Extensive Lesions of Cholinergic Basal Forebrain Neurons Do Not Impair Spatial Working Memory
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A recent studysuggests that lesions to all major areas of the cholinergic basal forebrain in the rat (medial septum, horizontal limb of the diagonal band of Broca, and nucleus basalis magnocellularis) impair a spatial working memory task. However, this experiment used a surgical technique that mayhave damaged cerebellar Purkinje cells. The present studytested rats with highlyselective lesions of cholinergic neurons in all major areas of the basal forebrain on a spatial working memorytask in the radial arm maze. In postoperative testing, there were no significant differences between lesion and control groups in working memory, even with a delayperiod of 8 h, with the exception of a transient impairment during the first 2 d of postoperative testing at shorter delays (0 or 2 h). This finding corroborates other results that indicate that the cholinergic basal forebrain does not playa significant role in spatial working memory. Furthermore, it underscores the presence of intact memoryfunctions after cholinergic basal forebrain damage, despite attentional impairments that follow these lesions, demonstrated in other task paradigms.
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Removal of forebrain cholinergic neurons does not have strong effects on the performance of animals in tasks that do not explicitly tax attentional processes.
“The robustness and the selectivity of the cognitive impairments produced by such lesions is further supported, albeit indirectly, by a substantial number of experiments which concluded that removal of forebrain cholinergic neurons does not have strong effects on the performance of animals in tasks that do not explicitly tax attentional processes (Vuckovich et al, 2004; Frick et al, 2004).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Vuckovich et al, 2004
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Self-citation
- Authors
- Vuckovich, J. A., Semel, M. E., & Baxter, M. G.
- Affiliations
- Harvard University (US)
- Corresponding author
- Baxter, Mark G.
- ORCID
- Baxter, Mark G.
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-01
- Volume
- 11
- Issue
- 1
- Pages
- 87-94
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC321318
- OpenAlex
- W2162431663
- Cited by
- 39
- References
- 44
- Citations by year
- 2022: 1 · 2020: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2012: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- basal forebrain cholinergic system, spatial working memory, medial septum, diagonal band of Broca, nucleus basalis magnocellularis, radial maze, attentional impairment
- MeSH terms
- Acetylcholine, Animals, Cholinergic Fibers, Male, Memory, Short-Term, Neurons, Space Perception, Prosencephalon, Rats, Long-Evans, Rats
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