The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis
Abstract
Background: Previous animal investigations link antenatal stress with a range of persistent behavioural abnormalities in the offspring. The current study examined if the effect was also found in humans through middle childhood. Methods: The current study is based on the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective, community‐based study that has followed a cohort of women from pregnancy. Self‐report measures of maternal anxiety and depression were assessed at repeated intervals in pregnancy and the postnatal period. Children's behavioural/emotional problems were assessed by parent report at age 47 and 81 months. Information on obstetric and psychosocial factors was obtained at several points in pregnancy and the postnatal period. Results: Children whose mothers experienced high levels of anxiety in late pregnancy exhibited higher rates of behavioural/emotional problems at 81 months of age after controlling for obstetric risks, psychosocial disadvantage, and postnatal anxiety and depression (for girls, OR = 1.91, 95%CI = 1.26–2.89; for boys, OR = 2.16, 95%CI = 1.41–3.30). Furthermore, the effect at 81 months was comparable to what was previously obtained at 47 months, suggesting the kind of persistent effect proposed in the animal literature. Conclusions: There is evidence that antenatal stress/anxiety has a programming effect on the fetus which lasts at least until middle childhood.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965
In utero programming of chronic disease
BARKER, D. J. P. (1998) · Clinical Science · doi:10.1042/cs0950115 · Cited by 1,765
Glucose tolerance in adults after prenatal exposure to famine
Ravelli, A., van der Meulen, J., Michels, R., Osmond, C., Barker, D., Hales, C., & Bleker, O. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07244-9 · Cited by 1,606
Goodman, R., & Scott, S. (1999) · Journal of Abnormal Child Psychology · doi:10.1023/a:1022658222914 · Cited by 1,420
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378
Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years
O'Connor, T. G., Heron, J., Golding, J., Beveridge, M., & Glover, V. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.180.6.502 · Cited by 1,070
Self-citationCopper, R. L., Goldenberg, R. L., Das, A., Elder, N., Swain, M., Norman, G., Ramsey, R., Cotroneo, P., Collins, B. A., Johnson, F., et al. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70042-x · Cited by 683
Teixeira, J. M. A., Fisk, N. M., & Glover, V. (1999) · BMJ · doi:10.1136/bmj.318.7177.153 · Cited by 526
Self-citationPsychological distress in pregnancy and preterm delivery.
Hedegaard, M., Henriksen, T. B., Sabroe, S., & Secher, N. J. (1993) · BMJ · doi:10.1136/bmj.307.6898.234 · Cited by 442
Maternal anxiety during pregnancy and subsequent infant development
Brouwers, E. P. M., van Baar, A. L., & Pop, V. J. M. (2001) · Infant Behavior and Development · doi:10.1016/s0163-6383(01)00062-5 · Cited by 225
Maternal stress and affect influence fetal neurobehavioral development
DiPietro, J. A., Hilton, S. C., Hawkins, M., Costigan, K. A., & Pressman, E. K. (2002) · Developmental Psychology · doi:10.1037/0012-1649.38.5.659 · Cited by 218
Altered neuroendocrine activity in maltreated children related to symptoms of depression
Hart, J., Gunnar, M., & Cicchetti, D. (1996) · Development and Psychopathology · doi:10.1017/s0954579400007045 · Cited by 188
Birtchnell, J., Evans, C., & Kennard, J. (1988) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1988.tb02787.x · Cited by 118
Cited by
Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., Henderson, J., Macleod, J., Molloy, L., Ness, A., et al. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys066 · Cited by 2,494
Self-citationOberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008) · Epigenetics · doi:10.4161/epi.3.2.6034 · Cited by 1,432
Antenatal maternal stress and long‐term effects on child neurodevelopment: how and why?
Talge, N. M., Neal, C., Glover, V., & the Early Stress, T. R. A. P. S. N. F. A. N. E. O. C. A. A. M. H. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01714.x · Cited by 1,349
Self-citationVan den Bergh, B. R. H., Mulder, E. J. H., Mennes, M., & Glover, V. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.007 · Cited by 1,104
Self-citationPsychiatric Disorders in Pregnant and Postpartum Women in the United States
Vesga-López, O., Blanco, C., Keyes, K., Olfson, M., Grant, B. F., & Hasin, D. S. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.7.805 · Cited by 1,065
Metadata
- Authors
- O'Connor, T. G., Heron, J., Golding, J., Glover, V., & the AL SPAC Study Team
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 2003-10
- Volume
- 44
- Issue
- 7
- Pages
- 1025-1036
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- OpenAlex
- W2117733693
- Cited by
- 702
- References
- 15
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
