The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Role of SCF Ubiquitin-Ligase and the COP9 Signalosome in the N Gene–Mediated Resistance Response to Tobacco mosaic virus
Open accessAbstract
The tobacco N gene confers resistance to Tobacco mosaic virus (TMV) and encodes a toll-interleukin-1 receptor/nucleotide binding/Leu-rich repeat class protein. Recent evidence indicates that the Nicotiana benthamiana Rar1 gene (NbRar1), which encodes a protein with a zinc finger motif called CHORD (Cys- and His-rich domain), is required for the function of N. To investigate the role of NbRar1 in plant defense, we identified its interaction partners. We show that the NbRar1 protein interacts with NbSGT1, a highly conserved component of the SCF (Skp1/Cullin/F-box protein)-type E3 ubiquitin ligase complex involved in protein degradation. In addition, we show that NbSGT1 interacts with NbSKP1. Suppression of NbSGT1 and NbSKP1 shows that these genes play an important role in the N-mediated resistance response to TMV. Both NbRar1 and NbSGT1 associate with the COP9 signalosome, another multiprotein complex involved in protein degradation via the ubiquitin-proteasome pathway. Silencing of the NbCOP9 signalosome also compromises N-mediated resistance to TMV. Our results reveal new roles for SCF and the COP9 signalosome in plant defense signaling.
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Cites
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Self-citationSCF and Cullin/RING H2-Based Ubiquitin Ligases
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Self-citationTechnical Advance: Tobacco rattle virus as a vector for analysis of gene function by silencing
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Self-citation
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Ubiquitin, Hormones and Biotic Stress in Plants
Dreher, K., & Callis, J. (2007) · Annals of Botany · doi:10.1093/aob/mcl255 · Cited by 503
Molecular players regulating the jasmonate signalling network
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Self-citationHemipterans as Plant Pathogens
Kaloshian, I., & Walling, L. L. (2005) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.43.040204.135944 · Cited by 264
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Metadata
- Authors
- Liu, Y., Schiff, M., Serino, G., Deng, X.-W., & Dinesh-Kumar, S. P.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-07
- Volume
- 14
- Issue
- 7
- Pages
- 1483-1496
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2167894564
- Cited by
- 346
- References
- 36
- FWCI
- 34.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, Y., Schiff, M., Serino, G., Deng, X.-W., & Dinesh-Kumar, S. P. (2002). Role of SCF Ubiquitin-Ligase and the COP9 Signalosome in the N Gene–Mediated Resistance Response to Tobacco mosaic virus. The Plant Cell. https://doi.org/10.1105/tpc.002493
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