The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Susceptibility to Effects of UVB Radiation on Induction of Contact Hypersensitivity as a Risk Factor for Skin Cancer in Humans
Open accessAbstract
Normal, healthy human volunteers and patients with proved history of non-melanoma skin cancer have been tested for their capacity to develop contact hypersensitivity to dinitrochlorobenzene (DNCB) following exposure of buttock skin to acute, low-dose ultraviolet B (UVB) radiation. Using a radiation protocol that achieves virtually complete depletion of normal-appearing Langerhans cells from irradiated skin, it was learned that approximately 60% of healthy volunteers developed vigorous contact hypersensitivity (CH) when 2000 micrograms DNCB was painted on the irradiated site. These individuals were designated UVB-resistant, and were distinguished from other individuals, designated UVB-susceptible, who failed to develop contact hypersensitivity following an identical treatment protocol. It was then discovered that virtually all (92%) skin cancer patients exposed to UVB and DNCB failed to develop CH, i.e., were UVB-susceptible. In subsequent experiments, epicutaneous application of 2000 micrograms DNCB to unirradiated skin of UVB-susceptible individuals revealed a further distinction between normal persons and skin cancer patients. Approximately 45% of the latter (and none of the former) remained unresponsive (failed to develop contact hypersensitivity following this second attempt at sensitization), implying that they had been rendered immunologically tolerant. These tolerant individuals responded normally to the unrelated hapten, diphencyprone. We conclude that human beings resemble inbred strains of laboratory mice in that some individuals are UVB-susceptible, whereas others are UVB-resistant. Because the incidence of UVB-susceptibility was significantly higher in skin cancer patients, and as specific unresponsiveness could be demonstrated only in these patients, we propose that UVB-susceptibility, as we define it in this hapten system, may be a risk factor for the development of skin cancer.
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Cites
Elmets, C. A., Bergstresser, P. R., Tigelaar, R. E., Wood, P. J., & Streilein, J. W. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.781 · Cited by 392
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Cited by
The Protective Role of Melanin Against UV Damage in Human Skin †
Brenner, M., & Hearing, V. J. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00226.x · Cited by 1,741
Nichols, J. A., & Katiyar, S. K. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-009-1001-3 · Cited by 1,103
Skin cancer and solar UV radiation
de Gruijl, F. R. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00283-x · Cited by 600
Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
Elmets, C. A., Singh, D., Tubesing, K., Matsui, M., Katiyar, S., & Mukhtar, H. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.112919 · Cited by 365
Shreedhar, V., Giese, T., Sung, V. W., & Ullrich, S. E. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.8.3783 · Cited by 345
Metadata
- Authors
- Yoshikawa, T., Rae, V., Bruins-Slot, W., van den Berg, J.-W., Taylor, J. R., & Streilein, J. W.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 1990-11
- Volume
- 95
- Issue
- 5
- Pages
- 530-536
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2072059088
- Cited by
- 430
- References
- 1
- FWCI
- 20.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Susceptibility to Effects of UVB Radiation on Induction of Contact Hypersensitivity as a Risk Factor for Skin Cancer in Humans. https://app.cochat.ai/papers/10.1111/1523-1747.ep12504877
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- Yoshikawa, T., Rae, V., Bruins-Slot, W., van den Berg, J.-W., Taylor, J. R., & Streilein, J. W. (1990). Susceptibility to Effects of UVB Radiation on Induction of Contact Hypersensitivity as a Risk Factor for Skin Cancer in Humans. Journal of Investigative Dermatology. https://doi.org/10.1111/1523-1747.ep12504877
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
