PreprintCited by 642Genomics and Chromatin DynamicsChromosomal and Genetic VariationsDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record.

Temporal Control of Puffing Activity in Polytene Chromosomes

Ashburner, M., Chihara, C., Meltzer, P., Richards, G.·1974·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.1974.038.01.070

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Abstract

The genetic organization of individual bands of polytene chromosomes is an enigma. On the one hand, we have evidence (Rudkin, 1965; Daneholt and Edström, 1967; Mulder et al, 1968; see also Rasch et al., 1971) that an “average” band contains DNA equivalent to 40,000 or so nucleotide pairs. The range is perhaps between 3000 and 100,000 nucleotide pairs (Beermann, 1972). On the other hand, classical (e.g., Painter, 1934; Bridges, 1935, 1936; Mackensen, 1935; Muller and Prokofyeva, 1935) and more modern (e.g., Hochman, 1971; Lefevre, 1971; Lim et al., 1971; Judd et al., 1972; Rayle, 1972) evidence strongly suggests that one band (or band plus adjacent interband(s), if you will: Crick, 1971) corresponds to a unit of genetic function.

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Crossref · 10.1101/sqb.1974.038.01.070

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“Central to this hierarchical model was the genes responsible for early 20E-induced puffs in the giant larval salivary gland polytene chromosomes (Ashburner et al., 1974).”
Background
Molecular cloning and induction of nuclear receptors from insect cell lines1The GenBank accession numbers for the sequences in this paper are: AF411254 (SfEcR), AF411255 (SfUSP), AF411256 (TnEcR), AF411257 (TnUSP), and AF411258 (TnHR4)1
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Transfer of [14C] cholesterol and its metabolites between adult male and female worms of Schistosoma mansoni
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Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation
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Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene
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ALTERED STEROID INDUCED PUFFING BY CHROMATIN BOUND ALUMINUM IN A POLYTENE CHROMOSOME OF THE BLACKFLY SIMULIUM VITTATUM
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Photoinduced bonding of endogenous ecdysterone to salivary gland chromosomes of Chironomus tentans
Gronemeyer, H., Hameister, H., & Pongs, O. (1981) · Chromosoma · doi:10.1007/bf00295012 · Cited by 22
“glands has also been used to demonstrate the temporal control of hormone induced puffing, in relation to developmental stages in vivo (Ashburner, 1972 b; Ashburner et al., 1974).”
Background
Structural and functional analysis of some moulting hormone-responsive genes from Drosophila
Cherbas, L., Beneš, H., Bourouis, M., et al. (1986) · Insect Biochemistry · doi:10.1016/0020-1790(86)90102-2 · Cited by 22
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Moulting hormone regulates its receptor level in Drosophila melanogaster
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“melanogaster salivary glands/~-ecdysone inactivates preexisting "intermolt puffs" and induces '~ early puffs" which are supposed to be responsible for the induction of "late puffs" (Ashburner et al., 1974).”
Background
Chapter 3 Hormones and programmed cell death: insights from invertebrate studies
Truman, J. W., Fahrbach, S. E., & Kimura, K. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)63164-7 · Cited by 21
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Injury response checkpoint and developmental timing in insects
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The genome of the nematode Pristionchus pacificus encodes putative homologs of RXR/Usp and EcR
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“Upon binding of 20E, the ecdysone receptor activates a cascade of early and late genes that regulate the cellular processes associated with molting and metamorphosis (Ashburner et al., 1974; Richards, 1997).”
Background
Broad‐Complex, E74, and E75 early genes control DNA puff BhC4‐1 expression in prepupal salivary glands
Júnior, L. R. B., Neves, M. D. C., Monesi, N., & Paçó‐Larson, M. L. (2006) · genesis · doi:10.1002/dvg.20239 · Cited by 20
Vacuole dynamics in the salivary glands ofDrosophila melanogasterduring prepupal development
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“The sequential changes in puffing patterns throughout the late larval and entire prepupal period have been analyzed in great detail (Ashburner 1972; Ashburner et al. 1974; Richards 1976a,b,c; Ashburner & Berendes 1978), and some of the cellular events that occur in the prepupal salivary glands…”
BackgroundInfluential
Nucleotide sequence of an adult‐specific cuticular protein gene from the beetle Tenebrio molitor: effects of 20‐hydroxyecdysone on mRNA accumulation
Bouhin, H., Braquart, C., Charles, J. P., et al. (1993) · Insect Molecular Biology · doi:10.1111/j.1365-2583.1993.tb00128.x · Cited by 20
Chromosome Puffing: Supramolecular Aspects of Ecdysone Action
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Authors: Ashburner, M., Chihara, C., Meltzer, P., & Richards, G.
Affiliations: University of Cambridge (GB)
ORCID: Ashburner, M.
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 1974-01-01
Volume: 38
Issue: 0
Pages: 655-662
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.1974.038.01.070
OpenAlex: W2136267625
Cited by: 641
References: 0
Citations by year: 2026: 6 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 5 · 2014: 12 · 2013: 11 · 2012: 14
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: polytene chromosomes, puffing, chromosome banding, genetic organization, interbands, Drosophila
MeSH terms: Animals, Anti-Bacterial Agents, Chromosomes, Cycloheximide, DNA, Drosophila melanogaster, Ecdysone, Enzyme Repression, Genes, Puromycin, RNA, Time Factors, Transcription, Genetic, Protein Biosynthesis

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Temporal Control of Puffing Activity in Polytene Chromosomes

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