PreprintCited by 642Genomics and Chromatin DynamicsChromosomal and Genetic VariationsDevelopmental Biology and Gene Regulation

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Temporal Control of Puffing Activity in Polytene Chromosomes

Ashburner, M., Chihara, C., Meltzer, P., Richards, G.·1974·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.1974.038.01.070

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Abstract

The genetic organization of individual bands of polytene chromosomes is an enigma. On the one hand, we have evidence (Rudkin, 1965; Daneholt and Edström, 1967; Mulder et al, 1968; see also Rasch et al., 1971) that an “average” band contains DNA equivalent to 40,000 or so nucleotide pairs. The range is perhaps between 3000 and 100,000 nucleotide pairs (Beermann, 1972). On the other hand, classical (e.g., Painter, 1934; Bridges, 1935, 1936; Mackensen, 1935; Muller and Prokofyeva, 1935) and more modern (e.g., Hochman, 1971; Lefevre, 1971; Lim et al., 1971; Judd et al., 1972; Rayle, 1972) evidence strongly suggests that one band (or band plus adjacent interband(s), if you will: Crick, 1971) corresponds to a unit of genetic function.

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Crossref · 10.1101/sqb.1974.038.01.070

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Authors: Ashburner, M., Chihara, C., Meltzer, P., & Richards, G.
Affiliations: University of Cambridge (GB)
ORCID: Ashburner, M.
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 1974-01-01
Volume: 38
Issue: 0
Pages: 655-662
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.1974.038.01.070
OpenAlex: W2136267625
Cited by: 641
References: 0
Citations by year: 2026: 6 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 5 · 2014: 12 · 2013: 11 · 2012: 14
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: polytene chromosomes, puffing, chromosome banding, genetic organization, interbands, Drosophila
MeSH terms: Animals, Anti-Bacterial Agents, Chromosomes, Cycloheximide, DNA, Drosophila melanogaster, Ecdysone, Enzyme Repression, Genes, Puromycin, RNA, Time Factors, Transcription, Genetic, Protein Biosynthesis

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Temporal Control of Puffing Activity in Polytene Chromosomes

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