Polystyrene Nanoparticles Perturb Lipid Membranes
Abstract
Polystyrene is abundant in marine debris. Like most synthetic polymers, it degrades very slowly, producing smaller and smaller particles easily ingested by wildlife. The presence of plastic microscopic particles in fish and marine wildlife is massive and well documented, but its impact on cellular activity is not understood. Biological activity generally requires interaction with biological membranes, but this is difficult to study at the molecular scale in vivo. Here we use coarse-grained molecular simulations to determine the effect of nanosized polystyrene (PS) particles on the properties of model biological membranes. We find that PS nanoparticles permeate easily into lipid membranes. Dissolved in the membrane core, PS chains alter membrane structure, significantly reduce molecular diffusion, and soften the membrane. Moreover, PS severely affects membrane lateral organization by stabilizing raft-like domains. Changes in membrane properties and lateral organization can severely affect the activity of membrane proteins and thereby cellular function.
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PS-nanoplastics can permeate into lipid bilayer membranes, alter membrane structure and reduce molecular diffusion, so cell functions are probably perturbed.
“An experimental study could show that PS-nanoplastics can easily permeate into lipid bilayer membranes, alter the membrane structure and reduce molecular diffusion, so that cell functions are probably perturbed.150”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [150]
Cites
Molecular dynamics with coupling to an external bath
Berendsen, H. J. C., Postma, J. P. M., van Gunsteren, W. F., DiNola, A., & Haak, J. R. (1984) · The Journal of Chemical Physics · doi:10.1063/1.448118 · Cited by 30,626 · see citing works
Polymorphic transitions in single crystals: A new molecular dynamics method
Parrinello, M., & Rahman, A. (1981) · Journal of Applied Physics · doi:10.1063/1.328693 · Cited by 19,668 · see citing works
Canonical sampling through velocity rescaling
Bussi, G., Donadio, D., & Parrinello, M. (2007) · The Journal of Chemical Physics · doi:10.1063/1.2408420 · Cited by 18,034 · see citing works
GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
Hess, B., Kutzner, C., van der Spoel, D., & Lindahl, E. R. (2008) · Journal of Chemical Theory and Computation · doi:10.1021/ct700301q · Cited by 15,830 · see citing works
Jorgensen, W. L., Maxwell, D. S., & Tirado-Rives, J. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9621760 · Cited by 14,078 · see citing works
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757 · see citing works
Microplastics in the marine environment
Andrady, A. L. (2011) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2011.05.030 · Cited by 8,105 · see citing works
Accumulation and fragmentation of plastic debris in global environments
Barnes, D. K. A., Galgani, F., Thompson, R. C., & Barlaz, M. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0205 · Cited by 6,126 · see citing works
Microplastics as contaminants in the marine environment: A review
Cole, M., Lindeque, P., Halsband, C., & Galloway, T. S. (2011) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2011.09.025 · Cited by 6,023 · see citing works
The MARTINI Force Field: Coarse Grained Model for Biomolecular Simulations
Marrink, . J., Risselada, H. J., Yefimov, S., Tieleman, D. P., & de Vries, A. H. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp071097f · Cited by 5,527 · see citing works
Hidalgo-Ruz, V., Gutow, L., Thompson, R. C., & Thiel, M. (2012) · Environmental Science & Technology · doi:10.1021/es2031505 · Cited by 5,440 · see citing works
Elastic Properties of Lipid Bilayers: Theory and Possible Experiments
Helfrich, W. (1973) · Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie · doi:10.1515/znc-1973-11-1209 · Cited by 5,438 · see citing works
Lipid rafts as a membrane-organizing principle
Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417 · see citing works
Plastics, the environment and human health: current consensus and future trends
Thompson, R. C., Moore, C. J., Saal, F. S. V., & Swan, S. H. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0053 · Cited by 3,068 · see citing works
The MARTINI Coarse-Grained Force Field: Extension to Proteins
Monticelli, L., Kandasamy, S. K., Périole, X., Larson, R. G., Tieleman, D. P., & Marrink, . J. (2008) · Journal of Chemical Theory and Computation · doi:10.1021/ct700324x · Cited by 2,491 · see citing works
Self-citationBrowne, M. A., Dissanayake, A., Galloway, T. S., Lowe, D. M., & Thompson, R. C. (2008) · Environmental Science & Technology · doi:10.1021/es800249a · Cited by 2,263 · see citing works
Synthetic polymers in the marine environment: A rapidly increasing, long-term threat
Moore, C. J. (2008) · Environmental Research · doi:10.1016/j.envres.2008.07.025 · Cited by 2,130 · see citing works
Classify plastic waste as hazardous
Rochman, C. M., Browne, M. A., Halpern, B. S., Hentschel, B. T., Hoh, E., Karapanagioti, H. K., Rios-Mendoza, L. M., Takada, H., Teh, S., & Thompson, R. C. (2013) · Nature · doi:10.1038/494169a · Cited by 1,752 · see citing works
Model Systems, Lipid Rafts, and Cell Membranes
Simons, K., & Vaz, W. L. C. (2004) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.141803 · Cited by 1,671 · see citing works
Plastic ingestion by planktivorous fishes in the North Pacific central gyre
Boerger, C. M., Lattin, G. L., Moore, S. L., & Moore, C. J. (2010) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2010.08.007 · Cited by 1,273 · see citing works
Polystyrene Spherules in Coastal Waters
Carpenter, E. J., Anderson, S. J., Harvey, G. R., Miklas, H. P., & Peck, B. B. (1972) · Science · doi:10.1126/science.178.4062.749 · Cited by 1,115 · see citing works
Cholesterol, lipid rafts, and disease
Simons, K., & Ehehalt, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16390 · Cited by 995 · see citing works
Cholesterol, lipid rafts, and disease
Simons, K., & Ehehalt, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216390 · Cited by 916 · see citing works
Hydrophobic mismatch between proteins and lipids in membranes
Killian, J. A. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(98)00017-3 · Cited by 647 · see citing works
Lindahl, E. R., & Edholm, O. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76304-1 · Cited by 624 · see citing works
Fossi, M. C., Panti, C., Guerranti, C., Coppola, D., Giannetti, M., Marsili, L., & Minutoli, R. (2012) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2012.08.013 · Cited by 589 · see citing works
The molecular face of lipid rafts in model membranes
Risselada, H. J., & Marrink, . J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807527105 · Cited by 540 · see citing works
The Effect of Cholesterol on the Lateral Diffusion of Phospholipids in Oriented Bilayers
Filippov, A. V., Orädd, G., & Lindblom, G. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)70033-2 · Cited by 433 · see citing works
Lateral Pressures in Cell Membranes: A Mechanism for Modulation of Protein Function
Cantor, R. S. (1997) · The Journal of Physical Chemistry B · doi:10.1021/jp963911x · Cited by 377 · see citing works
Pan, J., Tristram‐Nagle, S., & Nagle, J. F. (2009) · Physical Review E · doi:10.1103/physreve.80.021931 · Cited by 342 · see citing works
Coarse-graining polymers with the MARTINI force-field: polystyrene as a benchmark case
Rossi, G., Monticelli, L., Puisto, S. R., Vattulainen, I., & Ala-Nissilä, T. (2010) · Soft Matter · doi:10.1039/c0sm00481b · Cited by 271 · see citing works
Self-citationde Planque, M. R. R., Greathouse, D. V., Koeppe, R. E., Schäfer, H., Marsh, D., & Killian, J. A. (1998) · Biochemistry · doi:10.1021/bi980233r · Cited by 237 · see citing works
Pappo, J., & Ermak, T. H. (1989) · PubMed Central · Cited by 216 · see citing works
‘Nano-tree’—type spherical polymer brush particles as templates for metallic nanoparticles
Lu, Y. Q., Mei, Y., Walker, R., Ballauff, M., & Drechsler, M. (2006) · Polymer · doi:10.1016/j.polymer.2006.05.027 · Cited by 146 · see citing works
Cajaraville, M. P., & Pal, S. G. (1995) · Cell Structure and Function · doi:10.1247/csf.20.355 · Cited by 145 · see citing works
Filippov, A., Orädd, G., & Lindblom, G. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.111534 · Cited by 77 · see citing works
Computer simulations of the phase separation in model membranes
Baoukina, S., Mendez-Villuendas, E., Bennett, W. F., & Tieleman, D. P. (2012) · Faraday Discussions · doi:10.1039/c2fd20117h · Cited by 72 · see citing works
Polymer Confinement in Surfactant Bilayers of a Lyotropic Lamellar Phase
Radlińska, E. Z., Gulik‐Krzywicki, T., Lafuma, F., Langévin, D., Urbach, W., Williams, C. E., & Ober, R. (1995) · Physical Review Letters · doi:10.1103/physrevlett.74.4237 · Cited by 64 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Emergence of Nanoplastic in the Environment and Possible Impact on Human Health
Lehner, R., Weder, C., Petri-Fink, A., & Rothen-Rutishauser, B. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b05512 · Cited by 1,242 · see citing works
(Nano)plastics in the environment - Sources, fates and effects
da Costa, J. P., Santos, P. S. M., Duarte, A. C., & Rocha-Santos, T. (2016) · Science of The Total Environment · doi:10.1016/j.scitotenv.2016.05.041 · Cited by 1,139 · see citing works
Nanoplastic Affects Growth of <i>S. obliquus</i> and Reproduction of <i>D. magna</i>
Besseling, E., Wang, B., Lürling, M., & Koelmans, A. A. (2014) · Environmental Science & Technology · doi:10.1021/es503001d · Cited by 1,138 · see citing works
Impact of Microplastics and Nanoplastics on Human Health
Yee, M. S.-L., Hii, L., Looi, C.-K., Lim, W., Wong, S. F., Kok, Y.-Y., Tan, B.-K., Wong, C.-Y., & Leong, C. (2021) · Nanomaterials · doi:10.3390/nano11020496 · Cited by 1,077 · see citing works
The world of plastic waste: A review
Nayanathara Thathsarani Pilapitiya, P. G. C., & Ratnayake, A. S. (2024) · Cleaner Materials · doi:10.1016/j.clema.2024.100220 · Cited by 1,034 · see citing works
Qiao, R., Deng, Y., Zhang, S., Wolosker, M. B., Zhu, Q., Ren, H., & Zhang, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.07.065 · Cited by 924 · see citing works
Alimba, C. G., & Faggio, C. (2019) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2019.03.001 · Cited by 840 · see citing works
Microplastics: A Real Global Threat for Environment and Food Safety: A State of the Art Review
Ziani, K., Ioniță-Mîndrican, C.-B., Mititelu, M., Neacșu, S. M., Negrei, C., Moroșan, E., Drăgănescu, D., & Preda, O.-T. (2023) · Nutrients · doi:10.3390/nu15030617 · Cited by 782 · see citing works
Nanoplastics in the Aquatic Environment. Critical Review
Koelmans, A. A., Besseling, E., & Shim, W. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-16510-3_12 · Cited by 717 · see citing works
Microplastics in the Marine Environment: Distribution, Interactions and Effects
Lusher, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-16510-3_10 · Cited by 696 · see citing works
Recent advances in toxicological research of nanoplastics in the environment: A review
Shen, M., Zhang, Y., Zhu, Y., Song, B., Zeng, G., Hu, D., Wen, X., & Ren, X. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.05.102 · Cited by 686 · see citing works
Pitt, J., Kozal, J. S., Jayasundara, N., Massarsky, A., Trevisan, R., Geitner, N. K., Wiesner, M., Levin, E., & Giulio, R. D. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.11.017 · Cited by 546 · see citing works
Della Torre, C., Bergami, E., Salvati, A., Faleri, C., Cirino, P., Dawson, K. A., & Corsi, I. (2014) · Environmental Science & Technology · doi:10.1021/es502569w · Cited by 632 · see citing works
Malinowska, K., Bukowska, B., & Sicińska, P. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114297 · Cited by 612 · see citing works
Effects of microplastics on wastewater and sewage sludge treatment and their removal: A review
Zhang, Z., & Chen, Y. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.122955 · Cited by 586 · see citing works
Jeong, C.-B., Kang, H.-M., Lee, M.-C., Kim, D.-H., Han, J., Hwang, D.-S., Souissi, S., Lee, S.-J., Shin, K., Park, H., et al. (2017) · Scientific Reports · doi:10.1038/srep41323 · Cited by 524 · see citing works
Altered Behavior, Physiology, and Metabolism in Fish Exposed to Polystyrene Nanoparticles
Mattsson, K., Ekvall, M. T., Hansson, L.-A., Linse, S., Malmendal, A., & Cedervall, T. (2015) · Environmental Science & Technology · doi:10.1021/es5053655 · Cited by 581 · see citing works
Yin, L., Chen, B., Xia, B., Shi, X., & Qu, K. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.07.110 · Cited by 479 · see citing works
Cellular internalization and release of polystyrene microplastics and nanoplastics
Liu, L., Xu, K., Zhang, B., Ye, Y., Zhang, Q., & Jiang, W. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146523 · Cited by 463 · see citing works
Yin, K., Wang, Y., Zhao, H., Wang, D., Guo, M., Mu, M., Liu, Y., Nie, X., Li, B., Li, J., et al. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145758 · Cited by 437 · see citing works
Bergami, E., Pugnalini, S., Vannuccini, M., Manfra, L., Faleri, C., Savorelli, F., Dawson, K. A., & Corsi, I. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.06.008 · Cited by 351 · see citing works
Pitt, J. A., Trevisan, R., Massarsky, A., Kozal, J. S., Levin, E. D., & Di Giulio, R. T. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.06.186 · Cited by 413 · see citing works
The degradation potential of PET bottles in the marine environment: an ATR-FTIR based approach
Ioakeimidis, C., Fotopoulou, K. N., Karapanagioti, H. K., Geraga, M., Zeri, C., Papathanassiou, E., Galgani, F., & Papatheodorou, G. (2016) · Scientific Reports · doi:10.1038/srep23501 · Cited by 405 · see citing works
Al-Sid-Cheikh, M., Rowland, S. J., Stevenson, K., Rouleau, C., Henry, T. B., & Thompson, R. C. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b05266 · Cited by 397 · see citing works
Brandts, I., Teles, M., Gonçalves, A. P., Barreto, Â., Franco‐Martínez, L., Tvarijonaviciute, A., Martins, M. A., Soares, A. M. V. M., Tort, L., & Oliveira, M. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.06.257 · Cited by 389 · see citing works
Effects of polystyrene nanoparticles on the microbiota and functional diversity of enzymes in soil
Tsegai, A. T., Kohl, Y., Meier, F., Straskraba, S., Grün, A.-L., Ruf, T., Jost, C., Drexel, R., Tunç, E., & Emmerling, C. (2018) · Environmental Sciences Europe · doi:10.1186/s12302-018-0140-6 · Cited by 389 · see citing works
Bergami, E., Bocci, E., Vannuccini, M. L., Monopoli, M. P., Salvati, A. L., Dawson, K. A., & Corsi, I. (2015) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2015.09.021 · Cited by 380 · see citing works
Micro- and Nanoplastics Breach the Blood–Brain Barrier (BBB): Biomolecular Corona’s Role Revealed
Kopatz, V., Wen, K., Kovacs, T. G., Keimowitz, A. R., Pichler, V., Widder, J., Vethaak, A. D., Hollóczki, O., & Kenner, L. (2023) · Nanomaterials · doi:10.3390/nano13081404 · Cited by 364 · see citing works
Lee, W. S., Cho, H.-J., Kim, E., Huh, Y. H., Kim, H., Kim, B., Kang, T., Lee, J.-S., & Jeong, J. (2018) · Nanoscale · doi:10.1039/c8nr09321k · Cited by 346 · see citing works
The fate of plastic in the ocean environment – a minireview
Wayman, C., & Niemann, H. (2021) · Environmental Science: Processes & Impacts · doi:10.1039/d0em00446d · Cited by 325 · see citing works
Magrì, D., Sánchez‐Moreno, P., Caputo, G., Gatto, F., Veronesi, M., Bardi, G., Catelani, T., Guarnieri, D., Athanassiou, A., Pompa, P. P., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b01331 · Cited by 323 · see citing works
Nanoplastics impaired oyster free living stages, gametes and embryos
Tallec, K., Huvet, A., Poi, C. D., González-Fernández, C., Christophe Lambert, B., Petton, B., Goïc, N. L., Berchel, M., Soudant, P., & Paul-Pont, I. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.08.020 · Cited by 293 · see citing works
Enkavi, G., Javanainen, M., Kulig, W., Róg, T., & Vattulainen, I. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00538 · Cited by 285 · see citing works
Two decades of Martini: Better beads, broader scope
Marrink, S. J., Monticelli, L., Melo, M. N., Alessandri, R., Tieleman, D. P., & Souza, P. C. T. (2023) · WIREs Computational Molecular Science · doi:10.1002/wcms.1620 · Cited by 255 · see citing works
Self-citationPaul-Pont, I., Tallec, K., González-Fernández, C., Christophe Lambert, B., Vincent, D., Mazurais, D., Zambonino‐Infante, J., Brotons, G., Lagarde, F., Fabioux, C., et al. (2018) · Frontiers in Marine Science · doi:10.3389/fmars.2018.00252 · Cited by 270 · see citing works
Jeong, C.-B., Kang, H.-M., Lee, Y. H., Kim, M.-S., Lee, J.-S., Seo, J. S., Wang, M., & Lee, J.-S. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b03211 · Cited by 263 · see citing works
Brun, N. R., van Hage, P., Hunting, E. R., Haramis, A.-P. G., Vink, S. C., Vijver, M. G., Schaaf, M. J. M., & Tudorache, C. (2019) · Communications Biology · doi:10.1038/s42003-019-0629-6 · Cited by 246 · see citing works
Magid, A. S. I. A., Islam, M. S., Chen, Y., Weng, L., Li, J., Ma, J., & Li, Y. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147115 · Cited by 246 · see citing works
Sendra, M., Sparaventi, E., Novoa, B., & Figueras, A. J. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142024 · Cited by 225 · see citing works
Invertebrate responses to microplastic ingestion: Reviewing the role of the antioxidant system
Trestrail, C., Nugegoda, D., & Shimeta, J. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138559 · Cited by 212 · see citing works
Treatment of microplastics in water by anodic oxidation: A case study for polystyrene
Kiendrebeogo, M., Estahbanati, M. R. K., Mostafazadeh, A. K., Drogui, P., & Tyagi, R. D. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116168 · Cited by 214 · see citing works
Microbial remediation of micro-nano plastics: Current knowledge and future trends
Tiwari, N., Santhiya, D., & Sharma, J. G. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115044 · Cited by 211 · see citing works
Nanoplastics impair the intestinal health of the juvenile large yellow croaker Larimichthys crocea
Gu, H., Wang, S., Wang, X., Yu, X., Hu, M., Huang, W., & Wang, Y. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122773 · Cited by 205 · see citing works
Rai, P. K., Lee, J., Brown, R. J. C., & Kim, K. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.123910 · Cited by 202 · see citing works
Effects of nanomaterials on marine invertebrates
Canesi, L., & Corsi, I. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.01.085 · Cited by 199 · see citing works
Wang, T., Hu, M., Xu, G., Shi, H., Leung, J. Y. S., & Wang, Y. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142099 · Cited by 201 · see citing works
Microplastics destabilize lipid membranes by mechanical stretching
Fleury, J., & Baulin, V. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104610118 · Cited by 198 · see citing works
CHARMM-GUI Polymer Builder for Modeling and Simulation of Synthetic Polymers
Choi, Y. K., Park, S., Park, S., Kim, S., Kern, N. R., Lee, J., & Im, W. (2021) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.1c00169 · Cited by 185 · see citing works
Mofijur, M., Ahmed, S. F., Rahman, S. M. A., Arafat Siddiki, S. Y., Islam, A. B. M. S., Shahabuddin, M., Ong, H. C., Mahlia, T. M. I., Djavanroodi, F., & Show, P. L. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110857 · Cited by 172 · see citing works
Wang, W., Zhang, J., Qiu, Z., Cui, Z., Li, N., Li, X., Wang, Y., Zhang, H., & Zhao, C. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128323 · Cited by 170 · see citing works
Surface functionalization determines behavior of nanoplastic solutions in model aquatic environments
Tallec, K., Blard, O., González-Fernández, C., Brotons, G., Berchel, M., Soudant, P., Huvet, A., & Paul-Pont, I. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.03.077 · Cited by 165 · see citing works
Key mechanisms of micro- and nanoplastic (MNP) toxicity across taxonomic groups
Matthews, S., Mai, L., Jeong, C., Lee, J., Zeng, E. Y., & Xu, E. G. (2021) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2021.109056 · Cited by 167 · see citing works
Hu, X., Waigi, M. G., Yang, B., & Gao, Y. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c00745 · Cited by 162 · see citing works
Habumugisha, T., Zhang, Z., Uwizewe, C., Yan, C., Ndayishimiye, J. C., Rehman, A., & Zhang, X. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116426 · Cited by 169 · see citing works
González-Fernández, C., Tallec, K., Goïc, N. L., Christophe Lambert, B., Soudant, P., Huvet, A., Suquet, M., Berchel, M., & Paul-Pont, I. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.06.039 · Cited by 160 · see citing works
Feng, L., Wang, J.-J., Liu, S.-C., Sun, X.-D., Yuan, X.-Z., & Wang, S. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.03.101 · Cited by 159 · see citing works
Sendra, M., Pereiro, P., Yeste, M. P., Mercado, L. A., Figueras, A. J., & Novoa, B. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115769 · Cited by 159 · see citing works
Lai, W., Xu, D., Li, J., Wang, Z., Ding, Y., Wang, X., Li, X., Xu, N., Mai, K., & Ai, Q. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126454 · Cited by 159 · see citing works
Investigating the toxicities of different functionalized polystyrene nanoplastics on Daphnia magna
Lin, W., Jiang, R., Hu, S., Xiao, X., Wu, J., Wei, S., Xiong, Y., & Ouyang, G. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.05.036 · Cited by 158 · see citing works
Zhou, R., Lu, G., Yan, Z., Jiang, R., Bao, X., & Lu, P. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139222 · Cited by 156 · see citing works
Xu, E. G., Cheong, R. S., Liu, L., Hernandez, L. M., Azimzada, A., Bayen, S., & Tufenkji, N. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c00245 · Cited by 155 · see citing works
Kumar, C. M. V., Karthick, V., Kumar, V. G., Inbakandan, D., Rene, E. R., Suganya, K., Embrandiri, A., Dhas, T. S., Mani, R., & Sowmiya, P. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113202 · Cited by 155 · see citing works
Distinct lipid membrane interaction and uptake of differentially charged nanoplastics in bacteria
Dai, S., Ye, R., Huang, J., Wang, B., Xie, Z., Ou, X., Yu, N., Huang, C., Hua, Y., Zhou, R., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01321-z · Cited by 146 · see citing works
Feng, S., Zeng, Y., Cai, Z., Wu, J., Chan, L. L., Zhu, J., & Zhou, J. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143558 · Cited by 135 · see citing works
Gruber, E. S., Stadlbauer, V., Pichler, V., Resch‐Fauster, K., Todorovic, A., Meisel, T., Trawoeger, S., Hollóczki, O., Turner, S., Wadsak, W., et al. (2022) · Exposure and Health · doi:10.1007/s12403-022-00470-8 · Cited by 112 · see citing works
Baudrimont, M., Arini, A., Guégan, C., Venel, Z., Gigault, J., Pedrono, B., Prunier, J., Maurice, L., Ter Halle, A., & Feurtet-Mazel, A. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-04668-3 · Cited by 134 · see citing works
Micro(nano)-plastics in the environment and risk of carcinogenesis: Insight into possible mechanisms
Alimba, C. G., Faggio, C., Sivanesan, S., Ogunkanmi, A. L., & Krishnamurthi, K. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126143 · Cited by 136 · see citing works
Goswami, S., Adhikary, S., Bhattacharya, S., Agarwal, R., Ganguly, A., Nanda, S., & Rajak, P. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122937 · Cited by 134 · see citing works
Francia, V., Montizaan, D., & Salvati, A. L. (2020) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.11.25 · Cited by 137 · see citing works
Shi, Q., Tang, J., Liu, R., & Wang, L. (2021) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2021.1951528 · Cited by 132 · see citing works
Soil Pollution from Micro- and Nanoplastic Debris: A Hidden and Unknown Biohazard
Pathan, S. I., Arfaioli, P., Bardelli, T., Ceccherini, M. T., Nannipieri, P., & Pietramellara, G. (2020) · Sustainability · doi:10.3390/su12187255 · Cited by 131 · see citing works
Forrest, A., Giacovazzi, L., Dunlop, S. A., Reisser, J., Tickler, D. M., Jamieson, A. J., & Meeuwig, J. J. (2019) · Frontiers in Marine Science · doi:10.3389/fmars.2019.00627 · Cited by 134 · see citing works
Microplastic Polystyrene Ingestion Promotes the Susceptibility of Honeybee to Viral Infection
Deng, Y., Jiang, X., Zhao, H., Yang, S., Gao, J. Q., Wu, Y., Diao, Q., & Hou, C. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c01619 · Cited by 129 · see citing works
Hemolytic Activity of Nanoparticles as a Marker of Their Hemocompatibility
Yedgar, S., Barshtein, G., & Gural, A. (2022) · Micromachines · doi:10.3390/mi13122091 · Cited by 128 · see citing works
Anionic nanoplastic exposure induces endothelial leakiness
Wei, W., Li, Y., Lee, M., Andrikopoulos, N., Lin, S., Chen, C., Leong, D. T., Ding, F., Song, Y., & Ke, P. C. (2022) · Nature Communications · doi:10.1038/s41467-022-32532-5 · Cited by 127 · see citing works
Pearce, A. K., & O’Reilly, R. K. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c00434 · Cited by 126 · see citing works
MARTINI Coarse-Grained Models of Polyethylene and Polypropylene
Panizon, E., Bochicchio, D., Monticelli, L., & Rossi, G. (2015) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b03611 · Cited by 124 · see citing works
Self-citationNanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells
Pan, D. C., Myerson, J. W., Brenner, J. S., Patel, P., Anselmo, A. C., Mitragotri, S., & Muzykantov, V. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-19897-8 · Cited by 123 · see citing works
Microplastics and nanoplastics: would they affect global biodiversity change?
Hu, D., Shen, M., Zhang, Y., Li, H., & Zeng, G. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-05414-5 · Cited by 123 · see citing works
Force Field Development for Lipid Membrane Simulations
Lyubartsev, A. P., & Rabinovich, A. L. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.12.033 · Cited by 119 · see citing works
Sun, Z., Wen, Y., Zhang, F., Fu, Z., Yuan, Y., Kuang, H., Kuang, X., Huang, J., Zheng, L., & Zhang, D. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114796 · Cited by 117 · see citing works
Zhang, Z., Wuxing, P., Duan, C., Zhu, X., Wu, H., Zhang, X., & Fang, L. (2021) · Gondwana Research · doi:10.1016/j.gr.2021.07.028 · Cited by 108 · see citing works
Pinsino, A., Bergami, E., Torre, C. D., Vannuccini, M. L., Addis, P., Secci, M., Dawson, K. A., Matranga, V., & Corsi, I. (2017) · Nanotoxicology · doi:10.1080/17435390.2017.1279360 · Cited by 107 · see citing works
Microalgal ecotoxicity of nanoparticles: An updated review
Nguyen, M. K., Moon, J., & Lee, Y. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110781 · Cited by 107 · see citing works
Katsumiti, A., Losada-Carrillo, M. P., Barros, M., & Cajaraville, M. P. (2021) · Scientific Reports · doi:10.1038/s41598-021-01938-4 · Cited by 107 · see citing works
Treatment processes for microplastics and nanoplastics in waters: State-of-the-art review.
Karimiestahbanati, M., Kiendrebeogo, M., Mostafazadeh, A. K., Drogui, P., & Tyagi, R. (2021) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2021.112374 · Cited by 77 · see citing works
Imhof, H., & Laforsch, C. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.07.017 · Cited by 91 · see citing works
Bochicchio, D., & Pavan, G. M. (2016) · ACS Nano · doi:10.1021/acsnano.6b07628 · Cited by 102 · see citing works
Materials, surfaces, and interfacial phenomena in nanoplastics toxicology research
Martin, L. M. A., Gan, N., Wang, E., Merrill, M., & Xu, W. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118442 · Cited by 101 · see citing works
Research progress of nanoplastics in freshwater
Zhang, B., Chao, J., Chen, L., Liu, L., Yang, X., & Wang, Q. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143791 · Cited by 100 · see citing works
Toxicity of polystyrene nanoparticles for mouse ovary and cultured human granulosa cells
Huang, J., Zou, L., Bao, M., Feng, Q., Xia, W. J., & Zhu, C. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114371 · Cited by 99 · see citing works
Alqahtani, S., Alqahtani, S., Saquib, Q., & Mohiddin, F. A. (2023) · Frontiers in Toxicology · doi:10.3389/ftox.2023.1193386 · Cited by 98 · see citing works
Interaction of hydrophobic polymers with model lipid bilayers
Bochicchio, D., Panizon, E., Monticelli, L., & Rossi, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-06668-0 · Cited by 97 · see citing works
Self-citationZuo, J., Huo, T., Du, X., Yang, Q., Wu, Q., Shen, J., Liu, C., Hung, T., Yan, W., & Li, G. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124677 · Cited by 97 · see citing works
Liu, Y., Wang, Y., Ling, X. L., Yan, Z., Wu, D., Liu, J., & Lu, G. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c06479 · Cited by 93 · see citing works
Organic pollutants, nano- and microparticles in street sweeping road dust and washwater
Polukarova, M., Markiewicz, A., Björklund, K., Strömvall, A., Galfi, H., Sköld, Y. A., Gustafsson, M. E. R., Järlskog, I., & Aronsson, M. (2019) · Environment International · doi:10.1016/j.envint.2019.105337 · Cited by 91 · see citing works
Qian, J., He, X., Wang, P., Xu, B., Li, K., Lu, B., Jin, W., & Tang, S. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116904 · Cited by 88 · see citing works
Transgenerational impacts of micro(nano)plastics in the aquatic and terrestrial environment
Junaid, M., Liu, S., Chen, G., Liao, H., & Wang, J. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130274 · Cited by 88 · see citing works
A growing crisis for One Health: Impacts of plastic pollution across layers of biological function
Morrison, M., Trevisan, R., Ranasinghe, P., Merrill, G. B., Santos, J., Hong, A., Edward, W. C., Jayasundara, N., & Somarelli, J. A. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.980705 · Cited by 89 · see citing works
Molecular Mechanism of Lipid Nanodisk Formation by Styrene-Maleic Acid Copolymers
Xue, M., Cheng, L., Faustino, I., Guo, W., & Marrink, . J. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2018.06.018 · Cited by 83 · see citing works
- Authors
- Rossi, G., Barnoud, J., & Monticelli, L.
- Affiliations
- Inserm (FR)
- Corresponding author
- Monticelli, Luca
- Venue
- The Journal of Physical Chemistry Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-12-23
- Volume
- 5
- Issue
- 1
- Pages
- 241-246
- ISSN
- 1948-7185 (ISSN-L)
- OpenAlex
- W2319556041
- Cited by
- 373
- References
- 38
- Citations by year
- 2026: 23 · 2025: 47 · 2024: 45 · 2023: 46 · 2022: 49 · 2021: 48 · 2020: 41 · 2019: 18 · 2018: 23 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 1
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Physical Chemistry Letters (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Advanced Physical and Chemical Molecular Interactions
- Keywords
- polystyrene nanoparticles, marine plastic debris, lipid membranes, membrane permeation, membrane softening, molecular diffusion, lipid rafts, membrane lateral organization, coarse-grained molecular simulation, nanoparticle-membrane interactions
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