Cited by 775Gene Regulatory Network AnalysisDevelopmental Biology and Gene RegulationGenomics and Chromatin Dynamics

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Cell Fates as High-Dimensional Attractor States of a Complex Gene Regulatory Network

Huang, Sui, Eichler, Gabriel, Bar-Yam, Yaneer, Ingber, Donald E.·2005·Physical Review Letters

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Abstract

Cells in multicellular organisms switch between distinct cell fates, such as proliferation or differentiation into specialized cell types. Genome-wide gene regulatory networks govern this behavior. Theoretical studies of complex networks suggest that they can exhibit ordered (stable) dynamics, raising the possibility that cell fates may represent high-dimensional attractor states. We used gene expression profiling to show that trajectories of neutrophil differentiation converge to a common state from different directions of a 2773-dimensional gene expression state space, providing the first experimental evidence for a high-dimensional stable attractor that represents a distinct cellular phenotype.

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Authors: Huang, S., Eichler, G., Bar-Yam, Y., & Ingber, D. E.
Affiliations: Boston Children's Hospital (US)
ORCID: Huang, Sui
Eichler, Gabriel
Ingber, Donald E.
Venue: Physical Review Letters
Publisher: American Physical Society (APS)
Published: 2005-04-01
Volume: 94
Issue: 12
Pages: 128701-128701
ISSN: 0031-9007 (ISSN-L)
1079-7114
DOI: 10.1103/physrevlett.94.128701
OpenAlex: W2141545875
Cited by: 775
References: 33
Citations by year: 2026: 42 · 2025: 33 · 2024: 30 · 2023: 31 · 2022: 49 · 2021: 42 · 2020: 56 · 2019: 30 · 2018: 54 · 2017: 39 · 2016: 34 · 2015: 32 · 2014: 34 · 2013: 42 · 2012: 26
FWCI: 10.04
Type: journal article
Language: en
Open access: closed
Licence: link.aps.org/licenses/aps-default-license (vor)
Locations: Physical Review Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: cell fate, gene regulatory networks, granulocytic differentiation, cell phenotype, gene expression profiling, network theory
MeSH terms: Cell Differentiation, Dimethyl Sulfoxide, Gene Expression Regulation, Humans, Neutrophils, RNA, Messenger, Tretinoin, HL-60 Cells, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling

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Cell Fates as High-Dimensional Attractor States of a Complex Gene Regulatory Network

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