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Cited by 187Skin Protection and AgingAntioxidant Activity and Oxidative Stressmelanin and skin pigmentation

Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin

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Jurkiewicz, Beth Anne, Bissett, Donald L., Buettner, Garry R.·1995·Journal of Investigative Dermatology
DOI 10.1111/1523-1747.ep12605921
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Abstract

Previously, we demonstrated by electron paramagnetic resonance (EPR) spectroscopy that ultraviolet radiation induces free-radical formation in Skh-1 hairless mouse skin. Because free-radical oxidative stress is thought to play a principal role in skin photoaging and cancer, oxidative stress and subsequent photodamage should be decreased by supplementation of skin with antioxidants. Using both the ascorbate free radical and an EPR spin-trapping system to detect short-lived radicals, we evaluated the effect of the topically applied antioxidants tocopherol sorbate, alpha-tocopherol, and tocopherol acetate on ultraviolet radiation-induced free-radical formation. We show that tocopherol sorbate significantly decreases the ultraviolet radiation-induced radical flux in skin. With our chronically exposed mouse model, tocopherol sorbate was also found to be significantly more protective against skin photoaging than alpha-tocopherol and tocopherol acetate. These results extend our previous observations of ultraviolet radiation-induced free-radical generation in skin and indicate the utility of tocopherol sorbate as an antioxidant in providing significant protection against ultraviolet radiation-induced oxidative damage.

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Crossref · 10.1111/1523-1747.ep12605921

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1 of 1 references verified0 citation errors · 0 not checkable

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  • a-Tocopheryl acetate and a-tocopheryl succinate are less effective than a-tocopherol in protecting the skin against UV-induced erythema, photoaging, immunosuppression, and carcinogenesis.

    “However, both substitutes are less effective than a-tocopherol in protecting the skin against UV-induced erythema, photoaging, immunosuppression, and carcinogenesis (124,125,127).”

    From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [125]

  • Topical application of a-tocopherol has demonstrated reduction in erythema, photoaging, photocarcinogenesis, and immunosuppression.

    “Topical application of a-tocopherol has demonstrated a number of protective effects including reduction in erythema (124), photoaging (125), photocarcinogenesis (111), and immunosuppression (110).”

    From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [125]

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Authors
Jurkiewicz, B. A., Bissett, D. L., & Buettner, G. R.
Affiliations
  • University of Iowa (US)
  • Procter & Gamble (United States) (US)
ORCID
Buettner, Garry R.
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
1995-04
Volume
104
Issue
4
Pages
484-488
ISSN
0022-202X (ISSN-L)
DOI
10.1111/1523-1747.ep12605921
OpenAlex
W2072207162
Cited by
187
References
1
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 5
FWCI
12.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
alpha-tocopherol, tocopherol acetate, ultraviolet radiation, free radicals, oxidative stress, photoaging, antioxidants, photodamage, ascorbate free radical, EPR spin trapping
MeSH terms
Administration, Topical, Aging, Animals, Ascorbic Acid, Female, Free Radicals, Mice, Hairless, Skin, Ultraviolet Rays, Vitamin E, Oxidative Stress, Mice

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