The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Spreading of RNA Targeting and DNA Methylation in RNA Silencing Requires Transcription of the Target Gene and a Putative RNA-Dependent RNA Polymerase
Open accessAbstract
RNA silencing is a sequence-specific RNA degradation process that follows the recognition of double-stranded RNA. Here, we show that virus vectors carrying parts of a green fluorescent protein (GFP) transgene targeted RNA silencing in Nicotiana benthamiana and Arabidopsis against the entire GFP RNA. These results indicate that there was spreading of RNA targeting from the initiator region into the adjacent 5' and 3' regions of the target gene. Spreading was accompanied by methylation of the corresponding GFP DNA. It also was dependent on transcription of the transgene and on the putative RNA-dependent RNA polymerase, SDE1/SGS2. These findings indicate that SDE1/SGS2 produces double-stranded RNA using the target RNA as a template. RNA silencing of ribulose-1,5-bisphosphate carboxylase/oxygenase and phytoene desaturase was not associated with the spreading of RNA targeting or DNA methylation, indicating that these endogenous RNAs are not templates for SDE1/SGS2.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Role for a bidentate ribonuclease in the initiation step of RNA interference
Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 4,892
RNA interference is mediated by 21- and 22-nucleotide RNAs
Elbashir, S. M., Lendeckel, W., & Tuschl, T. (2001) · Genes & Development · doi:10.1101/gad.862301 · Cited by 3,310
A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants
Hamilton, A. J., & Baulcombe, D. C. (1999) · Science · doi:10.1126/science.286.5441.950 · Cited by 3,041
Self-citationAn RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
Hammond, S. M., Bernstein, E., Beach, D., & Hannon, G. J. (2000) · Nature · doi:10.1038/35005107 · Cited by 3,003
Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, E., Tuschl, T., & Zamore, P. D. (2001) · Science · doi:10.1126/science.1062961 · Cited by 2,781
Zamore, P. D., Tuschl, T., Sharp, P. A., & Bartel, D. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80620-0 · Cited by 2,676
The Role of DNA Methylation in Mammalian Epigenetics
Jones, P. A., & Takai, D. (2001) · Science · doi:10.1126/science.1063852 · Cited by 2,070
On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing
Sijen, T., Fleenor, J., Simmer, F., Thijssen, K. L., Parrish, S., Timmons, L., Plasterk, R. H. A., & Fire, A. (2001) · Cell · doi:10.1016/s0092-8674(01)00576-1 · Cited by 1,277
Mourrain, P., Béclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.-B., Jouette, D., Lacombe, A.-M., Nikic, S., Picault, N., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80863-6 · Cited by 1,095
Cited by
RNA Interference: Biology, Mechanism, and Applications
Agrawal, N., Dasaradhi, P. V. N., Mohmmed, A., Malhotra, P., Bhatnagar, R. K., & Mukherjee, S. K. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.657-685.2003 · Cited by 1,305
Two classes of short interfering RNA in RNA silencing
Hamilton, A., Voinnet, O., Chappell, L., & Baulcombe, D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf464 · Cited by 809
Self-citationThe diversity of RNA silencing pathways in plants
BRODERSEN, P., & VOINNET, O. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.03.003 · Cited by 732
microRNA biogenesis and function in plants
Chen, X. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.071 · Cited by 567
Transcriptional Control of Gene Expression by MicroRNAs
Khraiwesh, B., Arif, M. A., Seumel, G. I., Ossowski, S., Weigel, D., Reski, R., & Frank, W. (2010) · Cell · doi:10.1016/j.cell.2009.12.023 · Cited by 494
Metadata
- Authors
- Vaistij, F. E., Jones, L., & Baulcombe, D. C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-04
- Volume
- 14
- Issue
- 4
- Pages
- 857-867
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2101372151
- Cited by
- 444
- References
- 46
- FWCI
- 50.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vaistij, F. E., Jones, L., & Baulcombe, D. C. (2002). Spreading of RNA Targeting and DNA Methylation in RNA Silencing Requires Transcription of the Target Gene and a Putative RNA-Dependent RNA Polymerase. The Plant Cell. https://doi.org/10.1105/tpc.010480
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