The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction
Open accessAbstract
We present the first study of the effects of monolayer shell physicochemical properties on the destruction of lipid-coated microbubbles during insonification with single, one-cycle pulses at 2.25 MHz and low-duty cycles. Shell cohesiveness was changed by varying phospholipid and emulsifier composition, and shell microstructure was controlled by postproduction processing. Individual microbubbles with initial resting diameters between 1 and 10 microm were isolated and recorded during pulsing with bright-field and fluorescence video microscopy. Microbubble destruction occurred through two modes: acoustic dissolution at 400 and 600 kPa and fragmentation at 800 kPa peak negative pressure. Lipid composition significantly impacted the acoustic dissolution rate, fragmentation propensity, and mechanism of excess lipid shedding. Less cohesive shells resulted in micron-scale or smaller particles of excess lipid material that shed either spontaneously or on the next pulse. Conversely, more cohesive shells resulted in the buildup of shell-associated lipid strands and globular aggregates of several microns in size; the latter showed a significant increase in total shell surface area and lability. Lipid-coated microbubbles were observed to reach a stable size over many pulses at intermediate acoustic pressures. Observations of shell microstructure between pulses allowed interpretation of the state of the shell during oscillation. We briefly discuss the implications of these results for therapeutic and diagnostic applications involving lipid-coated microbubbles as ultrasound contrast agents and drug/gene delivery vehicles.
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Cites
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Microbubbles in medical imaging: current applications and future directions
Lindner, J. R. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1417 · Cited by 872
Therapeutic applications of lipid-coated microbubbles
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Mechanisms of contrast agent destruction
Chomas, J. E., Dayton, P., Allen, J., Morgan, K., & Ferrara, K. W. (2001) · IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control · doi:10.1109/58.896136 · Cited by 362
Self-citationBorden, M. A., & Longo, M. L. (2002) · Langmuir · doi:10.1021/la026082h · Cited by 340
Self-citationOptical and acoustical observations of the effects of ultrasound on contrast agents
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Self-citationDuncan, P. B., & Needham, D. (2004) · Langmuir · doi:10.1021/la034930i · Cited by 250
Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow
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Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents
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Self-citationA method for radiation-force localized drug delivery using gas-filled lipospheres
Shortencarier, M. J., Dayton, P. A., Bloch, S. H., Schumann, P. A., Matsunaga, T. O., & Ferrara, K. W. (2004) · IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2004.1320741 · Cited by 200
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Applications of Acoustics and Cavitation to Noninvasive Therapy and Drug Delivery
Coussios, C. C., & Roy, R. A. (2008) · Annual Review of Fluid Mechanics · doi:10.1146/annurev.fluid.40.111406.102116 · Cited by 532
Schroeder, A., Kost, J., & Barenholz, Y. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2009.08.003 · Cited by 485
Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery
Paefgen, V., Doleschel, D., & Kiessling, F. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00197 · Cited by 272
Novel microbubble preparation technologies
Stride, E., & Edirisinghe, M. (2008) · Soft Matter · doi:10.1039/b809517p · Cited by 262
Ultrasound targeted CNS gene delivery for Parkinson's disease treatment
Fan, C.-H., Lin, C.-Y., Liu, H.-L., & Yeh, C.-K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.004 · Cited by 97
Metadata
- Authors
- Borden, M. A., Kruse, D. E., Caskey, C. F., Zhao, S., Dayton, P. A., & Ferrara, K. W.
- Venue
- IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
- Published
- 2005-11
- Volume
- 52
- Issue
- 11
- Pages
- 1992-2002
- ISSN
- 0885-3010 (ISSN-L)
- OpenAlex
- W2156270047
- Cited by
- 293
- References
- 13
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Borden, M. A., Kruse, D. E., Caskey, C. F., Zhao, S., Dayton, P. A., & Ferrara, K. W. (2005). Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. https://doi.org/10.1109/tuffc.2005.1561668
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