The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Human proteins that interact with RNA/DNA hybrids
Open accessAbstract
RNA/DNA hybrids form when RNA hybridizes with its template DNA generating a three-stranded structure known as the R-loop. Knowledge of how they form and resolve, as well as their functional roles, is limited. Here, by pull-down assays followed by mass spectrometry, we identified 803 proteins that bind to RNA/DNA hybrids. Because these proteins were identified using in vitro assays, we confirmed that they bind to R-loops in vivo. They include proteins that are involved in a variety of functions, including most steps of RNA processing. The proteins are enriched for K homology (KH) and helicase domains. Among them, more than 300 proteins preferred binding to hybrids than double-stranded DNA. These proteins serve as starting points for mechanistic studies to elucidate what RNA/DNA hybrids regulate and how they are regulated.
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Crossley, M. P., Bocek, M., & Cimprich, K. A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.024 · Cited by 746
R Loops: From Physiological to Pathological Roles
García-Muse, T., & Aguilera, A. (2019) · Cell · doi:10.1016/j.cell.2019.08.055 · Cited by 697
G-quadruplexes are transcription factor binding hubs in human chromatin
Spiegel, J., Cuesta, S. M., Adhikari, S., Hänsel-Hertsch, R., Tannahill, D., & Balasubramanian, S. (2021) · Genome Biology · doi:10.1186/s13059-021-02324-z · Cited by 267
Genome editing technologies: CRISPR, LEAPER, RESTORE, ARCUT, SATI, and RESCUE
Görücü Yılmaz, Ş. (2021) · IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund · doi:10.17179/excli2020-3070
Metadata
- Authors
- Wang, I. X., Grunseich, C., Fox, J., Burdick, J., Zhu, Z., Ravazian, N., Hafner, M., & Cheung, V. G.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2018-08-14
- Volume
- 28
- Issue
- 9
- Pages
- 1405-1414
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2886727482
- Cited by
- 198
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Wang, I. X., Grunseich, C., Fox, J., Burdick, J., Zhu, Z., Ravazian, N., Hafner, M., & Cheung, V. G. (2018). Human proteins that interact with RNA/DNA hybrids. Genome Research. https://doi.org/10.1101/gr.237362.118
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