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Cited by 465

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Genome-Wide Analysis of the Odorant-Binding Protein Gene Family in Drosophila melanogaster

Open access
Hekmat-Scafe, Daria S., Scafe, Charles R., McKinney, Aimee J., Tanouye, Mark A.·2002·Genome Research
DOI 10.1101/gr.239402
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Abstract

Olfaction is of considerable importance to many insects in behaviors critical for survival and reproduction, including location of food sources, selection of mates, recognition of colony con-specifics, and determination of oviposition sites. An ubiquitous, but poorly understood, component of the insect's olfactory system is a group of odorant-binding proteins (OBPs) that are present at high concentrations in the aqueous lymph surrounding the dendrites of olfactory receptor neurons. OBPs are believed to shuttle odorants from the environment to the underlying odorant receptors, for which they could potentially serve as odorant presenters. Here we show that the Drosophila genome carries 51 potential OBP genes, a number comparable to that of its odorant-receptor genes. We find that the majority (73%) of these OBP-like genes occur in clusters of as many as nine genes, in contrast to what has been observed for the Drosophila odorant-receptor genes. Two of the presumptive OBP gene clusters each carries an odorant-receptor gene. We also report an intriguing subfamily of 12 putative OBPs that share a unique C-terminal structure with three conserved cysteines and a conserved proline. Members of this subfamily have not previously been described for any insect. We have performed phylogenetic analyses of the OBP-related proteins in Drosophila as well as other insects, and we discuss the duplication and divergence of the genes for this large family. [The sequence data from this study have been submitted to FlyBase. Annotations for these sequences are available as supplementary material at http://www.genome.org.]

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Metadata

Authors
Hekmat-Scafe, D. S., Scafe, C. R., McKinney, A. J., & Tanouye, M. A.
Venue
Genome Research
Publisher
Cold Spring Harbor Laboratory
Published
2002-09-01
Volume
12
Issue
9
Pages
1357-1369
ISSN
  • 1088-9051 (ISSN-L)
  • 1549-5469
DOI
10.1101/gr.239402
OpenAlex
W2157665519
Cited by
465
References
45
Type
posted content
Language
en
Open access
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