Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

Arenas‐Jal, Marta; Suñé‐Negre, J. M.; García‐Montoya, Encarna

doi:10.1111/1541-4337.12539

Cited by 239Coenzyme Q10 studies and effectsAntioxidant Activity and Oxidative StressNutrition and Health Studies

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

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Arenas‐Jal, Marta, Suñé‐Negre, J. M., García‐Montoya, Encarna·2020·Comprehensive Reviews in Food Science and Food Safety

DOI 10.1111/1541-4337.12539

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Abstract

World population growth and aging are posing unprecedented challenges in sustaining the health of 9.1 billion people that will be occupying the planet by 2050. Although noncommunicable diseases such as cardiovascular and neurodegenerative diseases, cancer, and diabetes are among the top 10 global causes of death, they can be prevented by risk factor reduction, early detection, and adequate treatment. Since a healthy diet along with dietary supplementation could play an important role to reduce morbidity and cut off its associated health care costs, research in the food and nutrition area is required to find solutions to global challenges affecting health. As a result of the healthy living trend, dietary supplements category is growing fast, leading to an urgent need for dietitians, physicians, and policy makers to broaden the scientific evidence on the efficacy and safety of a wide range of active ingredients. Coenzyme Q10 (CoQ10), as the third most consumed dietary supplement, and as a potential candidate for the treatment of various noncommunicable diseases that are among the global top 10 causes of death, has gained interest over years. Scientific evidence regarding mainly CoQ10 efficacy and safety, as well as formulation challenges, is addressed in this review.

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CoQ10 has a fundamental function in mitochondrial bioenergetics because of its powerful antioxidant activity.
“Arenas-Jal et al. (2020) and Botelho et al. (2020) mentioned that CoQ10 has a fundamental function in bioenergetics of mitochondria because of its powerful antioxidant activity.”
From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Arenas-Jal et al. 2020
Section 2 (Overview of CoQ10; page not provided) describes CoQ10 as an antioxidant and says it plays an essential role in ATP synthesis through its participation in the mitochondrial electron transport chain and oxidative phosphorylation. It does not say that its bioenergetic role is because of its antioxidant activity; it presents these as distinct functions. (LLM, conf=0.88)
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Global status report on noncommunicable diseases 2010.
Alwan, A. (2011) · Cited by 8,494 · see citing works
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461 · see citing works
Diabetes, oxidative stress, and antioxidants: A review
Maritim, A. C., Sanders, R. A., & Watkins, J. B. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10058 · Cited by 3,128 · see citing works
The World Report on Ageing and Health
Beard, J., Officer, A. M., & Cassels, A. (2016) · The Gerontologist · doi:10.1093/geront/gnw037 · Cited by 2,899 · see citing works
Martindale: the complete drug reference
(2005) · Choice Reviews Online · doi:10.5860/choice.42-6228 · Cited by 2,684 · see citing works
Food consumption trends and drivers
Kearney, J. (2010) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0149 · Cited by 1,987 · see citing works
Role of oxygen radicals in DNA damage and cancer incidence
Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., & Telser, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049134.69131.89 · Cited by 1,820 · see citing works
Active Ageing: A Policy Framework
(2002) · The Aging Male · doi:10.1080/tam.5.1.1.37 · Cited by 1,567 · see citing works
Oxidative stress and cancer: An overview
Iglesias, V. S., Moliné, T., Somoza, R., Paciucci, R., Kondoh, H., & LLeonart, M. E. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.10.004 · Cited by 1,445 · see citing works
Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study
Bruckert, E., Hayem, G., Dejager, S., Yau, C., & Bégaud, B. (2005) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-005-5686-z · Cited by 1,226 · see citing works
Trends in the Use of Complementary Health Approaches Among Adults in the United States
Jackson, C. (2015) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000088 · Cited by 1,174 · see citing works
World Health Statistics 2023
(2024) · Climate Change and Law Collection · doi:10.1163/9789004322714_cclc_2023-0172-0836 · Cited by 1,138 · see citing works
Oxidative stress and male infertility
Bisht, S., Faiq, M. A., Tolahunase, M., & Dada, R. (2017) · Nature reviews. Urology · doi:10.1038/nrurol.2017.69 · Cited by 958 · see citing works
Untitled work
(2015) · PubMed · Cited by 926 · see citing works
Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics
Bhagavan, H. N., & Chopra, R. K. (2006) · Free Radical Research · doi:10.1080/10715760600617843 · Cited by 550 · see citing works
The Role of Coenzyme Q10 in Statin-Associated Myopathy
Marcoff, L., & Thompson, P. D. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.049 · Cited by 537 · see citing works
The role of mitochondrial dysfunction in cardiovascular disease: a brief review
Chistiakov, D. A., Shkurat, T. P., Melnichenko, A. А., Grechko, A. V., & Orekhov, A. N. (2017) · Annals of Medicine · doi:10.1080/07853890.2017.1417631 · Cited by 497 · see citing works
The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure
Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., Alehagen, U., Steurer, G., & Littarru, G. P. (2014) · JACC: Heart Failure · doi:10.1016/j.jchf.2014.06.008 · Cited by 488 · see citing works
Coenzyme Q – Biosynthesis and functions
Bentinger, M., Tekle, M., & Dallner, G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.147 · Cited by 429 · see citing works
Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility.
Wright, C., Milne, S., & Leeson, H. (2014) · Reproductive Biomedicine Online · doi:10.1016/j.rbmo.2014.02.004 · Cited by 389 · see citing works
Nonvitamin and Nonmineral Nutritional Supplements
Nabavi, S. F., & Sanches-Silva, A. T. (2018) · Elsevier eBooks · doi:10.1016/c2016-0-03546-5 · Cited by 382 · see citing works
Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial
Sándor, P. S., Clemente, L. D., Coppola, G., Saenger, U., Fumal, A., Magis, D., Seidel, L., Agosti, R. M., & Schoenen, J. E. (2005) · Neurology · doi:10.1212/01.wnl.0000151975.03598.ed · Cited by 371 · see citing works
Statin-induced myopathy: a review and update
Abd, T. T., & Jacobson, T. A. (2011) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2011.540568 · Cited by 320 · see citing works
Distribution and redox state of ubiquinones in rat and human tissues
Åberg, F. O., Appelkvist, E., Dallner, G., & Ernster, L. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90511-t · Cited by 316 · see citing works
Effect of Coenzyme Q10 on myopathic symptoms in patients treated with statins
Caso, G., Kelly, P., McNurlan, M. A., & Lawson, W. E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.063 · Cited by 286 · see citing works
Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems
Balakrishnan, P., Lee, B., Oh, D. H., Kim, J. O., Lee, Y.-I., Kim, D., Jee, J., Lee, Y., Woo, J. S., Yong, C. S., et al. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.03.008 · Cited by 278 · see citing works
Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations
Bhagavan, H. N., & Chopra, R. K. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.003 · Cited by 243 · see citing works
Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate
Majzoub, A. A., & Agarwal, A. K. (2018) · Arab Journal of Urology · doi:10.1016/j.aju.2017.11.013 · Cited by 232 · see citing works
Coenzyme Q10 Contents in Foods and Fortification Strategies
Pravst, I., Žmitek, K., & Žmitek, J. (2010) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390902773037 · Cited by 224 · see citing works
Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease
Shults, C. W., Flint Beal, M., Song, D., & Fontaine, D. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.003 · Cited by 223 · see citing works
Coenzyme Q10
Molyneux, S. L., Florkowski, C. M., George, P. M., Pilbrow, A. P., FRAMPTON, C. M. A., Lever, M., & Richards, M. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.044 · Cited by 208 · see citing works
Statin-induced myalgia and myositis: an update on pathogenesis and clinical recommendations
Selva-O’Callaghan, A., Alvarado-Cárdenas, M., Pinal‐Fernandez, I., Araguás, E. T., Milisenda, J. C., Martínez, M. Á., Marín, A., Labrador‐Horrillo, M., Juárez, C., & Grau‐Junyent, J. M. (2018) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2018.1440206 · Cited by 202 · see citing works
Effects of Coenzyme Q10 on Statin-Induced Myopathy
Banach, M., Serban, C., Sahebkar, A., Ursoniu, S., Rysz, J., Muntner, P., Toth, P. P., Jones, S. R., Rizzo, M., Glasser, S. P., et al. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.08.021 · Cited by 198 · see citing works
Statin therapy and plasma coenzyme Q10 concentrations—A systematic review and meta-analysis of placebo-controlled trials
Banach, M., Serban, C., Ursoniu, S., Rysz, J., Muntner, P., Toth, P. P., Jones, S. R., Rizzo, M., Glasser, S. P., Watts, G. F., et al. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.07.008 · Cited by 195 · see citing works
Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients
Portakal, O., Özkaya, Ö., İnal, M., Bozan, B., Koşan, M., & Sayek, İ. (2000) · Clinical Biochemistry · doi:10.1016/s0009-9120(00)00067-9 · Cited by 194 · see citing works
Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus
Watts, G. F., Playford, D. A., Croft, K. D., Ward, N. C., Mori, T. A., & Burke, V. (2002) · Diabetologia · doi:10.1007/s00125-001-0760-y · Cited by 193 · see citing works
Coenzyme Q10 effects in neurodegenerative disease
Henchcliffe, C. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s5212 · Cited by 188 · see citing works
Human Coenzyme Q10 Deficiency
Quinzii, C. M., DiMauro, S., & Hirano, M. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9190-z · Cited by 188 · see citing works
Safety assessment of coenzyme Q 10 (CoQ 10 )
Hidaka, T., Fujii, K., Funahashi, I., Fukutomi, N., & Hosoe, K. (2008) · BioFactors · doi:10.1002/biof.5520320124 · Cited by 187 · see citing works
Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10
Somayajulu, M., McCarthy, S., Hung, M.-Y., Sikorska, M., Borowy‐Borowski, H., & Pandey, S. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.021 · Cited by 183 · see citing works
Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment
Yasueda, A., Urushima, H., & Ito, T. (2015) · Integrative Cancer Therapies · doi:10.1177/1534735415610427 · Cited by 180 · see citing works
Oxidative Stress, Diabetes, and Diabetic Complications
Wei, W., Liu, Q., Tan, Y., Liu, L., Li, X., & Cai, L. (2009) · Hemoglobin · doi:10.3109/03630260903212175 · Cited by 178 · see citing works
Open Label Trial of Coenzyme Q10 as A Migraine Preventive
Rozen, T., Oshinsky, M. L., Gebeline, C., Bradley, K., Young, W., Shechter, A. L., & Silberstein, S. (2002) · Cephalalgia · doi:10.1046/j.1468-2982.2002.00335.x · Cited by 174 · see citing works
Coenzyme Q biosynthesis and its role in the respiratory chain structure
Alcázar‐Fabra, M., Navas, P., & Brea‐Calvo, G. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.03.010 · Cited by 173 · see citing works
Coenzyme Q10 for Prevention of Anthracycline-Induced Cardiotoxicity
Conklin, K. A. (2005) · Integrative Cancer Therapies · doi:10.1177/1534735405276191 · Cited by 165 · see citing works
Coenzyme Q10 and male infertility: a meta-analysis
Lafuente, R., González-Comadran, M., Solà, I., López, G., Brassesco, M., Carreras, R., & Checa, M. Á. (2013) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-013-0047-5 · Cited by 159 · see citing works
Trends in the food and sports nutrition industry: A review
Arenas‐Jal, M., Suñé-Negre, J. M., Pérez‐Lozano, P., & García‐Montoya, E. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1643287 · Cited by 156 · see citing works
Self-citation
Coenzyme Q10 Therapy
Garrido‐Maraver, J., Cordero, M. D., Oropesa-Ávila, M., Fernández-Vega, A., de la Mata, M., Pavón, A. D., de Miguel, M., Calero, C. P., Paz, M. V., Cotán, D., et al. (2014) · Molecular Syndromology · doi:10.1159/000360101 · Cited by 154 · see citing works
Coenzyme Q10 and Heart Failure
Sharma, A., Fonarow, G. C., Butler, J., Ezekowitz, J. A., & Felker, G. M. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002639 · Cited by 150 · see citing works
Warfarin and its interactions with foods, herbs and other dietary supplements
Nutescu, E. A., Shapiro, N. L., Ibrahim, S., & West, P. (2006) · Expert Opinion on Drug Safety · doi:10.1517/14740338.5.3.433 · Cited by 149 · see citing works
Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization
López‐Lluch, G., del Pozo-Cruz, J., Sánchez‐Cuesta, A., Cortés-Rodríguez, A. B., & Navas, P. (2018) · Nutrition · doi:10.1016/j.nut.2018.05.020 · Cited by 145 · see citing works
Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials
Gao, L., Mao, Q., Cao, J. J., Wang, Y., Zhou, X., & Li, F. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.10.027 · Cited by 139 · see citing works
Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial
Nadjarzadeh, A., Shidfar, F., Amirjannati, N., Vafa, M., Motevalian, S. A., Gohari, M. R., Kakhki, S. A. N., Akhondi, M. M., & Sadeghi, M. R. (2013) · Andrologia · doi:10.1111/and.12062 · Cited by 138 · see citing works
Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure
Rosenfeldt, F., Hilton, D. J., Pepe, S., et al. (2003) · BioFactors · doi:10.1002/biof.5520180211 · Cited by 135 · see citing works
Therapeutic use of coenzyme Q 10 and coenzyme Q 10 -related compounds and formulations
Villalba, J. M., Parrado‐Fernández, C., González, M. S., & Alcain, F. J. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543781003727495 · Cited by 134 · see citing works
Anti‐inflammatory effects of CoQ10 and colorless carotenoids
Fuller, B. B., Smith, D. R., Howerton, A., & Kern, D. G. (2006) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2006.00220.x · Cited by 132 · see citing works
Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis'
Chew, G., & Watts, G. F. (2004) · QJM · doi:10.1093/qjmed/hch089 · Cited by 132 · see citing works
The uptake and distribution of coenzyme Q(10)
Miles, M. V. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.012 · Cited by 126 · see citing works
Coenzymes Q9and Q10: Contents in Foods and Dietary Intake
Mattila, P. H., & Kumpulainen, J. T. (2001) · Journal of Food Composition and Analysis · doi:10.1006/jfca.2000.0983 · Cited by 125 · see citing works
Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation
Potgieter, M., Pretorius, E., & Pepper, M. S. (2013) · Nutrition Reviews · doi:10.1111/nure.12011 · Cited by 124 · see citing works
Encyclopedia of Human Nutrition
(2014) · Choice Reviews Online · doi:10.5860/choice.51-5352 · Cited by 121 · see citing works
Statin-Induced Rhabdomyolysis: A Comprehensive Review of Case Reports
Mendes, P. L., Robles, P., & Mathur, S. (2013) · Physiotherapy Canada · doi:10.3138/ptc.2012-65 · Cited by 119 · see citing works
Oxidative stress induced sperm DNA damage, a possible reason for male infertility.
Hosen, M. B., Islam, M. R., Begum, F., Kabir, Y., & Howlader, M. Z. H. (2015) · Europe PMC (PubMed Central) · Cited by 119 · see citing works
Risk assessment for coenzyme Q10 (Ubiquinone)
Hathcock, J. N., & Shao, A. (2006) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2006.05.006 · Cited by 114 · see citing works
The clinical use of HMG CoA‐reductase inhibitors and the associated depletion of coenzyme Q <sub>10</sub> . A review of animal and human publications
Langsjoen, P. H., & Langsjoen, A. M. (2003) · BioFactors · doi:10.1002/biof.5520180212 · Cited by 112 · see citing works
Discontinuation of statin therapy due to muscular side effects: A survey in real life
Rosenbaum, D., Dallongeville, J., Sabouret, P., & Bruckert, E. (2013) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.04.012 · Cited by 111 · see citing works
Primary and secondary CoQ10 deficiencies in humans
Quinzii, C. M., & Hirano, M. (2011) · BioFactors · doi:10.1002/biof.155 · Cited by 111 · see citing works
Enhancement of solubility and dissolution of Coenzyme Q10 using solid dispersion formulation
Nepal, P. R., Han, H.-K., & Choi, H. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.09.031 · Cited by 111 · see citing works
The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study
Safarinejad, M. R. (2011) · International Urology and Nephrology · doi:10.1007/s11255-011-0081-0 · Cited by 110 · see citing works
Distribution of antioxidants among blood components and lipoproteins: Significance of lipids/CoQ10 ratio as a possible marker of increased risk for atherosclerosis
Tomasetti, M., Alleva, R., Solenghi, M. D., & Littarru, G. P. (1999) · BioFactors · doi:10.1002/biof.5520090218 · Cited by 109 · see citing works
Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage
Niklowitz, P., Sonnenschein, A., Janetzky, B., Andler, W., & Menke, T. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.257 · Cited by 109 · see citing works
Coenzyme q10 and statin-induced mitochondrial dysfunction.
Deichmann, R. E., Lavie, C. J., & Andrews, S. S. (2010) · PubMed Central · Cited by 107 · see citing works
Optimization in the Preparation of Coenzyme Q 10 Nanoliposomes
Xia, S., Shi-ying, X., & Zhang, X. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060405o · Cited by 105 · see citing works
Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice
Witting, P. K., Pettersson, K. S., Letters, J., & Stocker, R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00311-7 · Cited by 104 · see citing works
The Emerging Role of Coenzyme Q-10 in Aging, Neurodegeneration, Cardiovascular Disease, Cancer and Diabetes Mellitus
Dhanasekaran, M., & Ren, J. (2005) · Current Neurovascular Research · doi:10.2174/156720205774962656 · Cited by 104 · see citing works
Biosynthesis and bioproduction of coenzyme Q 10 by yeasts and other organisms
Kawamukai, M. (2009) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20090035 · Cited by 101 · see citing works
Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: A double-blind, randomized, placebo-controlled trial
Ikematsu, H., Nakamura, K., Harashima, S., Fujii, K., & Fukutomi, N. (2006) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2005.12.002 · Cited by 101 · see citing works
Lehninger Principles of Biochemistry, 7th ed
Nelson, D., & Cox, M. (2021) · Cited by 101 · see citing works
Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes
Playford, D. A., Watts, G. F., Croft, K. D., & Burke, V. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00417-3 · Cited by 97 · see citing works
Enhancement of oral bioavailability of coenzyme Q10 by complexation with γ-cyclodextrin in healthy adults
Terao, K., Nakata, D., Fukumi, H., et al. (2006) · Nutrition Research · doi:10.1016/j.nutres.2006.08.004 · Cited by 94 · see citing works
Safety and tolerability of high‐dosage coenzyme Q10 in Huntington's disease and healthy subjects
The Huntington Study Group Pre2CARE Investigators (2010) · Movement Disorders · doi:10.1002/mds.22408 · Cited by 91 · see citing works
The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials
Zhu, Z., Sun, M.-X., Zhang, W., Wang, W., Jin, Y.-M., & Xie, C. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2757-9 · Cited by 88 · see citing works
Cellular factories for coenzyme Q10 production
Lee, S. Q. E., Tan, T. S., Kawamukai, M., & Chen, E. S. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0646-4 · Cited by 86 · see citing works
Strategies for oral delivery and mitochondrial targeting of CoQ10
Zaki, N. M. (2014) · Drug Delivery · doi:10.3109/10717544.2014.993747 · Cited by 85 · see citing works
Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers
Dahri, M., Tarighat‐Esfanjani, A., Jafarabadi, M. A., & Hashemilar, M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1421039 · Cited by 85 · see citing works
CoQ10 a super-vitamin: review on application and biosynthesis
Shukla, S., & Dubey, K. K. (2018) · 3 Biotech · doi:10.1007/s13205-018-1271-6 · Cited by 85 · see citing works
Coenzyme Q10 Reduces β-Amyloid Plaque in an APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease
Yang, X., Dai, G., Li, G., & Yang, E. S. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9297-1 · Cited by 83 · see citing works
Preparation and characterization of liposomal coenzyme Q10 for in vivo topical application
Lee, W.-C., & Tsai, T. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.05.006 · Cited by 81 · see citing works
HMG-CoA reductase inhibitors and coenzyme Q10
Nawarskas, J. J. (2005) · Cardiology in Review · doi:10.1097/01.crd.0000154790.42283.a1 · Cited by 80 · see citing works
Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction
Yang, Y.-K., Wang, L.-P., Chen, L., Yao, X.-P., Yang, K.-Q., Gao, L.-G., & Zhou, X.-L. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.08.002 · Cited by 78 · see citing works
Efficacy of Coenzyme Q10 for Improved Tolerability of Cancer Treatments: A Systematic Review
Roffe, L., Schmidt, K., & Ernst, E. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.02.034 · Cited by 78 · see citing works
Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines
Brea‐Calvo, G., Hernández, M., Fernández‐Ayala, D. J. M., Navas, P., & Sánchez-Alcázar, J. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.11.014 · Cited by 75 · see citing works
Microencapsulation of ubiquinone-10 in carbohydrate matrices for improved stability
Bule, M. V., Singhal, R. S., & Kennedy, J. F. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.07.012 · Cited by 75 · see citing works
Coenzyme Q10 supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise
Díaz‐Castro, J., Guisado, R., Kajarabille, N., García, C., Guisado-Requena, I. M., de Teresa, C., & Ochoa, J. J. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0257-5 · Cited by 75 · see citing works
The advantages of a novel CoQ10 delivery system in skin photo-protection
Yue, Y., Zhou, H., Liu, G., Li, Y., Yan, Z., & Duan, M. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.03.032 · Cited by 74 · see citing works
Pharmacokinetic study of deuterium-labelled coenzyme Q10 in man.
Tomono, Y., Hasegawa, J., Seki, T., Motegi, K., & Morishita, N. (1986) · PubMed · Cited by 73 · see citing works
The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial
Parohan, M., Sarraf, P., Javanbakht, M. H., et al. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1627770 · Cited by 73 · see citing works
A study of oxidative stress in migraine with special reference to prophylactic therapy
Tripathi, G. M., Kalita, J., & Misra, U. K. (2017) · International Journal of Neuroscience · doi:10.1080/00207454.2017.1374959 · Cited by 69 · see citing works
Coenzyme Q(10) in male infertility: physiopathology and therapy.
Mancini, A., & Balercia, G. (2011) · Biofactors · doi:10.1002/biof.164 · Cited by 68 · see citing works
Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model
Bhagavan, H. N., Chopra, R. K., Craft, N. E., Chitchumroonchokchai, C., & Failla, M. L. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.007 · Cited by 67 · see citing works
Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease
Flowers, N., Hartley, L., Todkill, D., Stranges, S., & Rees, K. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010405.pub2 · Cited by 64 · see citing works
Deficit of Coenzyme Q in Heart and Liver Mitochondria of Rats with Streptozotocin-Induced Diabetes
Kucharská, J., Braunová, Z., Uličná, O., et al. (2000) · Physiological Research · doi:10.33549/physiolres.930000.49.411 · Cited by 64 · see citing works
Studies of CoQ10 and cyclodextrin complexes: solubility, thermo- and photo-stability
Fir, M., Šmidovnik, A., Milivojević, L., et al. (2009) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-009-9555-4 · Cited by 63 · see citing works
Bioavailability Enhancement of Coenzyme Q10: An Extensive Review of Patents
Beg, S., Javed, S., & JKohli, K. (2010) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/187221110793237565 · Cited by 61 · see citing works
Coenzyme Q10 for the treatment of heart failure: a review of the literature
DiNicolantonio, J. J., Bhutani, J., McCarty, M. F., & O’Keefe, J. H. (2015) · Open Heart · doi:10.1136/openhrt-2015-000326 · Cited by 61 · see citing works
Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans
Östman, B., Sjödin, A. M., Michaëlsson, K., & Byberg, L. (2011) · Nutrition · doi:10.1016/j.nut.2011.07.010 · Cited by 60 · see citing works
Neuroprotective Actions of Coenzyme Q10 in Parkinson's Disease
Sharma, S., Kheradpezhou, M., Shavali, S., Refaey, H. E., Eken, J., Hagen, C., & Ebadi, M. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)82027-5 · Cited by 60 · see citing works
Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial
Shoeibi, A., Olfati, N., Sabi, M. S., Salehi, M., Mali, S., & Oryani, M. A. (2016) · Acta Neurologica Belgica · doi:10.1007/s13760-016-0697-z · Cited by 60 · see citing works
Coenzyme Q and vitamin E need each other as antioxidants
Kagan, V. E., Fabisiak, J. P., & Quinn, P. J. (2000) · PROTOPLASMA · doi:10.1007/bf02524257 · Cited by 58 · see citing works
The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials
Qu, H., Meng, Y., Chai, H., Liang, F., Zhang, J., Gao, Z.-Y., & Shi, D. (2018) · European journal of medical research · doi:10.1186/s40001-018-0353-6 · Cited by 58 · see citing works
Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression
Rusciani, L., Proietti, I., Rusciani, A., et al. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.08.031 · Cited by 56 · see citing works
Lipophilic antioxidants in neurodegenerative diseases
Chang, K., Cheng, M., Chiang, M.-C., & Chen, C. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.06.031 · Cited by 55 · see citing works
TPGS-chitosome as an effective oral delivery system for improving the bioavailability of Coenzyme Q10
Shao, Y.-T., Yang, L., & Han, H. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.12.026 · Cited by 54 · see citing works
Coenzyme Q10 production in plants: current status and future prospects
Parmar, S. S., Jaiwal, A., Dhankher, O. P., & Jaiwal, P. K. (2013) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2013.823594 · Cited by 52 · see citing works
Spray-drying microencapsulation of CoQ 10 in olive oil for enhanced water dispersion, stability and bioaccessibility: Influence of type of emulsifiers and/or wall materials
Zhao, X., & Tang, C. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.04.045 · Cited by 52 · see citing works
Behavioral Improvement after Chronic Administration of Coenzyme Q10 in P301S Transgenic Mice
Elipenahli, C., Stack, C., Jainuddin, S., Gerges, M., Yang, L., Starkov, A. A., Beal, M. F., & Dumont, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111190 · Cited by 48 · see citing works
Comparison of the relative bioavailability of different coenzyme Q 10 formulations with a novel solubilizate (Solu™ Q10)
Schulz, C., Obermüller-Jevic, U. C., Hasselwander, O., Bernhardt, J. H., & Biesalski, H. K. (2006) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480601058320 · Cited by 48 · see citing works
Coenzyme Q10 and Neurological Diseases
Mancuso, M., Orsucci, D., Calsolaro, V., Choub, A., & Siciliano, G. (2009) · Pharmaceuticals · doi:10.3390/ph203134 · Cited by 46 · see citing works
Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose–response meta-analysis of randomized controlled trials
Parohan, M., Sarraf, P., Javanbakht, M. H., et al. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1572940 · Cited by 43 · see citing works
Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system.
Liu, Z.-X., & Artmann, C. (2009) · PubMed · Cited by 41 · see citing works
An update of Coenzyme Q10 implications in male infertility: Biochemical and therapeutic aspects
Mancini, A., Marinis, L. D., Littarru, G. P., et al. (2005) · BioFactors · doi:10.1002/biof.5520250119 · Cited by 38 · see citing works
Coenzyme Q10 levels in human seminal fluid: Diagnostic and clinical implications
Mancini, A., Conte, B., Marinis, L. D., et al. (1994) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(94)90035-3 · Cited by 38 · see citing works
Coenzyme Q10 Supplementation Decreases Oxidative Stress and Improves Physical Performance in Young Swimmers: A Pilot Study
Leelarungrayub, D., Sawattikanon, N., Klaphajone, J., et al. (2010) · The Open Sports Medicine Journal · doi:10.2174/1874387001004010001 · Cited by 37 · see citing works
Coenzyme Q10 oral bioavailability: effect of formulation type
Barakat, A., Shegokar, R., Dittgen, M., & Müller, R. H. (2013) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-013-0101-4 · Cited by 35 · see citing works
Novel Carriers for Coenzyme Q10 Delivery
Kumar, S., Rao, R., Kumar, A., et al. (2016) · Current Drug Delivery · doi:10.2174/1567201813666160104130631 · Cited by 35 · see citing works
Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review
Ayers, J., Cook, J., Koenig, R. A., Sisson, E. M., & Dixon, D. L. (2018) · Current Atherosclerosis Reports · doi:10.1007/s11883-018-0730-1 · Cited by 35 · see citing works
Effect of Coenzyme Q10, Riboflavin and Niacin on Serum CEA and CA 15-3 Levels in Breast Cancer Patients Undergoing Tamoxifen Therapy
Premkumar, V. G., Yuvaraj, S., Vijayasarathy, K., et al. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.367 · Cited by 33 · see citing works
Bioavailability and Sustained Plasma Concentrations of CoQ10 in Healthy Volunteers by a Novel Oral Timed-Release Preparation
Martucci, A., Reurean‐Pintilei, D., & Manole, A. (2019) · Nutrients · doi:10.3390/nu11030527 · Cited by 33 · see citing works
Coenzyme Q10 as Treatment for Statin-Associated Muscle Symptoms—A Good Idea, but…
Zaleski, A. L., Taylor, B. A., & Thompson, P. D. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy010 · Cited by 32 · see citing works
Tunneling Effect in Regeneration Reaction of Vitamin E by Ubiquinol
Ouchi, A., Nagaoka, S., & Mukai, K. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp910856m · Cited by 31 · see citing works
Efficacy of CoQ10 as supplementation for migraine: A meta-analysis
Zeng, Z., Li, Y., Lu, S.-Y., Huang, W., & Di, W. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.13051 · Cited by 30 · see citing works
Increased oxidative stress and coenzyme Q10 deficiency in centenarians
Nagase, M., Yamamoto, Y., Matsumoto, N., Arai, Y., & Hirose, N. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.17.124 · Cited by 30 · see citing works
Antioxidant level and redox status of coenzyme Q10in the plasma and blood cells of children with diabetes mellitus type 1
Menke, T., Niklowitz, P., Wiesel, T., & Andler, W. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2008.00389.x · Cited by 29 · see citing works
Efficacy of coenzyme Q10 for the prevention of migraine in women: A randomized, double-blind, placebo-controlled study
Dahri, M., Hashemilar, M., Jafarabadi, M. A., & Tarighat‐Esfanjani, A. (2017) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2017.10.003 · Cited by 29 · see citing works
Enhanced production techniques, properties and uses of coenzyme Q10
Ndikubwimana, J. D. D., & Lee, B. H. (2014) · Biotechnology Letters · doi:10.1007/s10529-014-1587-1 · Cited by 28 · see citing works
The effect of short-term coenzyme Q10supplementation and pre-cooling strategy on cardiac damage markers in elite swimmers
Emami, A., Tofighi, A., Asri‐Rezaei, S., & Bazargani‐Gilani, B. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114517003774 · Cited by 28 · see citing works
Statins’ effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation
Littlefield, N., Beckstrand, R. L., & Luthy, K. E. (2013) · Journal of the American Association of Nurse Practitioners · doi:10.1002/2327-6924.12046 · Cited by 27 · see citing works
What You Need to Know About Dietary Supplements
Vogelzang, J. L. (2001) · Home Healthcare Now · doi:10.1097/00004045-200101000-00016 · Cited by 27 · see citing works
A novel tool for the prediction of tablet sticking during high speed compaction
Abdel-Hamid, S. M., & Betz, G. (2011) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2011.580761 · Cited by 26 · see citing works
Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes
Li, H., & Chen, F. (2015) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2015.10.025 · Cited by 23 · see citing works
The Plasma Bioavailability of Coenzyme Q10 Absorbed from the Gut and the Oral Mucosa
Vitetta, L., Leong, A., Zhou, J., Forno, S. D., Hall, S., & Rutolo, D. (2018) · Journal of Functional Biomaterials · doi:10.3390/jfb9040073 · Cited by 23 · see citing works
Recombinant interferon α-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-α and 5-year follow-up
Rusciani, L., Proietti, I., Paradisi, A., et al. (2007) · Melanoma Research · doi:10.1097/cmr.0b013e32818867a0 · Cited by 22 · see citing works
Predicting the Occurrence of Sticking during Tablet Production by Shear Testing of a Pharmaceutical Powder
Nakamura, S., Otsuka, N., Yoshino, Y., et al. (2016) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c15-00992 · Cited by 22 · see citing works
Regional permeability of coenzyme Q10 in isolated rat gastrointestinal tracts.
Palamakula, A., Soliman, M., & Khan, M. A. (2005) · PubMed · Cited by 22 · see citing works
Serum coenzyme Q10 levels as a predictor of dementia in a Japanese general population
Momiyama, Y. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.08.056 · Cited by 20 · see citing works
Co-Enzyme Q10 to Treat Neurological Disorders: Basic Mechanisms, Clinical Outcomes, and Future Research Direction
Salama, M., Yuan, T., Machado, S. E. D. C., Murillo‐Rodríguez, E., Vega, J. A., Menéndez‐González, M., Nardi, A. E., & Arias-Carrión, Ó. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113129990071 · Cited by 20 · see citing works
Increased oxidative stress and coenzyme Q10 deficiency in centenarians.
Nagase, M., Yamamoto, Y., Matsumoto, N., et al. (2018) · PubMed · doi:10.3164/jcbn.17-124 · Cited by 20 · see citing works
Dictionary of nutraceuticals and functional foods
(2006) · Choice Reviews Online · doi:10.5860/choice.43-5633 · Cited by 19 · see citing works
Pharmacokinetics of coenzyme Q10
Каленикова, Е. И., Gorodetskaya, E. A., & Os, M. (2008) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-008-0270-8 · Cited by 15 · see citing works
Vitamin C supplementation for the primary prevention of cardiovascular disease
Flowers, N., Wheelhouse, R., Stranges, S., & Rees, K. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011114 · Cited by 13 · see citing works
Scientific Opinion on the substantiation of health claims related to coenzyme Q10 and contribution to normal energy-yielding metabolism (ID 1508, 1512, 1720, 1912, 4668), maintenance of normal blood pressure (ID 1509, 1721, 1911), protection of DNA, prote
EFSA Panel on Dietetic Products, N. A. A. (. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1793 · Cited by 12 · see citing works
The effect of coenzyme Q10 on the pharmacokinetic parameters of theophylline
Baskaran, R., Shanmugam, S., Nagayya-Sriraman, S., Kim, J. H., Jeong, T. C., Yong, C. S., Choi, H.-G., & Yoo, B. K. (2008) · Archives of Pharmacal Research · doi:10.1007/s12272-001-1250-1 · Cited by 9 · see citing works
Coenzyme Q10 and its Effective Sources
Vaghari, H., Vaghari, R., Jafarizadeh‐Malmiri, H., et al. (2016) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2016.214.219 · Cited by 8 · see citing works
Effects of short-term coenzyme Q10 supplementation on markers of oxidative stress and inflammation after downhill running in male mountaineers
Abdizadeh, L., Jafari, A., & Armanfar, M. (2015) · Science & Sports · doi:10.1016/j.scispo.2015.02.012 · Cited by 7 · see citing works

Flagged first, then by citations

Research works printed but not linked: 7

Bonakdar, R. A., & Guarneri, E. (2005). Coenzyme Q10. American Fam- ily Physician, 72(6), 1065-1070.
Hosen, M. B., Islam, M. R., Begum, F., Kabir, Y. & Howlader, M. Z. H. (2015). Oxidative stress induced sperm DNA dam- age, a possible reason for male infertility. Iranian Jour- nal of Reproductive Medicine, 13, 525. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637119/
Mason, P. (Ed.). (2018). Coenzyme Q10. Dietary supplements. London: Pharmaceutical Press. Retrieved from www.medicinescomplete.com
O'Neil, M. J. (2013). The merck index (15th ed.). Cambridge: Royal Society of Chemistry. Retrieved from https://pubs.rsc.org/en/ content/ebook/978-1-84973-670-1
PubChem. (2019). NADH. Retrieved from https://pubchem.ncbi.nlm. nih.gov/compound/1_4-Dihydronicotinamide-adenine-dinucle otide#section=2D-Structure
ED · DOI
Ubidecarenone. (2019). European pharmacopoeia online (9th ed.). Retrieved from http://online.edqm.eu/EN/entry.htm

Sorted by citations

Changes in the Biomarkers of Oxidative/Nitrosative Stress and Endothelial Dysfunction Are Associated with Cardiovascular Risk in Periodontitis Patients
Ferlazzo, N., Currò, M., Isola, G., Maggio, S., Bertuccio, M. P., Trovato-Salinaro, A., Matarese, G., Alibrandi, A., Caccamo, D., & Ientile, R. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43020051 · Cited by 27 · see citing works
Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?
El-Bassouny, D. R., Mansour, A. A., Ellakkany, A. S., Ayuob, N. N., & AbdElfattah, A. A. (2023) · Histochemistry and Cell Biology · doi:10.1007/s00418-023-02205-5

Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases
Beal, M. F., & Matthews, R. T. (1997) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(97)00024-1 · Cited by 58 · see citing works
Neuroprotective Effect of Coenzyme Q10 in Hippocampal Injury in Balb/c Mouse
Rigi, S., Sakhaei, A., Asl, A. N., et al. (2014)
Heart Failure—Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10
Filipiak, K. J., Surma, S., Romańczyk, M., & Okopień, B. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9050161 · Cited by 5 · see citing works
Administration of coenzyme Q10 to a diabetic rat model: changes in biochemical, antioxidant, and histopathological indicators
Peter, J. S., Shalini, M., Giridharan, R., Basha, K. S., Baskaran, U. L., & Prince, S. E. (2019) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-019-00752-z · Cited by 3 · see citing works
Indian Public Health Students' Perspectives on Global Health Education
Sawleshwarkar, S., ZODPEY, S. P., & Negin, J. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2020.614744 · Cited by 2 · see citing works

Authors: Arenas‐Jal, M., Suñé‐Negre, J. M., & García‐Montoya, E.
Affiliations: Universitat de Barcelona (ES)
Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy and Food Sciences University of Barcelona Barcelona Spain
Corresponding author: Arenas‐Jal, Marta
ORCID: Arenas‐Jal, Marta
Suñé‐Negre, J. M.
García‐Montoya, Encarna
Venue: Comprehensive Reviews in Food Science and Food Safety
Publisher: Wiley
Published: 2020-02-19
Volume: 19
Issue: 2
Pages: 574-594
ISSN: 1541-4337 (ISSN-L)
DOI: 10.1111/1541-4337.12539
OpenAlex: W3006824993
Cited by: 239
References: 154
Citations by year: 2026: 37 · 2025: 50 · 2024: 58 · 2023: 42 · 2022: 32 · 2021: 15 · 2020: 4 · 2013: 1
FWCI: 2.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Comprehensive Reviews in Food Science and Food Safety (publishedVersion)
PubMed (publishedVersion)
Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
Funders: Agència de Gestió d'Ajuts Universitaris i de Recerca (2015DI021)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords: coenzyme Q10, dietary supplementation, supplement efficacy, supplement safety, supplement formulation, non-communicable diseases, cardiovascular disease, neurodegenerative diseases, diabetes mellitus, population aging
MeSH terms: Antioxidants, Humans, Ubiquinone, Dietary Supplements

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Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

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