The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Effect of cholesterol on structural and mechanical properties of membranes depends on lipid chain saturation
Open accessAbstract
The effects of cholesterol on membrane bending modulus K(C), membrane thickness D(HH), the partial and apparent areas of cholesterol and lipid, and the order parameter S(xray) are shown to depend upon the number of saturated hydrocarbon chains in the lipid molecules. Particularly striking is the result that up to 40% cholesterol does not increase the bending modulus K(C) of membranes composed of phosphatidylcholine lipids with two cis monounsaturated chains, although it does have the expected stiffening effect on membranes composed of lipids with two saturated chains. The B fluctuational modulus in the smectic liquid crystal theory is obtained and used to discuss the interactions between bilayers. Our K(C) results motivate a theory of elastic moduli in the high cholesterol limit and they challenge the relevance of universality concepts. Although most of our results were obtained at 30 degrees C , additional data at other temperatures to allow consideration of a reduced temperature variable do not support universality for the effect of cholesterol on all lipid bilayers. If the concept of universality is to be valid, different numbers of saturated chains must be considered to create different universality classes. The above experimental results were obtained from analysis of x-ray scattering in the low angle and wide angle regions.
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Cites
Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains
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Self-citationHeroux, J., & Gharib, A. M. (2008) · Molecular Imaging in Oncology · doi:10.3109/9781420019957-3 · Cited by 2,187
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Effect of Chain Length and Unsaturation on Elasticity of Lipid Bilayers
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Entropy-driven tension and bending elasticity in condensed-fluid membranes
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Kučerka, N., Tristram-Nagle, S., & Nagle, J. F. (2006) · Journal of Membrane Biology · doi:10.1007/s00232-005-7006-8 · Cited by 801
Self-citationLipid Bilayer Structure Determined by the Simultaneous Analysis of Neutron and X-Ray Scattering Data
Kučerka, N., Nagle, J. F., Sachs, J. N., Feller, S. E., Pencer, J., Jackson, A., & Katsaras, J. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.132662 · Cited by 597
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Cited by
Recent developments in the field of bending rigidity measurements on membranes
Dimova, R. (2014) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2014.03.003 · Cited by 503
An Extension and Further Validation of an All-Atomistic Force Field for Biological Membranes
Jämbeck, J. P. M., & Lyubartsev, A. P. (2012) · Journal of Chemical Theory and Computation · doi:10.1021/ct300342n · Cited by 444
The role of cholesterol in membrane fusion
Yang, S.-T., Kreutzberger, A. J. B., Lee, J., Kiessling, V., & Tamm, L. K. (2016) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2016.05.003 · Cited by 421
Polystyrene Nanoparticles Perturb Lipid Membranes
Rossi, G., Barnoud, J., & Monticelli, L. (2014) · The Journal of Physical Chemistry Letters · doi:10.1021/jz402234c · Cited by 373
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
Chrast, R., Saher, G., Nave, K.-A., & Verheijen, M. H. G. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009761 · Cited by 314
Metadata
- Authors
- Pan, J., Tristram-Nagle, S., & Nagle, J. F.
- Venue
- Physical Review E
- Publisher
- American Physical Society (APS)
- Published
- 2009-08-25
- Volume
- 80
- Issue
- 2
- Pages
- 021931-021931
- ISSN
- 1539-3755 (ISSN-L)
- 1550-2376
- OpenAlex
- W2104776612
- Cited by
- 340
- References
- 66
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Pan, J., Tristram-Nagle, S., & Nagle, J. F. (2009). Effect of cholesterol on structural and mechanical properties of membranes depends on lipid chain saturation. Physical Review E. https://doi.org/10.1103/physreve.80.021931
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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