The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
The YTH Domain Protein ECT2 Is an m 6 A Reader Required for Normal Trichome Branching in Arabidopsis
Open accessAbstract
Methylations at position N6 of internal adenosines (m6As) are the most abundant and widespread mRNA modifications. These modifications play crucial roles in reproduction, growth, and development by controlling gene expression patterns at the posttranscriptional level. Their function is decoded by readers that share the YTH domain, which forms a hydrophobic pocket that directly accommodates the m6A residues. While the physiological and molecular functions of YTH readers have been extensively studied in animals, little is known about plant readers, even though m6As are crucial for plant survival and development. Viridiplantae contains high numbers of YTH domain proteins. Here, we performed comprehensive evolutionary analysis of YTH domain proteins and demonstrated that they are highly likely to be actual readers with redundant as well as specific functions. We also show that the ECT2 protein from Arabidopsis thaliana binds to m6A-containing RNAs in vivo and that this property relies on the m6A binding pocket carried by its YTH domain. ECT2 is cytoplasmic and relocates to stress granules upon heat exposure, suggesting that it controls mRNA fate in the cytosol. Finally, we demonstrate that ECT2 acts to decode the m6A signal in the trichome and is required for their normal branching through controlling their ploidy levels.
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Cites
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“…allow us to identify any remarkable protein domains in ECT2, aswell as in any other plant DF-type protein, with the exception of a YPQ-rich region reminiscent of that found in human YTHDF proteins and in aggregation-prone factors suchasTIA-1, TIAR, andprionproteins (Wang et al., 2014) (Figure 3).”
BackgroundResultComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
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Cited by
Zhou, L., Tian, S., & Qin, G. (2019) · Genome Biology · doi:10.1186/s13059-019-1771-7 · Cited by 382
Insights into the conservation and diversification of the molecular functions of YTHDF proteins
(2023) · doi:10.1371/journal.pgen.1010980 · Cited by 29
Kairouani, A., Pontier, D., Picart, C., Mounet, F., Martinez, Y., Le-Bot, L., Fanuel, M., Hammann, P., Belmudes, L., Merret, R., et al. (2023) · eLife · doi:10.7554/elife.88207 · Cited by 7
Self-citationKairouani, A., Pontier, D., Picart, C., Mounet, F., Martinez, Y., Le-Bot, L., Fanuel, M., Hammann, P., Belmudes, L., Merret, R., et al. (2023) · eLife · doi:10.7554/elife.88207.3 · Cited by 3
Self-citationKairouani, A., Pontier, D., Picart, C., Mounet, F., Martinez, Y., Le-Bot, L., Fanuel, M., Hammann, P., Belmudes, L., Merret, R., et al. (2023) · doi:10.1101/2023.03.20.532888
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Metadata
- Authors
- Scutenaire, J., Deragon, J.-M., Jean, V., Benhamed, M., Raynaud, C., Favory, J.-J., Merret, R., & Bousquet-Antonelli, C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-04-04
- Volume
- 30
- Issue
- 5
- Pages
- 986-1005
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2795649819
- Cited by
- 292
- References
- 65
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Scutenaire, J., Deragon, J.-M., Jean, V., Benhamed, M., Raynaud, C., Favory, J.-J., Merret, R., & Bousquet-Antonelli, C. (2018). The YTH Domain Protein ECT2 Is an m 6 A Reader Required for Normal Trichome Branching in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.17.00854
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