Biomechanical Properties of In Vivo Human Skin From Dynamic Optical Coherence Elastography
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Dynamic optical coherence elastography is used to determine in vivo skin biomechanical properties based on mechanical surface wave propagation. Quantitative Young's moduli are measured on human skin from different sites, orientations, and frequencies. Skin thicknesses, including measurements from different layers, are also measured simultaneously. Experimental results show significant differences among measurements from different skin sites, between directions parallel and orthogonal to Langer's lines, and under different skin hydration states. Results also suggest surface waves with different driving frequencies represent skin biomechanical properties from different layers in depth. With features such as micrometer-scale resolution, noninvasive imaging, and real-time processing from the optical coherence tomography technology, this optical measurement technique has great potential for measuring skin biomechanical properties in dermatology.
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The elastomeric microfluidic devices exhibited an effective modulus of ~0.16 MPa, comparable to human skin and previously reported epidermal devices.
“These elastomeric microfluidic devices exhibited an effective modulus of ~0.16 MPa, comparable to human skin and previously reported epidermal devices (37, 38).”
From A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat (2016) · cites this paper as [38]
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- Authors
- Liang, X., & Boppart, S. A.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Boppart, S.A.
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2010-04
- Volume
- 57
- Issue
- 4
- Pages
- 953-959
- ISSN
- 0018-9294 (ISSN-L)
- PMC
- PMC3699319
- OpenAlex
- W2133147905
- Cited by
- 470
- References
- 50
- Citations by year
- 2026: 25 · 2025: 26 · 2024: 31 · 2023: 27 · 2022: 31 · 2021: 40 · 2020: 33 · 2019: 56 · 2018: 36 · 2017: 30 · 2016: 31 · 2015: 27 · 2014: 26 · 2013: 25 · 2012: 8
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Technische Universiteit Eindhoven
- University of Illinois at Urbana-Champaign
- National Institute of Biomedical Imaging and Bioengineering (R21EB005321, R01EB005221)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Keywords
- skin biomechanics, Young's modulus, skin thickness, Langer's lines, skin hydration, surface wave propagation, skin layers, non-invasive skin imaging, dermatology
- MeSH terms
- Algorithms, Arm, Biomechanical Phenomena, Humans, Male, Skin Physiological Phenomena, Poisson Distribution, Tomography, Optical Coherence, Elasticity Imaging Techniques, Elastic Modulus
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