An integrated system for simultaneous, multichannel neuronal stimulation and recording.
Abstract
Precision electronics that provide multi-electrode stimulation and recording capabilities are an important tool for the experimental study of neuronal development and plasticity. Towards this end, we present a custom analog integrated circuit (IC), fabricated in a 0.35-mum process, incorporating stimulation buffers and recording preamplifiers for multiple electrodes onto a single die. The architecture of the IC allows for arbitrary, independent configuration of electrodes for stimulation or recording, and the IC includes artifact-elimination circuitry that returns the stimulation electrode to its previous voltage following stimulation, minimizing the interference with recording. We analyze the thermal noise levels in the recording preamplifiers and experimentally measure input-referred noise as low as 4.77 muVrmsin the frequency range of 30 Hz-3 kHz at a power consumption of 100 muW from a total power supply of 3.8 V. We also consider the temporal response and stability of the artifact elimination circuitry. We demonstrate that the use of the artifact-elimination circuitry with a 30-mum diameter stimulation electrode permits a return to recording mode in les 2 ms after stimulation, facilitating near-simultaneous stimulation and recording of neuronal signals. (Patent applied for, U.S. No. 2007/0178579.)
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The blanking technique is effective in some applications, such as EMG signal acquisition.
“This method is effective in some applications, such as EMG signal acquisition.”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Blum et al., 2007
Such a stimulation artifact can be observed in most closed-loop recording and stimulation circuits.
“Such a stimulation artifact can be observed in most of the closed-loop recording and stimulation circuits (Yoshida and Horch, 1996; Blum et al., 2007; Venkatraman et al., 2009; Mc Laughlin et al., 2012; Ng et al., 2012; Xu et al., 2012).”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Blum et al., 2007
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Liu, X., & der Spiegel, J. V. (2017) · Springer eBooks · doi:10.1007/978-3-319-67940-2_1
Hsu, C.-H., Lin, Y.-W., & Tang, K. (2024) · IEEE International Symposium on Circuits and Systems proceedings · doi:10.1109/iscas58744.2024.10558265
Wang, W., Zheng, J., Zhou, Y., Su, R., Zhu, L., & Zhou, Z. (2024) · IEEE International Symposium on Circuits and Systems proceedings · doi:10.1109/iscas58744.2024.10558281
de Oliveira, J. V., Weiss, N. M., Wollenberg, B., & Wimmer, W. (2026) · Zeitschrift für Medizinische Physik · doi:10.1016/j.zemedi.2026.10.002
- Authors
- Blum, R. A., Ross, J. D., Brown, E. A., & DeWeerth, S. P.
- Affiliations
- Georgia Institute of Technology (US)
- Venue
- IEEE Transactions on Circuits and Systems I Regular Papers
- Published
- 2007-12
- Volume
- 54
- Issue
- 12
- Pages
- 2608-2618
- ISSN
- 1549-8328 (ISSN-L)
- 1558-0806
- OpenAlex
- W1964974938
- Cited by
- 74
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 8
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Circuits and Systems I Regular Papers (publishedVersion)
- Funders
- Korea Institute of Science and Technology
- Korea Advanced Institute of Science and Technology
- Wallace H. Coulter Department of Biomedical Engineering
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
- Keywords
- integrated circuits, artifact removal, thermal noise, input-referred noise, low-power analog circuits, neuroplasticity, neuronal development
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