Cited by 2,494Birth, Development, and HealthHealth, Environment, Cognitive AgingGenetic Associations and Epidemiology

Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

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Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., Henderson, J., Macleod, J. +5 more·2013·International Journal of Epidemiology

Abstract

Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13761 women (contributing 13867 pregnancies) were recruited. These women have been followed over the last 19-22 years and have completed up to 20 questionnaires, have had detailed data abstracted from their medical records and have information on any cancer diagnoses and deaths through record linkage. A follow-up assessment was completed 17-18 years postnatal at which anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken. The second follow-up clinic, which additionally measures cognitive function, physical capability, physical activity (with accelerometer) and wrist bone architecture, is underway and two further assessments with similar measurements will take place over the next 5 years. There is a detailed biobank that includes DNA, with genome-wide data available on >10000, stored serum and plasma taken repeatedly since pregnancy and other samples; a wide range of data on completed biospecimen assays are available. Details of how to access these data are provided in this cohort profile.

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  • We tried to identify outcomes in the ALSPAC cohort that would be affected by confounders important in the relation of breastfeeding to later offspring outcomes but for which a biological/causal effect of breastfeeding was unlikely.

    “We tried to identify outcomes in the ALSPAC cohort67,68 that would be affected by confounders that are important in the relation of breastfeeding to later offspring outcomes but for which a biological/causal effect of breastfeeding was unlikely”

    From Triangulation in aetiological epidemiology (2017) · cites this paper as [68]

  • Individual participant data from the large UK Biobank and the Avon Longitudinal Study of Parents and Children are available to researchers globally at modest cost.

    “For example, individual participant data from the large UK Biobank (which currently has genotypic, phenotypic and clinical data in up to 500 000 adults76) and the Avon Longitudinal Study of Parents and Children (with very detailed data across three generations across their life course67,68) are available to researchers globally at modest cost”

    From Triangulation in aetiological epidemiology (2017) · cites this paper as [68]

  • The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based birth cohort study that recruited 14 541 pregnant women resident in Avon, UK, with expected dates of delivery 1 April 1991 to 31 December 1992.

    “The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based birth cohort study that recruited 14 541 pregnant women resident in Avon, UK, with expected dates of delivery 1 April 1991 to 31 December 1992.26,27”

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Authors
Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., Henderson, J., Macleod, J., Molloy, L., Ness, A., Ring, S., Nelson, S. M., & Lawlor, D. A.
Affiliations
University of Bristol (GB)
Corresponding author
Lawlor, D. A.
Venue
International Journal of Epidemiology
Published
2012-04-16
Volume
42
Issue
1
Pages
97-110
ISSN
  • 0300-5771 (ISSN-L)
  • 1464-3685
OpenAlex
W2143509157
Cited by
2,494
References
76
Citations by year
2026: 157 · 2025: 238 · 2024: 241 · 2023: 252 · 2022: 277 · 2021: 320 · 2020: 240 · 2019: 204 · 2018: 143 · 2017: 90 · 2016: 80 · 2015: 88 · 2014: 82 · 2013: 67 · 2012: 14
FWCI
70.58
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • International Journal of Epidemiology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by-nc)
  • HighWire Press Open Archive (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Funders
  • Wellcome Trust (087997MA, 088806, WT087997MA, R01 DK077659, G0600705, G0701594, 092731, WT092830/Z/10, WT088806, WT092830/Z/10/Z, 92830/Z/10/Z, WT092830)
  • British Heart Foundation (SP/07 1008/24066, G0600705, WT092830/Z/10/Z)
  • University of Bristol (WT092830/Z/10/Z, G0600705, WT088806)
  • Medical Research Council (WT088806, G0701594, G1001357, G0600705)
  • Economic and Social Research Council (ES/G007543/1)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077659)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
Avon Longitudinal Study of Parents and Children, pregnancy, maternal health, child development, anthropometry, carotid intima-media thickness, bone mass, cognitive function, physical activity, biobanks, genome-wide data, data linkage
MeSH terms
Adult, Anthropometry, Blood Banks, Child, England, Female, Health Status, Humans, Longitudinal Studies, Medical Record Linkage, Mothers, Parents, Pregnancy, Pregnancy Outcome, Surveys and Questionnaires, Social Environment, Socioeconomic Factors, Health Behavior, Body Mass Index, DNA Methylation, Genome-Wide Association Study

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