Discrimination of Multidimensional Visual Stimuli by Mice: Intra- and Extradimensional Shifts.
Abstract
A visual discrimination protocol similar to that used with monkeys was adapted to measure attentional set-shifting in mice. An automated touchscreen procedure with compound visual stimuli was used to train mice to attend to 1 of 2 stimulus dimensions (lines or shapes). On a 2nd problem with new stimuli, the mice were required to attend to the same dimension (intradimensional [ID] shift) or switch to the previously irrelevant dimension (extradimensional [ED] shift). Mice readily learned the initial compound discrimination and following shift problem, but there was no ID-ED difference. The fact that mice can be tested with stimuli and task sequences similar to those used with primates suggests that this method can be used to directly compare higher cognitive functions in diverse species.
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Available mouse operant touchscreen paradigms seem to have face validity relative to human cognitive touchscreen tasks, although there is concern that the cognitive profile of Fmr1-KO mice may not emulate the cognitive deficits in the human syndrome.
“available mouse operant touchscreen paradigms seem to have face validity63,89,101–104 relative to human cognitive touchscreen tasks97, although there is concern that the cognitive profile of Fmr1-KO mice may not emulate the cognitive deficits in the human syndrome63.”
From Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome (2018) · cites this paper as [101]
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- Authors
- Brigman, J. L., Bussey, T. J., Saksida, L. M., & Rothblat, L. A.
- Affiliations
- George Washington University (US)
- University of Cambridge (GB)
- Venue
- Behavioral Neuroscience
- Published
- 2005
- Volume
- 119
- Issue
- 3
- Pages
- 839-842
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2094728989
- Cited by
- 85
- References
- 19
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 3
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- set-shifting, intradimensional shift, extradimensional shift, visual discrimination learning, mice
- MeSH terms
- Animals, Behavior, Animal, Discrimination, Psychological, Discrimination Learning, Male, Mice, Inbred C57BL, Photic Stimulation, Transfer, Psychology, Visual Perception, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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