The comings and goings of nucleotide excision repair factors on damaged DNA
Open accessAbstract
To understand the mechanism of nucleotide excision repair (NER), one of the major human DNA repair pathways, we have set up a DNA repair system in which a linear damaged DNA substrate is immobilized by its terminus. By isolating functionally active intermediate complexes, our data dissect the ordered arrival and displacement of NER factors in the progress of the dual incision step. We describe (i) the role of ATP in remodelling the NER-initiating complex of XPC/TFIIH/damaged DNA as a prerequisite for the recruitment of the next NER factors; (ii) the coordination between damage removal and DNA resynthesis and the release of XPC-HR23B, TFIIH and XPA upon arrival of XPG and XPF-ERCC1, respectively; (iii) how RPA remains associated with the excised DNA initiating the assembly of resynthesis factors such as PCNA; (iv) the recycling of XPC-HR23B, TFIIH and XPA in the NER; and the shuttling of TFIIH between NER and transcription. Thus, our findings define multiple functions of NER factors to explain the molecular basis of human NER disorders.
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Superposition of Rad33 in the Rad33-Rad14 complex model onto the TFIIH/Rad4-Rad23-Rad33 initial recognition complex shows how Rad14 can interact with the Rad4-Rad23-Rad33 recognition complex while maintaining the TFIIH interaction, bridging the steps of initial damage recognition and damage verification.
“Superposition of Rad33 in the Rad33-Rad14 complex model onto this structure (Fig. 5D) shows how Rad14 can interact with the Rad4–Rad23–Rad33 recognition complex (38,42) while maintaining the TFIIH interaction, bridging the steps of initial damage recognition and damage verification.”
From Computed structures of core eukaryotic protein complexes (2021) · cites this paper as [42]
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Cites
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works
Lindahl, T. L., & Wood, R. D. (1999) · Science · doi:10.1126/science.286.5446.1897 · Cited by 1,489 · see citing works
[36] Eukaryotic gene transcription with purified components
Dignam, J. D., Martin, P. L., Shastry, B. S., & Roeder, R. G. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)01039-3 · Cited by 963 · see citing works
Sugasawa, K., Ng, J. M. Y., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P. M., Hanaoka, F., Bootsma, D., & Hoeijmakers, J. H. J. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80132-x · Cited by 899 · see citing works
Self-citationMammalian DNA nucleotide excision repair reconstituted with purified protein components
Aboussekhra, A., Biggerstaff, M., Shivji, M. K. K., Vilpo, J. A., Moncollin, V., Podust, V. N., Protić, M., Hübscher, U., Egly, J.-M., & Wood, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90289-9 · Cited by 837 · see citing works
Self-citationDNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor
Schaeffer, L., Roy, R., Humbert, S., Moncollin, V., Vermeulen, W., Hoeijmakers, J. H. J., Chambon, P., & Egly, J. (1993) · Science · doi:10.1126/science.8465201 · Cited by 794 · see citing works
Self-citationSequential Assembly of the Nucleotide Excision Repair Factors In Vivo
Volker, M., Moné, M. J., Karmakar, P., van Hoffen, A., Schul, W., Vermeulen, W., Hoeijmakers, J. H. J., DRIEL, R. V., van Zeeland, A. A., & Mullenders, L. H. F. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00281-7 · Cited by 782 · see citing works
Recombinant replication protein A: expression, complex formation, and functional characterization
Henricksen, L. A., Umbricht, C. B., & Wold, M. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78100-9 · Cited by 597 · see citing works
Mellon, I., & Hanawalt, P. C. (1989) · Nature · doi:10.1038/342095a0 · Cited by 573 · see citing works
Xeroderma Pigmentosum Group F Caused by a Defect in a Structure-Specific DNA Repair Endonuclease
Sijbers, A. M., de Laat, W. L., Ariza, R. R., Biggerstaff, M., Wei, Y.-F., Moggs, J. G., Carter, K. C., Shell, B. K., Evans, E. L., de Jong, M. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80155-5 · Cited by 546 · see citing works
Mechanism of open complex and dual incision formation by human nucleotide excision repair factors
Evans, E., Moggs, J. G., Hwang, J. R., Egly, J., & Wood, R. D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6559 · Cited by 500 · see citing works
Self-citationXPG endonuclease makes the 3′ incision in human DNA nucleotide excision repair
O’Donovan, A., Davies, A. A., Moggs, J. G., West, S. C., & Wood, R. D. (1994) · Nature · doi:10.1038/371432a0 · Cited by 487 · see citing works
Huang, J. C., Svoboda, D. L., Reardon, J. T., & Sancar, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3664 · Cited by 437 · see citing works
A human RNA polymerase II complex associated with SRB and DNA-repair proteins
Maldonado, E., Shiekhattar, R., Sheldon, M., Cho, H. K., Drapkin, R., Rickert, P., Lees, E. M., Anderson, C. W., Linn, S., & Reinberg, D. (1996) · Nature · doi:10.1038/381086a0 · Cited by 351 · see citing works
Araújo, S. J., Tirode, F., Coin, F., Pospiech, H., Syväoja, J. E., Stucki, M., Hübscher, U., Egly, J., & Wood, R. D. (2000) · Genes & Development · doi:10.1101/gad.14.3.349 · Cited by 334 · see citing works
Self-citationde Laat, W. L., Appeldoorn, E., Sugasawa, K., Weterings, E., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1998) · Genes & Development · doi:10.1101/gad.12.16.2598 · Cited by 333 · see citing works
Recycling of the general transcription factors during RNA polymerase II transcription.Preprint
Zawel, L. S., Kumar, K. P., & Reinberg, D. (1995) · Genes & Development · doi:10.1101/gad.9.12.1479 · Cited by 320 · see citing works
Shivji, M. K. K., Podust, V. N., Hübscher, U., & Wood, R. D. (1995) · Biochemistry · doi:10.1021/bi00015a012 · Cited by 279 · see citing works
Svejstrup, J. Q., Wang, Z., Feave, W. J., Wu, X., Bushnell, D. A., Donahue, T. F., Friedberg, E. C., & Kornberg, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90447-6 · Cited by 278 · see citing works
Gary, R. K., Ludwig, D. L., Cornelius, H. L., MacInnes, M. A., & Park, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24522 · Cited by 239 · see citing works
Multiple competition reactions for RPA order the assembly of the DNA polymerase δ holoenzyme
Yuzhakov, A., Kelman, Z., Hurwitz, J., & O’Donnell, M. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6189 · Cited by 212 · see citing works
Batty, D. P., Rapić-Otrin, V., Levine, A. S., & Wood, R. D. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3857 · Cited by 208 · see citing works
Moggs, J. G., Yarema, K. J., Essigmann, J. M., & Wood, R. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.7177 · Cited by 205 · see citing works
3 Xeroderma pigmentosum and related disorders: Defects in DNA repair and transcription
Berneburgl, M., & Lehmann, A. R. (2001) · Advances in genetics · doi:10.1016/s0065-2660(01)43004-5 · Cited by 200 · see citing works
Gérard, M., Fischer, L., Moncollin, V., Chipoulet, J.-M., Chambon, P., & Egly, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54801-8 · Cited by 200 · see citing works
Self-citationOrder of Assembly of Human DNA Repair Excision Nuclease
Wakasugi, M., & Sancar, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18759 · Cited by 197 · see citing works
Park, C.-H., Mu, D., Reardon, J. T., & Sancar, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4896 · Cited by 191 · see citing works
Rapid Switching of TFIIH between RNA Polymerase I and II Transcription and DNA Repair In Vivo
Hoogstraten, D., Nigg, A. L., Heath, H., Mullenders, L. H. F., DRIEL, R. V., Hoeijmakers, J. H. J., Vermeulen, W., & Houtsmuller, A. B. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00709-8 · Cited by 191 · see citing works
Cisplatin‐ and UV‐damaged DNA lure the basal transcription factor TFIID/TBP
Vichi, P., Coin, F., Renaud, J., Vermeulen, W., Hoeijmakers, J. H. J., Moras, D., & Egly, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7444 · Cited by 172 · see citing works
Self-citationAssembly, subunit composition, and footprint of human DNA repair excision nuclease
Wakasugi, M., & Sancar, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6669 · Cited by 170 · see citing works
Reconstitution of Human Excision Nuclease with Recombinant XPF-ERCC1 Complex
Bessho, T., Sancar, A., Thompson, L. H., & Thelen, M. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3833 · Cited by 169 · see citing works
HHR23B, a Human Rad23 Homolog, Stimulates XPC Protein in Nucleotide Excision Repair In Vitro
Sugasawa, K., Masutani, C., Uchida, A., Maekawa, T., Spek, P. J. V. D., Bootsma, D., Hoeijmakers, J. H. J., & Hanaoka, F. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4852 · Cited by 164 · see citing works
Self-citationThe XPA protein is a zinc metalloprotein with an ability to recognize various kinds of DNA damage
Asahina, H., Kuraoka, I., Shirakawa, M., Morita, E. H., Miura, N., Miyamoto, I., Ohtsuka, E., Okada, Y., & Tanaka, K. (1994) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(94)90034-5 · Cited by 156 · see citing works
ATP Utilization by Yeast Replication Factor C
Gomes, X. V., & Burgers, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011631200 · Cited by 155 · see citing works
DNA Damage Recognition by XPA Protein Promotes Efficient Recruitment of Transcription Factor II H
Nocentini, S., Coin, F., Saijo, M., Tanaka, K., & Egly, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.22991 · Cited by 109 · see citing works
Self-citationBiochemical Analysis of the Damage Recognition Process in Nucleotide Excision Repair
You, J., Wang, M., & Lee, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210603200 · Cited by 104 · see citing works
Guzder, S. N., Sung, P., Prakash, L., & Prakash, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8903 · Cited by 100 · see citing works
Functional Analysis of Human Replication Protein A in Nucleotide Excision Repair
Stigger, E., Drissi, R., & Lee, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.9337 · Cited by 84 · see citing works
Molecular Anatomy of the Human Excision Nuclease Assembled at Sites of DNA Damage
Reardon, J. T., & Sancar, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5938-5945.2002 · Cited by 81 · see citing works
Dual-Incision Assays for Nucleotide Excision Repair Using DNA with a Lesion at a Specific Site
Shivji, M. K. K., Moggs, J. G., Kuraoka, I., & Wood, R. D. (2003) · Humana Press eBooks · doi:10.1385/1-59259-675-4:373 · Cited by 70 · see citing works
The DNA-dependent ATPase activity associated with the class II basic transcription factor BTF2/TFIIH
Roy, R., Schaeffer, L., Humbert, S., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36958-2 · Cited by 67 · see citing works
Transcriptional Activators Stimulate DNA Repair
Frit, P., Kwon, K.-R., Coin, F., Auriol, J., Dubaele, S., Salles, B., & Egly, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00732-3 · Cited by 59 · see citing works
Self-citationRPA Stabilizes the XPA-Damaged DNA Complex through Protein−Protein Interaction
Wang, M., Mahrenholz, A. M., & Lee, S. (2000) · Biochemistry · doi:10.1021/bi000472q · Cited by 53 · see citing works
Nucleotide excision repair and chromatin remodeling
Ura, K., & Hayes, J. J. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02888.x · Cited by 49 · see citing works
Spangler, L., Wang, X., Conaway, J. W., Conaway, R. C., & Dvir, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101004498 · Cited by 49 · see citing works
You, Z., Feaver, W. J., & Friedberg, E. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2668 · Cited by 37 · see citing works
Ku Entry into DNA Inhibits Inward DNA Transactions in Vitro
Frit, P., Li, R., Arzel, D., Salles, B., & Calsou, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004315200 · Cited by 30 · see citing works
Roles of XPG and XPF/ERCC1 Endonucleases in UV-Induced Immunostaining of PCNA in Fibroblasts
Miura, M., Nakamura, S., Sasaki, T., Takasaki, Y., Shiomi, T., & Yamaizumi, M. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0210 · Cited by 29 · see citing works
Mullenders, L. H. F., & Berneburg, M. (2001) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(01)00244-5 · Cited by 28 · see citing works
Mutagenicity of tryptophan photoproducts in the Ames Salmonella assay
Sjögren, M., Sjöberg, U., & Rannug, U. (1994) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(94)90074-4 · Cited by 20 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Batty D., Rapic’-Otrin,V., Levine,A.S. and Wood,R.D. (2000) Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J. Mol. Biol., 300, 275–290. [DOI] [PubMed] [Google Scholar]
- Vichi P., Coin,F., Renaud,J.P., Moras,D. and Egly,J.M. (1997) UV and cisplatin lesions lure basal transcription factor TFIID/TBP. EMBO J., 16, 7444–7456. [DOI] [PMC free article] [PubMed] [Google Scholar]
Cited by
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Marteijn, J. A., Lans, H., Vermeulen, W., & Hoeijmakers, J. H. J. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3822 · Cited by 1,192 · see citing works
Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642 · see citing works
UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex
Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Tanaka, K., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.035 · Cited by 576 · see citing works
Self-citationComputed structures of core eukaryotic protein complexes
Humphreys, I. R., Pei, J., Baek, M., Krishnakumar, A., Anishchenko, I., Ovchinnikov, S., Zhang, J., Ness, T. J., Banjade, S., Bagde, S. R., et al. (2021) · Science · doi:10.1126/science.abm4805 · Cited by 542 · see citing works
Cancer in xeroderma pigmentosum and related disorders of DNA repair
Cleaver, J. E. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1652 · Cited by 427 · see citing works
Fousteri, M., Vermeulen, W., van Zeeland, A. A., & Mullenders, L. H. F. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.029 · Cited by 387 · see citing works
RetractedReplication Protein A phosphorylation and the cellular response to DNA damage
Binz, S. K., Sheehan, A. M., & Wold, M. S. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.028 · Cited by 299 · see citing works
Coordination of dual incision and repair synthesis in human nucleotide excision repair
Staresincic, L., Fagbemi, A. F., Enzlin, J. H., Gourdin, A. M., Wijgers, N., Dunand‐Sauthier, I., Giglia‐Mari, G., Clarkson, S. G., Vermeulen, W., & Schärer, O. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.49 · Cited by 287 · see citing works
Moser, J., Kool, H., Giakzidis, I., Caldecott, K., Mullenders, L. H. F., & Fousteri, M. I. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.014 · Cited by 261 · see citing works
RetractedDNA Damage and Associated DNA Repair Defects in Disease and Premature Aging
Tiwari, V., & Wilson, D. M. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.005 · Cited by 244 · see citing works
Le May, N., Mota-Fernandes, D., Vélez-Cruz, R., Iltis, I., Biard, D., & Egly, J. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.004 · Cited by 228 · see citing works
Self-citationSugasawa, K., Akagi, J.-I., Nishi, R., Iwai, S., & Hanaoka, F. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.035 · Cited by 205 · see citing works
Self-citationMolecular bases of progeroid syndromes
Navarro, C. L., Cau, P., & Lévy, N. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl214 · Cited by 189 · see citing works
El-Mahdy, M. A., Zhu, Q., Wang, Q.-E., Wani, G., Prætorius-Ibba, M., & Wani, A. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511834200 · Cited by 151 · see citing works
Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC
Hoogstraten, D., Bergink, S., Ng, J. M. Y., Verbiest, V. H. M., Luijsterburg, M. S., Geverts, B., Raams, A., Dinant, C., Hoeijmakers, J. H. J., Vermeulen, W., et al. (2008) · Journal of Cell Science · doi:10.1242/jcs.031708 · Cited by 122 · see citing works
Luijsterburg, M. S., von Bornstaedt, G., Gourdin, A. M., Politi, A. Z., Moné, M. J., Warmerdam, D. O., Goedhart, J., Vermeulen, W., van Driel, R., & Höfer, T. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200909175 · Cited by 121 · see citing works
XPA: A key scaffold for human nucleotide excision repair
Sugitani, N., Sivley, R. M., Perry, K. E., Capra, J. A., & Chazin, W. J. (2016) · DNA Repair · doi:10.1016/j.dnarep.2016.05.018 · Cited by 116 · see citing works
Musich, P. R., & Zou, Y. (2009) · Aging · doi:10.18632/aging.100012 · Cited by 117 · see citing works
Orelli, B., McClendon, T. B., Tsodikov, O. V., Ellenberger, T., Niedernhofer, L. J., & Schärer, O. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.067538 · Cited by 116 · see citing works
Liu, Y., Wang, Y., Rusinol, A. E., Sinensky, M. S., Liu, J., Shell, S. M., & Zou, Y. (2008) · The FASEB Journal · doi:10.1096/fj.07-8598com · Cited by 115 · see citing works
ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation
Wu, X., Shell, S. M., Liu, Y., & Zou, Y. (2007) · Oncogene · doi:10.1038/sj.onc.1209828 · Cited by 102 · see citing works
Shell, S. M., Li, Z., Shkriabai, N., Kvaratskhelia, M., Brosey, C., Serrano, M. A., Chazin, W. J., Musich, P. R., & Zou, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000745 · Cited by 86 · see citing works
Xeroderma pigmentosum genes: Functions inside and outside DNA repair
Sugasawa, K. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm282 · Cited by 83 · see citing works
UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells
Nishi, R., Alekseev, S., Dinant, C., Hoogstraten, D., Houtsmuller, A. B., Hoeijmakers, J. H. J., Vermeulen, W., Hanaoka, F., & Sugasawa, K. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.02.004 · Cited by 76 · see citing works
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Coin, F., Auriol, J., Tapias, A., Clivio, P., Vermeulen, W., & Egly, J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600480 · Cited by 75 · see citing works
Self-citationYang, Z., Roginskaya, M., Colis, L. C., Basu, A. K., Shell, S. M., Liu, Y., Musich, P. R., Harris, C. M., Harris, T. M., & Zou, Y. (2006) · Biochemistry · doi:10.1021/bi061626q · Cited by 65 · see citing works
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Hilton, B. A., Liu, J., Cartwright, B. M., Liu, Y., Breitman, M., Wang, Y., Jones, R., Tang, H., Rusinol, A., Musich, P. R., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700014r · Cited by 52 · see citing works
Li, Z., Musich, P. R., Serrano, M. A., Dong, Z., & Zou, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028326 · Cited by 38 · see citing works
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“Functionally, XPA is believed to play roles in verifying DNA damage, stabilizing repair intermediates, and recruiting other NER factors to the damaged DNA [1,9,10,11,12,13,14,15,16,17,18].”
BackgroundNucleotide excision repair and related human diseases
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A new structural insight into XPA–DNA interactions
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- Authors
- Riedl, T., Hanaoka, F., & Egly, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- The University of Osaka (JP)
- Corresponding author
- Egly, Jean‐Marc
- Venue
- The EMBO Journal
- Published
- 2003-10-01
- Volume
- 22
- Issue
- 19
- Pages
- 5293-5303
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC204472
- OpenAlex
- W2006338892
- Cited by
- 439
- References
- 50
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 13 · 2021: 11 · 2020: 14 · 2019: 15 · 2018: 14 · 2017: 22 · 2016: 24 · 2015: 20 · 2014: 23 · 2013: 12 · 2012: 15
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- nucleotide excision repair, DNA repair proteins, XPG, XPA, TFIIH, RPA, PCNA, protein displacement, protein recycling, DNA damage response
- MeSH terms
- Adenosine Triphosphate, DNA Damage, DNA Repair, Humans, Models, Biological, Transcription Factors, TFII, Transcription Factor TFIIH
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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