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Cited by 523

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

Open access
Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D., Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D., Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A., Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P., Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H., Liu, Jiangang, Ehsani, Mariam E., Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T., Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M., Mao, Mao·2013·Genome Research
DOI 10.1101/gr.154492.113
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Abstract

Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet the molecular basis of hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study of 88 matched HCC tumor/normal pairs, 81 of which are Hepatitis B virus (HBV) positive, seeking to identify genetically altered genes and pathways implicated in HBV-associated HCC. We find beta-catenin to be the most frequently mutated oncogene (15.9%) and TP53 the most frequently mutated tumor suppressor (35.2%). The Wnt/beta-catenin and JAK/STAT pathways, altered in 62.5% and 45.5% of cases, respectively, are likely to act as two major oncogenic drivers in HCC. This study also identifies several prevalent and potentially actionable mutations, including activating mutations of Janus kinase 1 ( JAK1 ), in 9.1% of patients and provides a path toward therapeutic intervention of the disease.

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Metadata

Authors
Kan, Z., Zheng, H., Liu, X., Li, S., Barber, T. D., Gong, Z., Gao, H., Hao, K., Willard, M. D., Xu, J., Hauptschein, R., Rejto, P. A., Fernandez, J., Wang, G., Zhang, Q., Wang, B., Chen, R., Wang, J., Lee, N. P., Zhou, W., Lin, Z., Peng, Z., Yi, K., Chen, S., Li, L., Fan, X., Yang, J., Ye, R., Ju, J., Wang, K., Estrella, H., Deng, S., Wei, P., Qiu, M., Wulur, I. H., Liu, J., Ehsani, M. E., Zhang, C., Loboda, A., Sung, W. K., Aggarwal, A., Poon, R. T., Fan, S. T., Wang, J., Hardwick, J., Reinhard, C., Dai, H., Li, Y., Luk, J. M., & Mao, M.
Venue
Genome Research
Publisher
Cold Spring Harbor Laboratory
Published
2013-06-20
Volume
23
Issue
9
Pages
1422-1433
ISSN
1088-9051 (ISSN-L)
DOI
10.1101/gr.154492.113
OpenAlex
W2164241627
Cited by
523
References
13
Type
posted content
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. https://app.cochat.ai/papers/10.1101/gr.154492.113
The paper
Kan, Z., Zheng, H., Liu, X., Li, S., Barber, T. D., Gong, Z., Gao, H., Hao, K., Willard, M. D., Xu, J., Hauptschein, R., Rejto, P. A., Fernandez, J., Wang, G., Zhang, Q., Wang, B., Chen, R., Wang, J., Lee, N. P., . . . Mao, M. (2013). Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Research. https://doi.org/10.1101/gr.154492.113

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