A CMOS Synchronized Sample-and-Hold Artifact Blanking Analog Front-End Local Field Potential Acquisition Unit With ±3.6-V Stimulation Artifact Tolerance and Monopolar Electrode-Tissue Impedance Measurement Circuit for Closed-Loop Deep Brain Stimulation SoCs
Abstract
In this paper, an analog front-end (AFE) local-field potential (LFP) acquisition unit with real-time stimulation artifact removal is proposed and verified for closed-loop deep brain stimulation (DBS) applications. The proposed acquisition unit is called the synchronized sample-and-hold stimulation artifact blanking (SSAB) AFE LFP acquisition unit. Both right-leg-driven (RLD) circuit and monopolar electrode-tissue impedance (ETI) measurement circuit associated with the AFE amplifier are also proposed. During closed-loop stimulations, the artifact removal is realized through the SSAB-IPC by blanking the AR-CCIA with a clock synchronized to the stimulation-enable signal and holding the amplifier at its state before stimulation through a sample-and-hold operation. After stimulation, the acquisition unit can quickly recover from the holding state back to the LFP recording state to reduce the discontinuity in LFP recording. The proposed acquisition unit was fabricated in 0.18-$\mu {\mathrm{ m}}$CMOS technology. With the RLD circuit, the measured CMRR is 124– 145 dB in the signal bandwidth. The fabricated monopolar ETI measurement circuit has a measurement error less than 8.3% with an extra power consumption of$2.65 \mu \text{W}$. The experimental results have shown that the proposed SSAB AFE LFP acquisition unit is feasible for the integration of SoCs in real-time closed-loop DBS systems for various applications.
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Digital processing techniques such as reconstruction of the biopotentials use interpolation methods that can be applied in parallel to signal blanking to fill in the blocking phases of the synchronised sample-and-hold process.
“Digital processing techniques such as reconstruction of the biopotentials use interpolation methods that can be applied in parallel to signal blanking to fill in the blocking phases of the synchronised sample-and-hold process [192], [195].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [195]
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Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review
Habibollahi, M., Jiang, D., Lancashire, H. T., & Demosthenous, A. (2024) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2024.3430038 · Cited by 11 · see citing works
“3) Back-End Processing: Digital processing techniques such as reconstruction of the biopotentials use interpolation methods that can be applied in parallel to signal blanking to fill in the blocking phases of the synchronised sample-and-hold process [192], [195].”
- Authors
- Huang, C.-W., Lai, C.-K., Hung, C.-C., Wu, C.-Y., & Ker, M.-D.
- Affiliations
- National Yang Ming Chiao Tung University (TW)
- Venue
- IEEE Transactions on Circuits and Systems I: Regular Papers
- Published
- 2023-06
- Volume
- 70
- Issue
- 6
- Pages
- 2257-2270
- ISSN
- 1549-8328 (ISSN-L)
- 1558-0806
- OpenAlex
- W4327808024
- Cited by
- 16
- References
- 23
- Citations by year
- 2025: 5 · 2024: 8 · 2023: 3
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- IEEE Transactions on Circuits and Systems I Regular Papers (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
- Keywords
- deep brain stimulation, closed-loop stimulation, sample-and-hold circuit, CMOS analog front-end, impedance measurement, integrated circuits
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