The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
The Complete Genome Sequence of the Lactic Acid Bacterium Lactococcus lactis ssp. lactis IL1403
Open accessAbstract
Lactococcus lactis is a nonpathogenic AT-rich gram-positive bacterium closely related to the genus Streptococcus and is the most commonly used cheese starter. It is also the best-characterized lactic acid bacterium. We sequenced the genome of the laboratory strain IL1403, using a novel two-step strategy that comprises diagnostic sequencing of the entire genome and a shotgun polishing step. The genome contains 2,365,589 base pairs and encodes 2310 proteins, including 293 protein-coding genes belonging to six prophages and 43 insertion sequence (IS) elements. Nonrandom distribution of IS elements indicates that the chromosome of the sequenced strain may be a product of recent recombination between two closely related genomes. A complete set of late competence genes is present, indicating the ability of L. lactis to undergo DNA transformation. Genomic sequence revealed new possibilities for fermentation pathways and for aerobic respiration. It also indicated a horizontal transfer of genetic information from Lactococcus to gram-negative enteric bacteria of Salmonella-Escherichia group.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
A genomic perspective on protein families.
Tatusov, R., Koonin, E., & Lipman, D. (1997) · Science · doi:10.1126/science.278.5338.631 · Cited by 3,777
The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessières, P., Bolotin, A., Borchert, S., et al. (1997) · Nature · doi:10.1038/36786 · Cited by 3,679
Self-citationTreatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513
Gasson, M. J. (1983) · Journal of Bacteriology · doi:10.1128/jb.154.1.1-9.1983 · Cited by 1,313
Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58
Tettelin, H., Saunders, N. J. S. G., Heidelberg, J. F., Jeffries, A. C., Nelson, K. E., Eisen, J. A., Ketchum, K. A., Hood, D. W., Peden, J. F., Dodson, R. J., et al. (2000) · Science · doi:10.1126/science.287.5459.1809 · Cited by 1,084
GENMARK: Parallel gene recognition for both DNA strands
Borodovsky, M. Y., & McIninch, J. D. (1993) · Computers & Chemistry · doi:10.1016/0097-8485(93)85004-v · Cited by 730
Peptidases and amino acid catabolism in lactic acid bacteria
Christensen, J. E., Dudley, E. G., Pederson, J. A., & Steele, J. L. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002001919720 · Cited by 630
Transfer of Streptococcus lactis and Related Streptococci to the Genus Lactococcus gen. nov.
SCHLEIFER, K. H., Kraus, J., Dvorak, C., Kilpper-Bälz, R., Collins, M. D., & Fischer, W. (1985) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(85)80052-7 · Cited by 479
Calibrating bacterial evolution.
Ochman, H., Elwyn, S., & Moran, N. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.22.12638 · Cited by 457
Two plasmid-determined restriction and modification systems in Streptococcus lactis
Chopin, A., Chopin, M., Moillo-Batt, A., & Langella, P. (1984) · Plasmid · doi:10.1016/0147-619x(84)90033-7 · Cited by 400
Lee, M. S., & Morrison, D. A. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.16.5004-5016.1999 · Cited by 336
A sequence assembly and editing program for efficient management of large projects
Dear, S., & Staden, R. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.14.3907 · Cited by 324
Minimal Requirements for Exponential Growth of Lactococcus lactis
Jensen, P. R., & Hammer, K. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.12.4363-4366.1993 · Cited by 318
Searching for patterns in genomic data
D’Souza, M., Larsen, N., & Overbeek, R. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01347-4 · Cited by 304
A chloride‐inducible acid resistance mechanism in Lactococcus lactis and its regulation
Sanders, J.-W., Leenhouts, K. J., Burghoorn, J., Brands, J. R., Venema, G., & Kok, J. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00676.x · Cited by 276
Fox, P. F. (1993) · Springer eBooks · doi:10.1007/978-1-4615-2650-6_1 · Cited by 275
van Kranenburg, R., Marugg, J. D., van Swam, I. I., Willem, N. J., & de Vos, W. M. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.3521720.x · Cited by 262
Energy transduction in lactic acid bacteria
Poolman, B. (1993) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1993.tb00015.x · Cited by 241
de Felipe, F. L., Kleerebezem, M., de Vos, W. M., & Hugenholtz, J. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.15.3804-3808.1998 · Cited by 223
Retrohoming of a Bacterial Group II Intron
Cousineau, B., Smith, D., Lawrence, S., Mueller, J. E., Yang, J. T., Mills, D. A., Manias, D. A., Dunny, G. M., Lambowitz, A. M., & Belfort, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81586-x · Cited by 217
Poquet, I., Saint, V., Seznec, E., Simoes, N., Bolotin, A., & Gruss, A. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01757.x · Cited by 212
Self-citationSecD and SecF facilitate protein export in Escherichia coli.
Pogliano, J., & Beckwith, J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06293.x · Cited by 209
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems
Quentin, Y., Fichant, G. A., & Denizot, F. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2624 · Cited by 193
Chopin, A. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.3.644 · Cited by 183
Low-redundancy sequencing of the entire Lactococcus lactis IL1403 genome
Bolotin, A., Mauger, S., Malarme, K., Ehrlich, S. D., & Sorokin, A. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002048720611 · Cited by 180
Self-citationYvon, M., Chambellon, E., Bolotin, A., & Roudot-Algaron, F. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.2.571-577.2000 · Cited by 176
Self-citationLoir, Y. L., Gruss, A., Ehrlich, S. D., & Langella, P. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.7.1895-1903.1998 · Cited by 175
Self-citationPhysiology of pyruvate metabolism in Lactococcus lactis
Cocaign‐Bousquet, M., Garrigues, C., Loubière, P., & Lindley, N. D. (1996) · Antonie van Leeuwenhoek · doi:10.1007/bf00395936 · Cited by 174
Sanders, J.-W., Leenhouts, K. J., Haandrikman, A. J., Venema, G., & Kok, J. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.18.5254-5260.1995 · Cited by 151
Pestova, E. V., & Morrison, D. A. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.10.2701-2710.1998 · Cited by 135
Bolhuis, A., Broekhuizen, C. P., Sorokin, A., van Roosmalen, M. L., Venema, G., Bron, S., Quax, W. J., & van Dijl, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21217 · Cited by 134
Self-citationGene inactivation in Lactococcus lactis: branched-chain amino acid biosynthesis
Godon, J., Delorme, C., Bardowski, J. K., Chopin, M., Ehrlich, S. D., & Renault, P. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.14.4383-4390.1993 · Cited by 113
Self-citationEnergy recycling by lactate efflux in growing and nongrowing cells of Streptococcus cremoris
ten Brink, B., Otto, R., Hansen, U., & Konings, W. N. (1985) · Journal of Bacteriology · doi:10.1128/jb.162.1.383-390.1985 · Cited by 102
Sijpesteijn, A. K. (1970) · Antonie van Leeuwenhoek · doi:10.1007/bf02069035 · Cited by 98
Translation initiation factor 3 antagonizes authentic start codon selection on leaderless mRNAs
Tedin, K., Moll, I., Grill, S., Resch, A., Graschopf, A., Gualerzi, C. O., & Bläsi, U. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01147.x · Cited by 91
Valyasevi, R., Sandine, W. E., & Geller, B. L. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.6.1882-1889.1990 · Cited by 90
Strategies for whole microbial genome sequencing and analysis
Fraser, C. M., & Fleischmann, R. D. (1997) · Electrophoresis · doi:10.1002/elps.1150180803 · Cited by 90
Isolation of Lactococcus lactis nonsense suppressors and construction of a food‐grade cloning vector
Dickely, F., Nilsson, D., Hansen, E. B., & Johansen, E. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02354.x · Cited by 90
Autolysis of Lactococcus lactis caused by induced overproduction of its major autolysin AcmA
Buist, G., Karsens, H., Nauta, A., van Sinderen, D., Venema, G., & Kok, J. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.7.2722-2728.1997 · Cited by 84
Karudapuram, S., Zhao, X., & Barcak, G. J. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.11.3235-3240.1995 · Cited by 82
Etten, W. J. V., & Janssen, G. R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00744.x · Cited by 81
Bourgeois, P., Lautier, M., Berghe, L. V. D., Gasson, M. J., & Ritzenthaler, P. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.10.2840-2850.1995 · Cited by 81
Characterization of Lactococcus lactis UV-sensitive mutants obtained by ISS1 transposition
Duwat, P., Cochu, A., Ehrlich, S. D., & Gruss, A. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.14.4473-4479.1997 · Cited by 72
Self-citationChiaruttini, C., & Milet, M. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1126 · Cited by 61
Fernández, S., Sorokin, A., & Alonso, J. C. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.13.3405-3409.1998 · Cited by 60
Self-citationPhysical and genetic map of the chromosome of Lactococcus lactis subsp. lactis IL1403
Bourgeois, P., Lautier, M., Mata, M., & Ritzenthaler, P. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.21.6752-6762.1992 · Cited by 58
Peptidases and amino acid catabolism in lactic acid bacteria
Pederson, J. A., Steele, J. L., Christensen, J. E., & Dudley, E. G. (1999) · Springer eBooks · doi:10.1007/978-94-017-2027-4_11 · Cited by 52
Sorokin, A., Lapidus, A., Capuano, V., Galleron, N., Pujić, P., & Ehrlich, S. D. (1996) · Genome Research · doi:10.1101/gr.6.5.448 · Cited by 44
Self-citationMickelson, M. N. (1972) · Journal of Bacteriology · doi:10.1128/jb.109.1.96-105.1972 · Cited by 39
Griffin, H. G., Swindell, S. R., & Gasson, M. J. (1992) · Gene · doi:10.1016/0378-1119(92)90049-u · Cited by 33
Calibrating bacterial evolution
Matić, I. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01710-8 · Cited by 10
Aspartate metabolism in Lactobacillus murinus CNRS 313. I. Aspartase.
Rollán, G., de Nadra, M. C. M., Holgado, A. A. P. D. R., & OLIVER, G. (1985) · The Journal of General and Applied Microbiology · doi:10.2323/jgam.31.403 · Cited by 10
Physiology of pyruvate metabolism in Lactococcus lactis
Cocaign‐Bousquet, M., Garrigues, C., Loubière, P., & Lindley, N. D. (1996) · Springer eBooks · doi:10.1007/978-94-009-1774-3_10 · Cited by 5
Vv, K., Gileva, I. P., Vn, D., Filippov, S. A., & Korobko, V. G. (1988) · PubMed · Cited by 1
Yvon, M., Chambellon, É., Bolotin, A., et al. (2000) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 1
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Complete genome sequence of Lactobacillus plantarum WCFS1
Kleerebezem, M., Boekhorst, J., van Kranenburg, R., Molenaar, D., Kuipers, O. P., Leer, R., Tarchini, R., Peters, S. A., Sandbrink, H. M., Fiers, M. W. E. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337704100 · Cited by 1,472
Deutscher, J., Francke, C., & Postma, P. W. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00024-06 · Cited by 1,411
Comparative genomics of the lactic acid bacteria.
Makarova, K., Slesarev, A., Wolf, Y., Sorokin, A., Mirkin, B., Koonin, E., Pavlov, A., Pavlova, N., Karamychev, V., Polouchine, N., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607117103 · Cited by 1,391
Self-citationGenome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen
Ajdić, D., McShan, W. M., McLaughlin, R. E., Savić, G., Chang, J. S., Carson, M. B., Primeaux, C., Tian, R., Kenton, S., Jia, H., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172501299 · Cited by 1,013
The Complex Microbiota of Raw Milk
Quigley, L., O'Sullivan, O., Stanton, C., Beresford, T. P., Ross, R. P., Fitzgerald, G. F., & Cotter, P. D. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12030 · Cited by 919
Metadata
- Authors
- Bolotin, A., Wincker, P., Mauger, S., Jaillon, O., Malarme, K., Weissenbach, J., Ehrlich, S. D., & Sorokin, A.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-04-11
- Volume
- 11
- Issue
- 5
- Pages
- 731-753
- ISSN
- 1088-9051 (ISSN-L)
- PMC
- PMC311110
- OpenAlex
- W2168772829
- Cited by
- 1,139
- References
- 54
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 17 · 2023: 29 · 2022: 27 · 2021: 31 · 2020: 30 · 2019: 30 · 2018: 45 · 2017: 36 · 2016: 28 · 2015: 32 · 2014: 51 · 2013: 39 · 2012: 59
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genome Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HAL (submittedVersion, public-domain)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- complete genome sequence, lactic acid bacteria, cheese starter cultures, prophages, insertion sequences, recombination, DNA transformation, fermentation pathways, aerobic respiration, horizontal gene transfer
- MeSH terms
- Amino Acids, Bacterial Proteins, Bacteriophages, Biological Transport, Active, Cell Wall, DNA Transposable Elements, Energy Metabolism, Enterobacteriaceae, Gene Expression Regulation, Multigene Family, Molecular Sequence Data, Nucleotides, Endopeptidases, Proviruses, RNA, Bacterial, Lactococcus lactis, Transformation, Genetic, Vitamins, Signal Transduction, Open Reading Frames, Genome, Bacterial, Sequence Analysis, DNA, Lactic Acid, Gene Transfer, Horizontal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
