Cited by 85Neural and Behavioral Psychology StudiesCognitive Abilities and TestingPrimate Behavior and Ecology

Discrimination of Multidimensional Visual Stimuli by Mice: Intra- and Extradimensional Shifts.

Brigman, Jonathan L., Bussey, Timothy J., Saksida, Lisa M., Rothblat, Lawrence A.·2005·Behavioral Neuroscience

Abstract

A visual discrimination protocol similar to that used with monkeys was adapted to measure attentional set-shifting in mice. An automated touchscreen procedure with compound visual stimuli was used to train mice to attend to 1 of 2 stimulus dimensions (lines or shapes). On a 2nd problem with new stimuli, the mice were required to attend to the same dimension (intradimensional [ID] shift) or switch to the previously irrelevant dimension (extradimensional [ED] shift). Mice readily learned the initial compound discrimination and following shift problem, but there was no ID-ED difference. The fact that mice can be tested with stimuli and task sequences similar to those used with primates suggests that this method can be used to directly compare higher cognitive functions in diverse species.

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Crossref · 10.1037/0735-7044.119.3.839

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  • Available mouse operant touchscreen paradigms seem to have face validity relative to human cognitive touchscreen tasks, although there is concern that the cognitive profile of Fmr1-KO mice may not emulate the cognitive deficits in the human syndrome.

    “available mouse operant touchscreen paradigms seem to have face validity63,89,101–104 relative to human cognitive touchscreen tasks97, although there is concern that the cognitive profile of Fmr1-KO mice may not emulate the cognitive deficits in the human syndrome63.”

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Authors
Brigman, J. L., Bussey, T. J., Saksida, L. M., & Rothblat, L. A.
Affiliations
  • George Washington University (US)
  • University of Cambridge (GB)
Venue
Behavioral Neuroscience
Published
2005
Volume
119
Issue
3
Pages
839-842
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W2094728989
Cited by
85
References
19
Citations by year
2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 3
FWCI
2.65
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
Keywords
set-shifting, intradimensional shift, extradimensional shift, visual discrimination learning, mice
MeSH terms
Animals, Behavior, Animal, Discrimination, Psychological, Discrimination Learning, Male, Mice, Inbred C57BL, Photic Stimulation, Transfer, Psychology, Visual Perception, Mice

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