The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
A multistep damage recognition mechanism for global genomic nucleotide excision repair
Open accessAbstract
A mammalian nucleotide excision repair (NER) factor, the XPC–HR23B complex, can specifically bind to certain DNA lesions and initiate the cell-free repair reaction. Here we describe a detailed analysis of its binding specificity using various DNA substrates, each containing a single defined lesion. A highly sensitive gel mobility shift assay revealed that XPC–HR23B specifically binds a small bubble structure with or without damaged bases, whereas dual incision takes place only when damage is present in the bubble. This is evidence that damage recognition for NER is accomplished through at least two steps; XPC–HR23B first binds to a site that has a DNA helix distortion, and then the presence of injured bases is verified prior to dual incision. Cyclobutane pyrimidine dimers (CPDs) were hardly recognized by XPC–HR23B, suggesting that additional factors may be required for CPD recognition. Although the presence of mismatched bases opposite a CPD potentiated XPC–HR23B binding, probably due to enhancement of the helix distortion, cell-free excision of such compound lesions was much more efficient than expected from the observed affinity for XPC–HR23B. This also suggests that additional factors and steps are required for the recognition of some types of lesions. A multistep mechanism of this sort may provide a molecular basis for ensuring the high level of damage discrimination that is required for global genomic NER.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“hHR23B-XPC complex or only XPC exhibits a similar high affinity for both UV-induced single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) [230, 259], preferentially binds to DNA with various lesions [259] and even to small bubble structures with or without a lesion [260].”
From Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair (2010) · cites this paper as [260]
In the citing paper
“whereas 6-4PP lesions are directly recognized by XPC independent of DDB [5–8].”
From ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle (2016) · cites this paper as [7]
In the citing paper
“The DDB complex initially recognizes the CPD lesions and helps in recruiting XPC”
From ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle (2016) · cites this paper as [7]
In the citing paper
“In turn, XPC helps in recruiting XPA, XPG, and TFIIH components that enable opening of the DNA helix around the damage site to form a bubble [8].”
From NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites (2013) · cites this paper as [8]
In the citing paper
“The DDB complex initially recognizes the CPD lesions and recruits XPC [4, 5, 8, 9], whereas XPC can independently recognize 6-4PP lesions [5].”
From NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites (2013) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
3 retracted
Cooper, P. K., Nouspikel, T. P., Clarkson, S. G., & Leadon, S. A. (1997) · Science · doi:10.1126/science.275.5302.990 · Cited by 306
RetractedRETRACTED: Transcription-Coupled Repair of 8-oxoGuanine
Page, F. L., Kwoh, E. E., Avrutskaya, A. V., Gentil, A., Leadon, S. A., Sarasin, A. R., & Cooper, P. K. (2000) · Cell · doi:10.1016/s0092-8674(00)80827-2 · Cited by 280
RetractedPage, F. L., Kwoh, E. E., Avrutskaya, A. V., Gentil, A., Leadon, S. A., Sarasin, A. R., & Cooper, P. K. (2005) · Cell · doi:10.1016/j.cell.2005.11.005 · Cited by 271
RetractedThe Metabolic Basis of Inherited Disease.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-503_7 · Cited by 7,807
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Bohr, V (1985) · Cell · doi:10.1016/0092-8674(85)90150-3 · Cited by 1,237 · cited 1×
“In contrast, TCR specifically removes lesions that block RNA polymerases on the transcribed strands of active genes (Bohr et al. 1985; Mellon et al. 1987).”
BackgroundMELLON, I. (1987) · Cell · doi:10.1016/0092-8674(87)90151-6 · Cited by 1,228
Sugasawa, K., Ng, J. M. Y., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P. M., Hanaoka, F., Bootsma, D., & Hoeijmakers, J. H. J. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80132-x · Cited by 899
Self-citationDNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor
Schaeffer, L., Roy, R., Humbert, S., Moncollin, V., Vermeulen, W., Hoeijmakers, J. H. J., Chambon, P., & Egly, J. (1993) · Science · doi:10.1126/science.8465201 · Cited by 794
THE BIOLOGY OF THE (6–4) PHOTOPRODUCT
MITCHELL, D. L., & NAIRN, R. S. (1989) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1989.tb05578.x · Cited by 592
Flagged first, then by citations
Research works printed but not linked: 1
- Naegeli H. (1999) Enzymology of human nucleotide excision repair. in DNA recombination and repair, eds Smith P. Jones C. (Oxford University Press, Oxford, UK), pp 99–137.
Cited by
Sorted by citations
Items 201–300 of 433
PostExcision Events in Human Nucleotide Excision Repair
Kemp, M. G., & Hu, J. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12641 · Cited by 30
Mechanism of action of nucleotide excision repair machinery
D'Souza, A., Blee, A. M., & Chazin, W. (2022) · Biochemical Society Transactions · doi:10.1042/bst20210246 · Cited by 36
Wiebalk, K., Schmezer, P., Kropp, S., Chang-Claude, J. C., Celebi, O., Debus, J., Bartsch, H., & Popanda, O. (2007) · International Journal of Cancer · doi:10.1002/ijc.22981 · Cited by 31
Maltseva, E. A., Rechkunova, N. I., Gillet, L. C. J., Petruseva, I. O., Schärer, O. D., & Lavrik, O. I. (2007) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.01.007 · Cited by 32
Molecular mechanisms of xeroderma pigmentosum (XP) proteins
Koch, S. C., Simon, N., Ebert, C., & Carell, T. (2016) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583515000268 · Cited by 33
Nucleotide Excision Repair and Vitamin D—Relevance for Skin Cancer Therapy
Pawłowska, E., Wysokiński, D., & Błasiak, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040372 · Cited by 31
Ubiquitin at work: The ubiquitous regulation of the damage recognition step of NER
van Cuijk, L., Vermeulen, W., & Marteijn, J. A. F. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.07.018 · Cited by 32
DNA substrate preparation for atomic force microscopy studies of protein–DNA interactions
Buechner, C. N., & Teßmer, I. (2013) · Journal of Molecular Recognition · doi:10.1002/jmr.2311 · Cited by 30
TFIIH central activity in nucleotide excision repair to prevent disease
Theil, A. F., Häckes, D., & Lans, H. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103568 · Cited by 30
Muster, B., Rapp, A. W., & Cardoso, M. C. (2017) · Global Medical Genetics · doi:10.3934/genet.2017.1.47 · Cited by 29
Sakai, W., Yuasa‐Sunagawa, M., Kusakabe, M., Kishimoto, A., Matsui, T., Kaneko, Y., Akagi, J., Huyghe, N. D., Ikura, M., Ikura, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76898-2 · Cited by 30
Self-citationTranscription past DNA adducts derived from polycyclic aromatic hydrocarbons
Scicchitano, D. A. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.03.015 · Cited by 29
Timing of DNA lesion recognition: Ubiquitin signaling in the NER pathway
Chitale, S., & Richly, H. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1261227 · Cited by 32
Nucleotide Excision Repair: Finely Tuned Molecular Orchestra of Early Pre‐incision Events
Zhu, Q., & Wani, A. A. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12647 · Cited by 31
XPC: Its Product and Biological Roles
Sugasawa, K. (2008) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-09599-8_6 · Cited by 36
Self-citationGonzalo-Hansen, C., Steurer, B., Janssens, R. C., Zhou, D., van Sluis, M., Lans, H., & Marteijn, J. A. F. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae618 · Cited by 28
Kakumu, E., Nakanishi, S., Shiratori, H., Kato, A., Kobayashi, W., Machida, S., Yasuda, T., Adachi, N., Saito, N., Ikura, T., et al. (2017) · Genes to Cells · doi:10.1111/gtc.12479 · Cited by 29
Self-citationNeher, T. M., Rechkunova, N. I., Lavrik, O. I., & Turchi, J. J. (2009) · Biochemistry · doi:10.1021/bi901575h · Cited by 27
Simulating Structural and Thermodynamic Properties of Carcinogen-Damaged DNA
Yan, S. F., Wu, M., Patel, D. J., Geacintov, N. E., & Broyde, S. B. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)75020-6 · Cited by 27
Yu, J., Yan, C., Dodd, T., Tsai, C.-L., Tainer, J. A., Tsutakawa, S. E., & Ivanov, I. N. (2023) · Nature Communications · doi:10.1038/s41467-023-38416-6 · Cited by 33
Guillermo-Lagae, R., Deep, G., Ting, H., Agarwal, C., & Agarwal, R. (2015) · Oncotarget · doi:10.18632/oncotarget.5519 · Cited by 26
Rüthemann, P., Pogliano, C. B., Codilupi, T., Garajovà, Z., & Naegeli, H. (2017) · The EMBO Journal · doi:10.15252/embj.201695742 · Cited by 27
Ensuring the Stability of the Genome: DNA Damage Checkpoints
Latif, C., Harvey, S. H., & O'Connell, S. J. (2001) · The Scientific World JOURNAL · doi:10.1100/tsw.2001.297 · Cited by 26
Mu, H., Geacintov, N. E., Zhang, Y., & Broyde, S. B. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00840 · Cited by 25
Chakraborty, S., Steinbach, P. J., Paul, D., Mu, H., Broyde, S. B., Min, J., & Ansari, A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1216 · Cited by 26
Horikoshi, N., Tachiwana, H., Kagawa, W., Osakabe, A., Matsumoto, S., Iwai, S., Sugasawa, K., & Kurumizaka, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.01.170 · Cited by 24
Self-citationTranscription-coupled repair and the transcriptional response to UV-Irradiation
Gaul, L., & Svejstrup, J. Q. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103208 · Cited by 22
Song, Q., Cannistraro, V. J., & Taylor, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.183178 · Cited by 25
Alkyltransferase-like proteins: molecular switches between DNA repair pathways
Tubbs, J. L., & Tainer, J. A. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0405-8 · Cited by 24
Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers
Rüthemann, P., Pogliano, C. B., & Naegeli, H. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00068 · Cited by 28
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair
Shah, P., Zhao, B., Qiang, L., & He, Y. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky239 · Cited by 24
Xeroderma Pigmentosum: A Glimpse into Nucleotide Excision Repair, Genetic Instability, and Cancer
Dworaczek, H., & Xiao, W. (2007) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v13.i2.20 · Cited by 26
Maddukuri, L., Dudzińska, D., & Tudek, B. (2007) · Acta Biochimica Polonica · doi:10.18388/abp.2007_3222 · Cited by 24
Yu, J., Yan, C., Paul, T., Brewer, L. R., Tsutakawa, S. E., Tsai, C.-L., Hamdan, S. M., Tainer, J. A., & Ivanov, I. N. (2024) · Nature Communications · doi:10.1038/s41467-024-52860-y · Cited by 22
Shafirovich, V., Kolbanovskiy, M., Kropachev, K. Y., Liu, Z., Cai, Y., Terzidis, M. A., Masi, A., Chatgilialoglu, C., Amin, S., Dadali, A., et al. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b01066 · Cited by 23
Base-pair Opening Dynamics of Nucleic Acids in Relation to Their Biological Function
Choi, S., Kim, N., Jin, H.-S., Seo, Y., Lee, J., & Lee, J.-H. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.06.008 · Cited by 23
Roche, Y., Zhang, D., Segers-Nolten, G. M. J., Vermeulen, W., Wyman, C., Sugasawa, K., Hoeijmakers, J. H. J., & Otto, C. (2008) · Journal of Fluorescence · doi:10.1007/s10895-008-0390-6 · Cited by 25
Self-citationBatra, V. K., Shock, D. D., Prasad, R., Beard, W. A., Hou, E. W., Pedersen, L. C., Sayer, J. M., Yagi, H., Kumar, S., Jerina, D. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605069103 · Cited by 23
Research on Plants for the Understanding of Diseases of Nuclear and Mitochondrial Origin
Spampinato, C. P., & Gomez‐Casati, D. F. (2012) · BioMed Research International · doi:10.1155/2012/836196 · Cited by 22
Multiple roles of ubiquitination in the control of nucleotide excision repair
Nouspikel, T. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.03.003 · Cited by 26
Analysis of nucleotide excision repair by detection of single-stranded DNA transients
Rubbi, C. P., & Milner, J. (2001) · Carcinogenesis · doi:10.1093/carcin/22.11.1789 · Cited by 21
Shivji, M. K. K., Moggs, J. G., Kuraoka, I., & Wood, R. D. (2008) · Methods in molecular biology · doi:10.1385/1-59259-973-7:435 · Cited by 22
CPD-photolyase adenovirus-mediated gene transfer in normal and DNA-repair-deficient human cells
Chiganças, V., Sarasin, A. R., & Menck, C. F. M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01241 · Cited by 21
Itoh, T. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.10.010 · Cited by 25
Fousteri, M. I., & Lehmann, A. R. (2003) · CRC Press eBooks · doi:10.1201/9780203911709.ch17 · Cited by 21
Nishimoto, K., Niida, H., Uchida, C., Ohhata, T., Kitagawa, K., Motegi, A., Suda, T., & Kitagawa, M. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0214 · Cited by 21
Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair
Fu, I., Mu, H., Geacintov, N. E., & Broyde, S. B. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac496 · Cited by 20
Sarmini, L., Meabed, M., Emmanouil, E., Atsaves, G., Robeska, E., Karwowski, B. T., Campalans, A., Gimisis, T., & Khobta, A. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad256 · Cited by 20
Menzies, G. E., Reed, S. H., Brancale, A., & Lewis, P. D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv910 · Cited by 20
Kathuria, P., Sharma, P., & Wetmore, S. D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv701 · Cited by 20
Scanning the DNA for damage by the nucleotide excision repair machinery
Goosen, N. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.02.015 · Cited by 21
The HhH domain of the human DNA repair protein XPF forms stable homodimers
Das, D., Tripsianes, K., Jaspers, N. G. J., Hoeijmakers, J. H. J., Kaptein, R., Boelens, R., & Folkers, G. E. (2007) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.21635 · Cited by 20
New synthetic substrates of mammalian nucleotide excision repair system
Evdokimov, A. N., Petruseva, I. O., Tsidulko, A. Y., Королева, Л. С., Serpokrylova, I. Y., Silnikov, V. N., & Lavrik, O. I. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt301 · Cited by 20
Miccoli, L., Burr, K., Hickenbotham, P. T., Friedberg, E. C., Angulo, J. F., & Dubrova, Y. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3844 · Cited by 24
Carr, A. M. (2003) · Science · doi:10.1126/science.1085689 · Cited by 20
Wu, Q., Beland, F. A., Chang, C., & Fang, J. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.12.009 · Cited by 19
Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers
Bikle, D. D. (2021) · JBMR Plus · doi:10.1002/jbm4.10578 · Cited by 19
Thymine Dimer-Induced Structural Changes to the DNA Duplex Examined with Reactive Probes
Rumora, A. E., Kolodziejczak, K. M., Malhowski Wagner, A., & Núñez, M. E. (2008) · Biochemistry · doi:10.1021/bi801417u · Cited by 18
Hastak, K., Adimoolam, S., Trinklein, N. D., Myers, R., & Ford, J. M. (2012) · Genes & Cancer · doi:10.1177/1947601912456288 · Cited by 20
Chauhan, A. K., Sun, Y., Zhu, Q., & Wani, A. A. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103128 · Cited by 18
Kathuria, P., Sharma, P., Abendong, M. N., & Wetmore, S. D. (2015) · Biochemistry · doi:10.1021/bi501484m · Cited by 18
Stavros, K. M., Hawkins, E. K., Rizzo, C. J., & Stone, M. P. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1109 · Cited by 17
XPA gene rs1800975 single nucleotide polymorphism and lung cancer risk: a meta-analysis
Lou, Y., Li, R., Zhang, Y., Zhong, R., Pei, J., Xiong, L., Zhang, X., & Han, B. (2014) · Tumor Biology · doi:10.1007/s13277-014-1824-1 · Cited by 17
Crosslinking of nucleotide excision repair proteins with DNA containing photoreactive damages
Maltseva, E. A., Rechkunova, N. I., Petruseva, I. O., Vermeulen, W., Schärer, O. D., & Lavrik, O. I. (2008) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2007.11.004 · Cited by 17
Higurashi, M., Ohtsuki, T., Inase, A., Kusumoto, R., Masutani, C., Hanaoka, F., & Iwai, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307186200 · Cited by 17
Self-citationSaccharomyces cerevisiae Cmr1 protein preferentially binds to UV-damaged DNA in vitro
Choi, D.-H., Kwon, S.-H., Kim, J.-H., & Bae, S.-H. (2012) · The Journal of Microbiology · doi:10.1007/s12275-012-1597-4 · Cited by 16
Mourrain, L., & Boissonneault, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212418 · Cited by 17
Schärer, O. D., & Campbell, A. J. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb0209-102 · Cited by 16
XPC-RAD23B enhances UV-DDB binding to DNA to facilitate lesion search in nucleotide excision repair
An, S., Kusakabe, M., Kim, H.-S., Kozono, H., Cheon, N. Y., Kim, J., Kang, J., Jang, S., Sugasawa, K., Schärer, O. D., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf463 · Cited by 15
Self-citationToxicology of DNA Adducts Formed Upon Human Exposure to Carcinogens
Wilson, K. A., Kung, R. W., & Wetmore, S. D. (2016) · Advances in molecular toxicology · doi:10.1016/b978-0-12-804700-2.00007-6 · Cited by 15
Lim, K. K., Nguyen, T. T. T., Li, A. Y., Yeo, Y. P., & Chen, E. S. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky245 · Cited by 16
Paul, D., Mu, H., Tavakoli, A., Dai, Q., Chen, X.-J., Chakraborty, S., He, C., Ansari, A., Broyde, S., & Min, J.-H. (2020) · bioRxiv · doi:10.1093/nar/gkaa909 · Cited by 13
Krasikova, Y. S., Rechkunova, N. I., Maltseva, E. A., Anarbaev, R. O., Pestryakov, P. E., Sugasawa, K., Min, J., & Lavrik, O. I. (2013) · Journal of Molecular Recognition · doi:10.1002/jmr.2308 · Cited by 14
Self-citationY-box binding protein 1 (YB-1) promotes detection of DNA bulky lesions by XPC-HR23B factor
Fomina, E. E., Pestryakov, P. E., Maltseva, E. A., Petruseva, I. O., Kretov, D. A., Ovchinnikov, L. P., & Lavrik, O. I. (2015) · Biochemistry (Moscow) · doi:10.1134/s000629791502008x · Cited by 15
Construction and purification of site-specifically modified DNA templates for transcription assays
Perlow, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng040 · Cited by 15
A Molecular Basis for Damage Recognition in Eukaryotic Nucleotide Excision Repair
Schärer, O. D. (2007) · ChemBioChem · doi:10.1002/cbic.200700619 · Cited by 14
Evdokimov, A. N., Petruseva, I. O., Pestryakov, P. E., & Lavrik, O. I. (2011) · Biochemistry (Moscow) · doi:10.1134/s0006297911010159 · Cited by 14
Nishiwaki, T., Kobayashi, N., Iwamoto, T., Yamamoto, A., Sugiura, S., Liu, Y., Sarasin, A. R., Okahashi, Y., Hirano, M., Ueno, S., et al. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.08.009 · Cited by 15
Iwamoto, T., Brooks, P. J., Nishiwaki, T., Nishimura, K., Kobayashi, N., Sugiura, S., & Mori, T. (2014) · Photochemistry and Photobiology · doi:10.1111/php.12239 · Cited by 13
Starostenko, L. V., Maltseva, E. A., Lebedeva, N. A., Pestryakov, P. E., Lavrik, O. I., & Rechkunova, N. I. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916030056 · Cited by 13
Testing excision models for responses of mismatch‐repair systems to UV photoproducts in DNA
Wang, H., Hoffman, P. D., Lawrence, C. W., & Hays, J. B. (2006) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20206 · Cited by 13
Green tea extract promotes DNA repair in a yeast model
Chong, S. Y., Chiang, H.-Y., Chen, T.-H., Liang, Y.-J., & Lo, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-39082-9 · Cited by 15
Papel das proteínas XPD e DNA polimerase eta nas respostas de células humanas a danos no genoma
Lerner, L. K. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2014.tde-20102014-103732 · Cited by 13
Polymorphisms in XPC provide prognostic information in acute myeloid leukemia
Xu, P., Chen, B., Feng, J., Cheng, L., Xia, G., Li, Y., Qian, J., Ding, J.-H., & Lu, Z. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1145-3 · Cited by 12
Nucleotide Excision Repair from Bacteria to Humans: Structure–Function Studies
Ye, P., Wang, H., Santana‐Santos, L., Kisker, C., & Houten, B. V. (2010) · Humana Press eBooks · doi:10.1007/978-1-61737-995-6_13 · Cited by 12
Sassa, A., Tada, H., Takeishi, A., Kaho, H., Suzuki, M., Tsuda, M., Sasanuma, H., Takeda, S., Sugasawa, K., Yasui, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50421-8 · Cited by 12
Self-citationSharma, P., Yazdi, M. M., Merriman, A., Manderville, R. A., & Wetmore, S. D. (2015) · Chemical Research in Toxicology · doi:10.1021/tx500527p · Cited by 12
Nucleotide excision repair: DNA damage recognition and preincision complex assembly
Rechkunova, N. I., Krasikova, Y. S., & Lavrik, O. I. (2011) · Biochemistry (Moscow) · doi:10.1134/s0006297911010056 · Cited by 12
Zhu, Q., Wani, G., Sharma, N., & Wani, A. A. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.09.003 · Cited by 12
Recognition and Removal of Bulky DNA Lesions by the Nucleotide Excision Repair System
Cai, Y., Kropachev, K. Y., Kolbanovskiy, M., Kolbanovskiy, A., Broyde, S. B., Patel, D. J., & Geacintov, N. E. (2010) · Wiley eBooks · doi:10.1002/9783527630110.ch12 · Cited by 12
Transcription-Coupled Nucleotide Excision Repair: A Faster Solution or the Only Option?
Khobta, A., & Sarmini, L. (2025) · Biomolecules · doi:10.3390/biom15071026 · Cited by 14
Scheffold, A., Baig, A. H., Chen, Z., von Löhneysen, S., Becker, F. R., Morita, Y., Avila, A. I., Groth, M., Lechel, A., Schmid, F. T., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0641-3 · Cited by 10
USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors
Zhang, Y., Mandemaker, I. K., Matsumoto, S., Foreman, O., Holland, C. P., Lloyd, W. R., Sugasawa, K., Vermeulen, W., Marteijn, J. A. F., & Galardy, P. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663411 · Cited by 11
Self-citationKusakabe, M., Kakumu, E., Kurihara, F., Tsuchida, K., Maeda, T., Tada, H., Kusao, K., Kato, A., Yasuda, T., Matsuda, T., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104040 · Cited by 11
Self-citationKoyauchi, T., Niida, H., Motegi, A., Sakai, S., Uchida, C., Ohhata, T., Iijima, K., Yokoyama, A., Suda, T., & Kitagawa, M. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119332 · Cited by 11
Silva, W. G. M. D., McCarthy, B. Y., Han, J. Z. R., Yang, C., Holland, A. J. A., Stern, H. S., Dixon, K. M., Tang, E. K. Y., Tuckey, R. C., Rybchyn, M. S., et al. (2023) · Metabolites · doi:10.3390/metabo13070775 · Cited by 12
Chauhan, A. K., Li, P., Sun, Y., Wani, G., Zhu, Q., & Wani, A. A. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1860559 · Cited by 11
Impact of DNA sequences in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex
Paul, D., Mu, H., Tavakoli, A., Dai, Q., Chakraborty, S., He, C., Ansari, A., Broyde, S. B., & Min, J. (2020) · DNA repair · doi:10.1016/j.dnarep.2021.103194 · Cited by 11
Bang, J., Kang, Y., Park, C., Lee, J., & Choi, B. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.05.015 · Cited by 11
The role of human replicative DNA polymerases in DNA repair and replication
Rytkönen, A. K. (2006) · Cited by 11
Metadata
- Authors
- Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., & Hanaoka, F.
- Affiliations
- Japan Science and Technology Agency (JP)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-03-01
- Volume
- 15
- Issue
- 5
- Pages
- 507-521
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC312644
- OpenAlex
- W2106443150
- Cited by
- 435
- References
- 61
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 4 · 2023: 14 · 2022: 8 · 2021: 12 · 2020: 12 · 2019: 14 · 2018: 12 · 2017: 18 · 2016: 30 · 2015: 26 · 2014: 16 · 2013: 17 · 2012: 20
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Science and Technology Corporation (CREST)
- RIKEN
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- nucleotide excision repair, DNA damage recognition, helix distortion, cyclobutane pyrimidine dimers
- MeSH terms
- Deoxyribonuclease I, DNA Damage, DNA Repair, DNA-Binding Proteins, Humans, Models, Biological, Nucleic Acid Conformation, Plasmids, Protein Binding, Pyrimidine Dimers, Tumor Cells, Cultured, Genome, Human, DNA Footprinting, Base Pair Mismatch
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review