Serotonin transporter knockout rats show improved strategy set-shifting and reduced latent inhibition
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Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT−/−) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. This region shows functional changes in 5-HTT−/− rodents as well. Here we subjected 5-HTT−/− rats and their wild-type counterparts to an EDSS paradigm and a supplementary latent inhibition task. Results indicate that 5-HTT−/− rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism.
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SERT knockout mice perform better than control mice on the set-shifting task of the AST.
“SERT knockout mice perform better than control mice on the set-shifting task of AST (Nonkes et al 2012).”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Nonkes et al 2012
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- Authors
- Nonkes, L. J. P., van de Vondervoort, I. I. G. M., de Leeuw, M. J. C., Wijlaars, L. P., Maes, J. H. R., & Homberg, J. R.
- Affiliations
- Radboud University Nijmegen (NL)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-04-13
- Volume
- 19
- Issue
- 5
- Pages
- 190-193
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- OpenAlex
- W2135825073
- Cited by
- 37
- References
- 33
- Citations by year
- 2024: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 5 · 2012: 3
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (86410003)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- serotonin transporter knockout, latent inhibition, behavioral flexibility, medial prefrontal cortex, reversal learning, orbitofrontal cortex, cognitive flexibility
- MeSH terms
- Animals, Behavior, Animal, Inhibition, Psychological, Rats, Wistar, Prefrontal Cortex, Serotonin Plasma Membrane Transport Proteins, Rats, Gene Knockout Techniques
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