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Cited by 500

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

A model-based algorithm for blood glucose control in Type I diabetic patients

Parker, R.S., Doyle, F.J., Peppas, N.A.·1999·IEEE Transactions on Biomedical Engineering
DOI 10.1109/10.740877
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Abstract

A model-based predictive control algorithm is developed to maintain normoglycemia in the Type I diabetic patient using a closed-loop insulin infusion pump. Utilizing compartmental modeling techniques, a fundamental model of the diabetic patient is constructed. The resulting nineteenth-order nonlinear pharmacokinetic-pharmacodynamic representation is used in controller synthesis. Linear identification of an input-output model from noisy patient data is performed by filtering the impulse-response coefficients via projection onto the Laguerre basis. A linear model predictive controller is developed using the identified step response model. Controller performance for unmeasured disturbance rejection (50 g oral glucose tolerance test) is examined. Glucose setpoint tracking performance is improved by designing a second controller which substitutes a more detailed internal model including state-estimation and a Kalman filter for the input-output representation. The state-estimating controller maintains glucose within 15 mg/dl of the setpoint in the presence of measurement noise. Under noise-free conditions, the model-based predictive controller using state estimation outperforms an internal model controller from literature (49.4% reduction in undershoot and 45.7% reduction in settling time). These results demonstrate the potential use of predictive algorithms for blood glucose control in an insulin infusion pump.

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Metadata

Authors
Parker, R. S., Doyle, F. J., & Peppas, N. A.
Venue
IEEE Transactions on Biomedical Engineering
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Published
1999
Volume
46
Issue
2
Pages
148-157
ISSN
0018-9294 (ISSN-L)
DOI
10.1109/10.740877
OpenAlex
W2142962347
Cited by
500
References
2
FWCI
3.62
Type
journal article
Language
en
Open access
closed
Licence
ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)

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CoChat. (2026). Citation check: A model-based algorithm for blood glucose control in Type I diabetic patients. https://app.cochat.ai/papers/10.1109/10.740877
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Parker, R. S., Doyle, F. J., & Peppas, N. A. (1999). A model-based algorithm for blood glucose control in Type I diabetic patients. IEEE Transactions on Biomedical Engineering. https://doi.org/10.1109/10.740877

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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