Cited by 225Treatment of Major DepressionDiabetes Treatment and ManagementMetabolism, Diabetes, and Cancer

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Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus

Guo, Min, Mi, Jia, Jiang, Qiu‐Ming, Xu, Jin‐Mei, Tang, Ying‐Ying, Tian, Geng, Wang, Bin·2014·Clinical and Experimental Pharmacology and Physiology

DOI 10.1111/1440-1681.12265

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Abstract

Summary: Diabetes mellitus and depressive disorders are both common chronic diseases that increase functional disability and social burden. Cognitive impairment is a potentially debilitating feature of depression. Previous evidence indicates that the antidiabetic drug metformin could be suitable for diabetic patients with cognitive impairment. However, there is no direct evidence from clinical studies that metformin treatment improves cognitive function in diabetic patients suffering from depression. In the present study, 58 participants diagnosed with depression and type 2 diabetes mellitus ( T 2 DM ) were recruited and divided into two groups, one treated with metformin and the other treated with placebo for 24 weeks. Cognitive function, depressive behaviour and diabetes improvement were evaluated. Chronic treatment with metformin for 24 weeks improved cognitive performance, as assessed by the W echsler M emory S cale– R evised, in depressed patients with T 2 DM . In addition, metformin significantly improved depressive performance and changed the glucose metabolism in depressed patients with diabetes. Depressive symptoms were negatively correlated with cognitive performance in metformin‐treated participants. Furthermore, associations were observed between the parameters of blood glucose metabolism and the depression phenotype. These findings suggest that chronic treatment with metformin has antidepressant behavioural effects and that improved cognitive function is involved in the therapeutic outcome of metformin. The results of the present study also raise the possibility that supplementary administration of antidiabetic medications may enhance the recovery of depression, comorbid with T 2 DM , through improvements in cognitive performance.

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Authors: Guo, M., Mi, J., Jiang, Q., Xu, J., Tang, Y., Tian, G., & Wang, B.
Affiliations: Harbin Medical University (CN)
Binzhou Medical University (CN)
Division of Endocrinology Aerospace Center Hospital Aerospace Clinical Medical College Peking University Beijing China
Department of Endocrinology Fourth Affiliated Hospital of Harbin Medical University Harbin China
Corresponding author: Guo, Min
ORCID: Guo, Min
Mi, Jia
Tian, Geng
Wang, Bin
Venue: Clinical and Experimental Pharmacology and Physiology
Publisher: Wiley
Published: 2014-09
Volume: 41
Issue: 9
Pages: 650-656
ISSN: 0305-1870 (ISSN-L)
1440-1681
DOI: 10.1111/1440-1681.12265
OpenAlex: W2069494503
Cited by: 225
References: 46
Citations by year: 2026: 7 · 2025: 16 · 2024: 9 · 2023: 27 · 2022: 30 · 2021: 28 · 2020: 34 · 2019: 21 · 2018: 22 · 2017: 17 · 2016: 8 · 2015: 6
FWCI: 7.58
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 55 d)
Locations: Clinical and Experimental Pharmacology and Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: Peking University
Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: metformin, antidepressant effects, depression, type 2 diabetes, cognitive impairment, cognitive function, glucose metabolism, depressive symptoms, comorbidities, antidiabetic drugs
MeSH terms: Adult, Antidepressive Agents, Cognition, Depression, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Male, Metformin, Middle Aged, Psychiatric Status Rating Scales, Wechsler Scales

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Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus

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