The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
SCREAM/ICE1 and SCREAM2 Specify Three Cell-State Transitional Steps Leading to Arabidopsis Stomatal Differentiation
Open accessAbstract
Differentiation of specialized cell types in multicellular organisms requires orchestrated actions of cell fate determinants. Stomata, valves on the plant epidermis, are formed through a series of differentiation events mediated by three closely related basic-helix-loop-helix proteins: SPEECHLESS (SPCH), MUTE, and FAMA. However, it is not known what mechanism coordinates their actions. Here, we identify two paralogous proteins, SCREAM (SCRM) and SCRM2, which directly interact with and specify the sequential actions of SPCH, MUTE, and FAMA. The gain-of-function mutation in SCRM exhibited constitutive stomatal differentiation in the epidermis. Conversely, successive loss of SCRM and SCRM2 recapitulated the phenotypes of fama, mute, and spch, indicating that SCRM and SCRM2 together determined successive initiation, proliferation, and terminal differentiation of stomatal cell lineages. Our findings identify the core regulatory units of stomatal differentiation and suggest a model strikingly similar to cell-type differentiation in animals. Surprisingly, map-based cloning revealed that SCRM is INDUCER OF CBF EXPRESSION1, a master regulator of freezing tolerance, thus implicating a potential link between the transcriptional regulation of environmental adaptation and development in plants.
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Cites
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ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis
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Self-citationNakagawa, T., Kurose, T., Hino, T., Tanaka, K., Kawamukai, M., Niwa, Y., Toyooka, K., Matsuoka, K., Jinbo, T., & Kimura, T. (2007) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.104.34 · Cited by 1,643
The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage
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The Arabidopsis Basic/Helix-Loop-Helix Transcription Factor Family[W]
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Cited by
Research on plant abiotic stress responses in the post‐genome era: past, present and future
Hirayama, T., & Shinozaki, K. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04124.x · Cited by 1,215
OST1 Kinase Modulates Freezing Tolerance by Enhancing ICE1 Stability in Arabidopsis
Ding, Y., Li, H., Zhang, X., Xie, Q., Gong, Z., & Yang, S. (2015) · Developmental Cell · doi:10.1016/j.devcel.2014.12.023 · Cited by 676
Origin and Diversification of Basic-Helix-Loop-Helix Proteins in Plants
Pires, N., & Dolan, L. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msp288 · Cited by 640
Li, H., Ding, Y., Shi, Y., Zhang, X., Zhang, S., Gong, Z., & Yang, S. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.09.025 · Cited by 489
Saibo, N. J. M., Lourenço, T., & Oliveira, M. M. (2009) · Annals of Botany · doi:10.1093/aob/mcn227 · Cited by 483
Metadata
- Authors
- Kanaoka, M. M., Pillitteri, L. J., Fujii, H., Yoshida, Y., Bogenschutz, N. L., Takabayashi, J., Zhu, J.-K., & Torii, K. U.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07-01
- Volume
- 20
- Issue
- 7
- Pages
- 1775-1785
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2148822243
- Cited by
- 553
- References
- 27
- FWCI
- 28.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: SCREAM/ICE1 and SCREAM2 Specify Three Cell-State Transitional Steps Leading to Arabidopsis Stomatal Differentiation. https://app.cochat.ai/papers/10.1105/tpc.108.060848
- The paper
- Kanaoka, M. M., Pillitteri, L. J., Fujii, H., Yoshida, Y., Bogenschutz, N. L., Takabayashi, J., Zhu, J.-K., & Torii, K. U. (2008). SCREAM/ICE1 and SCREAM2 Specify Three Cell-State Transitional Steps Leading to Arabidopsis Stomatal Differentiation. The Plant Cell. https://doi.org/10.1105/tpc.108.060848
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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