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Temporal Control of Puffing Activity in Polytene Chromosomes
Abstract
The genetic organization of individual bands of polytene chromosomes is an enigma. On the one hand, we have evidence (Rudkin, 1965; Daneholt and Edström, 1967; Mulder et al, 1968; see also Rasch et al., 1971) that an “average” band contains DNA equivalent to 40,000 or so nucleotide pairs. The range is perhaps between 3000 and 100,000 nucleotide pairs (Beermann, 1972). On the other hand, classical (e.g., Painter, 1934; Bridges, 1935, 1936; Mackensen, 1935; Muller and Prokofyeva, 1935) and more modern (e.g., Hochman, 1971; Lefevre, 1971; Lim et al., 1971; Judd et al., 1972; Rayle, 1972) evidence strongly suggests that one band (or band plus adjacent interband(s), if you will: Crick, 1971) corresponds to a unit of genetic function.
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“This biological model allowed description of the induction by 20E of a specific sequence of puffs, and this was a key finding for understanding the mechanism of action of steroid hormones through their binding to nuclear receptors and inducing a sequence of gene activations (Figure 5) [15,16].”
From Ecdysteroids (2021) · cites this paper as [16]
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“The entire sequence of 196 puffs, which are induced and regressed in wild type during last 10 h of fully grown third instar larvae and 16 h after puparium formation, is known as the puffing pattern (Ashburner 1970, 1972, 1990; Ashburner et al. 1974; Ashburner and Berendes 1978).”
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“The technique for in vitro culture of salivary glands was developed already by Ashburner (1971), Ashburner (1972), Ashburner et al. (1974), Richards (1976a), Richards (1976b), and Richards (1976c) and used in landmark studies of the development (e.g., the documentation of chromosomal puffing…”
Buchert, E. M., Fogarty, E. A., Ma, Y., Mehta, S. J. K., McKay, D. J., & Buttitta, L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.16.752104
Haidvogl, M., & Urlesberger, H. (1977) · PubMed
Metadata
- Authors
- Ashburner, M., Chihara, C., Meltzer, P., & Richards, G.
- Affiliations
- University of Cambridge (GB)
- ORCID
- Ashburner, M.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1974-01-01
- Volume
- 38
- Issue
- 0
- Pages
- 655-662
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2136267625
- Cited by
- 641
- References
- 0
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 5 · 2014: 12 · 2013: 11 · 2012: 14
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- polytene chromosomes, puffing, chromosome banding, genetic organization, interbands, Drosophila
- MeSH terms
- Animals, Anti-Bacterial Agents, Chromosomes, Cycloheximide, DNA, Drosophila melanogaster, Ecdysone, Enzyme Repression, Genes, Puromycin, RNA, Time Factors, Transcription, Genetic, Protein Biosynthesis
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