The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Arabidopsis GCN5 , HD1 , and TAF1/HAF2 Interact to Regulate Histone Acetylation Required for Light-Responsive Gene Expression
Open accessAbstract
We previously showed that Arabidopsis thaliana histone acetyltransferase TAF1/HAF2 is required for the light regulation of growth and gene expression, and we show here that histone acetyltransferase GCN5 and histone deacetylase HD1/HDA19 are also involved in such regulation. Mutation of GCN5 resulted in a long-hypocotyl phenotype and reduced light-inducible gene expression, whereas mutation of HD1 induced opposite effects. The double mutant gcn5 hd1 restored a normal photomorphogenic phenotype. By contrast, the double mutant gcn5 taf1 resulted in further loss of light-regulated gene expression. gcn5 reduced acetylation of histones H3 and H4, mostly on the core promoter regions, whereas hd1 increased acetylation on both core and more upstream promoter regions. GCN5 and TAF1 were both required for H3K9, H3K27, and H4K12 acetylation on the target promoters, but H3K14 acetylation was dependent only on GCN5. Interestingly, gcn5 taf1 had a cumulative effect mainly on H3K9 acetylation. On the other hand, hd1 induced increased acetylation on H3K9, H3K27, H4K5, and H4K8. GCN5 was also shown to be directly associated with the light-responsive promoters. These results suggest that acetylation of specific histone Lys residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,742
Acetylation of Histones and Transcription-Related Factors
Sterner, D. E., & Berger, S. L. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.2.435-459.2000 · Cited by 1,780
Histone modifications in transcriptional regulation
Berger, S. L. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00279-4 · Cited by 1,220
Grant, P. A., Duggan, L., Côté, J., Roberts, S. M., Brownell, J. E., Candau, R., Ohba, R., Owen-Hughes, T., Allis, C. D., Winston, F., et al. (1997) · Genes & Development · doi:10.1101/gad.11.13.1640 · Cited by 1,085
Oyama, T., Shimura, Y., & Okada, K. (1997) · Genes & Development · doi:10.1101/gad.11.22.2983 · Cited by 833
Pandey, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf660 · Cited by 790
Huisinga, K. L., & Pugh, B. F. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00087-5 · Cited by 560
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation
Frank, S. R., Schroeder, M., Fernandez, P., Taubert, S., & Amati, B. (2001) · Genes & Development · doi:10.1101/gad.906601 · Cited by 499
The diverse functions of histone acetyltransferase complexes
Carrozza, M. J., Utley, R. T., Workman, J. L., & Côté, J. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00115-x · Cited by 487
Cited by
Kim, J.-M., To, T. K., Ishida, J., Morosawa, T., Kawashima, M., Matsui, A., Toyoda, T., Kimura, H., Shinozaki, K., & Seki, M. (2008) · Plant and Cell Physiology · doi:10.1093/pcp/pcn133 · Cited by 346
HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis
Wu, K., Zhang, L., Zhou, C., Yu, C.-W., & Chaikam, V. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/erm300 · Cited by 326
Histone Deacetylase Genes in Arabidopsis Development
Hollender, C., & Liu, Z. (2008) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2008.00704.x · Cited by 301
Histone modifications and dynamic regulation of genome accessibility in plants
Pfluger, J., & Wagner, D. (2007) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2007.07.013 · Cited by 290
Histone Modifications in Transcriptional Activation during Plant Development
Berr, A., Shafiq, S., & Shen, W.-H. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.07.001 · Cited by 251
Metadata
- Authors
- Benhamed, M., Bertrand, C., Servet, C., & Zhou, D.-X.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11
- Volume
- 18
- Issue
- 11
- Pages
- 2893-2903
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2046301815
- Cited by
- 356
- References
- 33
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Arabidopsis GCN5 , HD1 , and TAF1/HAF2 Interact to Regulate Histone Acetylation Required for Light-Responsive Gene Expression. https://app.cochat.ai/papers/10.1105/tpc.106.043489
- The paper
- Benhamed, M., Bertrand, C., Servet, C., & Zhou, D.-X. (2006). Arabidopsis GCN5 , HD1 , and TAF1/HAF2 Interact to Regulate Histone Acetylation Required for Light-Responsive Gene Expression. The Plant Cell. https://doi.org/10.1105/tpc.106.043489
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
