., Saji, M., Castagna, M. T., Shou, M., Kinnaird, T. D., Baffour, R., Ringel, M. D., Epstein, S. E., & Fuchs, S. (2003) · Circulation Research · doi:10.1161/01.res.0000105086.31909.1b · Cited by 111

TGF-β Signal Transduction in Corneal Wound Healing as a Therapeutic Target

Saika, S. (2004) · Cornea · doi:10.1097/01.ico.0000136668.41000.73 · Cited by 110

Transforming Growth Factor β1 Induces Apoptosis through Cleavage of BAD in a Smad3-Dependent Mechanism in FaO Hepatoma Cells

Kim, B.-C., Mamura, M., Choi, K. S., Calabretta, B., & Kim, S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.5.1369-1378.2002 · Cited by 107

TGF-beta in neural stem cells and in tumors of the central nervous system

Aigner, L., & Bogdahn, U. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0466-7 · Cited by 103

Prognostic Significance of Transforming Growth Factor β Receptor II in Estrogen Receptor-Negative Breast Cancer Patients

Buck, M. B., Fritz, P., Dippon, J., Zugmaier, G., & Knabbe, C. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0320-03 · Cited by 100

Insulin-like Growth Factor-I Inhibits Transcriptional Responses of Transforming Growth Factor-β by Phosphatidylinositol 3-Kinase/Akt-dependent Suppression of the Activation of Smad3 but Not Smad2

Song, K. W., Cornelius, S. C., Reiß, M., & Danielpour, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304583200 · Cited by 98

Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer

Sridharan, S., & Basu, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041199 · Cited by 95

Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification

Meeusen, B., & Janssens, V. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.10.002 · Cited by 96

TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease

Kim, S. I., & Choi, M. E. (2012) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2012.04.322 · Cited by 96

p70 Ribosomal protein S6 kinase ( Rps6kb1 ): an update

Bahrami-B, F., Ataie-Kachoie, P., Pourgholami, M. H., & Morris, D. L. (2014) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2014-202560 · Cited by 101

Suppressor and oncogenic roles of transforming growth factor-β and its signaling pathways in tumorigenesis

Piek, E., & Roberts, A. B. (2001) · Advances in cancer research · doi:10.1016/s0065-230x(01)83001-3 · Cited by 94

PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer

(2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2019.03.009 · Cited by 93

Regulation of TGF-β signalling by protein phosphatases

Liu, T., & Feng, X. (2010) · Biochemical Journal · doi:10.1042/bj20100427 · Cited by 93

Beyond controlling cell size: functional analyses of S6K in tumorigenesis

Wu, X., Xie, W., Xie, W., Wei, W., & Guo, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05081-4 · Cited by 96

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling

Nyati, S., Schinske, K. A., Pitchiaya, S., Chekhovskiy, K., Chator, A., Chaudhry, N., Dosch, J. S., Dort, M. E. V., Varambally, S., Kumar‐Sinha, C., et al. (2015) · Science Signaling · doi:10.1126/scisignal.2005379 · Cited by 90

Protein Kinase C-mediated Down-regulation of Cyclin D1 Involves Activation of the Translational Repressor 4E-BP1 via a Phosphoinositide 3-Kinase/Akt-independent, Protein Phosphatase 2A-dependent Mechanism in Intestinal Epithelial Cells

Guan, L., Song, K. W., Pysz, M. A., Curry, K., Hizli, A. A., Danielpour, D., Black, A. R., & Black, J. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610513200 · Cited by 80

Two highly related regulatory subunits of PP2A exert opposite effects on TGF-β/Activin/Nodal signalling

Batut, J., Schmierer, B., Cao, J., Raftery, L. A., Hill, C. S., & Howell, M. T. (2008) · Development · doi:10.1242/dev.020842 · Cited by 84

TGF‐β signaling in human skeletal and patterning disorders

Serra, R. A., & Chang, C. (2003) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.10023 · Cited by 80

TGF-β signaling in cancer

Gu, S., & Feng, X. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy092 · Cited by 80

Small heat shock proteins Hsp27 or αB‐crystallin and the protein components of neurofibrillary tangles: Tau and neurofilaments

Björkdahl, C., Sjögren, M. J. C., Zhou, X., Concha, H., Ávila, J., Winblad, B. G., & Pei, J.-J. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21589 · Cited by 78

p70 S6 Kinase and Tau in Alzheimer's Disease

Pei, J.-J., Björkdahl, C., Zhang, H., Zhou, X., & Winblad, B. G. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14405 · Cited by 75

CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells

Qi, C., Mårtensson, A., Mattioli, M., Dalla‐Favera, R., Lobanenkov, V. V., & Morse, H. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237127100 · Cited by 73

Mechanisms in Epithelial Plasticity and Metastasis: Insights from 3D Cultures and Expression Profiling

Jechlinger, M., Grünert, S., & Beug, H. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1024090116451 · Cited by 78

The role of transforming growth factor-beta in primary brain tumors

Rich, J. N. (2003) · Frontiers in bioscience · doi:10.2741/992 · Cited by 74

Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice

Francois, A., Terro, F., Quellard, N., Fernandez, B., Chassaing, D., Janet, T., Bilan, A. R., Paccalin, M., & Page, G. (2014) · Molecular Brain · doi:10.1186/s13041-014-0056-z · Cited by 62

Protein Kinase C Phosphorylates Ribosomal Protein S6 Kinase βII and Regulates Its Subcellular Localization

Valovka, T., Verdier, F., Cramer, R., Zhyvoloup, A., Fenton, T. R., Rebholz, H., Wang, M., Gzhegotsky, M. R., Lutsyk, A. D., Matsuka, G. K., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.852-863.2003 · Cited by 70

Epithelial-Mesenchymal Transition Stimulates Human Cancer Cells to Extend Microtubule-based Invasive Protrusions and Suppresses Cell Growth in Collagen Gel

Oyanagi, J., Ogawa, T., Sato, H., Higashi, S., & Miyazaki, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053209 · Cited by 71

Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells

Saika, S., Yamanaka, O., Ikeda, K., Kim‐Mitsuyama, S., Flanders, K. C., Yoo, J., Roberts, A. B., Ishida, I., Ohnishi, Y., Muragaki, Y., et al. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700294 · Cited by 67

TGFB1/INHBA Homodimer/Nodal-SMAD2/3 Signaling Network: A Pivotal Molecular Target in PDAC Treatment

Mouti, M. A., & Pauklin, S. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.01.002 · Cited by 70

Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-β and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells

Cao, Z., Flanders, K. C., Bertolette, D. C., Lyakh, L. A., Würthner, J., Parks, W. T., Letterio, J. J., Ruscetti, F. W., & Roberts, A. B. (2002) · Blood · doi:10.1182/blood-2002-05-1549 · Cited by 66

Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.

Peng, B., Fleming, J. B., Breslin, T. M., Grau, A. M., Fojioka, S., Abbruzzese, J. L., Evans, D. B., Ayers, D., Wathen, K., Wu, T., et al. (2002) · PubMed · Cited by 66

The Role of TGF-β Signaling Pathways in Cancer and Its Potential as a Therapeutic Target

Yang, Y., Ye, W.-L., Zhang, R., He, X., Wang, J., Liu, Y., Wang, Y., Yang, X., Zhang, Y., & Gan, W.-J. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6675208 · Cited by 66

TGFβ Signal Transduction

Silvestri, C., Bose, R., Attisano, L., & Wrana, J. L. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00070-x · Cited by 64

A Vitamin D Receptor-Ser/Thr Phosphatase-p70 S6 Kinase Complex and Modulation of Its Enzymatic Activities by the Ligand

Bettoun, D. J., Buck, D. W., Lu, J., Khalifa, B., Chin, W. W., & Nagpal, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200187200 · Cited by 63

Smad3 in the mammary epithelium has a nonredundant role in the induction of apoptosis, but not in the regulation of proliferation or differentiation by transforming growth factor-beta.

Yang, Y.-A., Tang, B., Robinson, G. W., Hennighausen, L. G., Brodie, S. G., Deng, C., & Wakefield, L. M. (2002) · PubMed · Cited by 63

Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner

Jackson, J. B., & Pallas, D. C. (2012) · Neoplasia · doi:10.1593/neo.12768 · Cited by 60

Smad inhibition by the Ste20 kinase Misshapen

Kaneko, S., Chen, X., Lu, P., Yao, X., Wright, T. G., Rajurkar, M., Kariya, K., Mao, J., Ip, Y. T., & Xu, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104128108 · Cited by 60

TGF-β S ignal T ransduction in O ro - facial H ealth and N on - malignant D isease (P art I)

Prime, S. S., Pring, M., Davies, M., & Paterson, I. C. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500602 · Cited by 61

LRP‐1/TβR‐V mediates TGF‐β1‐induced growth inhibition in CHO cells

Tseng, W.-F., Huang, S. S., & Huang, J. S. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00185-1 · Cited by 59

Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFβ-induced fibronectin expression in mesangial cells

Choudhury, G. G., & Abboud, H. E. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(03)00094-9 · Cited by 58

The Tumor Suppressor KLF11 Mediates a Novel Mechanism in Transforming Growth Factor β–Induced Growth Inhibition That Is Inactivated in Pancreatic Cancer

Buck, A., Buchholz, M., Wagner, M., Adler, G., Gress, T. M., & Ellenrieder, V. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0081 · Cited by 58

Mysteries of TGF-β Paradox in Benign and Malignant Cells

Zhang, Q., Yu, N., & Lee, C. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00094 · Cited by 57

Protein Phosphatase 2A Is a Negative Regulator of Transforming Growth Factor-β1-induced TAK1 Activation in Mesangial Cells

Kim, S. I., Kwak, J. H., Wang, L. Q., & Choi, M. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801263200 · Cited by 52

Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain Adult Heart Homeostasis

Umbarkar, P., Singh, A. P., Gupte, M., Verma, V. K., Galindo, C. L., Guo, Y., Zhang, Q., McNamara, J. W., Force, T. L., & Lal, H. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.10.003 · Cited by 53

PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1

Bengtsson, L., Schwappacher, R., Roth, M., Boergermann, J. H., Haßel, S., & Knaus, P. I. (2009) · Journal of Cell Science · doi:10.1242/jcs.039552 · Cited by 52

Regulation of TGF-?1-Induced Pro-Apoptotic Signaling by Growth Factor Receptors and Extracellular Matrix Receptor Integrins in the Liver

Ozaki, I., Hamajima, H., Matsuhashi, S., & Mizuta, T. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00078 · Cited by 52

Phosphorylation of eEF1A1 at Ser300 by TβR-I results in inhibition of mRNA translation.

Lin, K., Yakymovych, I., Jia, M., Yakymovych, M., & Souchelnytskyi, S. (2010) · Current Biology · doi:10.1016/j.cub.2010.08.017 · Cited by 59

Troglitazone acutely inhibits protein synthesis in endothelial cells via a novel mechanism involving protein phosphatase 2A-dependent p70 S6 kinase inhibition

Cho, D., Choi, Y. J., Jo, S. A., Ryou, J., Kim, J. Y., Chung, J., & Jo, I. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00491.2005 · Cited by 49

The rasGAP‐binding protein, Dok‐1, mediates activin signaling via serine/threonine kinase receptors

Yamakawa, N., Tsuchida, K., & Sugino, H. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1684 · Cited by 49

Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

Lee, M., Wan, J., & Goldman, D. J. (2020) · eLife · doi:10.7554/elife.55137 · Cited by 47

Pro‐metastasis function of TGFβ mediated by the smad pathway

Kang, Y. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20928 · Cited by 49

Biphasic role of TGF‐β1 in signal transduction and crosstalk

Wenner, C. E., & Yan, S. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10243 · Cited by 48

Smad3 Protein Levels Are Modulated by Ras Activity and during the Cell Cycle to Dictate Transforming Growth Factor-β Responses

Daly, A. C., Vizán, P., & Hill, C. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.043877 · Cited by 48

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors

Parathath, S. R., Mainwaring, L. A., Fernández-L, A., Campbell, D. O., & Kenney, A. M. (2008) · Development · doi:10.1242/dev.022871 · Cited by 48

Non-malignant and Tumor-derived Cells Differ in Their Requirement for p27Kip1 in Transforming Growth Factor-β-mediated G1 Arrest

Donovan, J. C. H., Rothenstein, J. M., & Slingerland, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204307200 · Cited by 19

TGFβ prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest

Lecanda, J., Ganapathy, V., D’Aquino-Ardalan, C., Evans, B. R., Cadacio, C., Ayala, A., & Gold, L. I. (2009) · Cell Cycle · doi:10.4161/cc.8.5.7871 · Cited by 51

Altered p27Kip1 Phosphorylation, Localization, and Function in Human Epithelial Cells Resistant to Transforming Growth Factor β-Mediated G1 Arrest

Ciarallo, S., Subramaniam, V., Hung, W., Lee, J. H., Kotchetkov, R., Sandhu, C., Milic, A., & Slingerland, J. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.9.2993-3002.2002 · Cited by 62

Mechanisms of TGF-β-Induced Cell Cycle Arrest

Hocevar, B. A., & Howe, P. H. (1998) · Mineral and Electrolyte Metabolism · doi:10.1159/000057360 · Cited by 55

TGF-beta 1 induces the cyclin-dependent kinase inhibitor p27Kip1 mRNA and protein in murine B cells.

Kamesaki, H., Nishizawa, K., Michaud, G. Y., Cossman, J., & Kiyono, T. (1998) · PubMed · Cited by 67