The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E
Open accessAbstract
Gene silencing by double-stranded RNA is a widespread phenomenon called RNAi, involving homology-dependent degradation of mRNAs. Here we show that RNAi is established in the Drosophila female germ line. mRNA transcripts are translationally quiescent at the arrested oocyte stage and are insensitive to RNAi. Upon oocyte maturation, transcripts that are translated become sensitive to degradation while untranslated transcripts remain resistant. Mutations in aubergine and spindleE, members of the PIWI/PAZ and DE-H helicase gene families, respectively, block RNAi activation during egg maturation and perturb translation control during oogenesis, supporting a connection between gene silencing and translation in the oocyte.
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Cites
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Ketting, R. F., Fischer, S. E. J., Bernstein, E., Sijen, T., Hannon, G. J., & Plasterk, R. H. A. (2001) · Genes & Development · doi:10.1101/gad.927801 · Cited by 1,852
Olsen, P. H., & Ambros, V. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9523 · Cited by 1,234
Cited by
Asymmetry in the Assembly of the RNAi Enzyme Complex
Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,922
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G., & Tuschl, T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.007 · Cited by 2,052
The Small RNA Profile during Drosophila melanogaster Development
Aravin, A. A., Lagos-Quintana, M., Yalcin, A., Zavolan, M., Marks, D., Snyder, B., Gaasterland, T., Meyer, J., & Tuschl, T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00228-4 · Cited by 802
Analysis of a piwi-Related Gene Implicates Small RNAs in Genome Rearrangement in Tetrahymena
Mochizuki, K., Fine, N. A., Fujisawa, T., & Gorovsky, M. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00909-1 · Cited by 608
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
Ishizuka, A., Siomi, M. C., & Siomi, H. (2002) · Genes & Development · doi:10.1101/gad.1022002 · Cited by 581
Metadata
- Authors
- Kennerdell, J. R., Yamaguchi, S., & Carthew, R. W.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-08-01
- Volume
- 16
- Issue
- 15
- Pages
- 1884-1889
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2113668592
- Cited by
- 183
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Kennerdell, J. R., Yamaguchi, S., & Carthew, R. W. (2002). RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes & Development. https://doi.org/10.1101/gad.990802
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