Cited by 568Memory and Neural MechanismsMemory Processes and InfluencesNeurogenesis and neuroplasticity mechanisms

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Object recognition memory and the rodent hippocampus

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Broadbent, Nicola J., Gaskin, Stephane, Squire, Larry R., Clark, Robert E.·2010·Learning & Memory

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Abstract

In rodents, the novel object recognition task (NOR) has become a benchmark task for assessing recognition memory. Yet, despite its widespread use, a consensus has not developed about which brain structures are important for task performance. We assessed both the anterograde and retrograde effects of hippocampal lesions on performance in the NOR task. Rats received 12 5-min exposures to two identical objects and then received either bilateral lesions of the hippocampus or sham surgery 1 d, 4 wk, or 8 wk after the final exposure. On a retention test 2 wk after surgery, the 1-d and 4-wk hippocampal lesion groups exhibited impaired object recognition memory. In contrast, the 8-wk hippocampal lesion group performed similarly to controls, and both groups exhibited a preference for the novel object. These same rats were then given four postoperative tests using unique object pairs and a 3-h delay between the exposure phase and the test phase. Hippocampal lesions produced moderate and reliable memory impairment. The results suggest that the hippocampus is important for object recognition memory.

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Authors: Broadbent, N. J., Gaskin, S., Squire, L. R., & Clark, R. E.
Affiliations: University of California System (US)
ORCID: Squire, Larry R.
Clark, Robert E.
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2009-12-22
Volume: 17
Issue: 1
Pages: 5-11
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.1650110
PMC: PMC2807177
OpenAlex: W2046922635
Cited by: 568
References: 24
Citations by year: 2026: 20 · 2025: 24 · 2024: 31 · 2023: 24 · 2022: 46 · 2021: 44 · 2020: 47 · 2019: 31 · 2018: 47 · 2017: 38 · 2016: 51 · 2015: 34 · 2014: 32 · 2013: 38 · 2012: 21
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (0542013)
U.S. Department of Veterans Affairs
James S. McDonnell Foundation
Kavli Foundation
National Institute on Aging (P50AG005131, P50-AG05131)
National Institute of Mental Health (P50 AG05131, AG05131, R01MH024600)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: object recognition memory, hippocampus, hippocampal lesions, anterograde amnesia, retrograde amnesia, memory impairment, rats
MeSH terms: Analysis of Variance, Animals, Behavior, Animal, Exploratory Behavior, Hippocampus, Male, Memory, Random Allocation, Time Factors, Rats, Long-Evans, Rats

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Object recognition memory and the rodent hippocampus

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