Ultrasound targeted CNS gene delivery for Parkinson's disease treatment

Epidemiology of Parkinson's disease

de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110 · see citing works

GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons

Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S. L., & Collins, F. (1993) · Science · doi:10.1126/science.8493557 · Cited by 3,206 · see citing works

Flow-mediated endothelial mechanotransduction

Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802 · see citing works

The epidemiology of Parkinson's disease: risk factors and prevention

Ascherio, A., & Schwarzschild, M. A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30230-7 · Cited by 1,837 · see citing works

The GDNF family: Signalling, biological functions and therapeutic value

Airaksinen, M. S., & Saarma, M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn812 · Cited by 1,832 · see citing works

A Five-Year Study of the Incidence of Dyskinesia in Patients with Early Parkinson's Disease Who Were Treated with Ropinirole or Levodopa

Rascol, O., Brooks, D. J., Korczyn, A. D., De Deyn, P. P., Clarke, C. E., & Lang, A. E. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422004 · Cited by 1,539 · see citing works

Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

Hynynen, K., McDannold, N. J., Vykhodtseva, N. I., & Jolesz, F. A. (2001) · Radiology · doi:10.1148/radiol.2202001804 · Cited by 1,463 · see citing works

Liposomes in drug delivery: Progress and limitations

Sharma, A. (1997) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00135-x · Cited by 1,253 · see citing works

A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor

Elias, W. J., Lipsman, N., Ondo, W. G., Ghanouni, P., Kim, Y. G., Lee, W., Schwartz, M., Hynynen, K., Lozano, A. M., Shah, B. B., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600159 · Cited by 1,167 · see citing works

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson’s disease: an open label, phase I trial

Kaplitt, M. G., Feigin, A., Tang, C., Fitzsimons, H. L., Mattis, P., Lawlor, P. A., Bland, R. J., Young, D., Strybing, K., Eidelberg, D., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60982-9 · Cited by 1,067 · see citing works

Healing sound: the use of ultrasound in drug delivery and other therapeutic applications

Mitragotri, S. (2005) · Nature reviews. Drug discovery · doi:10.1038/nrd1662 · Cited by 952 · see citing works

Blood-Brain Barrier in Physiology and Medicine

Rapoport, S. I. (1976) · Medical Entomology and Zoology · Cited by 882 · see citing works

A pilot study of focused ultrasound thalamotomy for essential tremor.

Elias, W., Huss, D., Voss, T., Loomba, J., Khaled, M., Zadicario, E., Frysinger, R. C., Sperling, S., Wylie, S., Monteith, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1300962 · Cited by 833 · see citing works

Genetic Animal Models of Parkinson's Disease

Dawson, T. M., Ko, H. S., & Dawson, V. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.034 · Cited by 825 · see citing works

Clinical trial of blood-brain barrier disruption by pulsed ultrasound

Carpentier, A., Canney, M., Vignot, A., Reina, V., Beccaria, K., Horodyckid, C., Karachi, C., Leclercq, D., Lafon, C., Chapelon, J.-Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6086 · Cited by 757 · see citing works

Dopamine Transporter Brain Imaging to Assess the Effects of Pramipexole vs Levodopa on Parkinson Disease Progression

Parkinson Study Group (2002) · JAMA · doi:10.1001/jama.287.13.1653 · Cited by 713 · see citing works

Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

Hynynen, K., McDannold, N., Sheikov, N. A., Jolesz, F. A., & Vykhodtseva, N. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.046 · Cited by 679 · see citing works

Epidemiology of parkinson’s disease

Tanner, C. M., & Goldman, S. M. (1996) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70259-0 · Cited by 640 · see citing works

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

Lechardeur, D., Sohn, K.-J., Haardt, M., Joshi, P. B., Monck, M. A., Graham, R. W., Beatty, B., Squire, J. A., O'Brodovich, H. M., & Lukács, G. L. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300867 · Cited by 632 · see citing works

Ultrasonic drug delivery – a general review

Pitt, W. G., Husseini, G. A., & Staples, B. J. (2004) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.1.1.37 · Cited by 624 · see citing works

MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study

Lipsman, N., Schwartz, M. L., Huang, Y., Lee, L., Sankar, T., Chapman, M., Hynynen, K., & Lozano, A. M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70048-6 · Cited by 604 · see citing works

Vibrating microbubbles poking individual cells: Drug transfer into cells via sonoporation

van Wamel, A. J. E. T., Kooiman, K., Harteveld, M., Emmer, M., ten Cate, F. J., Versluis, M., & de Jong, N. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.02.007 · Cited by 597 · see citing works

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

Connor, B., Young, D., Yan, Q., Faull, R. L. M., Synek, B., & Dragunow, M. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00125-3 · Cited by 581 · see citing works

Theory of Focusing Radiators

O'Neil, H. T. (1949) · The Journal of the Acoustical Society of America · doi:10.1121/1.1906542 · Cited by 576 · see citing works

Motor fluctuations and dyskinesias in Parkinson's disease: Clinical manifestations

Jankovic, J. J. (2005) · Movement Disorders · doi:10.1002/mds.20458 · Cited by 549 · see citing works

Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra

Howells, D. W., Porritt, M. J., Wong, J. Y. F., Batchelor, P. E., Kalnins, R., Hughes, A. J., & Donnan, G. A. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7483 · Cited by 513 · see citing works

Classic and New Animal Models of Parkinson's Disease

Blesa, J., Phani, S., Jackson-Lewis, V. R., & Przedborski, S. (2012) · BioMed Research International · doi:10.1155/2012/845618 · Cited by 502 · see citing works

Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium

Sheikov, N. A., McDannold, N. J., Sharma, S., & Hynynen, K. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2007.12.015 · Cited by 494 · see citing works

Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation

Meijering, B. D. M., Juffermans, L. J. M., van Wamel, A. J. E. T., Henning, R. H., Zuhorn, I. S., Emmer, M., Versteilen, A. M. G., Paulus, W. J., van Gilst, W. H., Kooiman, K., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.183806 · Cited by 484 · see citing works

Synucleinopathies

Galvin, J. E., Lee, V. M. ‐., & Trojanowski, J. Q. (2001) · Archives of Neurology · doi:10.1001/archneur.58.2.186 · Cited by 466 · see citing works

Formation and Intracellular Trafficking of Lipoplexes and Polyplexes

Elouahabi, A., & Ruysschaert, J. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2004.12.006 · Cited by 464 · see citing works

The threshold for thermally significant cavitation in dog's thigh muscle in vivo

Hynynen, K. (1991) · Ultrasound in Medicine & Biology · doi:10.1016/0301-5629(91)90123-e · Cited by 432 · see citing works

Convection-Enhanced Delivery of AAV Vector in Parkinsonian Monkeys; In Vivo Detection of Gene Expression and Restoration of Dopaminergic Function Using Pro-drug Approach

Bankiewicz, K. S., Eberling, J. L., Kohutnicka, M., Jagust, W. J., Pivirotto, P., Bringas, J., Cunningham, J., Budinger, T. F., & Harvey-White, J. D. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7408 · Cited by 406 · see citing works

Drug and Gene Delivery to the Brain

Pardridge, W. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01054-1 · Cited by 405 · see citing works

In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging

Huynh, E., Leung, B. Y. C., Helfield, B. L., Shakiba, M., Gandier, J., Jin, C. S., Master, E. R., Wilson, B. C., Goertz, D. E., & Zheng, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.25 · Cited by 366 · see citing works

Influence of hemodynamic forces on vascular endothelial function. In vitro studies of shear stress and pinocytosis in bovine aortic cells.

Davies, P. F., Dewey, C. F., Bussolari, S. R., Gordon, E. J., & Gimbrone, M. A. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111298 · Cited by 359 · see citing works

Ultrasound-induced cell membrane porosity

Deng, C. X., Sieling, F. H., Pan, H., & Cui, J. (2004) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2004.01.005 · Cited by 354 · see citing works

Blood-brain barrier in physiology and medicine

O’Brien, M. D. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90141-1 · Cited by 353 · see citing works

Current approaches to the treatment of Parkinson’s disease

Jankovic, J. J. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s2006 · Cited by 343 · see citing works

Ultrasound focal beam surgery

ter Haar, G. (1995) · Ultrasound in Medicine & Biology · doi:10.1016/0301-5629(95)02010-1 · Cited by 331 · see citing works

MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits

McDannold, N. J., Vykhodtseva, N. I., Raymond, S. B., Jolesz, F. A., & Hynynen, K. (2005) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2005.07.010 · Cited by 323 · see citing works

Ultrasound-Targeted Microbubble Destruction Can Repeatedly Direct Highly Specific Plasmid Expression to the Heart

Bekeredjian, R., Chen, S., Frenkel, P. A., Grayburn, P. A., & Shohet, R. V. (2003) · Circulation · doi:10.1161/01.cir.0000084535.35435.ae · Cited by 321 · see citing works

Design and Evaluation of Doxorubicin-containing Microbubbles for Ultrasound-triggered Doxorubicin Delivery: Cytotoxicity and Mechanisms Involved

Lentacker, I., Geers, B., Demeester, J., Smedt, S. C. D., & Sanders, N. N. (2009) · Molecular Therapy · doi:10.1038/mt.2009.160 · Cited by 312 · see citing works

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials

Dewey, R. A., Morrissey, G., Cowsill, C. M., Stone, D., Bolognani, F., Dodd, N. J. F., Southgate, T. D., Klatzmann, D., Lassmann, H., Castro, M. G., et al. (1999) · Nature Medicine · doi:10.1038/15207 · Cited by 311 · see citing works

Outcome after Stereotactic Thalamotomy for Parkinsonian, Essential, and Other Types of Tremor

Jankovic, J. J., Cardoso, F., Grossman, R. G., & Hamilton, W. J. (1995) · Neurosurgery · doi:10.1227/00006123-199510000-00011 · Cited by 309 · see citing works

Biophysical insight into mechanisms of sonoporation

Helfield, B. L., Chen, X., Watkins, S. C., & Villanueva, F. S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606915113 · Cited by 301 · see citing works

Randomized trial of the adenosine A 2A receptor antagonist istradefylline in advanced PD

Hauser, R. A., Hubble, J. P., Truong, D. D., & the Istradefylline US-001 Study Group (2003) · Neurology · doi:10.1212/01.wnl.0000081227.84197.0b · Cited by 300 · see citing works

Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction

Borden, M. A., Kruse, D. E., Caskey, C. F., Zhao, S., Dayton, P. A., & Ferrara, K. W. (2005) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2005.1561668 · Cited by 293 · see citing works

Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment

Ting, C.-Y., Fan, C., Liu, H.-L., Huang, C.-Y., Hsieh, H.-Y., Yen, T., Wei, K., & Yeh, C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.096 · Cited by 283 · see citing works

The magnitude of radiation force on ultrasound contrast agents

Dayton, P. A., Allen, J. S., & Ferrara, K. W. (2002) · The Journal of the Acoustical Society of America · doi:10.1121/1.1509428 · Cited by 280 · see citing works

Ultrasound-induced encapsulated microbubble phenomena

Postema, M., van Wamel, A. J. E. T., Lancée, C. T., & de Jong, N. (2004) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2004.02.010 · Cited by 275 · see citing works

Modulation of membrane traffic by mechanical stimuli

Apodaca, G. L. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2002.282.2.f179 · Cited by 273 · see citing works

High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo

Mesiwala, A. H., Farrell, L., Wenzel, H. J., Silbergeld, D. L., Crum, L. A., Winn, H. R., & Mourad, P. D. (2002) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(01)00521-x · Cited by 272 · see citing works

Acoustically Active Lipospheres Containing Paclitaxel

Unger, E. C., McCreery, T. P., Sweitzer, R. H., Caldwell, V. E., & WU, Y. (1998) · Investigative Radiology · doi:10.1097/00004424-199812000-00007 · Cited by 267 · see citing works

Aggregation of Neurofilament and α-Synuclein Proteins in Lewy Bodies

Trojanowski, J. Q., & Lee, V. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.2.151 · Cited by 255 · see citing works

Response of contrast agents to ultrasound

Sboros, V. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.011 · Cited by 252 · see citing works

Monitoring Response to Anticancer Therapy by Targeting Microbubbles to Tumor Vasculature

Korpanty, G. J., Carbon, J. G., Grayburn, P. A., Fleming, J. B., & Brekken, R. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1313 · Cited by 244 · see citing works

Direct observations of ultrasound microbubble contrast agent interaction with the microvessel wall

Caskey, C. F., Stieger‐Vanegas, S. M., Qin, S., Dayton, P. A., & Ferrara, K. W. (2007) · The Journal of the Acoustical Society of America · doi:10.1121/1.2747204 · Cited by 226 · see citing works

SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery

Fan, C.-H., Ting, C.-Y., Lin, H.-J., Wang, C.-H., Liu, H.-L., Yen, T.-C., & Yeh, C.-K. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.099 · Cited by 225 · see citing works

The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia

Kilic, E., Kilic, Ü., Wang, Y., Bassetti, C. L., Marti, H. H., Hermann, D. M., Kilic, E., Kilic, Ü., Wang, Y., Bassetti, C. L., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4829fje · Cited by 218 · see citing works

The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound

Park, J., Zhang, Y., Vykhodtseva, N. I., Jolesz, F. A., & McDannold, N. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.06.012 · Cited by 217 · see citing works

Treatment of Parkinson's disease.

Hardie, R. J. (1985) · PubMed · Cited by 217 · see citing works

Membrane Perforation and Recovery Dynamics in Microbubble-Mediated Sonoporation

Hu, Y., Wan, J. M. F., & Yu, A. C. H. (2013) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2013.08.003 · Cited by 209 · see citing works

Current status of research on biophysical effects of ultrasound

Barnett, S. B., ter Haar, G., Ziskin, M. C., Nyborg, W. L., Maeda, K., & Bang, J. (1994) · Ultrasound in Medicine & Biology · doi:10.1016/0301-5629(94)90060-4 · Cited by 206 · see citing works

Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound

Thévenot, E., Jordão, J. F., O’Reilly, M. A., Markham, K. A., Weng, Y., Foust, K. D., Kaspar, B. K., Hynynen, K., & Aubert, I. (2012) · Human Gene Therapy · doi:10.1089/hum.2012.013 · Cited by 202 · see citing works

Alpha-synuclein and transgenic mouse models

Fernagut, P., & Chesselet, M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.07.001 · Cited by 199 · see citing works

The correlation between acoustic cavitation and sonoporation involved in ultrasound-mediated DNA transfection with polyethylenimine (PEI) in vitro

Qiu, Y., Luo, Y., Zhang, Y. L., Cui, W., Zhang, D., Wu, J., Zhang, J., & Tu, J. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.04.010 · Cited by 198 · see citing works

Treatment of Parkinson's Disease

Wood, A. J. J., & Calne, D. B. (1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291408 · Cited by 196 · see citing works

Animal models of Parkinson's disease

Jackson-Lewis, V. R., Blesa, J., & Przedborski, S. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70057-8 · Cited by 193 · see citing works

The role of cavitation in acoustically activated drug delivery

Husseini, G. A., de la Rosa, M. A. D., Richardson, E. S., Christensen, D. A., & Pitt, W. G. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.06.015 · Cited by 179 · see citing works

Theoretical study on shear stress generated by microstreaming surrounding contrast agents attached to living cells

Wu, J. (2002) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(01)00497-5 · Cited by 175 · see citing works

A quantitative pressure and microbubble‐size dependence study of focused ultrasound‐induced blood‐brain barrier opening reversibility in vivo using MRI

Samiotaki, G., Vlachos, F., Tung, Y., & Konofagou, E. E. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.23063 · Cited by 173 · see citing works

Stereotactic ventrolateralis thalamotomy for medically refractory tremor in post-levodopa era Parkinson's disease patients

Fox, M. W., Ahlskog, J. E., & Kelly, P. J. (1991) · Journal of neurosurgery · doi:10.3171/jns.1991.75.5.0723 · Cited by 170 · see citing works

Ultrasound-mediated drug delivery to the brain: principles, progress and prospects

Dasgupta, A., Liu, M., Ojha, T., Storm, G., Kiessling, F. M., & Lammers, T. (2016) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2016.07.007 · Cited by 156 · see citing works

Non-invasive opening of BBB by focused ultrasound

Hynynen, K., McDannold, N., Vykhodtseva, N., & Jolesz, F. A. (2003) · Brain Edema XII · doi:10.1007/978-3-7091-0651-8_113 · Cited by 156 · see citing works

Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

Lin, C., Hsieh, H.-Y., Chen, C., Wu, S.-R., Tsai, C.-H., Huang, C.-Y., Hua, M., Wei, K., Yeh, C., & Liu, H.-L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.052 · Cited by 156 · see citing works

Use of Ultrasound Pulses Combined with Definity for Targeted Blood-Brain Barrier Disruption: A Feasibility Study

McDannold, N. J., Vykhodtseva, N. I., & Hynynen, K. (2007) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.10.004 · Cited by 150 · see citing works

Ca2+-sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids

Pollard, H., Toumaniantz, G., Amos, J.-L., Avet‐Loiseau, H., Guihard, G., Behr, J., & Escande, D. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.160 · Cited by 148 · see citing works

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound

Mead, B. P., Mastorakos, P., Suk, J. S., Klibanov, A. L., Hanes, J. S., & Price, R. J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.034 · Cited by 145 · see citing works

Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment

Fan, C., Ting, C.-Y., Liu, H.-L., Huang, C.-Y., Hsieh, H.-Y., Yen, T., Wei, K., & Yeh, C. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.11.048 · Cited by 145 · see citing works

Differential effects of dopamine D1 and D2 agonists and antagonists on velocity of movement, rearing and grooming in the mouse

Starr, B. S., & Starr, M. S. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90168-1 · Cited by 144 · see citing works

Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration

Anwer, K., Kao, G., Proctor, B., Anscombe, I., Florack, V. J., Earls, R. M., Wilson, E., McCreery, T. P., Unger, E. C., Rolland, A. P., et al. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301302 · Cited by 143 · see citing works

Noninvasive, neuron-specific gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated virus

Wang, S., Olumolade, O., Sun, T., Samiotaki, G., & Konofagou, E. E. (2014) · Gene Therapy · doi:10.1038/gt.2014.91 · Cited by 142 · see citing works

Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors

Fan, C., CHENG, Y.-H., Ting, C.-Y., Ho, Y.-J., Hsu, P., Liu, H.-L., & Yeh, C. (2016) · Theranostics · doi:10.7150/thno.15297 · Cited by 140 · see citing works

Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging.

Liu, H.-L., Wai, Y., Chen, W.-S., Chen, J.-C., Hsu, P.-H., Wu, X.-Y., Huang, W.-C., Yen, T., & Wang, J.-J. (2008) · Ultrasound in Medicine and Biology · doi:10.1016/j.ultrasmedbio.2008.01.011 · Cited by 139 · see citing works

Two-Photon Fluorescence Microscopy Study of Cerebrovascular Dynamics in Ultrasound-Induced Blood—Brain Barrier Opening

Cho, E. E., Drazic, J., Ganguly, M., Stefanovic, B., & Hynynen, K. (2011) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2011.59 · Cited by 139 · see citing works

Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound

Hsu, P.-H., Wei, K.-C., Huang, C.-Y., Wen, C.-J., Yen, T.-C., Liu, C.-L., Lin, Y.-T., Chen, J.-C., Shen, C.-R., & Liu, H.-L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057682 · Cited by 136 · see citing works

Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood–brain barrier using focused ultrasound and microbubbles

Baseri, B., Choi, J. J., Deffieux, T., Samiotaki, G., Tung, Y., Olumolade, O., Small, S. A., Morrison, B., & Konofagou, E. E. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/7/n65 · Cited by 131 · see citing works

Epidemiology of Parkinson’s Disease

Tanner, C. M. (1992) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30212-3 · Cited by 127 · see citing works

Anionic liposomal delivery system for DNA transfection

Patil, S. D., Rhodes, D. G., & Burgess, D. J. (2004) · The AAPS Journal · doi:10.1208/aapsj060429 · Cited by 126 · see citing works

Drug delivery to the brain by focused ultrasound induced blood–brain barrier disruption: Quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy

Nhan, T., Burgess, A., Cho, E. E., Stefanovic, B., Lilge, L. D., & Hynynen, K. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.029 · Cited by 124 · see citing works

Intracellular Trafficking of Plasmids for Gene Therapy: Mechanisms of Cytoplasmic Movement and Nuclear Import

Vaughan, E. E., DeGiulio, J. V., & Dean, D. A. (2006) · Current Gene Therapy · doi:10.2174/156652306779010688 · Cited by 123 · see citing works

Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound

Song, K.-H., Fan, A. C., Hinkle, J. J., Newman, J., Borden, M. A., & Harvey, B. K. (2016) · Theranostics · doi:10.7150/thno.15987 · Cited by 123 · see citing works

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda -7/IL-24–mediated toxicity

Dash, R., Azab, B., Quinn, B. A., Shen, X., Wang, X., Das, S. K., Rahmani, M., Wei, J., Hedvat, M., Dent, P., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100769108 · Cited by 123 · see citing works

Carboxyl-directed Pegylation of Brain-derived Neurotrophic Factor Markedly Reduces Systemic Clearance with Minimal Loss of Biologic Activity

Sakane, T., & Pardridge, W. M. (1997) · Pharmaceutical Research · doi:10.1023/a:1012117815460 · Cited by 121 · see citing works

Treatment of Acute Myocardial Infarction by Hepatocyte Growth Factor Gene Transfer

Kondô, I., Ohmori, K., Oshita, A., Takeuchi, H., Fuke, S., Shinomiya, K., Noma, T., Namba, T., & Kohno, M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.04.042 · Cited by 120 · see citing works

The Role of Caveolin-1 in Blood–Brain Barrier Disruption Induced by Focused Ultrasound Combined with Microbubbles

Deng, J., Huang, Q., Wang, F., Liu, Y., Wang, Z.-B., Wang, Z.-G., Zhang, Q., Lei, B., & Cheng, Y. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9629-9 · Cited by 117 · see citing works

mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells

Temmerman, M. D., Dewitte, H., Vandenbroucke, R. E., Lucas, B., Libert, C., Demeester, J., Smedt, S. C. D., Lentacker, I., & Rejman, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.024 · Cited by 116 · see citing works

Noninvasive, Targeted and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease

Fan, C., Ting, C.-Y., Lin, C., Chan, H., Chang, Y., Chen, Y., Liu, H.-L., & Yeh, C. (2016) · Scientific Reports · doi:10.1038/srep19579 · Cited by 115 · see citing works

Regulated Delivery of Glial Cell Line-Derived Neurotrophic Factor into Rat Striatum, Using a Tetracycline-Dependent Lentiviral Vector

Georgievska, B., Jakobsson, J., Persson, E. B., Ericson, C., Kirik, D., & Lundberg, C. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.934 · Cited by 112 · see citing works

Gene Transfer to Corneal Epithelium and Keratocytes Mediated by Ultrasound with Microbubbles

Sonoda, S., Tachibana, K., Uchino, E., Okubo, A., Yamamoto, M., Sakoda, K., Hisatomi, T., Sonoda, K., Negishi, Y., Izumi, Y., et al. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0889 · Cited by 112 · see citing works

Cell adhesion, cell junctions and the blood—brain barrier

Staddon, J. M., & Rubin, L. L. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80094-8 · Cited by 110 · see citing works

Permeability dependence study of the focused ultrasound‐induced blood–brain barrier opening at distinct pressures and microbubble diameters using DCE‐MRI

Vlachos, F., Tung, Y., & Konofagou, E. E. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22848 · Cited by 110 · see citing works

Ultrasound-Mediated Gene and Drug Delivery Using a Microbubble-Liposome Particle System

Yoon, Y. I., Kwon, Y., Cho, H.-S., Heo, S., Park, K. S., Park, S. G., Lee, S.-H., Hwang, S. I., Kim, Y. I., Jae, H. J., et al. (2014) · Theranostics · doi:10.7150/thno.9945 · Cited by 107 · see citing works

Vascular Gene Transfer of Phosphomimetic Endothelial Nitric Oxide Synthase (S1177D) Using Ultrasound-Enhanced Destruction of Plasmid-Loaded Microbubbles Improves Vasoreactivity

Teupe, C., Richter, S., Fißlthaler, B., Randriamboavonjy, V., Ihling, C. H., Fleming, I., Busse, R., Zeiher, A. M., & Dimmeler, S. (2002) · Circulation · doi:10.1161/hc0902.104720 · Cited by 105 · see citing works

Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene delivery

Fan, C., Chang, E.-L., Ting, C.-Y., Lin, Y., Liao, E., Huang, C.-Y., Chang, Y., Chan, H., Wei, K., & Yeh, C. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.017 · Cited by 104 · see citing works

Sonoprinting and the importance of microbubble loading for the ultrasound mediated cellular delivery of nanoparticles

Cock, I. D., Lajoinie, G. P. R., Versluis, M., Smedt, S. C. D., & Lentacker, I. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.022 · Cited by 101 · see citing works

Antitumor Effect of Docetaxel-Loaded Lipid Microbubbles Combined With Ultrasound-Targeted Microbubble Activation on VX2 Rabbit Liver Tumors

Kang, J., Wu, X., Wang, Z., Ran, H., Xu, C., Wu, J., Wang, Z., & Zhang, Y. (2010) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2010.29.1.61 · Cited by 96 · see citing works

Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood–brain barrier opening and brain-tumor drug delivery

Fan, C., Ting, C.-Y., Chang, Y., Wei, K., Liu, H.-L., & Yeh, C. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.12.026 · Cited by 96 · see citing works

New doxorubicin-loaded phospholipid microbubbles for targeted tumor therapy: Part I — Formulation development and in-vitro characterization

Tinkov, S., Winter, G., Coester, C., & Bekeredjian, R. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.12.026 · Cited by 95 · see citing works

Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery

Lin, C., Hsieh, H.-Y., Pitt, W. G., Huang, C.-Y., Tseng, I.-C., Yeh, C., Wei, K., & Liu, H.-L. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.010 · Cited by 94 · see citing works

Phospholipids-based microbubbles sonoporation pore size and reseal of cell membrane culturedin vitro

Zhao, Y., Luo, Y.-K., Lu, C., Jing-feng, X., Tang, J., Zhang, M., Zhang, Y., & Liang, H. (2008) · Journal of drug targeting · doi:10.1080/10611860701637792 · Cited by 94 · see citing works

Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

Alonso, A., Reinz, E., Leuchs, B., Kleinschmidt, J., Fatar, M., Geers, B., Lentacker, I., Hennerici, M. G., de Smedt, S. C., & Meairs, S. (2013) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2012.64 · Cited by 93 · see citing works

Targeted gene delivery to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption

Huang, Q., Deng, J., Wang, F., Chen, S., Liu, Y., Wang, Z., Wang, Z., & Cheng, Y. Z. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.10.027 · Cited by 93 · see citing works

Targeting Neurotherapeutic Agents Through the Blood-Brain Barrier

Pardridge, W. M. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.35 · Cited by 91 · see citing works

Ultrasound with microbubbles enhances gene expression of plasmid DNA in the liver via intraportal delivery

Shen, Z.-P., Brayman, A., Chen, L., & Miao, C.-C. (2008) · Gene Therapy · doi:10.1038/gt.2008.51 · Cited by 91 · see citing works

Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility

Fan, Z., Sun, Y., Chen, D., Tay, D., Chen, W., Deng, C. X., & Fu, J. (2013) · Scientific Reports · doi:10.1038/srep02176 · Cited by 90 · see citing works

Clinically Relevant Effects of Convection-Enhanced Delivery of AAV2-GDNF on the Dopaminergic Nigrostriatal Pathway in Aged Rhesus Monkeys

Johnston, L. C., Eberling, J. L., Pivirotto, P., Hadaczek, P., Federoff, H. J., Forsayeth, J., & Bankiewicz, K. S. (2009) · Human Gene Therapy · doi:10.1089/hum.2008.137 · Cited by 88 · see citing works

Lipid Shedding from Single Oscillating Microbubbles

Luan, Y., Lajoinie, G. P. R., Gelderblom, E. C., Skachkov, I., van der Steen, A. F. W., Vos, H. J., Versluis, M., & de Jong, N. (2014) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2014.02.031 · Cited by 87 · see citing works

A cell culture model for monitoring α-synuclein cell-to-cell transfer

Reyes, J. F., Olsson, T. T., Lamberts, J. T., Devine, M. J., Kunath, T., & Brundin, P. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.003 · Cited by 84 · see citing works

Angiogenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors

Chang, E.-L., Ting, C.-Y., Hsu, P.-H., Lin, Y., Liao, E., Huang, C.-Y., Chang, Y., Chan, H., Chiang, C., Liu, H.-L., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.010 · Cited by 84 · see citing works

Ultrasound enhanced drug delivery to the brain and central nervous system

O’Reilly, M. A., & Hynynen, K. (2012) · International Journal of Hyperthermia · doi:10.3109/02656736.2012.666709 · Cited by 81 · see citing works

Enhanced Caveolae-Mediated Endocytosis by Diagnostic Ultrasound In Vitro

Lionetti, V., Fittipaldi, A., Agostini, S., Giacca, M., Recchia, F. A., & Picano, E. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2008.07.011 · Cited by 79 · see citing works

Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood–brain-barrier disruption

Yang, F., Fu, W., Chen, W., Yeh, W., & Lin, W.-L. (2007) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2007.08.003 · Cited by 78 · see citing works

Modelling Parkinson‐like neurodegeneration via osmotic minipump delivery of MPTP and probenecid

Alvarez‐Fischer, D., Guerreiro, S., Hunot, S., Saurini, F., Marien, M. R., Sokoloff, P., Hirsch, É. C., Hartmann, A., & Michel, P. P. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05651.x · Cited by 75 · see citing works

Targeted Antiangiogenesis Gene Therapy Using Targeted Cationic Microbubbles Conjugated with CD105 Antibody Compared with Untargeted Cationic and Neutral Microbubbles

Zhou, Y., Gu, H., Xu, Y., Li, F., Kuang, S., Wang, Z., Zhou, X., Ma, H., Li, P., Zheng, Y., et al. (2015) · Theranostics · doi:10.7150/thno.10351 · Cited by 73 · see citing works

Novel cell-penetrating peptide-loaded nanobubbles synergized with ultrasound irradiation enhance EGFR siRNA delivery for triple negative Breast cancer therapy

Jing, H., Cheng, W., Li, S., Wu, B., Leng, X., Xu, S., & Tian, J. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.06.037 · Cited by 71 · see citing works

A study of the formulation design of acoustically active lipospheres as carriers for drug delivery

Fang, J., Hung, C., Liao, M.-H., & Chien, C.-C. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.01.008 · Cited by 70 · see citing works

Biophysical characterization of anionic lipoplexes

Patil, S. D., Rhodes, D. G., & Burgess, D. J. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.03.004 · Cited by 69 · see citing works

Neurotrophins, neuroprotection and the blood-brain barrier.

Pardridge, W. M. (2002) · PubMed · Cited by 69 · see citing works

Parkinson disease: Insights in clinical, genetic and pathological features of monogenic disease subtypes

Crosiers, D., Theuns, J., Cras, P. P., & Broeckhoven, C. V. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.07.003 · Cited by 68 · see citing works

Enhancement of Blood–Brain Barrier Permeability and Delivery of Antisense Oligonucleotides or Plasmid DNA to the Brain by the Combination of Bubble Liposomes and High-Intensity Focused Ultrasound

Negishi, Y., Yamane, M., Kurihara, N., Endo‐Takahashi, Y., Sashida, S., Takagi, N., Suzuki, R., & Maruyama, K. (2015) · Pharmaceutics · doi:10.3390/pharmaceutics7030344 · Cited by 68 · see citing works

Brain tumor-targeted delivery and therapy by focused ultrasound introduced doxorubicin-loaded cationic liposomes

Lin, Q., Mao, K.-L., Tian, F.-R., Yang, J.-J., Chen, P.-P., Xu, J., Fan, Z.-L., Zhao, Y.-P., Li, W.-F., Zheng, L., et al. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-015-2926-1 · Cited by 67 · see citing works

Reorganization of Gap Junctions after Focused Ultrasound Blood–Brain Barrier Opening in the Rat Brain

Alonso, A., Reinz, E., Jenne, J., Fatar, M., Schmidt‐Glenewinkel, H., Hennerici, M. G., & Meairs, S. P. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.41 · Cited by 65 · see citing works

Ultrasound guided site specific gene delivery system using adenoviral vectors and commercial ultrasound contrast agents

Howard, C. M., Forsberg, F., Minimo, C., Liu, J., Merton, D. A., & Claudio, P. P. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20736 · Cited by 65 · see citing works

Studies on neutral, cationic and biotinylated cationic microbubbles in enhancing ultrasound-mediated gene delivery in vitro and in vivo

Nomikou, N., Tiwari, P., Trehan, T., Gulati, K., & McHale, A. P. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.09.010 · Cited by 65 · see citing works

Magnetic-resonance imaging for kinetic analysis of permeability changes during focused ultrasound-induced blood–brain barrier opening and brain drug delivery

Chai, W., Chu, P., Tsai, M.-Y., Lin, Y., Wang, J., Wei, K., Wai, Y., & Liu, H.-L. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.023 · Cited by 64 · see citing works

Detection of intracerebral hemorrhage and transient blood-supply shortage in focused-ultrasound-induced blood-brain barrier disruption by ultrasound imaging.

Fan, C.-H., Liu, H.-L., Huang, C.-Y., Ma, Y.-J., Yen, T., & Yeh, C. (2012) · Ultrasound in Medicine and Biology · doi:10.1016/j.ultrasmedbio.2012.03.013 · Cited by 64 · see citing works

Targeted Delivery of GDNF through the Blood–Brain Barrier by MRI-Guided Focused Ultrasound

Wang, F., Shi, Y., Lu, L., Liu, L., Cai, Y., Zheng, H., Liu, X., Yan, F., Zou, C., Sun, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052925 · Cited by 61 · see citing works

Image-guided convection-enhanced delivery of GDNF protein into monkey putamen

Gimenez, F., Krauze, M. T., Valles, F. E., Hadaczek, P., Bringas, J., Sharma, N., Forsayeth, J., & Bankiewicz, K. S. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.023 · Cited by 57 · see citing works

Gene therapy for Parkinson's disease: Disease modification by GDNF family of ligands

Kirik, D., Cederfjäll, E. A., Halliday, G. M., & Petersén, Å. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.09.008 · Cited by 56 · see citing works

The use of pramipexole, a novel dopamine (DA) agonist, in advanced Parkinson's disease.

Molho, E., Factor, S. A., Weiner, W. J., Sanchez‐Ramos, J., Singer, C., Shulman, L., Brown, D. L., & Sheldon, C. (1995) · PubMed · Cited by 56 · see citing works

Osmotic blood-brain barrier disruption: a new means of increasing chemotherapeutic agent delivery.

Neuwelt, E. A., Frenkel, E. P., Diehl, J. T., Maravilla, K. R., Vu, L. H., Clark, W. K., Рапопорт, С. И., Barnett, P. A., Hill, S. A., Lewis, S. E., et al. (1979) · PubMed · Cited by 52 · see citing works

Mechanisms of the increase in the permeability of the blood–tumor barrier obtained by combining low-frequency ultrasound irradiation with small-dose bradykinin

Chun-yi, X., Zhang, Z., Xue, Y., Wang, P., & Liu, Y. (2009) · Journal of Neuro-Oncology · doi:10.1007/s11060-009-9812-9 · Cited by 51 · see citing works

Contrast-Enhanced Ultrasound Imaging for the Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening

Fan, C., Lin, W.-H., Ting, C.-Y., Chai, W., Yen, T., Liu, H.-L., & Yeh, C. (2014) · Theranostics · doi:10.7150/thno.9575 · Cited by 48 · see citing works

Differences in definity and optison microbubble destruction rates at a similar mechanical index with different real-time perfusion systems

Sonne, C., Xie, F., Lof, J., Oberdorfer, J., Phillips, P., Everbach, E. C., & Porter, T. R. (2003) · Journal of the American Society of Echocardiography · doi:10.1067/j.echo.2003.07.001 · Cited by 47 · see citing works

Current Approaches in the Treatment of Parkinson's Disease

Stacy, M. A., & Jankovic, J. J. (1993) · Annual Review of Medicine · doi:10.1146/annurev.me.44.020193.002243 · Cited by 46 · see citing works

Targeted retroviral gene delivery using ultrasound

Taylor, S., Rahim, A. A., Bush, N. L., Bamber, J. C., & Porter, C. D. (2007) · The Journal of Gene Medicine · doi:10.1002/jgm.1003 · Cited by 42 · see citing works

Outcome after Stereotactic Thalamotomy for Parkinsonian, Essential, and Other Types of Tremor

Jankovic, J. J., Cardoso, F., Grossman, R. G., & Hamilton, W. J. (1995) · Neurosurgery · doi:10.1097/00006123-199510000-00011 · Cited by 40 · see citing works

Treatment of Parkinson's disease in rats by Nrf2 transfection using MRI-guided focused ultrasound delivery of nanomicrobubbles.

Long, L., Cai, X.-D., Guo, R.-M., Wang, P., Wu, L., Yin, T.-H., Liao, S.-Y., & Lu, Z.-Q. (2017) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2016.10.141 · Cited by 39 · see citing works

Paramagnetic perfluorocarbon-filled albumin-(Gd-DTPA) microbubbles for the induction of focused-ultrasound-induced blood–brain barrier opening and concurrent MR and ultrasound imaging

Liao, A.-H., Liu, H.-L., Su, C.-H., Hua, M., Yang, H.-W., Weng, Y.-T., Hsu, P.-H., Huang, S.-M., Wu, S.-Y., Wang, H.-E., et al. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/9/2787 · Cited by 37 · see citing works

8TH International Symposium on Therapeutic Ultrasound

Ebbini, E. S. (2009) · CERN Document Server (European Organization for Nuclear Research) · Cited by 33 · see citing works

Efficient, glucose responsive and islet-specific transgene expression by a modified rat insulin promoter

Chai, R., Chen, S., Ding, J., & Grayburn, P. A. (2009) · Gene Therapy · doi:10.1038/gt.2009.114 · Cited by 31 · see citing works

Evaluation of the stability of polymer-based plasmid DNA delivery systems after ultrasound exposure

Kuo, J.-H. S., Jan, M., & Sung, K. C. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00107-8 · Cited by 31 · see citing works

Cardiac Gene Expression Knockdown Using Small Inhibitory RNA-Loaded Microbubbles and Ultrasound

Kopechek, J. A., Carson, A. R., McTiernan, C. F., Chen, X., Klein, E. C., & Villanueva, F. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159751 · Cited by 31 · see citing works

DNA uptake, intracellular trafficking and gene transfection after ultrasound exposure

Liu, Y., Yan, J., Santangelo, P. J., & Prausnitz, M. R. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.013 · Cited by 28 · see citing works

370 Magnetic Resonance-Guided Focused Ultrasound Delivery of Polymeric Brain-Penetrating Nanoparticle MicroRNA Conjugates in Glioblastoma

Vega, R. A., Zhang, Y., Curley, C. T., Price, R. L., & Abounader, R. (2016) · Neurosurgery · doi:10.1227/01.neu.0000489858.08559.c8 · Cited by 24 · see citing works

Population PK–PD model for Fc-osteoprotegerin in healthy postmenopausal women

Zierhut, M. L., Gastonguay, M. R., Martin, S. W., Vicini, P., Bekker, P. J., Holloway, D. L., Leese, P. T., & Peterson, M. C. (2008) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-008-9093-5 · Cited by 17 · see citing works

Development and progression of motor fluctuations and side effects in Parkinson's disease: comparison of Sinemet CR versus carbidopa/levodopa.

Goetz, C. G., Tanner, C. M., Gilley, D. W., & Klawans, H. L. (1989) · PubMed · Cited by 17 · see citing works

Gene-based vaccines and immunotherapeutic strategies against neurodegenerative diseases: Potential utility and limitations

Kudrna, J. J., & Ugen, K. E. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1065364 · Cited by 16 · see citing works

A cell-based model of ?-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease

Zhao, D.-L., Zou, L., Zhou, L.-F., Zhu, P., & Zhu, H. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00539.x · Cited by 11 · see citing works

Evaluation of an Experimental Anticholinergic Drug, Elantrine, in Treating the Tremor of Parkinsonism

Rix, A. (1977) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-2511-6_18 · Cited by 5 · see citing works

Current health behaviors and readiness to pursue life-style changes among men and women diagnosed with early stage prostate and breast carcinomas

Demark-Wahnefried, W., Peterson, B., McBride, C., Lipkus, I., & Clipp, E. (2000) · Cancer · doi:10.1002/(sici)1097-0142(20000201)88:3

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

Boland, B., Yu, W. H., Corti, O., Mollereau, B., Henriques, A., Bézard, E., Pastores, G., Rubinsztein, D. C., Nixon, R. A., Duchen, M. R., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.109 · Cited by 552 · see citing works

Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Meng, Y., Hynynen, K., & Lipsman, N. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-00418-z · Cited by 518 · see citing works

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Yin, Y., Hu, B., Yuan, X., Cai, L., Gao, H., & Yang, Q. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030290 · Cited by 290 · see citing works

Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy

Zhang, N., Yan, F., Liang, X., Wu, M., Shen, Y., Chen, M., Xu, Y., Zou, G., Jiang, P., Tang, C., et al. (2018) · Theranostics · doi:10.7150/thno.23734 · Cited by 180 · see citing works

Mechanisms underlying sonoporation: Interaction between microbubbles and cells

Yang, Y., Li, Q., Guo, X., Tu, J., & Zhang, D. (2020) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2020.105096 · Cited by 177 · see citing works

Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases

Wang, J., Li, Z., Pan, M., Fiaz, M., Hao, Y., Yan, Y., Sun, L., & Yan, F. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114539 · Cited by 161 · see citing works

Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors

Tu, J., & Yu, A. C. H. (2022) · BME Frontiers · doi:10.34133/2022/9807347 · Cited by 152 · see citing works

Engineering NIR-IIb fluorescence of Er-based lanthanide nanoparticles for through-skull targeted imaging and imaging-guided surgery of orthotopic glioma

Ren, F. Z., Liu, H., Zhang, H., Jiang, Z., Xia, B., Genevois, C., He, T., Allix, M. M. B., Sun, Q., Li, Z., et al. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100905 · Cited by 144 · see citing works

Monitoring the Opening and Recovery of the Blood–Brain Barrier with Noninvasive Molecular Imaging by Biodegradable Ultrasmall Cu2–xSe Nanoparticles

Zhang, H., Wang, T., Qiu, W., Han, Y., Sun, Q., Zeng, J., Yan, F., Zheng, H., Li, Z., & Gao, M. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b01818 · Cited by 121 · see citing works

Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

Rizvanov, A. A., Shaimardanova, A. A., Solovyeva, V. V., Chulpanova, D. S., James, V. H., & Kitaeva, K. V. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266908 · Cited by 103 · see citing works

Ultrasound-responsive neurotrophic factor-loaded microbubble- liposome complex: Preclinical investigation for Parkinson's disease treatment

Lin, C., Lin, Y.-C., Huang, C.-Y., Wu, S.-R., Chen, C., & Liu, H.-L. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.02.044 · Cited by 94 · see citing works

Non-viral nanocarriers for intracellular delivery of microRNA therapeutics

Bai, Z., Wei, J., Yu, C., Han, X., Qin, X., Zhang, C., Liao, W., Li, L., & Huang, W. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb02946f · Cited by 91 · see citing works

Application of quercetin in neurological disorders: from nutrition to nanomedicine

Jajin, E. A., Esmaeili, A., Rahgozar, S., & Noorbakhshnia, M. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0080 · Cited by 92 · see citing works

Focused ultrasound-induced blood-brain barrier opening improves adult hippocampal neurogenesis and cognitive function in a cholinergic degeneration dementia rat model

Shin, J., Kong, C., Lee, J., Choi, B. Y., Sim, J., Koh, C. S., Park, M., Na, Y. C., Suh, S. W., Chang, W. S., et al. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0569-x · Cited by 91 · see citing works

Ultrasonic Cavitation‐Assisted and Acid‐Activated Transcytosis of Liposomes for Universal Active Tumor Penetration

Wang, G., Zhang, C., Jiang, Y., Song, Y. H., Chen, J., Sun, Y., Li, Q., Zhou, Z., Shen, Y., & Huang, P. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202102786 · Cited by 90 · see citing works

Nanogels: An overview of properties, biomedical applications, future research trends and developments

Anooj, E., Charumathy, M., Sharma, V. K., Vibala, B. V., Gopukumar, S. T., Jainab, S. I. B., & Vallinayagam, S. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.130446 · Cited by 78 · see citing works

Ultrasound Responsive Magnetic Mesoporous Silica Nanoparticle-Loaded Microbubbles for Efficient Gene Delivery

Du, M., Chen, Y., Tu, J., Liufu, C., Yu, J., Yuan, Z., Gong, X., & Chen, Z. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00014 · Cited by 78 · see citing works

Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus

Li, B., Aid, R., Labour, M.-N., Zenych, A., Juenet, M., Choqueux, C., Ollivier, V., Couture, O., Letourneur, D., & Chauvierre, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.12.023 · Cited by 75 · see citing works

Evaluation of ultrasound and microbubbles effect on pork meat during brining process

Visy, A., Jónás, G., Szakos, D., Horváth-Mezőfi, Z., Hidas, K. I., Barkó, A., & Friedrich, L. F. (2021) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2021.105589 · Cited by 73 · see citing works

A Multifaceted Approach to Optimizing AAV Delivery to the Brain for the Treatment of Neurodegenerative Diseases

Fischell, J. M., & Fishman, P. S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.747726 · Cited by 66 · see citing works

Liposomes: An emerging carrier for targeting Alzheimer's and Parkinson's diseases

Pandian, S. R. K., Vijayakumar, K. K., Murugesan, S., & Kunjiappan, S. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09575 · Cited by 67 · see citing works

Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB

Kimura, S., & Harashima, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121216 · Cited by 64 · see citing works

The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication

Jangjou, A., Meisami, A. H., Jamali, K., Niakan, M. H., Abbasi, M., Shafiee, M., Salehi, M., Hosseinzadeh, A., Amani, A. M., & Vaez, A. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00744-4 · Cited by 60 · see citing works

Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model

Lin, C., Tsai, C.-H., Feng, L.-Y., Chai, W., Lin, C.-J., Huang, C.-Y., Wei, K., Yeh, C., Chen, C., & Liu, H.-L. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.04.011 · Cited by 59 · see citing works

Blood–brain barrier opening with focused ultrasound in experimental models of Parkinson's disease

Karakatsani, M. E., Blesa, J., & Konofagou, E. E. (2019) · Movement Disorders · doi:10.1002/mds.27804 · Cited by 57 · see citing works

Mapping Knowledge Structure and Research Frontiers of Ultrasound-Induced Blood-Brain Barrier Opening: A Scientometric Study

Wu, H., Zhou, Y., Xu, L., Tong, L., Wang, Y., Liu, B., Yan, H., & Sun, Z. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.706105 · Cited by 54 · see citing works

Ultrasonic particles: An approach for targeted gene delivery

Walsh, A. P. G., Gordon, H. N., Peter, K., & Wang, X. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113998 · Cited by 54 · see citing works

The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications

Xia, Y., Na, X., Wu, J., & Ma, G. (2018) · Advanced Materials · doi:10.1002/adma.201801159 · Cited by 52 · see citing works

Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedside

Xu, L., Yao, S., Ding, Y. E., Xie, M., Feng, D., Sha, P., Tan, L., Bei, F., & Yao, Y. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05661-2 · Cited by 48 · see citing works

Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy

Tu, J., Zhang, H., Yu, J., Liufu, C., & Chen, Z. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s171019 · Cited by 44 · see citing works

Translating ultrasound-mediated drug delivery technologies for CNS applications

Perolina, E., Meissner, S., Raos, B. J., Harland, B. C., Thakur, S. S., & Svirskis, D. M. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115274 · Cited by 45 · see citing works

Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases

Zhao, P., Wu, T., Tian, Y., You, J. E., & Cui, X. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115323 · Cited by 39 · see citing works

Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery: Taking Lessons from the Past to Inform the Future

Jung, N., & Chang, J. W. (2018) · Journal of Korean medical science · doi:10.3346/jkms.2018.33.e279 · Cited by 34 · see citing works

Non-invasive ultrasonic modulation of visual evoked response by GABA delivery through the blood brain barrier

Constans, C., Ahnine, H., Santin, M. D., Lehéricy, S., Tanter, M., Pouget, P., & Aubry, J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.006 · Cited by 34 · see citing works

Ascorbic acid-modified brain-specific liposomes drug delivery system with “lock-in” function

Xiao, W., Fu, Q., Zhao, Y., Zhang, L., Yue, Q., Hai, L., Guo, L., & Wu, Y. (2019) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2019.01.005 · Cited by 32 · see citing works

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders: drug stability, targeting efficiency, and safety

Zhang, M., Xiang, C., Niu, R., He, X., Luo, W., Liu, W., & Gu, R. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00048 · Cited by 28 · see citing works

Sonodynamic therapy induces oxidative stress, DNA damage and apoptosis in glioma cells

Sun, Y. L., Wang, H., Zhang, K., Liu, J., Wang, P., Wang, X., & Liu, Q. (2018) · RSC Advances · doi:10.1039/c8ra07099g · Cited by 25 · see citing works

New attempts for central nervous infiltration of pediatric acute lymphoblastic leukemia

Zhou, F., Wen, Y., Jin, R., & Chen, H. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09827-z · Cited by 25 · see citing works

Synergistic ultrasonic biophysical effect-responsive nanoparticles for enhanced gene delivery to ovarian cancer stem cells

Liufu, C., Li, Y., Lin, Y., Yu, J., Du, M., Chen, Y., Yang, Y., Gong, X., & Chen, Z. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1785583 · Cited by 25 · see citing works

Cascade‐Amplifying Synergistic Therapy for Intracranial Glioma via Endogenous Reactive Oxygen Species‐Triggered “All‐in‐One” Nanoplatform

Wu, P., Zhu, M., Li, Y., Ya, Z., Yang, Y., Yuan, Y., Dong, W., Guo, S., Lu, S., Zhang, L., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202105786 · Cited by 25 · see citing works

Enhancing Cancer Immunotherapeutic Efficacy with Sonotheranostic Strategies

Zafar, A., Hasan, M., Tariq, T., & Dai, Z. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00437 · Cited by 25 · see citing works

Quantum dot: Heralding a brighter future in neurodegenerative disorders

Singh, A., Mallika, T. N., Gorain, B., Yadav, A. K., Tiwari, S., Flora, S. J. S., Shukla, R., & Kesharwani, P. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102700 · Cited by 24 · see citing works

Overview of nanogel and its applications

Ghaywat, S. D., Mate, P. S., Parsutkar, Y. M., Chandimeshram, A. D., & Umekar, M. J. (2021) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2021.16.1.0196 · Cited by 24 · see citing works

Applications of Ultrasound to Stimulate Therapeutic Revascularization

Gorick, C. M., Chappell, J. C., & Price, R. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123081 · Cited by 23 · see citing works

A narrative review: Ultrasound-Assisted drug delivery: Improving treatments via multiple mechanisms

Tao, W., Lai, Y., Zhou, X., Yang, G., Wu, P., & Yuan, L. (2025) · Ultrasonics · doi:10.1016/j.ultras.2025.107611 · Cited by 20 · see citing works

Nanodroplet‐Coated Microbubbles Used in Sonothrombolysis with Two‐Step Cavitation Strategy

Pan, Y., Li, Y., Li, Y., Zheng, X., Zou, C., Li, J., & Chen, H. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202202281 · Cited by 20 · see citing works

Preparation of [Amine-Terminated Generation 5 Poly(amidoamine)]-graft-Poly(lactic-co-glycolic acid) Electrospun Nanofibrous Mats for Scaffold-Mediated Gene Transfection

Xiao, S., Peng, Q., Yang, Y., Tao, Y., Zhou, Y. M., Xu, W., & Shi, X. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00848 · Cited by 18 · see citing works

Echogenic, Ultrasound-Sensitive Chitosan Nanodroplets for Spatiotemporally Controlled DKK-2 Gene Delivery to Prostate Cancer Cells

Liu, X., Shi, D., Guo, L., Zhou, X., Shang, M., Sun, X. Y., Meng, D., Zhao, Y., & Li, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s286474 · Cited by 17 · see citing works

Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?

Price, R. J., Fisher, D. G., Suk, J. S., Hanes, J. S., Ko, H. S., & Kordower, J. H. (2019) · Movement Disorders · doi:10.1002/mds.27675 · Cited by 16 · see citing works

Nanogel: Types, Methods of Preparation, Limitation, Evaluation and Application – A Systematic Review

Srivastava, S., Saha, S., & Jakhmola, V. (2023) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.13.4.77 · Cited by 15 · see citing works

Parkinson's Disease: Current Status, Diagnosis, and Treatment Using Nanomedicines

Hasan, I., Roy, S., Guo, B., & Chang, C. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300058 · Cited by 14 · see citing works

Improving DNA vaccination performance through a new microbubble design and an optimized sonoporation protocol

Shi, Y., Weng, W., Chen, M., Huang, H., Chen, X., Peng, Y., & Hu, Y. (2023) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2023.106685 · Cited by 14 · see citing works

Focused Ultrasound-Induced Blood–Brain Barrier Opening Enhanced α-Synuclein Expression in Mice for Modeling Parkinson’s Disease

Lin, C., Huang, C.-Y., Chen, C., & Liu, H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020444 · Cited by 14 · see citing works

Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound

Yao, X., Adams, M. S., Jones, P. D., Diederich, C. J., & Verkman, A. S. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly107 · Cited by 14 · see citing works

Focused ultrasound: growth potential and future directions in neurosurgery

Zhang, M., Rodrigues, A. J., Zhou, Q., & Li, G. (2021) · Journal of Neuro-Oncology · doi:10.1007/s11060-021-03820-9 · Cited by 15 · see citing works

Transcutaneous Ultrasound-Mediated Nonviral Gene Delivery to the Liver in a Porcine Model

Tran, D. M., Zhang, F., Morrison, K. P., Loeb, K. R., Harrang, J., Kajimoto, M., Chavez, F., Wu, L. G., & Miao, C. H. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.07.005 · Cited by 12 · see citing works

Bone-targeted ultrasound-responsive nanobubbles for siRNA delivery to treat osteoporosis in mice

Sotoudehbagha, P., Flores, A. C., Hartmann, T., Pattilachan, T. M., & Razavi, M. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.214078 · Cited by 11 · see citing works

Low‐Intensity Focused Ultrasound‐Responsive Nanobubbles Enhance Thrombus Targeting and Penetration for Highly Effective Thrombolytic Therapy

Zhang, W., Sun, M., Xu, L., Chen, S., Rong, X., Wang, J., Liu, J., Liu, B., Xu, J., Luo, Y., et al. (2024) · Small Structures · doi:10.1002/sstr.202400541 · Cited by 11 · see citing works

Tissue blood volumes and weights in adult beagle dogs.

Cuddihy, R. G., Hall, R. P., HOBBS, C. H., Boecker, B. B., & Muggenburg, B. A. (1972) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 10 · see citing works

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

Kumar, J., Karim, A., Sweety, U. H., Sarma, H., Nurunnabi, M., & Narayan, M. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00842 · Cited by 9 · see citing works

The influence of ultrasound-induced microbubble cavitation on the viability, migration and cell cycle distribution of melanoma cells

Yang, D., Zhang, Q., Zhang, Z., Yuan, Z., Xu, G., Wu, J., Zhang, M., Guo, X., Tu, J., & Zhang, D. (2021) · Applied Acoustics · doi:10.1016/j.apacoust.2021.108056 · Cited by 9 · see citing works

Direct reprogramming of hepatocytes into insulin-producing cells for anti-diabetic treatment by ultrasound-targeted microbubble destruction enhanced hydrodynamic gene delivery.

Yang, X., Wang, H., Lu, W.-L., Ma, W., Zhang, H., & Li, F. (2020) · PubMed Central · Cited by 8 · see citing works

Focused Ultrasound for Neurodegenerative Diseases

Mehta, R. I., Ranjan, M., Haut, M. W., Carpenter, J., & Rezai, A. R. (2024) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2024.03.001 · Cited by 8 · see citing works

Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery

Lin, C.-J., Lin, C., Lin, Y., Huang, C.-Y., Wei, K., Chen, J., Lee‐Chen, G., & Liu, H.-L. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.07.017 · Cited by 8 · see citing works

Physically open BBB

Chen, R., Zhao, X. G., & Hu, K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814001-7.00009-3 · Cited by 7 · see citing works

Experiment research of focused ultrasound combined with drug and microbubble for treatment of central nervous system leukemia

Xi, X.-P., Zong, Y., Ji, Y., Wang, B., & Liu, H. (2017) · Oncotarget · doi:10.18632/oncotarget.23521 · Cited by 7 · see citing works

Medical Ultrasound Application Beyond Diagnosis: Insights From Ultrasound Sensing and Biological Response

Lai, Y., Tao, W., Wang, L., Liu, Z., Wu, P., Yang, G., & Yuan, L. (2024) · Biotechnology Journal · doi:10.1002/biot.202400561 · Cited by 6 · see citing works

Parkinson’s disease: genetics and neuroinflammatory insights

Chandel, I., Kumari, S., Bagri, K., Bhatia, A., & Deshmukh, R. R. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01832-9 · Cited by 6 · see citing works

Neuro-Nanocarriers: Redefining Treatment Pathways for Brain Disorders

Chauhan, A., Mori, D., Soniwala, M., Prajapati, B. G., & Shah, S. (2024) · BioNanoScience · doi:10.1007/s12668-024-01730-4 · Cited by 4 · see citing works

A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model

Rich, M. C., Whitsitt, Q. A., Lubin, F. D., & Bolding, M. (2020) · Journal of Visualized Experiments · doi:10.3791/61113 · Cited by 6 · see citing works

Transcutaneous ultrasound-mediated gene delivery into canine livers achieves therapeutic levels of factor VIII expression

Manson, M. A., Zhang, F., Novokhodko, A., Chen, C., Parker, M. H., Loeb, K. R., Kajimoto, M., Campbell, C., Storb, R. F., & Miao, C. H. (2022) · Blood Advances · doi:10.1182/bloodadvances.2021006016 · Cited by 5 · see citing works

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

Liu, H., Hua, M., Zheng, Q. Y., Gao, Y., & Li, Z. (2023) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.47 · Cited by 5 · see citing works

Verification of Blood-Brain Barrier Disruption Based on the Clinical Validation Platform Using a Rat Model with Human Skull

Park, C. Y., Seo, H., Lee, E., Han, M., Choi, H., Park, K., Yoon, S.-Y., Chang, S. H., & Park, J. (2021) · Brain Sciences · doi:10.3390/brainsci11111429 · Cited by 5 · see citing works

Bibliometric and visualized analysis of ultrasound combined with microbubble therapy technology from 2009 to 2023

Tu, B., Yan, L., Wen, W., & Jian, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1418142 · Cited by 4 · see citing works

Biomaterials and Stem Cells as Drug/Gene-Delivery Vehicles for Parkinson’s Treatment: An Update

Roshani, M., Kiaie, N., & Aghdam, R. M. (2021) · Regenerative Medicine · doi:10.2217/rme-2021-0050 · Cited by 4 · see citing works

Adeno-associated Virus-Mediated Gene Delivery Across the Blood-Brain Barrier

Yao, Y., & Bei, F. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-69188-1_4 · Cited by 3 · see citing works

Smart Stimuli-responsive Nanogels: A Potential Tool for Targeted Drug Delivery

Dhanawat, M., Garima, G., Wilson, K., Bhushan, B., Chalotra, R., Gupta, S., & Chaubey, P. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128353985241231111149 · Cited by 2 · see citing works

Recent Advances about Local Gene Delivery by Ultrasound

Chen, Z., Du, M., & Yan, F. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80036 · Cited by 2 · see citing works

Exploring self-nanoemulsifying drug delivery system (SNEDDS) in combating neurodegeneration: a revolutionary tool for drug targeting in Alzheimer’s and Parkinson’s disease

Tyagi, S., Kumar, J., & Kumar, S. (2025) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2025.2580488 · Cited by 1 · see citing works

Ultrasound-mediated targeted micro/nanobubbles: breaking new boundaries in precision tumor therapy

Yang, M., Zhang, Z., Zhou, H., Luo, Z., Wang, Y., Li, S., Liu, Z., & Zhang, X. (2026) · International Journal of Surgery · doi:10.1097/js9.0000000000004796 · Cited by 1 · see citing works

Stem Cell Therapy in Parkinson’s Disease: Advances in Regenerative Medicine and Clinical Applications

Kumar, D. S., Ravi, R., Mahmood, A. A. R., Amirkhanyan, N., & Polevoy, G. G. (2025) · Global Journal of Medical Pharmaceutical and Biomedical Update · doi:10.25259/gjmpbu_42_2024 · Cited by 1 · see citing works

Controlled Formation of Oil-Free Soft Biomaterials Using All-Aqueous Fluid Systems

Jeyhani, M. (2022) · doi:10.32920/19929758 · Cited by 1 · see citing works

Quantitative analysis of the focused ultrasound-induced blood-brain barrier opening with applications in neurodegenerative disorders

Karakatsani, M. E. (2020) · doi:10.7916/d8-gvqg-2009

WAVE-2 and Its Role in LRRK2 Mediated Neuroinflammation

Abdali, J. (2019) · doi:10.22215/etd/2019-13730

The effect and mechanism of low intensity focused ultrasound in the treatment of Parkinson's diseasePreprint

Long, L., Zhong, Y., Cai, X., Liao, J., Liu, X., & Huang, Y. (2021) · doi:10.22541/au.162577714.48647639/v1

Liposomes: An Emerging Carrier for Brain Targetting and DeliveryPreprint

Pandian, S. R. K., Vijayakumar, K. K., Murugesan, S., & Kunjiappan, S. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3988692

Effects of Conditioned Media from Cell Cultures Stimulated with LIPUS on the Viability of Retinal Neurons and Müller Glia

Poblete-Naredo, I., Leija, L., Vera, A., Gutiérrez-Martínez, J., Albores, A., & Gutiérrez, M. I. (2022) · Global Medical Engineering Physics Exchanges/Pan American Health Care Exchanges (GMEPE/PAHCE) · doi:10.1109/gmepe/pahce55115.2022.9757778

Introducing, OncoTarget

Blagosklonny, M. V., & Gudkov, A. V. (2010) · Oncotarget · doi:10.18632/oncotarget.23525

Controlled Formation of Oil-Free Soft Biomaterials Using All-Aqueous Fluid Systems

Jeyhani, M. (2022) · doi:10.32920/19929758.v1

Fickian and Non-Fickian Transports in Ultrasound Enhanced Drug Delivery: Modeling and Numerical Simulation

Azhdari, E., Emami, A., & Ferreira, J. A. (2022) · Advances in mathematical fluid mechanics · doi:10.1007/978-3-031-14324-3_13

Neuroradiology: Focused Ultrasound in Neurosurgery

Bene, M. D., Eleopra, R., Prada, F. U., & DiMeco, F. (2024) · Cambridge University Press eBooks · doi:10.1017/9781108917339.029

Recent Advances of Ultrasound-Based Nano-Delivery Systems in Prostate Cancer Imaging and TreatmentPreprint

Yang, L., Xie, X., zhang, J., & Du, Z. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4804071

Barriers to progress of neurotherapeutics: Getting drugs to the brain

Patel, V., Momin, M. M., Mehta, T. A., & Patel, R. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23841-3.00003-0

Intra-arterial Gene Delivery for Neurodegenerative Diseases

Fischell, J. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-80173-0_14

History and development of nanoscale thin films for biomedical applications

Raj, A., Vidya, L., Mathew, R. J., Aparna, V. M., Sajeev, U. S., & Sudarsanakumar, C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-18929-6.00006-2

Traitement ciblé des maladies thrombotiques grâce à des particules de polsaccharides submicroniques fonctionnalisées

Zenych, A. (2021) · doi:10.70675/cd0fc8cfz0d9cz4ea6z9921zffad2b1e28ed

Application of Low-Intensity Focused Ultrasound in Parkinson’s Disease

Dai, Y., Mao, J., Yang, T., Luo, J., Yan, X., & Yang, G. (2026) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2026.07.003

Ultrasound Noninvasive Gene Delivery for Parkinson's Disease Treatment

Liu, H.-L. (2017) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2017.08.1817

Focused ultrasound opening of the blood–brain barrier for treatment of Parkinson's disease

LeWitt, P. A., Lipsman, N., & Kordower, J. H. (2019) · Movement Disorders · doi:10.1002/mds.27722 · Cited by 45 · see citing works

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primatesPreprint

Batts, A. J., Ji, R., Bae, S., Tsitsos, F. N., Jiménez-Gambín, S., Kwon, N., Gorman, S. L., Tsakri, D., Noel, R. L., Bendig, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.02.639893 · Cited by 2 · see citing works

Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson’s Disease Model

Mead, B. P., Kim, N.-H., Miller, G. W., Hodges, D., Mastorakos, P., Klibanov, A. L., Mandell, J. W., Hirsh, J., Suk, J. S., Hanes, J. S., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b00616 · Cited by 162 · see citing works

Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

Lin, C., Hsieh, H.-Y., Chen, C., Wu, S.-R., Tsai, C.-H., Huang, C.-Y., Hua, M., Wei, K., Yeh, C., & Liu, H.-L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.052 · Cited by 156 · see citing works