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Cited by 320

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Recycling of the general transcription factors during RNA polymerase II transcription.

Open access
Zawel, L, Kumar, K P, Reinberg, D·1995·Genes & Development

Abstract

We have analyzed the fate of the RNA polymerase II (RNAPII) general transcription factors during the transition from initiation to elongation using multiple approaches. We demonstrate that all of the basal factors coexist in mature initiation complexes but that following nucleotide addition, this complex becomes disrupted. During this transition, TFIID remains promoter-bound whereas TFIIB, TFIIE, TFIIF, and TFIIH are released. Upon release, TFIIB reassociates with TFIID, reforming the RNAPII docking site, the DB complex. TFIIE is released before formation of the tenth phosphodiester bond. This precedes TFIIH release, which occurrs after the transcription complex reaches +30. TFIIF is unique in that it is the only basal factor detected in the RNAPII elongation complex. Following its release from the initiation complex, TFIIF has the ability to reassociate with a stalled RNAPII.

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Metadata

Authors
Zawel, L., Kumar, K. P., & Reinberg, D.
Venue
Genes & Development
Published
1995-06-15
Volume
9
Issue
12
Pages
1479-1490
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2030509081
Cited by
320
References
58
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Recycling of the general transcription factors during RNA polymerase II transcription. https://app.cochat.ai/papers/10.1101/gad.9.12.1479
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Zawel, L., Kumar, K. P., & Reinberg, D. (1995). Recycling of the general transcription factors during RNA polymerase II transcription. Genes & Development. https://doi.org/10.1101/gad.9.12.1479

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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