Cited by 1,139Probiotics and Fermented FoodsGenomics and Phylogenetic StudiesBacterial Genetics and Biotechnology

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

The Complete Genome Sequence of the Lactic Acid Bacterium Lactococcus lactis ssp. lactis IL1403

Open access

Bolotin, A., Wincker, P., Mauger, S., Jaillon, O., Malarme, K., Weissenbach, J., Ehrlich, S. D., Sorokin, A.·2001·Genome Research

DOI 10.1101/gr.gr-1697rPMC PMC311110

Open this paper in CoChat — free account Open PDF

Abstract

Lactococcus lactis is a nonpathogenic AT-rich gram-positive bacterium closely related to the genus Streptococcus and is the most commonly used cheese starter. It is also the best-characterized lactic acid bacterium. We sequenced the genome of the laboratory strain IL1403, using a novel two-step strategy that comprises diagnostic sequencing of the entire genome and a shotgun polishing step. The genome contains 2,365,589 base pairs and encodes 2310 proteins, including 293 protein-coding genes belonging to six prophages and 43 insertion sequence (IS) elements. Nonrandom distribution of IS elements indicates that the chromosome of the sequenced strain may be a product of recent recombination between two closely related genomes. A complete set of late competence genes is present, indicating the ability of L. lactis to undergo DNA transformation. Genomic sequence revealed new possibilities for fermentation pathways and for aerobic respiration. It also indicated a horizontal transfer of genetic information from Lactococcus to gram-negative enteric bacteria of Salmonella-Escherichia group.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gr.gr-1697r

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
A genomic perspective on protein families.
Tatusov, R., Koonin, E., & Lipman, D. (1997) · Science · doi:10.1126/science.278.5338.631 · Cited by 3,777
The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessières, P., Bolotin, A., Borchert, S., et al. (1997) · Nature · doi:10.1038/36786 · Cited by 3,679
Self-citation
Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513
Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing
Gasson, M. J. (1983) · Journal of Bacteriology · doi:10.1128/jb.154.1.1-9.1983 · Cited by 1,313
Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58
Tettelin, H., Saunders, N. J. S. G., Heidelberg, J. F., Jeffries, A. C., Nelson, K. E., Eisen, J. A., Ketchum, K. A., Hood, D. W., Peden, J. F., Dodson, R. J., et al. (2000) · Science · doi:10.1126/science.287.5459.1809 · Cited by 1,084
GENMARK: Parallel gene recognition for both DNA strands
Borodovsky, M. Y., & McIninch, J. D. (1993) · Computers & Chemistry · doi:10.1016/0097-8485(93)85004-v · Cited by 730
Peptidases and amino acid catabolism in lactic acid bacteria
Christensen, J. E., Dudley, E. G., Pederson, J. A., & Steele, J. L. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002001919720 · Cited by 630
Transfer of Streptococcus lactis and Related Streptococci to the Genus Lactococcus gen. nov.
SCHLEIFER, K. H., Kraus, J., Dvorak, C., Kilpper-Bälz, R., Collins, M. D., & Fischer, W. (1985) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(85)80052-7 · Cited by 479
Calibrating bacterial evolution.
Ochman, H., Elwyn, S., & Moran, N. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.22.12638 · Cited by 457

Show all 54 references

Sorted by citations

Items 501–600 of 1,000

Conservation of key elements of natural competence inLactococcus lactisssp.
Wydau-Dematteis, S., Dervyn, R., Anba‐Mondoloni, J., Ehrlich, S. D., & Maguin, E. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00141.x · Cited by 38
Self-citation
Diversity of Oligopeptide Transport Specificity in Lactococcus lactis Species
Charbonnel, P., Lamarque, M. H., Piard, J.-C., Gilbert, C., Juillard, V., & Atlan, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212454200 · Cited by 40
Screening genomes of Gram-positive bacteria for double-glycine-motif-containing peptides
Dirix, G., Monsieurs, P., Kathleen Marchal, D., Vanderleyden, J., & Michiels, J. J. (2004) · Microbiology · doi:10.1099/mic.0.27040-0 · Cited by 38
Metabolic Engineering of Mannitol Production inLactococcus lactis: Influence of Overexpression of Mannitol 1-Phosphate Dehydrogenase in Different Genetic Backgrounds
Wisselink, H. W., Mars, A. E., van der Meer, P., Eggink, G., & Hugenholtz, J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.7.4286-4292.2004 · Cited by 38
Identification of Candidate Carrier Proteins for Surface Display on Lactococcus lactis by Theoretical and Experimental Analyses of the Surface Proteome
Berlec, A., Zadravec, P., Jevnikar, Z., & Štrukelj, B. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02102-10 · Cited by 39
A Foreign Protein Incorporated on the Tip of T3 Pili in Lactococcus lactis Elicits Systemic and Mucosal Immunity
Quigley, B. R., Hatkoff, M., Thanassi, D. G., Ouattara, M., Eichenbaum, Z., & Scott, J. R. (2009) · Infection and Immunity · doi:10.1128/iai.01037-09 · Cited by 38
Maturation by LctT Is Required for Biosynthesis of Full-Length Lantibiotic Lacticin 481
Uguen, P., Hindré, T., Didelot, S., Marty, C., Haras, D., LePennec, J. P., Vallée‐Rehel, K., & Dufour, A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.1.562-565.2005 · Cited by 38
Amino Acid-Derived Bacterial Metabolites in the Colorectal Luminal Fluid: Effects on Microbial Communication, Metabolism, Physiology, and Growth
Blachier, F. (2023) · Microorganisms · doi:10.3390/microorganisms11051317 · Cited by 38
Using herbal medicine to target the “microbiota-metabolism-immunity” axis as possible therapy for cardiovascular disease
Wang, A., Dongcheng, C., Zhang, H., Li, Q., Yan, Z., Qiu, Y., Xu, H., & Keji, C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.018 · Cited by 37
Whole-Genome Sequence of Lactococcus lactis Subsp. lactis LL16 Confirms Safety, Probiotic Potential, and Reveals Functional Traits
Milerienė, J., Aksomaitienė, J., Kondrotienė, K., Asledottir, T., Vegarud, G. E., Šernienė, L., & Malakauskas, M. (2023) · Microorganisms · doi:10.3390/microorganisms11041034 · Cited by 37
Prophage induction in Lactococcus lactis by the bacteriocin Lactococcin 972
Madera, C., García, P., Rodrı́guez, A., Suárez, J. E., & Martı́nez, B. (2008) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2008.11.004 · Cited by 41
Introducing glutathione biosynthetic capability into Lactococcus lactis subsp. cremoris NZ9000 improves the oxidative-stress resistance of the host
Fu, R., Bongers, R. S., van Swam, I. I., Chen, J., Douwe Molenaar, B., Kleerebezem, M., Hugenholtz, J., & Li, Y. (2006) · Metabolic Engineering · doi:10.1016/j.ymben.2006.07.004 · Cited by 37
Biosynthetic characterization and biochemical features of the third natural nisin variant, nisin Q, produced byLactococcus lactis61-14
Yoneyama, F., Fukao, M., Zendo, T., Nakayama, J., & Sonomoto, K. (2008) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2008.03958.x · Cited by 36
Genotype-phenotype matching analysis of 38 Lactococcus lactisstrains using random forest methods
Bayjanov, J. R., Starrenburg, M. J. C., van der Sijde, M. R., Siezen, R. J., & van Hijum, S. A. F. T. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-68 · Cited by 37
Genome Organization and Characterization of the Virulent Lactococcal Phage 1358 and Its Similarities to Listeria Phages
Dupuis, M.-È., & Moineau, S. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02173-09 · Cited by 37
Lipoprotein signal peptidase of Streptococcus suis serotype 2
de Greeff, A., Hamilton, A., Sutcliffe, I. C., Buys, H., van Alphen, L., & Smith, H. E. (2003) · Microbiology · doi:10.1099/mic.0.26329-0 · Cited by 37
Metabolic engineering of Lactococcus lactis: the impact of genomics and metabolic modelling
Kleerebezem, M., Boels, I. C., Groot, M. N. N., Mierau, I., Sybesma, W., & Hugenholtz, J. (2002) · Journal of Biotechnology · doi:10.1016/s0168-1656(02)00132-3 · Cited by 37
Exopolysaccharides from Lactic Acid Bacteria
Vuyst, L. D., & de Vin, F. (2007) · Elsevier eBooks · doi:10.1016/b978-044451967-2/00129-x · Cited by 38
Screening of Riboflavin-Producing Lactobacilli by a Polymerase-Chain-Reaction-Based Approach and Microbiological Assay
Thakur, K., Tomar, S. K., Brahma, B., & De, S. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b06165 · Cited by 36
P087, a lactococcal phage with a morphogenesis module similar to an Enterococcus faecalis prophage
Villion, M., Chopin, M., Deveau, H., Ehrlich, S. D., Moineau, S., & Chopin, A. (2009) · Virology · doi:10.1016/j.virol.2009.03.011 · Cited by 36
Self-citation
Monocarboxylic acid production by lactococci and lactobacilli
Ganesan, B., Seefeldt, K., Koka, R., Dias, B., & Weimer, B. C. (2003) · International Dairy Journal · doi:10.1016/j.idairyj.2003.07.004 · Cited by 36
Improvement in lactic acid production from starch using α-amylase-secreting Lactococcus lactis cells adapted to maltose or starch
Okano, K., Kimura, S., Narita, J., Fukuda, H., & Kondo, A. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-0905-0 · Cited by 36
Gene regulation in Lactococcus lactis: the gap between predicted and characterized regulators
Guédon, É., Jamet, E., & Renault, P. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020680926267 · Cited by 36
Genome update: lactic acid bacteria genome sequencing is booming
Liu, M., van Enckevort, F. H. J., & Siezen, R. J. (2005) · Microbiology · doi:10.1099/mic.0.28557-0 · Cited by 36
Natural sweetening of food products by engineering Lactococcus lactis for glucose production
Pool, W. A., Neves, A. R., Kok, J., Santos, H., & Kuipers, O. P. (2006) · Metabolic Engineering · doi:10.1016/j.ymben.2006.05.003 · Cited by 35
Phage Biodiversity in Artisanal Cheese Wheys Reflects the Complexity of the Fermentation Process
Mahony, J., Moscarelli, A., Kelleher, P., Lugli, G. A., Ventura, M., Settanni, L., & van Sinderen, D. (2017) · Viruses · doi:10.3390/v9030045 · Cited by 35
Lifestyle of Lactobacillus hordei isolated from water kefir based on genomic, proteomic and physiological characterization
Xu, D., Bechtner, J. D., Behr, J., Eisenbach, L., Geißler, A. J., & Vogel, R. F. (2018) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2018.10.004 · Cited by 36
The Microbiome as a Therapeutic Target for Multiple Sclerosis: Can Genetically Engineered Probiotics Treat the Disease?
Kohl, H. M., Castillo, A., & Ochoa‐Repáraz, J. (2020) · Diseases · doi:10.3390/diseases8030033 · Cited by 36
Plasmid Transfer via Transduction from Streptococcus thermophilus to Lactococcus lactis
Ammann, A., Neve, H., Geis, A., & Heller, K. J. (2008) · Journal of Bacteriology · doi:10.1128/jb.01448-07 · Cited by 35
Complete Nucleotide Sequence of the LE1 Prophage from the SpirocheteLeptospira biflexaand Characterization of Its Replication and Partition Functions
Bourhy, P., Frangeul, L., Couvé, E., Glaser, P., Girons, I. S., & Picardeau, M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.12.3931-3940.2005 · Cited by 35
Identification and Characterization of the Phage Gene sav , Involved in Sensitivity to the Lactococcal Abortive Infection Mechanism AbiV
Haaber, J., Rousseau, G. M., Hammer, K., & Moineau, S. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02093-08 · Cited by 35
Lactococcus lactis HemW (HemN) is a haem-binding protein with a putative role in haem trafficking
Abicht, H. K., Martinez, J., Layer, G., Jahn, D., & Solioz, M. (2011) · Biochemical Journal · doi:10.1042/bj20111618 · Cited by 35
Transcriptional analysis of the cyclopropane fatty acid synthase gene ofLactococcus lactisMG1363 at low pH
Budin‐Verneuil, A., Maguin, E., Auffray, Y., Ehrlich, S. D., & Pichereau, V. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.07.007 · Cited by 35
Self-citation
Induction of Heavy-Metal-Transporting CPX-Type ATPases during Acid Adaptation in Lactobacillus bulgaricus
Penaud, S., Fernandez, A., Boudebbouze, S., Ehrlich, S. D., Maguin, E., & van de Guchte, M. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01109-06 · Cited by 35
Self-citation
Two Nucleoside Uptake Systems in Lactococcus lactis : Competition between Purine Nucleosides and Cytidine Allows for Modulation of Intracellular Nucleotide Pools
Martinussen, J., Wadskov-Hansen, S. L. L., & Hammer, K. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.5.1503-1508.2003 · Cited by 35
Physical and genetic map of the Lactobacillus sakei 23K chromosome The GenBank accession numbers for the sequences reported in this paper are given in Table 2 and the legend to Fig. 3.
Dudez, A.-M., Chaillou, S., Hissler, L., Stentz, R., Champomier‐Vergès, M., Alpert, C.-A., & Zagorec, M. (2002) · Microbiology · doi:10.1099/00221287-148-2-421 · Cited by 35
Impact of thermal and biocidal treatments on lactococcal 936-type phages
Murphy, J., Mahony, J., Bonestroo, M. H., Nauta, A., & van Sinderen, D. (2013) · International Dairy Journal · doi:10.1016/j.idairyj.2013.06.011 · Cited by 34
Heterologous expression of carcinoembryonic antigen in Lactococcus lactis via LcsB-mediated surface displaying system for oral vaccine development
Zhang, X., Hu, S., Du, X. Y., Li, T., Han, L., & Kong, J. (2014) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2014.11.009 · Cited by 34
Structure and Function of CinD (YtjD) ofLactococcus lactis, a Copper-Induced Nitroreductase Involved in Defense against Oxidative Stress
Mermod, M., Mourlane, F., Waltersperger, S., Oberholzer, A. E., Baumann, U., & Solioz, M. (2010) · Journal of Bacteriology · doi:10.1128/jb.00372-10 · Cited by 34
Assessing the functionality and genetic diversity of lactococcal prophages
Kelleher, P., Mahony, J., Schweinlin, K., Neve, H., Franz, C. M. A. P., & van Sinderen, D. (2018) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2018.02.024 · Cited by 34
Lactobacillus gasseriPA-3 utilizes the purines GMP and guanosine and decreases their absorption in rats
Yamada, N., Saito, C., Murayama-Chiba, Y., Kano, H., Asami, Y., & Itoh, H. (2018) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2018.1454949 · Cited by 34
Metabolic footprint analysis of volatile metabolites by gas chromatography-ion mobility spectrometry to discriminate between different fermentation temperatures during Streptococcus thermophilus milk fermentation
Guo, S., Wu, T., Peng, C., Wang, J., Sun, T., & Zhang, H. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19555 · Cited by 34
Physiological function of the maltose operon regulator, MalR, in Lactococcus lactis
Andersson, U., & Rådström, P. (2002) · BMC Microbiology · doi:10.1186/1471-2180-2-28 · Cited by 34
Role of Aminotransferase IlvE in Production of Branched-Chain Fatty Acids by Lactococcus lactis subsp. lactis
Ganesan, B., & Weimer, B. C. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.1.638-641.2004 · Cited by 34
Identification of a Novel Streptococcal Gene Cassette Mediating SOS Mutagenesis in Streptococcus uberis
Varhimo, E., Savijoki, K., Jalava, J., Kuipers, O. P., & Varmanen, P. (2007) · Journal of Bacteriology · doi:10.1128/jb.00473-07 · Cited by 35
Influence of the Dairy Environment on Gene Expression and Substrate Utilization in Lactic Acid Bacteria1, ,
Klaenhammer, T. R., Azcárate-Peril, M. A., Altermann, E., & Barrangou, R. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.748s · Cited by 34
Expression in Lactococcus lactis of functional genes related to amino acid catabolism and cheese aroma formation is influenced by branched chain amino acids
García‐Cayuela, T., de Cadiñanos, L. P. G., Peláez, C., & Requena, T. (2012) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2012.09.002 · Cited by 33
The significance of translation regulation in the stress response
Picard, F., Loubière, P., Girbal, L., & Cocaign‐Bousquet, M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-588 · Cited by 33
Evolutionary Origins of Two-Barrel RNA Polymerases and Site-Specific Transcription Initiation
Fouqueau, T., Blombach, F., & Werner, F. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104145 · Cited by 32
Characterization of Lactobacillus amylolyticus L6 as potential probiotics based on genome sequence and corresponding phenotypes
Fei, Y., Li, L., Zheng, Y., Liu, D., Zhou, Q., & Fu, L. (2017) · LWT · doi:10.1016/j.lwt.2017.12.028 · Cited by 34
Unleashing Natural Competence in Lactococcus lactis by Induction of the Competence Regulator ComX
Mulder, J., Wels, M., Kuipers, O. P., Kleerebezem, M., & Bron, P. A. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01320-17 · Cited by 34
A cell wall‐associated polysaccharide is required for bacteriophage adsorption to the Streptococcus thermophilus cell surface
McDonnell, B., Hanemaaijer, L., Bottacini, F., Kelleher, P., Lavelle, K., Sadovskaya, I., VINOGRADOV, E. V., van Themaat, E. V. L., Kouwen, T. R. H. M., Mahony, J., et al. (2020) · Molecular Microbiology · doi:10.1111/mmi.14494 · Cited by 33
Probiotic Characterization of Lactobacillus brevis MJM60390 and In Vivo Assessment of Its Antihyperuricemic Activity
Lee, Y., Kim, N., Werlinger, P., Suh, D.-A., Lee, H., Cho, J.-H., & Cheng, J. (2022) · Journal of Medicinal Food · doi:10.1089/jmf.2021.k.0171 · Cited by 34
Influence of Lipoteichoic Acid d -Alanylation on Protein Secretion in Lactococcus lactis as Revealed by Random Mutagenesis
Nouaille, S., Commissaire, J., Gratadoux, J., Ravn, P., Bolotin, A., Gruss, A., Loir, Y. L., & Langella, P. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.3.1600-1607.2004 · Cited by 33
Self-citation
Genetic traceability of the geographical origin of typical Italian water buffalo Mozzarella cheese: a preliminary approach
Bonizzi, I., Feligini, M., Aleandri, R., & Enne, G. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.03131.x · Cited by 33
Heterologous expression of Brucella abortus GroEL heat-shock protein in Lactococcus lactis
Miyoshi, A., Bermúdez‐Humarán, L. G., Ribeiro, L. A., Loir, Y. L., Oliveira, S. C., Langella, P., & Azevedo, V. (2006) · Microbial Cell Factories · doi:10.1186/1475-2859-5-14 · Cited by 33
Starvation induces physiological changes that act on the cryotolerance of Lactobacillus acidophilus RD758
Wang, Y., Delettre, J., Corrieu, G., & Béal, C. (2011) · Biotechnology Progress · doi:10.1002/btpr.566 · Cited by 32
Effect of Indian monsoon on the glacial airborne bacteria over the Tibetan Plateau
Qi, J. Y., Ji, M., Wang, W., Zhang, Z., Liu, K., Huang, Z., & Liu, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154980 · Cited by 32
Citrate Uptake in Exchange with Intermediates in the Citrate Metabolic Pathway in Lactococcus lactis IL1403
Pudlik, A. M., & Lolkema, J. S. (2010) · Journal of Bacteriology · doi:10.1128/jb.01171-10 · Cited by 32
Spontaneous resistance inLactococcus lactisIL1403 to the lantibiotic lacticin 3147
Guinane, C. M., Cotter, P. D., Hill, C., & Ross, R. P. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00302.x · Cited by 32
Unity in organisation and regulation of catabolic operons in Lactobacillus plantarum, Lactococcus lactis and Listeria monocytogenes
Andersson, J., Douwe Molenaar, B., Rådström, P., & de Vos, W. M. (2005) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2004.11.004 · Cited by 32
thyA as a Selection Marker in Construction of Food-Grade Host-Vector and Integration Systems for Streptococcus thermophilus
Sasaki, Y., Ito, Y., & Sasaki, T. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.3.1858-1864.2004 · Cited by 32
Surface Mold–Ripened Cheeses
Spinnler, H.-E. (2017) · Cheese · doi:10.1016/b978-0-12-417012-4.00036-3 · Cited by 32
Transporters and their roles in LAB cell physiology
Poolman, B. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020658831293 · Cited by 33
Kinetics of Lactococcus lactis growth and metabolite formation under aerobic and anaerobic conditions in the presence or absence of hemin
Lan, C. Q., Oddone, G. M., Mills, D. A., & Block, D. E. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.21070 · Cited by 32
Garvicin Q: characterization of biosynthesis and mode of action
Desiderato, C. K., Hasenauer, K. M., Reich, S. J., Goldbeck, O., Holivololona, L., Ovchinnikov, K. V., Reiter, A., Oldiges, M., Diep, D. B., Eikmanns, B. J., et al. (2022) · Microbial Cell Factories · doi:10.1186/s12934-022-01952-9 · Cited by 32
7. Genetically modified microorganisms and their potential effects on human health and nutrition
von Wright, A., & Bruce, Å. (2003) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(03)00068-2 · Cited by 31
Glycerol Metabolism of Lactobacillus rhamnosus ATCC 7469: Cloning and Expression of Two Glycerol Kinase Genes
Álvarez, M. D. F., Medina, R. B., Pasteris, S. E., de Saad, A. M. S., & Sesma, F. J. M. (2004) · Microbial Physiology · doi:10.1159/000079826 · Cited by 31
Biotechnology of Riboflavin Production
Hohmann, H., & Stahmann, K. ‐. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00667-5 · Cited by 31
Phylogenesis and Evolution of Lactic Acid Bacteria
Sun, Z., Yu, J. Z., Tong, D., Zhang, W., & Zhang, H. (2014) · Springer eBooks · doi:10.1007/978-94-017-8841-0_1 · Cited by 31
A rapid PCR procedure for the specific identification of Lactobacillus sanfranciscensis, based on the 16S-23S intergenic spacer regions
Valcheva, R. S., Kabadjova, P., Rachman, C., Иванова, И., Onno, B., Prévost, H., & Dousset, X. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.03039.x · Cited by 31
Roles of Environmental Heme, and Menaquinone, in Streptococcus Agalactiae
Yamamoto, Y., Poyart, C., Trieu‐Cuot, P., Lamberet, G., Gruss, A., & Gaudu, P. (2006) · BioMetals · doi:10.1007/s10534-005-5419-6 · Cited by 34
Dairy Starter Cultures
Ustunol, Z. (2014) · CRC Press eBooks · doi:10.1201/b17297-3 · Cited by 31
A new lactobacilliin vivoexpression system for the production and delivery of heterologous proteins at mucosal surfaces
Allain, T., Mansour, N. M., Bahr, M. M. A., Martín, R., Florent, I., Langella, P., & Bermúdez‐Humarán, L. G. (2016) · FEMS Microbiology Letters · doi:10.1093/femsle/fnw117 · Cited by 30
Horizontal Gene Transfer in Bacteria, an Overview of the Mechanisms Involved
Villa, T. G., Feijoo-Siota, L., Sánchez-Pérez, A., Rama, J. R., & Sieiro, C. (2019) · Springer eBooks · doi:10.1007/978-3-030-21862-1_1 · Cited by 29
Anchoring of heterologous proteins in multiple Lactobacillus species using anchors derived from Lactobacillus plantarum
Mathiesen, G., Øverland, L., Kuczkowska, K., & Eijsink, V. G. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-66531-7 · Cited by 30
Bacterial Communities Associated with the Pine Wilt Disease Insect Vector Monochamus alternatus (Coleoptera: Cerambycidae) during the Larvae and Pupae Stages
Chen, H., Hao, D., Wei, Z., Wang, L., & Lin, T. (2020) · Insects · doi:10.3390/insects11060376 · Cited by 30
The Lactococcin G Immunity Protein Recognizes Specific Regions in Both Peptides Constituting the Two-Peptide Bacteriocin Lactococcin G
Oppegård, C., Emanuelsen, L., Thorbek, L., Fimland, G., & Nissen-Meyer, J. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02600-09 · Cited by 34
Sigma X induces competence gene expression in Streptococcus pyogenes
Woodbury, R. L., Wang, X., & Moran, C. P. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2006.07.002 · Cited by 30
Frequent oligonucleotide motifs in genomes of three streptococci
Mrazek, J. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf534 · Cited by 30
Multicopy Integration of Heterologous Genes, Using the Lactococcal Group II Intron Targeted to Bacterial Insertion Sequences
Rawsthorne, H., Turner, K. N., & Mills, D. A. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.02992-05 · Cited by 30
The α-Phosphoglucomutase of Lactococcus lactis Is Unrelated to the α-d-Phosphohexomutase Superfamily and Is Encoded by the Essential Gene pgmH
Neves, A. R., Pool, W. A., Castro, R., Mingote, A. I., dos Santos, F. B., Kok, J., Kuipers, O. P., & Santos, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607044200 · Cited by 30
Overview on sugar metabolism and its control inLactococcus lactis— The input from in vivo NMR
Neves, A. R., Pool, W. A., Kok, J., Kuipers, O. P., & Santos, H. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.fmrre.2005.04.005 · Cited by 30
Dynamic Changes in Flavor and Microbiota in Traditionally Fermented Bamboo Shoots (Chimonobambusa szechuanensis (Rendle) Keng f.)
Long, Z., Zhao, S., Xu, X., Du, W., Chen, Q., & Hu, S. (2023) · Foods · doi:10.3390/foods12163035 · Cited by 29
Getting value from the waste: recombinant production of a sweet protein by Lactococcus lactis grown on cheese whey
Boumaiza, M., Colarusso, A., Parrilli, E., García‐Fruitós, E., Casillo, A., Arı́s, A., Corsaro, M. M., Picone, D., Leone, S., & Tutino, M. L. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0974-z · Cited by 29
Genetic Engineering of Lactococcus lactis Co-producing Antigen and the Mucosal Adjuvant 3′ 5′- cyclic di Adenosine Monophosphate (c-di-AMP) as a Design Strategy to Develop a Mucosal Vaccine Prototype
Quintana, I. M., Espariz, M., Villar, S. R., González, F. B., Pacini, M. F., Cabrera, G., Bontempi, I., Prochetto, E., Stülke, J., Pérez, A. R., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02100 · Cited by 29
Responses of Lactic Acid Bacteria to Heavy Metal Stress
Solioz, M., Mermod, M., Abicht, H. K., & Mancini, S. (2011) · Springer eBooks · doi:10.1007/978-0-387-92771-8_9 · Cited by 29
Efficient transformation of Lactococcus lactis IL1403 and generation of knock‐out mutants by homologous recombination
Gerber, S. D., & Solioz, M. (2007) · Journal of Basic Microbiology · doi:10.1002/jobm.200610297 · Cited by 29
Lactococcus lactis M4, a potential host for the expression of heterologous proteins
Nanyan, N. S. M., Hooi, W. Y., Baradaran, A., Rosfarizan, M., Sieo, C. C., Rosli, M. I., Yusoff, K., & Raha, A. R. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-28 · Cited by 29
The PurR regulon in Lactococcus lactis – transcriptional regulation of the purine nucleotide metabolism and translational machinery
Jendresen, C. B., Martinussen, J., & Kilstrup, M. (2012) · Microbiology · doi:10.1099/mic.0.059576-0 · Cited by 29
Lipoprotein Signal Peptides Are Processed by Lsp and Eep of Streptococcus uberis
Denham, E. L., Ward, P. N., & Leigh, J. A. (2008) · Journal of Bacteriology · doi:10.1128/jb.00287-08 · Cited by 29
Natural DNA Transformation Is Functional in Lactococcus lactis subsp. cremoris KW2
David, B., Radziejwoski, A., Toussaint, F., Fontaine, L., de Frahan, M. H., Patout, C., van Dillen, S., Boyaval, P., Horvath, P., Fremaux, C., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01074-17 · Cited by 29
Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength
Price, C. E., dos Santos, F. B., Hesseling, A., Uusitalo, J. J., Bachmann, H., Benavente, V., Goel, A., Berkhout, J., Bruggeman, F. J., Marrink, ‪. J., et al. (2019) · BMC Evolutionary Biology · doi:10.1186/s12862-018-1331-x · Cited by 29
Metabolism of lactic acid bacteria studied by nuclear magnetic resonance
Ramos, A., Neves, A. R., & Santos, H. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020664422633 · Cited by 29
Mutagenesis in the post genomics era: tools for generating insertional mutations in the lactic acid bacteria
Mills, D. A. (2001) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(00)00254-8 · Cited by 29
High-throughput PCR Screening of Genes for Three-component Regulatory System Putatively Involved in Quorum Sensing from Low-G+C Gram-positive Bacteria
Nakayama, J., Akkermans, A. D. L., & de Vos, W. M. (2003) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.67.480 · Cited by 29
Optimization of fed‐batch production of the model recombinant protein GFP in Lactococcus lactis
Oddone, G. M., Lan, C., Rawsthorne, H., Mills, D. A., & Block, D. E. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.21192 · Cited by 29
Identification of a nisI Promoter within the nisABCTIP Operon That May Enable Establishment of Nisin Immunity Prior to Induction of the Operon via Signal Transduction
Li, H., & O’Sullivan, D. J. (2006) · Journal of Bacteriology · doi:10.1128/jb.00946-06 · Cited by 29
Pili and other surface proteins influence the structure and the nanomechanical properties of Lactococcus lactis biofilms
Drame, I., Lafforgue, C., Formosa-Dague, C., Chapot-Chartier, M.-P., Piard, J.-C., Castelain, M., & Dague, E. (2021) · Scientific Reports · doi:10.1038/s41598-021-84030-1 · Cited by 28
Altering textural properties of fermented milk by using surface‐engineered Lactococcus lactis
Mariya, T., Huppertz, T., Kok, J., & Bachmann, H. (2018) · Microbial Biotechnology · doi:10.1111/1751-7915.13278 · Cited by 27

Authors: Bolotin, A., Wincker, P., Mauger, S., Jaillon, O., Malarme, K., Weissenbach, J., Ehrlich, S. D., & Sorokin, A.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
ORCID: Wincker, P.
Mauger, S.
Jaillon, O.
Ehrlich, S. D.
Sorokin, A.
Venue: Genome Research
Publisher: Cold Spring Harbor Laboratory
Published: 2001-04-11
Volume: 11
Issue: 5
Pages: 731-753
ISSN: 1088-9051 (ISSN-L)
DOI: 10.1101/gr.gr-1697r
PMC: PMC311110
OpenAlex: W2168772829
Cited by: 1,139
References: 54
Citations by year: 2026: 8 · 2025: 11 · 2024: 17 · 2023: 29 · 2022: 27 · 2021: 31 · 2020: 30 · 2019: 30 · 2018: 45 · 2017: 36 · 2016: 28 · 2015: 32 · 2014: 51 · 2013: 39 · 2012: 59
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genome Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
HAL (submittedVersion, public-domain)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: complete genome sequence, lactic acid bacteria, cheese starter cultures, prophages, insertion sequences, recombination, DNA transformation, fermentation pathways, aerobic respiration, horizontal gene transfer
MeSH terms: Amino Acids, Bacterial Proteins, Bacteriophages, Biological Transport, Active, Cell Wall, DNA Transposable Elements, Energy Metabolism, Enterobacteriaceae, Gene Expression Regulation, Multigene Family, Molecular Sequence Data, Nucleotides, Endopeptidases, Proviruses, RNA, Bacterial, Lactococcus lactis, Transformation, Genetic, Vitamins, Signal Transduction, Open Reading Frames, Genome, Bacterial, Sequence Analysis, DNA, Lactic Acid, Gene Transfer, Horizontal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Complete Genome Sequence of the Lactic Acid Bacterium Lactococcus lactis ssp. lactis IL1403

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks