The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Spreading of RNA Targeting and DNA Methylation in RNA Silencing Requires Transcription of the Target Gene and a Putative RNA-Dependent RNA Polymerase
Open accessAbstract
RNA silencing is a sequence-specific RNA degradation process that follows the recognition of double-stranded RNA. Here, we show that virus vectors carrying parts of a green fluorescent protein (GFP) transgene targeted RNA silencing in Nicotiana benthamiana and Arabidopsis against the entire GFP RNA. These results indicate that there was spreading of RNA targeting from the initiator region into the adjacent 5' and 3' regions of the target gene. Spreading was accompanied by methylation of the corresponding GFP DNA. It also was dependent on transcription of the transgene and on the putative RNA-dependent RNA polymerase, SDE1/SGS2. These findings indicate that SDE1/SGS2 produces double-stranded RNA using the target RNA as a template. RNA silencing of ribulose-1,5-bisphosphate carboxylase/oxygenase and phytoene desaturase was not associated with the spreading of RNA targeting or DNA methylation, indicating that these endogenous RNAs are not templates for SDE1/SGS2.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Role for a bidentate ribonuclease in the initiation step of RNA interference
Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 4,892
RNA interference is mediated by 21- and 22-nucleotide RNAs
Elbashir, S. M., Lendeckel, W., & Tuschl, T. (2001) · Genes & Development · doi:10.1101/gad.862301 · Cited by 3,310
A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants
Hamilton, A. J., & Baulcombe, D. C. (1999) · Science · doi:10.1126/science.286.5441.950 · Cited by 3,041
Self-citationAn RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
Hammond, S. M., Bernstein, E., Beach, D., & Hannon, G. J. (2000) · Nature · doi:10.1038/35005107 · Cited by 3,003
Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, E., Tuschl, T., & Zamore, P. D. (2001) · Science · doi:10.1126/science.1062961 · Cited by 2,781
Zamore, P. D., Tuschl, T., Sharp, P. A., & Bartel, D. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80620-0 · Cited by 2,676
The Role of DNA Methylation in Mammalian Epigenetics
Jones, P. A., & Takai, D. (2001) · Science · doi:10.1126/science.1063852 · Cited by 2,070
On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing
Sijen, T., Fleenor, J., Simmer, F., Thijssen, K. L., Parrish, S., Timmons, L., Plasterk, R. H. A., & Fire, A. (2001) · Cell · doi:10.1016/s0092-8674(01)00576-1 · Cited by 1,277
Mourrain, P., Béclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.-B., Jouette, D., Lacombe, A.-M., Nikic, S., Picault, N., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80863-6 · Cited by 1,095
Dalmay, T., Hamilton, A., Rudd, S., Angell, S., & Baulcombe, D. C. (2000) · Cell · doi:10.1016/s0092-8674(00)80864-8 · Cited by 1,068
Self-citationInitiation and Maintenance of Virus-Induced Gene Silencing
Ruiz, M. T., Voinnet, O., & Baulcombe, D. C. (1998) · The Plant Cell · doi:10.1105/tpc.10.6.937 · Cited by 998
Self-citationGene silencing as an adaptive defence against viruses
Waterhouse, P. M., Wang, M.-B., & Lough, T. (2001) · Nature · doi:10.1038/35081168 · Cited by 980
Technical Advance: Tobacco rattle virus as a vector for analysis of gene function by silencing
Ratcliff, F., Martin‐Hernandez, A. M., & Baulcombe, D. C. (2001) · The Plant Journal · doi:10.1046/j.0960-7412.2000.00942.x · Cited by 960
Self-citationTotal silencing by intron-spliced hairpin RNAs
Smith, N. A., Singh, S. P., Wang, M.-B., Stoutjesdijk, P. A., Green, A. G., & Waterhouse, P. M. (2000) · Nature · doi:10.1038/35030305 · Cited by 957
A Similarity Between Viral Defense and Gene Silencing in Plants
Ratcliff, F., Harrison, B. D., & Baulcombe, D. C. (1997) · Science · doi:10.1126/science.276.5318.1558 · Cited by 838
Self-citationAravin, A. A., Naumova, N. M., Tulin, A. V., Vagin, V. V., Rozovsky, Y. M., & Gvozdev, V. A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00299-8 · Cited by 795
Palauqui, J.-C. (1997) · The EMBO Journal · doi:10.1093/emboj/16.15.4738 · Cited by 780
Voinnet, O., Vain, P., Angell, S., & Baulcombe, D. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81749-3 · Cited by 706
Self-citationSpecific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana
Chuang, C.-F., & Meyerowitz, E. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.060034297 · Cited by 646
Systemic signalling in gene silencing
Voinnet, O., & Baulcombe, D. C. (1997) · Nature · doi:10.1038/39215 · Cited by 619
Self-citationGene Silencing without DNA: RNA-Mediated Cross-Protection between Viruses
Ratcliff, F. G., MacFarlane, S. A., & Baulcombe, D. C. (1999) · The Plant Cell · doi:10.1105/tpc.11.7.1207 · Cited by 476
Self-citationRNA–DNA Interactions and DNA Methylation in Post-Transcriptional Gene Silencing
Jones, L., Hamilton, A. J., Voinnet, O., Thomas, C. L., Maule, A. J., & Baulcombe, D. C. (1999) · The Plant Cell · doi:10.1105/tpc.11.12.2291 · Cited by 461
Self-citationJorgensen, R. A., Cluster, P. D., English, J., Que, Q., & Napoli, C. A. (1996) · Plant Molecular Biology · doi:10.1007/bf00040715 · Cited by 384
Plants combat infection by gene silencing
Covey, S. N., Al-Kaff, N. S., Lángara, A., & Turner, D. S. (1997) · Nature · doi:10.1038/385781a0 · Cited by 376
RNAi as Random Degradative PCR
Lipardi, C., Wei, Q., & Paterson, B. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00537-2 · Cited by 374
Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes.
English, J. J., Mueller, E., & Baulcombe, D. C. (1996) · The Plant Cell · doi:10.1105/tpc.8.2.179 · Cited by 371
Self-citationJones, L., Ratcliff, F., & Baulcombe, D. C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00226-3 · Cited by 368
Self-citationSDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis
Dalmay, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.8.2069 · Cited by 361
Elmayan, T., & Vaucheret, H. (1996) · The Plant Journal · doi:10.1046/j.1365-313x.1996.9060787.x · Cited by 294
Lindbo, J. A., Silva-Rosales, L., Proebsting, W. M., & Dougherty, W. G. (1993) · The Plant Cell · doi:10.2307/3869691 · Cited by 286
Transgene and Transposon Silencing in Chlamydomonas reinhardtii by a DEAH-Box RNA Helicase
Wu-Scharf, D., Jeong, B.-R., Zhang, C., & Cerutti, H. (2000) · Science · doi:10.1126/science.290.5494.1159 · Cited by 280
Wassenegger, M. (2000) · Plant Molecular Biology · doi:10.1023/a:1006479327881 · Cited by 243
Arabidopsis Mutants Impaired in Cosuppression
Elmayan, T., Balzergue, S., Béon, F., Bourdon, V., Daubremet, J., Guénet, Y., Mourrain, P., Palauqui, J.-C., Vernhettes, S., Vialle, T., et al. (1998) · The Plant Cell · doi:10.1105/tpc.10.10.1747 · Cited by 242
Thomas, C. L., Jones, L., Baulcombe, D. C., & Maule, A. J. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.00976.x · Cited by 235
Self-citationTaming of transposable elements by homology-dependent gene silencing
Jensen, S., Gassama, M.-P., & Heidmann, T. (1999) · Nature Genetics · doi:10.1038/5997 · Cited by 222
A genetic link between co-suppression and RNA interference in C. elegans
Ketting, R. F., & Plasterk, R. H. A. (2000) · Nature · doi:10.1038/35005113 · Cited by 214
De novo methylation and co-suppression induced by a cytoplasmically replicating plant RNA virus
Jones, A. L., Thomas, C. L., & Maule, A. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6385 · Cited by 194
Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity
Jähner, D., & Jaenisch, R. (1985) · Nature · doi:10.1038/315594a0 · Cited by 192
Potato Virus X Amplicons in Arabidopsis Mediate Genetic and Epigenetic Gene Silencing
Dalmay, T., Hamilton, A. J., Mueller, E., & Baulcombe, D. C. (2000) · The Plant Cell · doi:10.1105/tpc.12.3.369 · Cited by 187
Self-citationSuppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes
English, J. J., Mueller, E., & Baulcombe, D. C. (1996) · The Plant Cell · doi:10.2307/3870263 · Cited by 144
Self-citationGene silencing: RNA makes RNA makes no protein
Baulcombe, D. C. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80383-2 · Cited by 105
Self-citationWang, M. B., Wesley, S. V., Finnegan, E. J., et al. (2001) · RNA · doi:10.1017/s1355838201001224 · Cited by 97
Pal‐Bhadra, M., Bhadra, U., & Birchler, J. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80060-4 · Cited by 87
Wassenegger, M. (2000) · Springer eBooks · doi:10.1007/978-94-011-4183-3_6 · Cited by 31
Arabidopsis Mutants Impaired in Cosuppression
Elmayan, T., Balzergue, S., Béon, F., Bourdon, V., Daubremet, J., Guenet, Y., Mourrain, P., Palauqui, J., Vernhettes, S., Vialle, T., et al. (1998) · The Plant Cell · doi:10.2307/3870771 · Cited by 15
Cited by
RNA Interference: Biology, Mechanism, and Applications
Agrawal, N., Dasaradhi, P. V. N., Mohmmed, A., Malhotra, P., Bhatnagar, R. K., & Mukherjee, S. K. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.657-685.2003 · Cited by 1,305
Two classes of short interfering RNA in RNA silencing
Hamilton, A., Voinnet, O., Chappell, L., & Baulcombe, D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf464 · Cited by 809
Self-citationThe diversity of RNA silencing pathways in plants
BRODERSEN, P., & VOINNET, O. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.03.003 · Cited by 732
microRNA biogenesis and function in plants
Chen, X. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.071 · Cited by 567
Transcriptional Control of Gene Expression by MicroRNAs
Khraiwesh, B., Arif, M. A., Seumel, G. I., Ossowski, S., Weigel, D., Reski, R., & Frank, W. (2010) · Cell · doi:10.1016/j.cell.2009.12.023 · Cited by 494
Metadata
- Authors
- Vaistij, F. E., Jones, L., & Baulcombe, D. C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-04
- Volume
- 14
- Issue
- 4
- Pages
- 857-867
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2101372151
- Cited by
- 444
- References
- 46
- FWCI
- 50.30
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
