A micropower low-noise monolithic instrumentation amplifier for medical purposes
Abstract
A CMOS low-power low-noise monolithic instrumentation amplifier (IA) is described. The power drain is reduced by use of current feedback and by use of only single-stage operational transconductance amplifiers in the low-frequency loop. The bandwidth of the IA is designed for medical purposes (0.5-500 Hz) and it can produce variable gains of 14/20/26/40 dB, which are set by control software.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The noise efficiency factor (NEF) is commonly used as a figure of merit.
“The noise efficiency factor (NEF) is commonly used as a figure of merit [165].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [165]
Cites
A Micropower CMOS-Instrumentation Amplifier
Degrauwe, M. G. R., Vittoz, E. A., & Verbauwhede, I. M. R. (1985) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.1985.1052386 · Cited by 126 · see citing works
Micropower high-performance SC building block for integrated low-level signal processing
Peteghem, P. M. V., Verbauwhede, I. M. R., & Sansen, W. (1985) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.1985.1052397 · Cited by 41 · see citing works
Self-citationLow-power, low-noise instrumentation amplifier for physiological signals
Hamstra, G. H., Peper, A., & Grimbergen, C. A. (1984) · Medical & Biological Engineering & Computing · doi:10.1007/bf02442756 · Cited by 34 · see citing works
On the integration of an internal human conditioning system
Sansen, W. (1982) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.1982.1051768 · Cited by 25 · see citing works
Self-citationA Fast Settling FET Input Monolithic Instrumentation Amplifier
Bowers, D. F. (1985) · Proceedings of ESSCIRC · doi:10.1109/esscirc.1985.5468143 · Cited by 6 · see citing works
A microprocessor compatible multi-channel interface system for sensor signal processing
Sansen, W., Steyaert, M. S. J., & Damme, C. V. (1985) · Cited by 4 · see citing works
Self-citationA very low noise instrumentation amplifier for biomedical applications
BERTOLACCINI, M., & PADOVINI, G. M. (1986) · Virtual Community of Pathological Anatomy (University of Castilla La Mancha) · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A low-power low-noise cmos for amplifier neural recording applications
Harrison, R. R., & Charles, C. (2003) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2003.811979 · Cited by 1,695 · see citing works
Revealing neuronal function through microelectrode array recordings
Obien, M. E. J., Deligkaris, K., Bullmann, T., Bakkum, D. J., & Frey, U. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00423 · Cited by 705 · see citing works
An Energy-Efficient Micropower Neural Recording Amplifier
Wattanapanitch, W., Fee, M., & Sarpeshkar, R. (2007) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2007.907868 · Cited by 441 · see citing works
A 1-V 450-nW fully integrated programmable biomedical sensor interface chip.
Zou, X., Xu, X., Yao, L., & Lian, Y. (2009) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2009.2014707 · Cited by 414 · see citing works
Muller, R., Gambini, S., & Rabaey, J. M. (2012) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2011.2163552 · Cited by 338 · see citing works
The Design of Integrated Circuits to Observe Brain Activity
Harrison, R. R. (2008) · Proceedings of the IEEE · doi:10.1109/jproc.2008.922581 · Cited by 330 · see citing works
An Implantable 455-Active-Electrode 52-Channel CMOS Neural Probe
Lopez, C. M., Andrei, A., Mitra, S., Welkenhuysen, M., Eberle, W., Bartic, C., Puers, R., Yazicioglu, R. F., & Gielen, G. G. E. (2014) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2013.2284347 · Cited by 264 · see citing works
256-Channel Neural Recording and Delta Compression Microsystem With 3D Electrodes
Aziz, J. N. Y., Abdelhalim, K., Shulyzki, R., Genov, R., Bardakjian, B. L., Derchansky, M., Serletis, D., & Carlen, P. L. (2009) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2008.2010997 · Cited by 184 · see citing works
Energy Efficient Low-Noise Neural Recording Amplifier With Enhanced Noise Efficiency Factor
Majidzadeh, V., Schmid, A., & Leblebici, Y. (2011) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2010.2078815 · Cited by 165 · see citing works
Han, D., Zheng, Y., Rajkumar, R., Dawe, G. S., & Je, M. (2013) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2014.2298860 · Cited by 147 · see citing works
A Low-Power 32-Channel Digitally Programmable Neural Recording Integrated Circuit
Wattanapanitch, W., & Sarpeshkar, R. (2011) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2011.2163404 · Cited by 146 · see citing works
A Micropower Low-Noise Neural Recording Front-End Circuit for Epileptic Seizure Detection
Qian, C., Parramon, J., & Sanchez-Sinencio, E. (2011) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2011.2126370 · Cited by 145 · see citing works
Nason, S. R., Vaskov, A. K., Willsey, M. S., Welle, E. J., An, H., Vu, P. P., Bullard, A. J., Nu, C. S., Kao, J. C., Shenoy, K. V., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-0591-0 · Cited by 113 · see citing works
A 0.20 $\text {mm}^2$ 3 nW Signal Acquisition IC for Miniature Sensor Nodes in 65 nm CMOS
Harpe, P., Gao, H., Dommele, R. V., Cantatore, E., & van Roermund, A. H. M. (2016) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2015.2487270 · Cited by 124 · see citing works
Perelman, Y., & Ginosar, R. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2006.883732 · Cited by 116 · see citing works
Rodriguez-Perez, A., Ruiz-Amaya, J., Delgado-Restituto, M., & Rodriguez-Vazquez, Á. (2012) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2012.2187352 · Cited by 103 · see citing works
Analysis and Design of Tunable Amplifiers for Implantable Neural Recording Applications
Rezaee-Dehsorkh, H., Ravanshad, N., Lotfi, R., Mafinezhad, K., & Sodagar, A. M. (2011) · IEEE Journal on Emerging and Selected Topics in Circuits and Systems · doi:10.1109/jetcas.2011.2174492 · Cited by 103 · see citing works
A 1-V 0.25- $\mu \text{W}$ Inverter Stacking Amplifier With 1.07 Noise Efficiency Factor
Shen, L., Lu, N., & Sun, N. (2018) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2017.2786724 · Cited by 101 · see citing works
Implantable neurotechnologies: a review of integrated circuit neural amplifiers
Ng, K. A., Greenwald, E., Xu, Y. P., & Thakor, N. V. (2016) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-015-1431-3 · Cited by 83 · see citing works
A Compact, Low Input Capacitance Neural Recording Amplifier
Ng, K. A., & Xu, Y. P. (2013) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2013.2280066 · Cited by 81 · see citing works
An Orthogonal Current-Reuse Amplifier for Multi-Channel Sensing
Johnson, B., & Molnar, A. (2013) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2013.2257478 · Cited by 80 · see citing works
Design of a low-noise preamplifier for nerve cuff electrode recording
Rieger, R., Taylor, J., Demosthenous, A., Donaldson, N., & Langlois, P. J. (2003) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2003.814437 · Cited by 78 · see citing works
An integrated system for simultaneous, multichannel neuronal stimulation and recording.
Blum, R. A., Ross, J. D., Brown, E. A., & DeWeerth, S. P. (2007) · IEEE Transactions on Circuits and Systems I Regular Papers · doi:10.1109/tcsi.2007.906071 · Cited by 74 · see citing works
Multi-Channel Neural Recording Implants: A Review
Hashemi Noshahr, F., Nabavi, M., & Sawan, M. (2020) · Sensors · doi:10.3390/s20030904 · Cited by 66 · see citing works
Very Low-Noise ENG Amplifier System Using CMOS Technology
Rieger, R., Schuettler, M., Pal, D., Clarke, C., Langlois, P., Taylor, J., & Donaldson, N. (2006) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2006.886731 · Cited by 57 · see citing works
Yuan, X., Hierlemann, A., & Frey, U. (2021) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2021.3066043 · Cited by 50 · see citing works
A 430nW 64nV/vHz current-reuse telescopic amplifier for neural recording applications
Song, S., Rooijakkers, M. J., Harpe, P., Rabotti, C., Mischi, M., van Roermund, A. H. M., & Cantatore, E. (2013) · 2013 IEEE Biomedical Circuits and Systems Conference (BioCAS) · doi:10.1109/biocas.2013.6679704 · Cited by 33 · see citing works
A Low-Power 0.7 $\mu {\rm V_{rms}}$ 32-Channel Mixed-Signal Circuit for ECoG Recordings
Robinet, S., Audebert, P., Regis, G., Zongo, B., Beche, J.-F., Condemine, C., Filipe, S., & Charvet, G. (2011) · IEEE Journal on Emerging and Selected Topics in Circuits and Systems · doi:10.1109/jetcas.2011.2180835 · Cited by 30 · see citing works
Al-Ashmouny, K. M., Chang, S.-I., & Yoon, E. (2012) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2012.2218105 · Cited by 28 · see citing works
A Low Noise Amplifier for Neural Spike Recording Interfaces
Ruiz-Amaya, J., Rodriguez-Perez, A., & Delgado-Restituto, M. (2015) · Sensors · doi:10.3390/s151025313 · Cited by 23 · see citing works
Huang, C.-W., Lai, C.-K., Hung, C.-C., Wu, C.-Y., & Ker, M.-D. (2023) · IEEE Transactions on Circuits and Systems I: Regular Papers · doi:10.1109/tcsi.2023.3254891 · Cited by 16 · see citing works
High-density neural recording system design
Lee, H.-S., Eom, K., Park, M., Ku, S.-B., Lee, K., & Lee, H.-M. (2022) · Biomedical Engineering Letters · doi:10.1007/s13534-022-00233-z · Cited by 17 · see citing works
Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review
Habibollahi, M., Jiang, D., Lancashire, H. T., & Demosthenous, A. (2024) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2024.3430038 · Cited by 11 · see citing works
“The noise efficiency factor (NEF) is commonly used as a figure of merit [165].”
A Tunable Gain and Bandwidth Low-Noise Amplifier with 1.44 NEF for EMG and EOG Biopotential Signal
Vieira, R., Näf, F., Martins, R., Horta, N., Lourenço, N., & Póvoa, R. (2023) · Electronics · doi:10.3390/electronics12122592 · Cited by 8 · see citing works
Design Considerations for Implantable Neural Circuits and Systems
Hsu, W.-Y., Hsieh, P.-H., & Chen, H. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_19 · Cited by 1 · see citing works
- Authors
- Steyaert, M. S. J., & Sansen, W. M. C.
- Venue
- IEEE Journal of Solid-State Circuits
- Published
- 1987-12
- Volume
- 22
- Issue
- 6
- Pages
- 1163-1168
- ISSN
- 0018-9200 (ISSN-L)
- OpenAlex
- W1965291684
- Cited by
- 577
- References
- 7
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 29 · 2023: 27 · 2022: 27 · 2021: 27 · 2020: 33 · 2019: 28 · 2018: 36 · 2017: 28 · 2016: 20 · 2015: 46 · 2014: 30 · 2013: 39 · 2012: 29
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Journal of Solid-State Circuits (publishedVersion)
- Lirias (acceptedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Low-power high-performance VLSI design
- Keywords
- instrumentation amplifier, CMOS, low-power circuits, low noise, current feedback, operational transconductance amplifier, single-stage amplifier, variable gain, medical instrumentation, micro-power
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review