Metformin: Repurposing Opportunities for Cognitive and Mood Dysfunction

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works

Insights into the ageing mind: a view from cognitive neuroscience

Hedden, T., & Gabrieli, J. D. E. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1323 · Cited by 2,223 · see citing works

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157 · see citing works

Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications

Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947 · see citing works

Cellular and molecular mechanisms of metformin: an overview

Viollet, B., Guigas, B., Garcia, N. S., Leclerc, J., Foretz, M., & Andreelli, F. (2012) · Clinical Science · doi:10.1042/cs20110386 · Cited by 1,720 · see citing works

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638 · see citing works

Metformin improves healthspan and lifespan in mice

Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399 · see citing works

Cytokines and the Brain: Implications for Clinical Psychiatry

Kronfol, Z., & Remick, D. G. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.683 · Cited by 784 · see citing works

COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS: Review: Cognitive Deficits and Functional Outcomes in MDD

McIntyre, R. S., Cha, D. S., Soczynska, J. K., Woldeyohannes, H. O., Gallaugher, L. A., Kudlow, P., Alsuwaidan, M., & Baskaran, A. (2013) · Depression and Anxiety · doi:10.1002/da.22063 · Cited by 765 · see citing works

Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: Randomised placebo controlled trial

de Jager, J., Kooy, A., Lehert, P., Wulffele, M. G., van der Kolk, J., Bets, D., Verburg, J., Donker, A. J. M., & Stehouwer, C. D. A. (2010) · BMJ · doi:10.1136/bmj.c2181 · Cited by 702 · see citing works

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

Hawley, S. A., Gadalla, A. E., Olsen, G. S., & Hardie, D. G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2420 · Cited by 696 · see citing works

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

Kleinridders, A., Ferris, H. A., Cai, W., & Kahn, C. R. (2014) · Diabetes · doi:10.2337/db14-0568 · Cited by 688 · see citing works

Increased risk of depressive disorders in women with polycystic ovary syndrome

Hollinrake, E., Abreu, A., Maifeld, M., Van Voorhis, B. J., & Dokras, A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.039 · Cited by 631 · see citing works

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

Wang, J., Gallagher, D., DeVito, L. M., Cancino, G. I., Tsui, D., He, L., Keller, G. M., Frankland, P. W., Kaplan, D. R., & Miller, F. D. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.03.016 · Cited by 474 · see citing works

Dicarbonyl Intermediates in the Maillard Reaction

THORNALLEY, P. J. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.014 · Cited by 459 · see citing works

Metformin reduces systemic methylglyoxal levels in type 2 diabetes.

Beisswenger, P. J., Howell, S. K., Touchette, A. D., Lal, S., & Szwergold, B. S. (1999) · Diabetes · doi:10.2337/diabetes.48.1.198 · Cited by 446 · see citing works

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

Kickstein, E., Krauß, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., Köhler, A., Glossmann, H. H., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912793107 · Cited by 432 · see citing works

Reactive oxygen species and synaptic plasticity in the aging hippocampus

Serrano, F., & Klann, E. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.05.002 · Cited by 421 · see citing works

Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin

Bauman, W. A., Shaw, S., Jayatilleke, E., Spungen, A. M., & Herbert, V (2000) · Diabetes Care · doi:10.2337/diacare.23.9.1227 · Cited by 412 · see citing works

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

Łabuzek, K., Suchy, D., Gabryel, B., Bielecka, A., Liber, S., & Okopień, B. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70357-1 · Cited by 405 · see citing works

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

Moore, E. M., Mander, A. G., Ames, D. J., Kotowicz, M. A., Carne, R. P., Brodaty, H., Woodward, M., Boundy, K. L., Ellis, K. A., Bush, A. I., et al. (2013) · Diabetes Care · doi:10.2337/dc13-0229 · Cited by 405 · see citing works

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

Butterfield, D. A., Di Domenico, F., & Barone, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.010 · Cited by 402 · see citing works

Antidiabetic drug metformin (Glucophage ^R ) increases biogenesis of Alzheimer's amyloid peptides via up-regulating <i>BACE1</i> transcription

Chen, Y., Zhou, K., Wang, R., Liu, Y., Kwak, Y.-D., Ma, T., Thompson, R. C., Zhao, Y., Smith, L., Gasparini, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807991106 · Cited by 390 · see citing works

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

Mairet-Coello, G., Courchet, J., Pieraut, S., Courchet, V., Maximov, A., & Polleux, F. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.003 · Cited by 351 · see citing works

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

Ng, T. P., Feng, L., Yap, K. B., Lee, T. S., Tan, C. H., & Winblad, B. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-131901 · Cited by 334 · see citing works

Risk Factors of Vitamin B12 Deficiency in Patients Receiving Metformin

Ting, R. Z.-W. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.18.1975 · Cited by 333 · see citing works

Molecular mechanisms of insulin resistance in polycystic ovary syndrome

Diamanti-Kandarakis, E., & Papavassiliou, A. G. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.05.006 · Cited by 301 · see citing works

Cognitive impairment and vitamin B12: a review

Moore, E. M., Mander, A. G., Ames, D. J., Carne, R. P., Sanders, K. M., & Watters, D. A. (2012) · International Psychogeriatrics · doi:10.1017/s1041610211002511 · Cited by 265 · see citing works

Metformin attenuates Alzheimer’s disease-like neuropathology in obese, leptin-resistant mice

Li, J., Deng, J., Sheng, W., & Zuo, Z. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.03.002 · Cited by 260 · see citing works

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

Saito, K., Suyama, K., Nishida, K., Sei, Y., & Basile, A. S. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)12460-5 · Cited by 257 · see citing works

Neuroprotective Role of Antidiabetic Drug Metformin Against Apoptotic Cell Death in Primary Cortical Neurons

El‐Mir, M., Détaille, D., R-Villanueva, G., Delgado‐Esteban, M., Guigas, B., Attia, S., Fontaine, E. M., Almeida, Á., & Leverve, X. M. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-9002-1 · Cited by 243 · see citing works

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK ‐dependent autophagy

Jiang, T., Yu, J., Zhu, X., Wang, H.-F., Tan, M., Cao, L., Zhang, Q.-Q., Gao, L., Shi, J., Zhang, Y., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12655 · Cited by 238 · see citing works

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

Pintana, H., Apaijai, N., Pratchayasakul, W., Chattipakorn, N., & Chattipakorn, S. C. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.08.017 · Cited by 236 · see citing works

Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus

Guo, M., Mi, J., Jiang, Q., Xu, J., Tang, Y., Tian, G., & Wang, B. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12265 · Cited by 225 · see citing works

Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial

Esteghamati, A., Eskandari, D., Mirmiranpour, H., Noshad, S., Mousavizadeh, M., Hedayati, M., & Nakhjavani, M. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.006 · Cited by 212 · see citing works

Metabolic syndrome and major depression

Marazziti, D., Rutigliano, G., Baroni, S., Landi, P., & Dell’Osso, L. (2013) · CNS Spectrums · doi:10.1017/s1092852913000667 · Cited by 212 · see citing works

The management of patients with polycystic ovary syndrome

Jayasena, C. N., & Franks, S. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.102 · Cited by 196 · see citing works

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK

Potter, W. B., O’Riordan, K. J., Barnett, D. G. S., Osting, S., Wagoner, M. P., Bürger, C., & Roopra, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008996 · Cited by 189 · see citing works

Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)*

Cao, J., Meng, S., Chang, E., Beckwith-Fickas, K., Xiong, L., Cole, R. N., Radovick, S., Wondisford, F. E., & He, L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.567271 · Cited by 169 · see citing works

Metformin Down-regulates TNF-α Secretion via Suppression of Scavenger Receptors in Macrophages

Hyun, B., Shin, S., Lee, A., Lee, S., Song, Y., Ha, N., Cho, K., & Kim, K. (2013) · Immune Network · doi:10.4110/in.2013.13.4.123 · Cited by 148 · see citing works

Modification of the glyoxalase system in streptozotocin-induced diabetic rats

Phillips, S. A., Mirrlees, D. J., & Thornalley, P. J. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90488-i · Cited by 141 · see citing works

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

Bélanger, M., Yang, J.-Y., Petit, J.-M., Laroche, T., Magistretti, P. J., & Allaman, I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1249-11.2011 · Cited by 137 · see citing works

LKB1 and AMPK in cell polarity and division

Williams, T., & Brenman, J. E. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.01.008 · Cited by 135 · see citing works

AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization

Amato, S., Liu, X., Zheng, B., Cantley, L. C., RAKIC, P. T., & Man, H. (2011) · Science · doi:10.1126/science.1201678 · Cited by 129 · see citing works

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

Chen, Y., Yang, Z., Dai, C., Liang, Z., Run, X., Iqbal, K., Liu, F., & Gong, C. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.06.004 · Cited by 125 · see citing works

Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice

Zhao, R., Xu, X., Xu, F., Zhang, W.-L., Zhang, W.-L., Liu, L.-M., & Wang, W. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.130 · Cited by 123 · see citing works

AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

Williams, T., Courchet, J., Viollet, B., Brenman, J. E., & Polleux, F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013660108 · Cited by 123 · see citing works

Association between folate, vitamin B6 and vitamin B12 intake and depression in the SUN cohort study

Sánchez‐Villegas, A., Doreste‐Alonso, J., Schlatter, J., Pla, J., Bes‐Rastrollo, M., & Martínez‐González, M. Á. (2009) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2008.00931.x · Cited by 114 · see citing works

Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights

Distler, M. G., & Palmer, A. A. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00250 · Cited by 112 · see citing works

Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats

de Morais, H., de Souza, C. P., da Silva, L. M., Ferreira, D. M., Werner, M. F., Andreatini, R., da Cunha, J. M., & Zanoveli, J. M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.011 · Cited by 111 · see citing works

Metformin Protects the Brain Against the Oxidative Imbalance Promoted by Type 2 Diabetes

Correia, S. C., Carvalho, C., Santos, M. S., Proenca, T., Nunes, E., Duarte, A. I., Monteiro, P. F., Seiça, R. M. F., Oliveira, C. R., & Moreira, P. I. (2008) · Medicinal Chemistry · doi:10.2174/157340608784872299 · Cited by 110 · see citing works

Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons

Loreto, S. D., Zimmitti, V., Sebastiani, P., Cervelli, C., Falone, S., & Amicarelli, F. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.07.019 · Cited by 101 · see citing works

Methylglyoxal, Cognitive Function and Cerebral Atrophy in Older People

Srikanth, V. K., Westcott, B., Forbes, J. M., Phan, T. G., Beare, R. J., Venn, A., Pearson, S., Greenaway, T. M., Parameswaran, V., & Münch, G. W. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls100 · Cited by 98 · see citing works

Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels

Anedda, A., Rial, E., & González-Barroso, M. M. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0278 · Cited by 98 · see citing works

Rosiglitazone and Cognitive Stability in Older Individuals With Type 2 Diabetes and Mild Cognitive Impairment

Abbatecola, A. M., Lattanzio, F., Molinari, A. M., Cioffi, M., Mansi, L., Rambaldi, P., DiCioccio, L., Cacciapuoti, F., Canonico, R., & Paolisso, G. (2010) · Diabetes Care · doi:10.2337/dc09-2030 · Cited by 93 · see citing works

Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism

Ota, S., Horigome, K., Ishii, T., Nakai, M., Hayashi, K., Kawamura, T., Kishino, A., Taiji, M., & Kimura, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.164 · Cited by 92 · see citing works

The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

Hettich, M. M., Matthes, F., Ryan, D. P., Griesche, N., Schröder, S., Dorn, S., Krauß, S., & Ehninger, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102420 · Cited by 90 · see citing works

Vitamin B12 deficiency and the lack of its consequences in type 2 diabetes patients using metformin.

de Groot-Kamphuis, D. M., van Dijk, P. R., Groenier, K. H., Houweling, S. T., Bilo, H. J. G., & Kleefstra, N. (2013) · PubMed · Cited by 88 · see citing works

A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

McNeilly, A. D., Williamson, R., Balfour, D. J. K., Stewart, C. A., & Sutherland, C. D. (2012) · Diabetologia · doi:10.1007/s00125-012-2686-y · Cited by 81 · see citing works

Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

Lennox, R., Porter, D. W., Flatt, P. R., Hölscher, C., Irwin, N., & Gault, V. A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.06.026 · Cited by 78 · see citing works

Cognition and behavior

Aizawa, K. (2015) · Synthese · doi:10.1007/s11229-014-0645-5 · Cited by 78 · see citing works

Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo

Nigro, C., Raciti, G. A., Leone, A., Fleming, T. H., Longo, M., Prevenzano, I., Fiory, F., Mirra, P., D’Esposito, V., Ulianich, L., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3243-7 · Cited by 77 · see citing works

Increased plasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes 初诊2型糖尿病患者血浆甲基乙二醛水平升高

Kong, X., Ma, M., Huang, K., Li, Q., Zhang, H., YANG, Z. K., Li, X., & Su, Q. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12160 · Cited by 76 · see citing works

Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes

Obeid, R., Jung, J., Falk, J., Herrmann, W., Geisel, J., Friesenhahn‐Ochs, B., Lammert, F., Fassbender, K. C., & Kostopoulos, P. (2012) · Biochimie · doi:10.1016/j.biochi.2012.10.028 · Cited by 73 · see citing works

Methylglyoxal Induces Tau Hyperphosphorylation via Promoting AGEs Formation

Li, X., Xie, J., Jiang, X., Lv, B.-L., Cheng, X., Du, L., Zhang, J. Y., Wang, J., & Zhou, X. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8191-0 · Cited by 72 · see citing works

Reduced expression of glyoxalase-1 mRNA in mood disorder patients

Fujimoto, M., Uchida, S., Watanuki, T., Wakabayashi, Y., Otsuki, K., Matsubara, T., Suetsugi, M., Funato, H., & Watanabe, Y. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.024 · Cited by 70 · see citing works

Novel action of metformin in the prevention of haloperidol-induced catalepsy in mice: Potential in the treatment of Parkinson's disease?

Adedeji, H. A., Ishola, I. O., & Adeyemi, O. O. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.014 · Cited by 68 · see citing works

Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption

Ghasemi, R., Zarifkar, A., Rastegar, K., Maghsoudi, N., & Moosavi, M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.036 · Cited by 67 · see citing works

Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells

Ota, K., Nakamura, J., Li, W., Kozakae, M., Watarai, A., Nakamura, N., Yasuda, Y., Nakashima, E., Naruse, K., Watabe, K., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.140 · Cited by 64 · see citing works

Effect of Metformin on Methylglyoxal Metabolism in Patients with Type 2 Diabetes

Κender, Ζ., Fleming, T. H., Kopf, S., Torzsa, P., Grolmusz, V. K., Herzig, S., Schleicher, E., Rácz, K., Reismann, P., & Nawroth, P.-P. (2014) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0034-1371818 · Cited by 64 · see citing works

Increased risk of affective disorders in type 2 diabetes is minimized by sulfonylurea and metformin combination: a population-based cohort study

Wahlqvist, M. L., Lee, M.-S., Chuang, S., Hsu, C., Tsai, H.-N., Yu, S.-H., & Chang, H. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-150 · Cited by 62 · see citing works

Restoration of Glyoxalase Enzyme Activity Precludes Cognitive Dysfunction in a Mouse Model of Alzheimer’s Disease

More, S. S., Vartak, A. P., & Vince, R. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn3001679 · Cited by 55 · see citing works

Comparative effects of pioglitazone and metformin on oxidative stress markers in newly diagnosed type 2 diabetes patients: A randomized clinical trial

Mirmiranpour, H., Mousavizadeh, M., Noshad, S., Ghavami, M., Ebadi, M., Ghasemiesfe, M., Nakhjavani, M., & Esteghamati, A. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.05.006 · Cited by 51 · see citing works

Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal

Huang, X., Wang, F., Chen, W., Chen, Y., Wang, N., & von Maltzan, K. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.011 · Cited by 48 · see citing works

Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes

Mehta, R., Wong, L. T. L., & O’Brien, P. J. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.10.026 · Cited by 44 · see citing works

Metformin Normalizes Type 2 Diabetes-Induced Decrease in Cell Proliferation and Neuroblast Differentiation in the Rat Dentate Gyrus

Hwang, I. K., Kim, I. Y., Joo, E. J., Shin, J. H., Choi, J. W., Won, M., Yoon, Y. S., & Seong, J. K. (2010) · Neurochemical Research · doi:10.1007/s11064-009-0115-5 · Cited by 43 · see citing works

Reduced Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus of High Fat Diet-Fed Mice are Ameliorated by Metformin and Glimepiride Treatment

Yoo, D. Y., Kim, W., Nam, S. M., Yoo, K., Lee, C. H., Choi, J. H., Won, M., Hwang, I. K., & Yoon, Y. S. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0566-3 · Cited by 37 · see citing works

Intracellular cytokine production and cognition in healthy older adults

Simpson, E. E. A., Hodkinson, C. F., Maylor, E. A., McCormack, J. M., Rae, G., Strain, J., Alexander, H. D., & Wallace, J. M. W. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.04.007 · Cited by 32 · see citing works

DTI Correlates of Cognition in Conventional MRI of Normal-Appearing Brain in Patients with Clinical Features of Subacute Combined Degeneration and Biochemically Proven Vitamin B12 Deficiency

Gupta, P. K., Gupta, R. K., Garg, R. K., Rai, Y., Roy, B., Pandey, C. M., Malhotra, H. S., & Narayana, P. A. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3785 · Cited by 31 · see citing works

Impaired mitochondrial respiration promotes dendritic branching via the AMPK signaling pathway

Gioran, A., Nicotera, P., & Bano, D. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.144 · Cited by 29 · see citing works

Insulin inhibits Abeta production through modulation of APP processing in a cellular model of Alzheimer's disease.

Wang, X., Yu, S. Y., Gao, S., Hu, J.-P., Wang, Y., & Liu, H. (2014) · PubMed · Cited by 26 · see citing works

Miglitol, an Anti-diabetic Drug, Inhibits Oxidative Stress^|^ndash;Induced Apoptosis and Mitochondrial ROS Over-Production in Endothelial Cells by Enhancement of AMP-Activated Protein Kinase

Aoki, C., Suzuki, K., Yanagi, K., Satoh, H., Niitani, M., & Aso, Y. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12108fp · Cited by 25 · see citing works

Effects of Metformin on the Cerebral Metabolic Changes in Type 2 Diabetic Patients

Huang, Y., Hsu, C.-C., Lin, W., Yin, T.-K., Huang, C., Wang, P., Chang, H.-H., & Chiu, N.-T. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/694326 · Cited by 24 · see citing works

The therapy of insulin resistance in other diseases besides type 2 diabetes

Pala, L., Barbaro, V., Dicembrini, I., & Rotella, C. M. (2014) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-014-0139-y · Cited by 18 · see citing works

Cognitive remission: a novel objective for the treatment of major depression?

Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works

Type 2 diabetes mellitus-associated cognitive dysfunction: Advances in potential mechanisms and therapies

Luo, A., Xie, Z., Wang, Y., Wang, X., Li, S., Yan, J., Zhan, G., Zhou, Z., Zhao, Y., & Li, S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104642 · Cited by 167 · see citing works

Evaluation of Metformin on Cognitive Improvement in Patients With Non-dementia Vascular Cognitive Impairment and Abnormal Glucose Metabolism

Lin, Y., Wang, K., Ma, C., Wang, X., Gong, Z., Zhang, R., Zang, D., & Cheng, Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00227 · Cited by 87 · see citing works

Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

Teo, E., Ravi, S., Barardo, D., Kim, H.-S., Fong, S., Cazenave-Gassiot, A., Tan, T. Y., Ching, J., Kovalik, J.-P., Wenk, M. R., et al. (2019) · eLife · doi:10.7554/elife.50069 · Cited by 72 · see citing works

Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia

Mone, P., Gambardella, J., Pansini, A., Donato, A. D., Martinelli, G., Boccalone, E., Matarese, A., Frullone, S., & Santulli, G. (2021) · Cells · doi:10.3390/cells10082115 · Cited by 70 · see citing works

Neuromodulatory effects of anti-diabetes medications: A mechanistic review

Yaribeygi, H., Ashrafizadeh, M., Henney, N. C., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104611 · Cited by 70 · see citing works

Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type Calcium Channel Antagonists, and Biguanides With Rates of Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness

Hayes, J., Lundin, A., Wicks, S., Lewis, G., Wong, I. C. K., Osborn, D., & Dalman, C. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.3907 · Cited by 63 · see citing works

Hypoglycemic medicines in the treatment of Alzheimer’s disease: Pathophysiological links between AD and glucose metabolism

Wang, Y., Hu, H., Liu, X., & Guo, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1138499 · Cited by 67 · see citing works

Antipsychotic-Induced Weight Gain in Severe Mental Illness: Risk Factors and Special Considerations

Stogios, N., Humber, B. E., Agarwal, S. M., & Hahn, M. (2023) · Current Psychiatry Reports · doi:10.1007/s11920-023-01458-0 · Cited by 60 · see citing works

Metformin and cognition from the perspectives of sex, age, and disease

Chaudhari, K., Reynolds, C. D., & Yang, S.-H. (2020) · GeroScience · doi:10.1007/s11357-019-00146-3 · Cited by 41 · see citing works

Clinical Evidence of Antidepressant Effects of Insulin and Anti-Hyperglycemic Agents and Implications for the Pathophysiology of Depression—A Literature Review

Woo, Y. S., Lim, H. K., Wang, S., & Bahk, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186969 · Cited by 41 · see citing works

Metformin mitigates amyloid β1-40-induced cognitive decline via attenuation of oxidative/nitrosative stress and neuroinflammation

Khaleghi-Mehr, M., Delshad, A.-A., Shafie-Damavandi, S., & Roghani, M. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01170-1 · Cited by 35 · see citing works

Exploring the Mechanism of Adjuvant Treatment of Glioblastoma Using Temozolomide and Metformin

Feng, S.-W., Chang, P.-C., Chen, H., Hueng, D., Li, Y., & Huang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158171 · Cited by 34 · see citing works

Drug repurposing may generate novel approaches to treating depression

Ebada, M. E. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12815 · Cited by 33 · see citing works

Metformin Treatment Attenuates Brain Inflammation and Rescues PACAP/VIP Neuropeptide Alterations in Mice Fed a High-Fat Diet

Mandwie, M., Karunia, J., Niaz, A., Keay, K. A., Musumeci, G., Rennie, C., McGrath, K. C. Y., Al‐Badri, G., & Castorina, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413660 · Cited by 25 · see citing works

Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons

Chen, W., Chen, J., Liu, Z., Luo, B., Zhou, T. G., & Fei, E. (2020) · Brain Sciences · doi:10.3390/brainsci10100706 · Cited by 22 · see citing works

The neurobiology of the Prader-Willi phenotype of fragile X syndrome

Muzar, Z., Lozano, R., Kolevzon, A. L., & Hagerman, R. J. (2016) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2016.01082 · Cited by 22 · see citing works

Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis

Karami, F., Jamaati, H., Coleman‐Fuller, N., Zeini, M. S., Hayes, A. W., Gholami, M., Salehirad, M., Darabi, M., & Motaghinejad, M. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00469-1 · Cited by 21 · see citing works

Effect of metformin on intact mitochondria from liver and brain: Concept revisited

Yoval‐Sánchez, B., Ansari, F., Lange, D., & Galkin, A. S. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175177 · Cited by 20 · see citing works

Drug repurposing candidates to treat core symptoms in autism spectrum disorder

Koch, E. M., & Demontis, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.995439 · Cited by 16 · see citing works

Insulin resistance is associated with verbal memory impairment in bipolar disorders

Salvi, V., Salvo, G. D., Korčáková, J., Torriero, S., Aragno, E., Kolenič, M., Ungrmanová, M., Maina, G., Mencacci, C., & Hájek, T. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.145 · Cited by 17 · see citing works

Interactive relationships of Type 2 diabetes and bipolar disorder with cognition: evidence of putative premature cognitive ageing in the UK Biobank Cohort

Ringin, E., Dunstan, D. W., McIntyre, R. S., Berk, M., Owen, N. G., Rossell, S. L., & Rheenen, T. E. V. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01471-6 · Cited by 16 · see citing works

Exploring the clinical connections between epilepsy and diabetes mellitus: Promising therapeutic strategies utilizing agmatine and metformin

Nangia, A., Saravanan, J. S., Hazra, S., Priya, V., Sudesh, R., Rana, S. S., & Ahmad, F. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03295-1 · Cited by 14 · see citing works

Unveiling new secrets in Parkinson’s disease: The glycatome

Chegão, A., & Miranda, H. V. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114309 · Cited by 14 · see citing works

Candidates for Drug Repurposing to Address the Cognitive Symptoms in Schizophrenia

Koch, E. M., Kauppi, K., & Chen, C. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110637 · Cited by 13 · see citing works

Syringic acid loaded chitosan nanoparticles mitigate glycation associated oxidative stress and inflammation in hyperglycaemic rat model

Rasheed, A., Kamran, S. H., Hameed, M., Siddique, F., Latif, S., Bibi, M., & Rizwan, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-05469-0 · Cited by 9 · see citing works

Effects of turmeric curcuminoids and metformin against central sensitivity to pain in mice

Verma, S., Mundkinajeddu, D., Agarwal, A., Chatterjee, S. S., & Kumar, V. (2016) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2016.04.001 · Cited by 5 · see citing works

Metformin for neurocognitive dysfunction in schizophrenia: a systematic review

Qin, Z.-J., Shi, Z.-M., Li, L., Wei, X., Hu, H.-L., Wei, W., Xie, Z.-Y., Ji, H. L., Wei, Y., & Zheng, W. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1540153 · Cited by 3 · see citing works

Pharmacological interventions for cognitive dysfunction

Baune, B. T. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198835554.003.0007

Metformin therapy and cognitive dysfunction in patients with type 2 diabetes

Zhang, Q., Li, W., Liu, Z., Zhang, H., Ba, Y., & Zhang, R. (2020) · Medicine · doi:10.1097/md.0000000000019378 · Cited by 58 · see citing works

Investigating the pro-cognitive and anti-depressant efficacy of metformin: A systematic review and meta-analysis of randomised controlled trials

Nibber, A., Singh, H., Burnet, P., Lennox, B., & Minichino, A. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.04.156 · Cited by 21 · see citing works

Metformin and Cognitive Performance in Patients With Type 2 Diabetes: An Umbrella Review

Enderami, A., Shariati, B., Zarghami, M., Aliasgharian, A., Ghazaiean, M., & Darvishi‐Khezri, H. (2025) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12528 · Cited by 9 · see citing works

Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus

Guo, M., Mi, J., Jiang, Q., Xu, J., Tang, Y., Tian, G., & Wang, B. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12265 · Cited by 225 · see citing works

Metformin use is associated with a reduced risk of cognitive impairment in adults with diabetes mellitus: A systematic review and meta-analysis

Zhang, J., Zhang, X., Sun, Y., Lv, R.-H., Chen, M., & Li, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.984559 · Cited by 42 · see citing works