Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
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Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13761 women (contributing 13867 pregnancies) were recruited. These women have been followed over the last 19-22 years and have completed up to 20 questionnaires, have had detailed data abstracted from their medical records and have information on any cancer diagnoses and deaths through record linkage. A follow-up assessment was completed 17-18 years postnatal at which anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken. The second follow-up clinic, which additionally measures cognitive function, physical capability, physical activity (with accelerometer) and wrist bone architecture, is underway and two further assessments with similar measurements will take place over the next 5 years. There is a detailed biobank that includes DNA, with genome-wide data available on >10000, stored serum and plasma taken repeatedly since pregnancy and other samples; a wide range of data on completed biospecimen assays are available. Details of how to access these data are provided in this cohort profile.
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We tried to identify outcomes in the ALSPAC cohort that would be affected by confounders important in the relation of breastfeeding to later offspring outcomes but for which a biological/causal effect of breastfeeding was unlikely.
“We tried to identify outcomes in the ALSPAC cohort67,68 that would be affected by confounders that are important in the relation of breastfeeding to later offspring outcomes but for which a biological/causal effect of breastfeeding was unlikely”
From Triangulation in aetiological epidemiology (2017) · cites this paper as [68]
Individual participant data from the large UK Biobank and the Avon Longitudinal Study of Parents and Children are available to researchers globally at modest cost.
“For example, individual participant data from the large UK Biobank (which currently has genotypic, phenotypic and clinical data in up to 500 000 adults76) and the Avon Longitudinal Study of Parents and Children (with very detailed data across three generations across their life course67,68) are available to researchers globally at modest cost”
From Triangulation in aetiological epidemiology (2017) · cites this paper as [68]
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based birth cohort study that recruited 14 541 pregnant women resident in Avon, UK, with expected dates of delivery 1 April 1991 to 31 December 1992.
“The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based birth cohort study that recruited 14 541 pregnant women resident in Avon, UK, with expected dates of delivery 1 April 1991 to 31 December 1992.26,27”
From A structured approach to hypotheses involving continuous exposures over the life course (2016) · cites this paper as [26]
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Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
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Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood
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Self-citationLongitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort
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- Authors
- Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., Henderson, J., Macleod, J., Molloy, L., Ness, A., Ring, S., Nelson, S. M., & Lawlor, D. A.
- Affiliations
- University of Bristol (GB)
- Corresponding author
- Lawlor, D. A.
- ORCID
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-16
- Volume
- 42
- Issue
- 1
- Pages
- 97-110
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- PMC
- PMC3600619
- OpenAlex
- W2143509157
- Cited by
- 2,494
- References
- 76
- Citations by year
- 2026: 157 · 2025: 238 · 2024: 241 · 2023: 252 · 2022: 277 · 2021: 320 · 2020: 240 · 2019: 204 · 2018: 143 · 2017: 90 · 2016: 80 · 2015: 88 · 2014: 82 · 2013: 67 · 2012: 14
- FWCI
- 70.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- International Journal of Epidemiology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- Wellcome Trust (087997MA, 088806, WT087997MA, R01 DK077659, G0600705, G0701594, 092731, WT092830/Z/10, WT088806, WT092830/Z/10/Z, 92830/Z/10/Z, WT092830)
- British Heart Foundation (SP/07 1008/24066, G0600705, WT092830/Z/10/Z)
- University of Bristol (WT092830/Z/10/Z, G0600705, WT088806)
- Medical Research Council (WT088806, G0701594, G1001357, G0600705)
- Economic and Social Research Council (ES/G007543/1)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077659)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- Avon Longitudinal Study of Parents and Children, pregnancy, maternal health, child development, anthropometry, carotid intima-media thickness, bone mass, cognitive function, physical activity, biobanks, genome-wide data, data linkage
- MeSH terms
- Adult, Anthropometry, Blood Banks, Child, England, Female, Health Status, Humans, Longitudinal Studies, Medical Record Linkage, Mothers, Parents, Pregnancy, Pregnancy Outcome, Surveys and Questionnaires, Social Environment, Socioeconomic Factors, Health Behavior, Body Mass Index, DNA Methylation, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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