Cited by 1,679Plant Micronutrient Interactions and EffectsIron Metabolism and DisordersPlant nutrient uptake and metabolism

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IRT1, an Arabidopsis Transporter Essential for Iron Uptake from the Soil and for Plant Growth

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Vert, Grégory, Grotz, Natasha, Dédaldéchamp, Fabienne, Gaymard, Frédéric, Guerinot, Mary Lou, Briat, Jean-François, Curie, Catherine·2002·The Plant Cell

DOI 10.1105/tpc.001388PMC PMC150776

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Abstract

Plants are the principal source of iron in most diets, yet iron availability often limits plant growth. In response to iron deficiency, Arabidopsis roots induce the expression of the divalent cation transporter IRT1. Here, we present genetic evidence that IRT1 is essential for the uptake of iron from the soil. An Arabidopsis knockout mutant in IRT1 is chlorotic and has a severe growth defect in soil, leading to death. This defect is rescued by the exogenous application of iron. The mutant plants do not take up iron and fail to accumulate other divalent cations in low-iron conditions. IRT1-green fluorescent protein fusion, transiently expressed in culture cells, localized to the plasma membrane. We also show, through promoter::beta-glucuronidase analysis and in situ hybridization, that IRT1 is expressed in the external cell layers of the root, specifically in response to iron starvation. These results clearly demonstrate that IRT1 is the major transporter responsible for high-affinity metal uptake under iron deficiency.

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Authors: Vert, G., Grotz, N., Dédaldéchamp, F., Gaymard, F., Guerinot, M. L., Briat, J.-F., & Curie, C.
Affiliations: Centre National de la Recherche Scientifique (FR)
Dartmouth College (US)
ORCID: Vert, Grégory
Dédaldéchamp, Fabienne
Gaymard, Frédéric
Guerinot, Mary Lou
Briat, Jean-François
Curie, Catherine
Venue: The Plant Cell
Publisher: Oxford University Press (OUP)
Published: 2002-06
Volume: 14
Issue: 6
Pages: 1223-1233
ISSN: 1040-4651 (ISSN-L)
1532-298X
DOI: 10.1105/tpc.001388
PMC: PMC150776
OpenAlex: W2124946184
Cited by: 1,679
References: 42
Citations by year: 2026: 89 · 2025: 80 · 2024: 81 · 2023: 100 · 2022: 121 · 2021: 113 · 2020: 98 · 2019: 92 · 2018: 82 · 2017: 78 · 2016: 75 · 2015: 73 · 2014: 77 · 2013: 66 · 2012: 73
FWCI: 37.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: aspb.org/publications/aspb-journals/open-articles (vor, 365 d)
Locations: The Plant Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
Keywords: IRT1, iron absorption, iron deficiency, Arabidopsis thaliana, plasma membrane localization, chlorosis, knockout mutants, iron starvation response
MeSH terms: Base Sequence, Biological Transport, Cations, Divalent, Genes, Lethal, Homeostasis, Iron, Luminescent Proteins, NADH, NADPH Oxidoreductases, Plant Proteins, Plasmids, Recombinant Fusion Proteins, Soil, Genes, Plant, Gene Deletion, Arabidopsis, DNA Primers, Plant Roots, Cation Transport Proteins, Arabidopsis Proteins, Plants, Genetically Modified, FMN Reductase, Green Fluorescent Proteins

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IRT1, an Arabidopsis Transporter Essential for Iron Uptake from the Soil and for Plant Growth

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