Cited by 568Memory and Neural MechanismsMemory Processes and InfluencesNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Object recognition memory and the rodent hippocampus

Open access

Broadbent, Nicola J., Gaskin, Stephane, Squire, Larry R., Clark, Robert E.·2010·Learning & Memory

Open this paper in CoChat — free account Open PDF

Abstract

In rodents, the novel object recognition task (NOR) has become a benchmark task for assessing recognition memory. Yet, despite its widespread use, a consensus has not developed about which brain structures are important for task performance. We assessed both the anterograde and retrograde effects of hippocampal lesions on performance in the NOR task. Rats received 12 5-min exposures to two identical objects and then received either bilateral lesions of the hippocampus or sham surgery 1 d, 4 wk, or 8 wk after the final exposure. On a retention test 2 wk after surgery, the 1-d and 4-wk hippocampal lesion groups exhibited impaired object recognition memory. In contrast, the 8-wk hippocampal lesion group performed similarly to controls, and both groups exhibited a preference for the novel object. These same rats were then given four postoperative tests using unique object pairs and a 3-h delay between the exposure phase and the test phase. Hippocampal lesions produced moderate and reliable memory impairment. The results suggest that the hippocampus is important for object recognition memory.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/lm.1650110

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
The organization of recent and remote memories
Frankland, P. W., & Bontempi, B. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1607 · Cited by 2,138
Recognition memory and the medial temporal lobe: a new perspective
Squire, L. R., Wixted, J. T., & Clark, R. E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2154 · Cited by 1,059
Self-citation
Spatial memory, recognition memory, and the hippocampus
Broadbent, N. J., Squire, L. R., & Clark, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406344101 · Cited by 985
Self-citation
Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats
Maren, S., Aharonov, G., & Fanselow, M. S. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00088-0 · Cited by 765
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740
Self-citation
Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval
Winters, B. D., Saksida, L. M., & Bussey, T. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.04.004 · Cited by 600
Double Dissociation between the Effects of Peri-Postrhinal Cortex and Hippocampal Lesions on Tests of Object Recognition and Spatial Memory: Heterogeneity of Function within the Temporal Lobe
Winters, B. D., Forwood, S., Cowell, R. A., Saksida, L. M., & Bussey, T. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1346-04.2004 · Cited by 588
Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region
Zola, S. M., Squire, L. R., Teng, E., Stefanacci, L., Buffalo, E. A., & Clark, R. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00451.2000 · Cited by 477
Self-citation

Flagged first, then by citations

Show all 24 references

Research works printed but not linked: 1

Squire LR Clark RE Bayley P (2004) in The cognitive neurosciences, Medial temporal lobe functions and memory, ed Gazzaniga M (MIT, Cambridge, MA), 3rd ed, pp 691â708.

Sorted by citations

The novel object recognition memory: neurobiology, test procedure, and its modifications
Antunes, M., & Biala, G. (2012) · Cognitive Processing · doi:10.1007/s10339-011-0430-z · Cited by 2,390
Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication
Fröhlich, E. E., Farzi, A., Mayerhofer, R., Reichmann, F., Jačan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.020 · Cited by 720
Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694
Assessing rodent hippocampal involvement in the novel object recognition task. A review
Cohen, S. J., & Stackman, R. W. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.002 · Cited by 592
Fear memory
Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453
Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors
Ivy, A. S., Rex, C. S., Chen, Y., Dubé, C., Maras, P. M., Grigoriadis, D. E., Gall, C. M., Lynch, G., & Baram, T. Z. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1784-10.2010 · Cited by 402
The longer-term impacts of Western diet on human cognition and the brain
Francis, H., & Stevenson, R. J. (2013) · Appetite · doi:10.1016/j.appet.2012.12.018 · Cited by 368
The rodent hippocampus is essential for nonspatial object memory
Cohen, S. J., Munchow, A. H., Rios, L. M., Zhang, G., Ásgeirsdóttir, H. N., & Stackman, R. W. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.002 · Cited by 325
Gpr158 mediates osteocalcin’s regulation of cognition
Khrimian, L., Obri, A., Ramos-Brossier, M., Rousseaud, A., Moriceau, S., Nicot, A.-S., Mera, P., Kosmidis, S., Karnavas, T., Saudou, F., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171320 · Cited by 308
GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity
Shipton, O. A., & Paulsen, O. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0163 · Cited by 297
Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling
Chen, Y., Rex, C. S., Rice, C. J., Dubé, C. M., Gall, C. M., Lynch, G., & Baram, T. Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003825107 · Cited by 256
The Cholinergic System Modulates Memory and Hippocampal Plasticity via Its Interactions with Non-Neuronal Cells
Maurer, S. V., & Williams, C. L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01489 · Cited by 276
Memory and cognition in schizophrenia
Guo, J. Y., Ragland, J. D., & Carter, C. S. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0231-1 · Cited by 270
Post-training reversible inactivation of the hippocampus enhances novel object recognition memory
Oliveira, A. M. M., Hawk, J. D., Abel, T., & Havekes, R. (2010) · Learning & Memory · doi:10.1101/lm.1625310 · Cited by 222
The medial temporal lobe and the attributes of memory
Wixted, J. T., & Squire, L. R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.03.005 · Cited by 222
Self-citation
The hippocampus is crucial for forming non-hippocampal long-term memory during sleep
Sawangjit, A., Oyanedel, C. N., Niethard, N., Salazar, C., Born, J., & Inostroza, M. (2018) · Nature · doi:10.1038/s41586-018-0716-8 · Cited by 208
Early Stress Evokes Age-Dependent Biphasic Changes in Hippocampal Neurogenesis, Bdnf Expression, and Cognition
Suri, D., Veenit, V., Sarkar, A., Thiagarajan, D., Kumar, A., Nestler, E. J., Galande, S., & Vaidya, V. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.023 · Cited by 208
Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: Involvement of BDNF and Akt/GSK-3β signaling pathway
Hoppe, J. B., Coradini, K., Frozza, R. L., de Oliveira, C. M., Meneghetti, A., Bernardi, A., Pires, E. N. S., Beck, R. C. R., & Salbego, C. G. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.001 · Cited by 209
Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms
Mahmoud, R., Wainwright, S. R., & Galea, L. A. M. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.002 · Cited by 208
Understanding stress: Insights from rodent models
Atrooz, F., Alkadhi, K. A., & Salim, S. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100013 · Cited by 213
Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers
Figueiredo, C. P., Clarke, J. R., Ledo, J. H., Ribeiro, F. C., Costa, C., Melo, H. M., Mota-Sales, A. P., Saraiva, L. M., Klein, W. L., Sebollela, A. S., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0482-13.2013 · Cited by 186
Reciprocal effects on neurocognitive and metabolic phenotypes in mouse models of 16p11.2 deletion and duplication syndromes
Arbogast, T., Ouagazzal, A.-M., Chevalier, C., Kopanitsa, M., Afinowi, N., Migliavacca, E., Cowling, B. S., Birling, M.-C., Champy, M.-F., Reymond, A., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1005709 · Cited by 151
Mood and Memory Deficits in a Model of Gulf War Illness Are Linked with Reduced Neurogenesis, Partial Neuron Loss, and Mild Inflammation in the Hippocampus
Parihar, V. K., Hattiangady, B., Shuai, B., & Shetty, A. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.158 · Cited by 178
Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules
Frozza, R. L., Bernardi, A., Hoppe, J. B., Meneghetti, A. B., Matté, A., Battastini, A. M. O., Pohlmann, A. R., Guterres, S. S., & Salbego, C. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8401-2 · Cited by 165
The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158
Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity
Foster, T. C. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.007 · Cited by 163
Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory
Pearson-Leary, J., & McNay, E. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1700-16.2016 · Cited by 167
Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling
Wang, X., Chen, Y., Wolf, M., Wagner, K. V., Liebl, C., Scharf, S. H., Harbich, D., Mayer, B., Wurst, W., Holsboer, F., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.020 · Cited by 164
Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement
Corpas, R., Griñán‐Ferré, C., Rodrı́guez-Farré, E., Pallàs, M., & Sanfeliu, C. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1157-y · Cited by 164
New neurons in an aged brain
Lee, S. W., Clemenson, G. D., & Gage, F. H. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.009 · Cited by 164
Neuronal circuitry for recognition memory of object and place in rodent models
Chao, O. Y.-H., Nikolaus, S., Yang, Y., & Huston, J. P. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104855 · Cited by 171
Cannabidiol administration after hypoxia–ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
Pazos, M. R., Cinquina, V., Gómez, A., Layunta, R., Santos, M., Fernández‐Ruíz, J., & Martínez-Orgado, J. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.034 · Cited by 151
The evolving role of dendritic spines and memory: Interaction(s) with estradiol
Frankfurt, M., & Luine, V. N. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.004 · Cited by 159
Selective Inhibition of Microglia-Mediated Neuroinflammation Mitigates Radiation-Induced Cognitive Impairment
Jenrow, K. A., Brown, S. L., Lapanowski, K., Naei, H., Kolozsvary, A. J. J., & Kim, J. H. (2013) · Radiation Research · doi:10.1667/rr3026.1 · Cited by 141
Mangiferin: A review of sources and interventions for biological activities
Jyotshna, Khare, P., & Shanker, K. (2016) · BioFactors · doi:10.1002/biof.1308 · Cited by 144
Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats
Riga, D., Kramvis, I., Koskinen, M. K., van Bokhoven, P., van der Harst, J. E., Heistek, T. S., Jaap Timmerman, A., van Nierop, P., van der Schors, R. C., Pieneman, A. W., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8753 · Cited by 128
Early life manipulations alter learning and memory in rats
Kosten, T. A., Kim, J. J., & Lee, H. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.003 · Cited by 136
Regulation of object recognition and object placement by ovarian sex steroid hormones
Tuscher, J. J., Fortress, A. M., Kim, J., & Frick, K. M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.001 · Cited by 142
Object recognition and Morris water maze to detect cognitive impairment from mild hippocampal damage in rats: A reflection based on the literature and experience
Lissner, L. J., Wartchow, K. M., Toniazzo, A. P., Gonçalves, C., & Rodrigues, L. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173273 · Cited by 141
Toxicity of polystyrene nanoplastics and zinc oxide to mice
Estrela, F. N., Guimarães, A. T. B., Araújo, A. P. D. C., Silva, F. G., da Luz, T. M., Silva, A. M., Pereira, P. S., & Malafaia, G. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.129476 · Cited by 132
A review of behavioral methods for the evaluation of cognitive performance in animal models: Current techniques and links to human cognition
Ghafarimoghadam, M., Mashayekh, R., Gholami, M., Fereydani, P., Shelley-Tremblay, J. F., Kandezi, N., Sabouri, E., & Motaghinejad, M. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113652 · Cited by 138
A key role for TGF-β1 in hippocampal synaptic plasticity and memory
Caraci, F., Gulisano, W., Guida, C. A., Impellizzeri, A. A. R., Drago, F., Puzzo, D., & Palmeri, A. (2015) · Scientific Reports · doi:10.1038/srep11252 · Cited by 133
Female mice are protected from space radiation-induced maladaptive responses
Krukowski, K., Grue, K. A., Frias, E. S., Pietrykowski, J., Jones, T., Nelson, G. A., & Rosi, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.08.008 · Cited by 126
The Nucleus of the Solitary Tract→Nucleus Paragigantocellularis→Locus Coeruleus→CA1 region of dorsal hippocampus pathway is important for consolidation of object recognition memory
Mello‐Carpes, P. B., & Izquierdo, I. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.12.002 · Cited by 120
Behavioral tagging of extinction learning
Myskiw, J. D. C., Benetti, F., & Izquierdo, I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220875110 · Cited by 126
SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms
Corpas, R., Revilla, S., Ursulet, S., Castro, M., Kaliman, P., Petegnief, V., Giménez‐Llort, L., Sarkis, C., Pallàs, M., & Sanfeliu, C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0087-9 · Cited by 124
The role of the citric acid cycle in cells of the immune system and its importance in sepsis, trauma and burns.
Newsholme, E. A., Newsholme, P., & Curi, R. (1987) · PubMed · Cited by 121
Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress
Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118
De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus
Stilling, R. M., Benito, E., Barth, J., Gertig, M., Capece, V., Burckhardt, S., Bonn, S., & Fischer, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00373 · Cited by 115
Hippocampal activation of Rac1 regulates the forgetting of object recognition memory
Liu, Y., Du, S., Lv, L., Lei, B., Shi, W., Tang, Y., Wang, L., & Zhong, Y. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.056 · Cited by 114
A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease
Chen, Q., Prior, M., Dargusch, R., Roberts, A. J., Riek, R., Eichmann, C., Chiruta, C., Akaishi, T., Abe, K., Maher, P. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027865 · Cited by 116
MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early‐life adversity
Molet, J., Maras, P. M., Kinney‐Lang, E., Harris, N. G., Rashid, F. M., Ivy, A. S., Solodkin, A., Obenaus, A., & Baram, T. Z. (2016) · Hippocampus · doi:10.1002/hipo.22661 · Cited by 119
Maternal stress during pregnancy causes sex-specific alterations in offspring memory performance, social interactions, indices of anxiety, and body mass
Schulz, K. M., Pearson-Smith, J. N., Neeley, E. W., Berger, R., Leonard, S. S., Adams, C. E., & Stevens, K. E. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.021 · Cited by 109
Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner
Johnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A., Steiner, R. D., Sullivan, P. M., Maeda, N., & Raber, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.016 · Cited by 107
Microglia control glutamatergic synapses in the adult mouse hippocampus
Basilico, B., Ferrucci, L., Ratano, P., Golia, M. T., Grimaldi, A., Rosito, M., Ferretti, V., Reverte, I., Sanchini, C., Marrone, M. C., et al. (2021) · Glia · doi:10.1002/glia.24101 · Cited by 104
Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory.
Li, E., Chung, H., Kim, Y., Kim, D. H., Ryu, J., Sato, T., Kojima, M., & Park, S. (2013) · Endocrine journal · doi:10.1507/endocrj.ej13-0008 · Cited by 100
TNF-like weak inducer of apoptosis promotes blood brain barrier disruption and increases neuronal cell death in MRL/lpr mice
Wen, J., Doerner, J., Weidenheim, K. M., Xia, Y., Stock, A. D., Michaelson, J. S., Baruch, K., Deczkowska, A., Gulinello, M. E., Schwartz, M., et al. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.03.005 · Cited by 106
Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse
Lim, S., Moon, M., Oh, H., Kim, H. G., Kim, S. Y., & Oh, M. S. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.05.009 · Cited by 102
Review of preclinical studies on pediatric general anesthesia-induced developmental neurotoxicity
Walters, J. L., & Paule, M. G. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.11.005 · Cited by 101
Episodic-like memory in zebrafish
Hamilton, T. J., Myggland, A., Duperreault, E., May, Z., Gallup, J., Powell, R. A., Schalomon, M., & Digweed, S. M. (2016) · Animal Cognition · doi:10.1007/s10071-016-1014-1 · Cited by 99
Behavioural phenotypes in the cuprizone model of central nervous system demyelination
Sen, M. K., Mahns, D. A., Coorssen, J. R., & Shortland, P. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.008 · Cited by 101
Sleep-dependency of episodic-like memory consolidation in rats
Inostroza, M., Binder, S., & Jan Born, A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.011 · Cited by 105
Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity
Lima, M. G. P., Schimidt, H. L., Garcia, A., Daré, L. R., Carpes, F. P., Izquierdo, I., & Mello‐Carpes, P. B. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718435115 · Cited by 95
Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48
Pavlopoulos, E., Jones, S., Kosmidis, S., Close, M., Kim, C., Kovalerchik, O., Small, S. A., & Kandel, E. R. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006373 · Cited by 109
Modulation of learning and memory by natural polyamines
Guerra, G. P., Rubin, M. A., & Mello, C. F. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.023 · Cited by 103
Neurobiological effects of neonatal maternal separation and post-weaning environmental enrichment.
Vivinetto, A. L., Suárez, M. M., & Rivarola, M. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.11.014 · Cited by 103
Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐ AD mice
Baglietto‐Vargas, D., Chen, Y., Suh, D., Ager, R. R., Rodríguez‐Ortiz, C. J., Medeiros, R., Myczek, K., Green, K. N., Baram, T. Z., & LaFerla, F. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13195 · Cited by 97
Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events
dos Santos, A. A., Naime, A. A., de Oliveira, J., Colle, D., Santos, D. B., Hort, M. A., Moreira, E. L. G., Sunol, C. E., Bem, A. F. D., & Farina, M. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1466-0 · Cited by 93
Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits
Krukowski, K., Feng, X., Paladini, M. S., Chou, A., Sacramento, K., Grue, K., Riparip, L.-K., Jones, T., Campbell-Beachler, M., Nelson, G., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26039-7 · Cited by 92
Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1
McCauley, J. P., Petroccione, M. A., D’Brant, L. Y., Todd, G. C., Affinnih, N., Wisnoski, J. J., Zahid, S., Shree, S., Sousa, A. A., Guzman, R. M. D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108255 · Cited by 95
Pretreatment with Resveratrol Prevents Neuronal Injury and Cognitive Deficits Induced by Perinatal Hypoxia-Ischemia in Rats
Arteaga, O., Revuelta, M., Urigüen, L., Alvarez, A. A., Montalvo, H., & Hilario, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142424 · Cited by 91
Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice
Tuscher, J. J., Taxier, L. R., Fortress, A. M., & Frick, K. M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.002 · Cited by 88
Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer’s disease
Cantarella, G., Benedetto, G. D., Puzzo, D., Privitera, L., Loreto, C., Saccone, S., Giunta, S., Palmeri, A., & Bernardini, R. (2014) · Brain · doi:10.1093/brain/awu318 · Cited by 87
Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth Factor-β1
Torrisi, S. A., Geraci, F., Tropea, M. R., Grasso, M., Caruso, G., Fidilio, A., Musso, N., Sanfilippo, G., Tascedda, F., Palmeri, A., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00693 · Cited by 90
Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice
Santos, D. B., Peres, K. C., Ribeiro, R. P., Colle, D., dos Santos, A. A., Moreira, E. L. G., Souza, D. O., Figueiredo, C. P., & Farina, M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.036 · Cited by 88
Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus
Jara, C., Aránguiz, A., Cerpa, W. F., Tapia‐Rojas, C., & Quintanilla, R. A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.07.010 · Cited by 85
Positive allosteric modulation of alpha 7 nicotinic acetylcholine receptors enhances recognition memory and cognitive flexibility in rats
Nikiforuk, A., Kos, T., Potasiewicz, A., & Popik, P. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.018 · Cited by 83
Natural hypothalamic circuit dynamics underlying object memorization
Kosse, C., & Burdakov, D. (2019) · Nature Communications · doi:10.1038/s41467-019-10484-7 · Cited by 84
New behavioral protocols to extend our knowledge of rodent object recognition memory
Albasser, M. M., Chapman, R. J., Amin, E., Iordanova, M. D., Vann, S. D., & Aggleton, J. P. (2010) · Learning & Memory · doi:10.1101/lm.1879610 · Cited by 79
Contrasting brain activity patterns for item recognition memory and associative recognition memory: insights from immediate-early gene functional imaging
Aggleton, J. P., Brown, M. W., & Albasser, M. M. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.05.018 · Cited by 79
Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory
Palmeri, A., Ricciarelli, R., Gulisano, W., Rivera, D., Rebosio, C., Calcagno, E., Tropea, M. R., Conti, S., Das, U., Roy, S., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3607-16.2017 · Cited by 79
Object Recognition Memory: Distinct Yet Complementary Roles of the Mouse CA1 and Perirhinal Cortex
Cinalli Jr., D. A., Cohen, S. J., Guthrie, K., & Stackman Jr., R. W. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.527543 · Cited by 79
Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model
Hüttenrauch, M., Brauß, A., Kurdakova, A., Borgers, H., Klinker, F., Liebetanz, D., Salinas-Riester, G., Wiltfang, J., Klafki, H. W., & Wirths, O. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.65 · Cited by 78
Cognitive Impairments Accompanying Rodent Mild Traumatic Brain Injury Involve p53-Dependent Neuronal Cell Death and Are Ameliorated by the Tetrahydrobenzothiazole PFT-α
Rachmany, L., Tweedie, D., Rubovitch, V., Yu, Q.-S., Li, Y., Wang, J., Pick, C. G., & Greig, N. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079837 · Cited by 79
Prefrontal Cortex Dysfunction Increases Susceptibility to Schizophrenia-Like Changes Induced by Adolescent Stress Exposure
Gomes, F. V., & Grace, A. (2016) · Schizophrenia bulletin · doi:10.1093/schbul/sbw156 · Cited by 84
Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia
Gleason, K. A., Birnbaum, S. G., Shukla, A., & Ghose, S. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.122 · Cited by 77
RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss
Kosmidis, S., Polyzos, A., Harvey, L., Youssef, M., Denny, C. A., Dranovsky, A., & Kandel, E. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.077 · Cited by 74
Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory
Palmeri, A., Privitera, L., Giunta, S., Loreto, C., & Puzzo, D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.060 · Cited by 76
Propofol Limits Microglial Activation after Experimental Brain Trauma through Inhibition of Nicotinamide Adenine Dinucleotide Phosphate Oxidase
Luo, T., Wu, J., Kabadi, S. V., Sabirzhanov, B. E., Guanciale, K., Hanscom, M., Faden, J., Cardiff, K., Bengson, C. J., & Faden, A. I. (2013) · Anesthesiology · doi:10.1097/aln.0000000000000020 · Cited by 76
Physiological synaptic activity and recognition memory require astroglial glutamine
Cheung, G. T. Y., Bataveljić, D., Visser, J., Kumar, N., Moulard, J., Dallérac, G. M., Mozheiko, D., Rollenhagen, A., Ezan, P., Mongin, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28331-7 · Cited by 75
Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer’s Disease-Like Features in Rats
Zeng, P. H., Shi, Y., Wang, X., Li, L., Du, Y., Tang, N., Wang, Q., Fang, Y., Wang, J., Zhou, X., et al. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy090 · Cited by 74
Infant maternal separation impairs adult cognitive performance in BALB/cJ mice
Wang, L., Jiao, J., & Dulawa, S. C. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2209-4 · Cited by 80
Nuclear Factor κB-Dependent Histone Acetylation is Specifically Involved in Persistent Forms of Memory
Federman, N., de la Fuente, V., Zalcman, G., Corbi, N., Onori, A., Passananti, C., & Romano, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4181-12.2013 · Cited by 73
Intracerebroventricular streptozotocin induces impaired Barnes maze spatial memory and reduces astrocyte branching in the CA1 and CA3 hippocampal regions
Villar, M. F. Z., Hanotte, J. L., Lockhart, E. F., Tripodi, L., Morel, G. R., & Reggiani, P. C. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1928-7 · Cited by 68
Enhanced hippocampus‐dependent memory and reduced anxiety in mice over‐expressing human catalase in mitochondria
Olsen, R. H. J., Johnson, L. A., Zuloaga, D. G., Limoli, C. L., & Raber, J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12187 · Cited by 72
Effects of acute restraint stress on different components of memory as assessed by object-recognition and object-location tasks in mice
Li, S., Fan, Y., Wang, W., & Tang, Y. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.007 · Cited by 71
Therapeutic Potential of Selectively Targeting the α2C-Adrenoceptor in Cognition, Depression, and Schizophrenia—New Developments and Future Perspective
Uys, M. M., Shahid, M., & Harvey, B. H. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00144 · Cited by 79
Assessing recollection and familiarity of similar lures in a behavioral pattern separation task
Kim, J., & Yassa, M. A. (2013) · Hippocampus · doi:10.1002/hipo.22087 · Cited by 73
Zinc transporter ZnT3 is involved in memory dependent on the hippocampus and perirhinal cortex
Martel, G., Hevi, C., Kane‐Goldsmith, N., & Shumyatsky, G. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.020 · Cited by 71
Recognition memory for social and non-social odors: Differential effects of neurotoxic lesions to the hippocampus and perirhinal cortex
Feinberg, L. M., Allen, T. A., Ly, D., & Fortin, N. J. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.008 · Cited by 75

Authors: Broadbent, N. J., Gaskin, S., Squire, L. R., & Clark, R. E.
Affiliations: University of California System (US)
ORCID: Squire, Larry R.
Clark, Robert E.
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2009-12-22
Volume: 17
Issue: 1
Pages: 5-11
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.1650110
PMC: PMC2807177
OpenAlex: W2046922635
Cited by: 568
References: 24
Citations by year: 2026: 20 · 2025: 24 · 2024: 31 · 2023: 24 · 2022: 46 · 2021: 44 · 2020: 47 · 2019: 31 · 2018: 47 · 2017: 38 · 2016: 51 · 2015: 34 · 2014: 32 · 2013: 38 · 2012: 21
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (0542013)
U.S. Department of Veterans Affairs
James S. McDonnell Foundation
Kavli Foundation
National Institute on Aging (P50AG005131, P50-AG05131)
National Institute of Mental Health (P50 AG05131, AG05131, R01MH024600)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: object recognition memory, hippocampus, hippocampal lesions, anterograde amnesia, retrograde amnesia, memory impairment, rats
MeSH terms: Analysis of Variance, Animals, Behavior, Animal, Exploratory Behavior, Hippocampus, Male, Memory, Random Allocation, Time Factors, Rats, Long-Evans, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Object recognition memory and the rodent hippocampus

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks