The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability
Open accessAbstract
Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of “looping” by which HPV integrant-mediated DNA replication and recombination may result in viral–host DNA concatemers, frequently disrupting genes involved in oncogenesis and amplifying HPV oncogenes E6 and E7. Our high-resolution results shed new light on a catastrophic process, distinct from chromothripsis and other mutational processes, by which HPV directly promotes genomic instability.
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Cites
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Cited by
The role of integration in oncogenic progression of HPV-associated cancers
McBride, A. A., & Warburton, A. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006211 · Cited by 376
Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway
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HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers
Ren, S., Gaykalova, D. A., Guo, T., Favorov, A. V., Fertig, E. J., Tamayo, P., Callejas-Valera, J. L., Allevato, M., Gilardi, M., Santos, J., et al. (2020) · Oncogene · doi:10.1038/s41388-020-01431-8 · Cited by 93
Engineering virus resistance via CRISPR–Cas systems
Mahas, A., & Mahfouz, M. (2018) · Current Opinion in Virology · doi:10.1016/j.coviro.2018.06.002 · Cited by 74
Morgan, I., DiNardo, L., & Windle, B. (2017) · Viruses · doi:10.3390/v9080208 · Cited by 65
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Metadata
- Authors
- Akagi, K., Li, J., Broutian, T. R., Padilla-Nash, H., Xiao, W., Jiang, B., Rocco, J. W., Teknos, T. N., Kumar, B., Wangsa, D., He, D., Ried, T., Symer, D. E., & Gillison, M. L.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-11-07
- Volume
- 24
- Issue
- 2
- Pages
- 185-199
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W2081116295
- Cited by
- 468
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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