The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Cell Fates as High-Dimensional Attractor States of a Complex Gene Regulatory Network
Abstract
Cells in multicellular organisms switch between distinct cell fates, such as proliferation or differentiation into specialized cell types. Genome-wide gene regulatory networks govern this behavior. Theoretical studies of complex networks suggest that they can exhibit ordered (stable) dynamics, raising the possibility that cell fates may represent high-dimensional attractor states. We used gene expression profiling to show that trajectories of neutrophil differentiation converge to a common state from different directions of a 2773-dimensional gene expression state space, providing the first experimental evidence for a high-dimensional stable attractor that represents a distinct cellular phenotype.
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“Theoretically, this model can be represented by “attractor states” within a genome-wide gene regulatory network (47).”
From Single-cell transcriptional diversity is a hallmark of developmental potential (2020) · cites this paper as [47]
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“In this context, differentiating cells descend toward stable regions of the network (attractor states), characterized by restricted gene expression, whereas metastable cells broadly sample the network, maintaining higher differentiation potential (47).”
From Single-cell transcriptional diversity is a hallmark of developmental potential (2020) · cites this paper as [47]
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Metadata
- Authors
- Huang, S., Eichler, G., Bar-Yam, Y., & Ingber, D. E.
- Affiliations
- Boston Children's Hospital (US)
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 2005-04-01
- Volume
- 94
- Issue
- 12
- Pages
- 128701-128701
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- OpenAlex
- W2141545875
- Cited by
- 775
- References
- 33
- Citations by year
- 2026: 42 · 2025: 33 · 2024: 30 · 2023: 31 · 2022: 49 · 2021: 42 · 2020: 56 · 2019: 30 · 2018: 54 · 2017: 39 · 2016: 34 · 2015: 32 · 2014: 34 · 2013: 42 · 2012: 26
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physical Review Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- cell fate, gene regulatory networks, granulocytic differentiation, cell phenotype, gene expression profiling, network theory
- MeSH terms
- Cell Differentiation, Dimethyl Sulfoxide, Gene Expression Regulation, Humans, Neutrophils, RNA, Messenger, Tretinoin, HL-60 Cells, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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