The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing
Open accessAbstract
Half of prostate cancers harbor gene fusions between TMPRSS2 and members of the ETS transcription factor family. To date, little is known about the presence of non-ETS fusion events in prostate cancer. We used next-generation transcriptome sequencing (RNA-seq) in order to explore the whole transcriptome of 25 human prostate cancer samples for the presence of chimeric fusion transcripts. We generated more than 1 billion sequence reads and used a novel computational approach (FusionSeq) in order to identify novel gene fusion candidates with high confidence. In total, we discovered and characterized seven new cancer-specific gene fusions, two involving the ETS genes ETV1 and ERG, and four involving non-ETS genes such as CDKN1A(p21),CD9, and IKBKB(IKK-beta), genes known to exhibit key biological roles in cellular homeostasis or assumed to be critical in tumorigenesis of other tumor entities, as well as the oncogene PIGU and the tumor suppressor gene RSRC2. The novel gene fusions are found to be of low frequency, but, interestingly, the non-ETS fusions were all present in prostate cancer harboring the TMPRSS2–ERG gene fusion. Future work will focus on determining if the ETS rearrangements in prostate cancer are associated or directly predispose to a rearrangement-prone phenotype.
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Cites
Mapping and quantifying mammalian transcriptomes by RNA-Seq
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Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
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Self-citationThe impact of translocations and gene fusions on cancer causation
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“Multiple studies have identified recurrent somatic mutations, copy number alterations, and oncogenic structural DNA rearrangements (chromoplexy) in primary prostate cancer (Baca et al., 2013; Barbieri et al., 2012; Berger et al., 2011; Cooper et al., 2015; Pflueger et al., 2011; Taylor et al., 2010; Tomlins et al., 20…”
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Metadata
- Authors
- Pflueger, D., Terry, S., Sboner, A., Habegger, L., Esgueva, R., Lin, P.-C., Svensson, M. A., Kitabayashi, N., Moss, B. J., MacDonald, T. Y., Cao, X., Barrette, T., Tewari, A. K., Chee, M. S., Chinnaiyan, A. M., Rickman, D. S., Demichelis, F., Gerstein, M. B., & Rubin, M. A.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-10-29
- Volume
- 21
- Issue
- 1
- Pages
- 56-67
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W2136810701
- Cited by
- 201
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Pflueger, D., Terry, S., Sboner, A., Habegger, L., Esgueva, R., Lin, P.-C., Svensson, M. A., Kitabayashi, N., Moss, B. J., MacDonald, T. Y., Cao, X., Barrette, T., Tewari, A. K., Chee, M. S., Chinnaiyan, A. M., Rickman, D. S., Demichelis, F., Gerstein, M. B., & Rubin, M. A. (2011). Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing. Genome Research. https://doi.org/10.1101/gr.110684.110
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