The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
A Cytokine Cascade Including Prostaglandin E2, IL-4, and IL-10 Is Responsible for UV-Induced Systemic Immune Suppression
Abstract
Even though all of the energy contained with the UV wavelengths of solar radiation is absorbed within the epidermis and upper layers of the dermis, UV irradiation can suppress immune responses to Ag introduced at distant nonirradiated sites. In addition, data from a number of laboratories have suggested that one consequence of UV exposure is suppressed Th1 cell activation with normal or enhanced Th2 cell activation, resulting in a shift to a Th2-like phenotype. Cytokines secreted by UV-irradiated keratinoctyes, particularly IL-10, have been shown to play a major role in the induction of systemic immune suppression and differential activation of T helper cell subsets. Although IL-10 can influence Th1 cell activation by altering Ag presentation and suppressing IFN-γ secretion, the major signal for the development of a Th2 response is IL-4. Here we tested the hypothesis that UV irradiation induces IL-4 secretion. UV irradiation induced serum IL-4 in a dose-dependent fashion. Injecting UV-irradiated mice with anti-IL-4 blocked immune suppression. We could find no evidence, however, supporting secretion of IL-4 by UV-irradiated keratinocytes. Rather, we suggest that prostaglandins released by irradiated keratinocytes induce serum IL-4 since treating UV-irradiated mice with a cyclooxygenase-2 inhibitor blocked its production. Moreover, we found that treating UV-irradiated mice with anti-IL-4 suppressed serum IL-10 levels. In addition, injecting normal mice with PGE2 induced serum IL-4 and IL-10. We suggest that UV exposure activates a cytokine cascade (PGE2 → IL-4 → IL-10) that ultimately results in systemic immune suppression.
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Cites
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
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IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
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Disruption of the murine IL-4 gene blocks Th2 cytokine responses
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Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.
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Antigenicity of Murine Skin Tumors Induced by Ultraviolet Light2
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Cited by
T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal
Kaliński, P., Hilkens, C. M. U., Wierenga, E. A., & Kapsenberg, M. L. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01547-9 · Cited by 933
Pillai, S., Oresajo, C., & Hayward, J. (2005) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2004.00241.x · Cited by 706
Grimbaldeston, M. A., Nakae, S., Kalesnikoff, J., Tsai, M., & Galli, S. J. (2007) · Nature Immunology · doi:10.1038/ni1503 · Cited by 485
IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes
Moreau, P., Adrian-Cabestre, F., Menier, C., Guiard, V., Gourand, L., Dausset, J., Carosella, E. D., & Paul, P. (1999) · International Immunology · doi:10.1093/intimm/11.5.803 · Cited by 411
The role of antioxidants in photoprotection: A critical review
Chen, L., Hu, J. Y., & Wang, S. Q. (2012) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2012.02.009 · Cited by 402
Metadata
- Authors
- Shreedhar, V., Giese, T., Sung, V. W., & Ullrich, S. E.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-04
- Volume
- 160
- Issue
- 8
- Pages
- 3783-3789
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1944006756
- Cited by
- 345
- References
- 41
- FWCI
- 22.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shreedhar, V., Giese, T., Sung, V. W., & Ullrich, S. E. (1998). A Cytokine Cascade Including Prostaglandin E2, IL-4, and IL-10 Is Responsible for UV-Induced Systemic Immune Suppression. The Journal of Immunology. https://doi.org/10.4049/jimmunol.160.8.3783
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