The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
The touchscreen cognitive testing method for rodents: How to get the best out of your rat
Open accessAbstract
The touchscreen testing method for rodents is a computer-automated behavioral testing method that allows computer graphic stimuli to be presented to rodents and the rodents to respond to the computer screen via a nose-poke directly to the stimulus. The advantages of this method are numerous; however, a systematic study of the parameters that affect learning has not yet been conducted. We therefore sought to optimize stimuli and task parameters in this method. We found that when parameters were optimized, Lister Hooded rats could learn rapidly using this method, solving a discrimination of two-dimensional stimuli to a level of 80% within five to six sessions lasting ∼30 min each. In a final experiment we tested both male and female rats of the albino Sprague-Dawley strain, which are often assumed to have visual abilities far too poor to be useful for studies of visual cognition. The performance of female Sprague-Dawley rats was indistinguishable from that of their male counterparts. Furthermore, performance of male Sprague-Dawley rats was indistinguishable from that of their Lister Hooded counterparts. Finally, Experiment 5 examined the ability of Lister Hooded rats to learn a discrimination between photographic stimuli. Under conditions in which parameters were optimized, rats were remarkably adept at this discrimination. Taken together, these experiments served to optimize the touchscreen method and have demonstrated its usefulness as a high-throughput method for the cognitive testing of rodents.
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“available mouse operant touchscreen paradigms seem to have face validity63,89,101–104 relative to human cognitive touchscreen tasks97, although there is concern that the cognitive profile of Fmr1-KO mice may not emulate the cognitive deficits in the human syndrome63.”
From Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome (2018) · cites this paper as [104]
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The touchscreen operant platform for testing learning and memory in rats and mice
Horner, A. E., Heath, C. J., Hvoslef‐Eide, M., Kent, B. A., Kim, C. H., Nilsson, S. R. O., Alsiö, J., Oomen, C. A., Holmes, A., Saksida, L. M., et al. (2013) · Nature Protocols · doi:10.1038/nprot.2013.122 · Cited by 412
Self-citationDrug development for neurodevelopmental disorders: lessons learned from fragile X syndrome
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Bussey, T. J., Holmes, A., Lyon, L., Mar, A. C., McAllister, K. A. L., Nithianantharajah, J., Oomen, C. A., & Saksida, L. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.011 · Cited by 299
Self-citationThe touchscreen operant platform for assessing executive function in rats and mice
Mar, A. C., Horner, A. E., Nilsson, S. R. O., Alsiö, J., Kent, B. A., Kim, C. H., Holmes, A., Saksida, L. M., & Bussey, T. J. (2013) · Nature Protocols · doi:10.1038/nprot.2013.123 · Cited by 271
Self-citationSchnabel, U. H., Bossens, C., Lorteije, J. A. M., Self, M. W., de Beeck, H. O., & Roelfsema, P. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-36087-8 · Cited by 227
Metadata
- Authors
- Bussey, T. J., Padain, T. L., Skillings, E. A., Winters, B. D., Morton, A. J., & Saksida, L. M.
- Affiliations
- University of Cambridge (GB)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-07
- Volume
- 15
- Issue
- 7
- Pages
- 516-523
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC2505319
- OpenAlex
- W2052032617
- Cited by
- 255
- References
- 29
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 15 · 2023: 16 · 2022: 18 · 2021: 17 · 2020: 17 · 2019: 15 · 2018: 23 · 2017: 21 · 2016: 14 · 2015: 21 · 2014: 11 · 2013: 14 · 2012: 13
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- visual discrimination learning, Lister hooded rats, Sprague-Dawley rats, sex differences in learning, visual cognition
- MeSH terms
- Animals, Cognition, Discrimination Learning, Female, Learning, Male, Psychological Tests, Touch, Visual Perception, Rats, Sprague-Dawley, Models, Animal, Rats
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